Usefulness of lymphocyte transformation test and in vitro cytokine release in differentiating between independent and cross‐reacting nickel/palladium allergy

Tytuł:: Usefulness of lymphocyte transformation test and in vitro cytokine release in differentiating between independent and cross‐reacting nickel/palladium allergy
Autorzy:: Florian Kapp
Burkhard Summer
Peter Thomas
Temat:: cross‐reactivity
IL‐5
LTT
metals
nickel
palladium
Immunologic diseases. Allergy
RC581-607
Źródło:: Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 483-492 (2020)
Wydawca:: Wiley, 2020.
Rok publikacji:: 2020
Kolekcja:: LCC:Immunologic diseases. Allergy
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 2050-4527
Relacje:: https://doaj.org/toc/2050-4527
DOI:: 10.1002/iid3.329
Dostęp URL:: https://doaj.org/article/fbf1d8daa3764aa2bc7d4f02d2b5d896 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.fbf1d8daa3764aa2bc7d4f02d2b5d896
: Czasopismo naukowe

Pełny tekst

Abstract Background Often concomitant patch test (PT) reactivity to palladium (Pd) and nickel (Ni) is found. Objectives To determine whether lymphocyte transformation test (LTT) could be useful in discrimination between cross‐reacting or distinct PT results, and to compare the results with in vitro cytokine production upon Pd or Ni stimulation. Materials and Methods The study population consisted of two groups: 13 individuals with Pd PT reactions (10 with concomitant Ni PT reaction, 3 individuals with only Pd PT reactivity) and 10 Ni/Pd PT negative individuals. LTT and assessment of cytokine release (interferon‐gamma, interleukin‐5 [IL‐5], IL‐8, IL‐17A, tumor necrosis factor alpha) by cytometric bead assay were performed. Results All 10 patients with positive PT to Ni and Pd showed positive LTT to Ni (P

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