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Tytuł pozycji:

Developmental fluoride neurotoxicity: an updated review

Tytuł:
Developmental fluoride neurotoxicity: an updated review
Autorzy:
Philippe Grandjean
Temat:
Cognitive disorder
Dental caries
Drinking water
Fluoridation
Fluoride poisoning
Intellectual disability
Industrial medicine. Industrial hygiene
RC963-969
Public aspects of medicine
RA1-1270
Źródło:
Environmental Health, Vol 18, Iss 1, Pp 1-17 (2019)
Wydawca:
BMC, 2019.
Rok publikacji:
2019
Kolekcja:
LCC:Industrial medicine. Industrial hygiene
LCC:Public aspects of medicine
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1476-069X
Relacje:
https://doaj.org/toc/1476-069X
DOI:
10.1186/s12940-019-0551-x
Dostęp URL:
https://doaj.org/article/fbce0974c4e74b66a49fd27e7122bec6  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.fbce0974c4e74b66a49fd27e7122bec6
Czasopismo naukowe
Abstract Background After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice results in elevated fluoride intake and has become controversial for two reasons. First, topical fluoride application in the oral cavity appears to be a more direct and appropriate means of preventing caries. Second, systemic fluoride uptake is suspected of causing adverse effects, in particular neurotoxicity during early development. The latter is supported by experimental neurotoxicity findings and toxicokinetic evidence of fluoride passing into the brain. Method An integrated literature review was conducted on fluoride exposure and intellectual disability, with a main focus on studies on children published subsequent to a meta-analysis from 2012. Results Fourteen recent cross-sectional studies from endemic areas with naturally high fluoride concentrations in groundwater supported the previous findings of cognitive deficits in children with elevated fluoride exposures. Three recent prospective studies from Mexico and Canada with individual exposure data showed that early-life exposures were negatively associated with children’s performance on cognitive tests. Neurotoxicity appeared to be dose-dependent, and tentative benchmark dose calculations suggest that safe exposures are likely to be below currently accepted or recommended fluoride concentrations in drinking water. Conclusion The recent epidemiological results support the notion that elevated fluoride intake during early development can result in IQ deficits that may be considerable. Recognition of neurotoxic risks is necessary when determining the safety of fluoride-contaminated drinking water and fluoride uses for preventive dentistry purposes.
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