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Tytuł pozycji:

A practical nomogram and risk stratification system predicting the cancer‐specific survival for patients with early hepatocellular carcinoma

Tytuł :
A practical nomogram and risk stratification system predicting the cancer‐specific survival for patients with early hepatocellular carcinoma
Autorzy :
Bing Yan
Bing‐Bing Su
Dou‐Sheng Bai
Jian‐Jun Qian
Chi Zhang
Sheng‐Jie Jin
Guo‐Qing Jiang
Pokaż więcej
Temat :
cancer‐specific survival
hepatocellular carcinoma
nomogram
predict
risk stratification
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło :
Cancer Medicine, Vol 10, Iss 2, Pp 496-506 (2021)
Wydawca :
Wiley, 2021.
Rok publikacji :
2021
Kolekcja :
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
2045-7634
Relacje :
https://doaj.org/toc/2045-7634
DOI :
10.1002/cam4.3613
Dostęp URL :
https://doaj.org/article/fcca3f8474924871a55c52bf772e9204
Numer akcesji :
edsdoj.fcca3f8474924871a55c52bf772e9204
Czasopismo naukowe
Abstract Background Our purpose was to establish and validate a nomogram model in early hepatocellular carcinoma (HCC) patients for predicting the cancer‐specific survival (CSS). Methods We extracted eligible data of relevant patients between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Further, we divided all patients into two groups (training and validation cohorts) at random (7:3). Nomogram was established using effective risk factors based on univariate and multivariate analysis. The effective performance of nomogram was evaluated using concordance index (C‐index), calibration plots, decision curve analysis (DCA), and receiver operating characteristic curve (ROC). Results We selected 3620 patients with early HCC including the training cohort (70%, 2536) and the validation cohort (30%, 1084). The nomogram‐related C‐indexes were 0.755 (95% CI: 0.739–0.771) and 0.737 (95% CI: 0.712–0.762), in the training and validation cohorts, respectively. The calibration plots showed good consistency of 3‐and 5‐year CSS between the actual observation and the nomogram prediction. The 3‐, 5‐year DCA curves also indicated that the nomogram has excellent clinical utility. The 3‐, 5‐year area under curve (AUC) of ROC in the training cohort were 0.783, 0.779, respectively, and 0.767, 0.766 in the validation cohort, respectively. With the establishment of nomogram, a risk stratification system was also established that could divide all patients into three risk groups, and the CSS in different groups (i.e., low risk, intermediate risk, and high risk) had a good regional division. Conclusions We developed a practical nomogram in early HCC patients for predicting the CSS, and a risk stratification system follow arisen, which provided an applicable tool for clinical management.
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