Myocardial native T2 measurement to differentiate light-chain and transthyretin cardiac amyloidosis and assess prognosis

Tytuł:: Myocardial native T2 measurement to differentiate light-chain and transthyretin cardiac amyloidosis and assess prognosis
Autorzy:: Fourat Ridouani
Thibaud Damy
Vania Tacher
Haytham Derbel
François Legou
Islem Sifaoui
Etienne Audureau
Diane Bodez
Alain Rahmouni
Jean-François Deux
Temat:: Amyloidosis
CMR
T2 mapping
Diseases of the circulatory (Cardiovascular) system
RC666-701
Źródło:: Journal of Cardiovascular Magnetic Resonance, Vol 20, Iss 1, Pp 1-11 (2018)
Wydawca:: BMC, 2018.
Rok publikacji:: 2018
Kolekcja:: LCC:Diseases of the circulatory (Cardiovascular) system
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 1532-429X
Relacje:: http://link.springer.com/article/10.1186/s12968-018-0478-3; https://doaj.org/toc/1532-429X
DOI:: 10.1186/s12968-018-0478-3
Dostęp URL:: https://doaj.org/article/cfee185d9dbf45f58cd801b5a5b1745f Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.fee185d9dbf45f58cd801b5a5b1745f
: Czasopismo naukowe

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Abstract Background To assess the diagnostic and prognosis value of myocardial native T2 measurement in the distinction between Light-chain (AL) and Transthyretin (ATTR) cardiac amyloidosis (CA). Methods Forty-four patients with CA (24 AL; 20 ATTR) and 40 healthy subjects underwent 1.5 T cardiovascular magnetic resonance (CMR). They all underwent T1 and T2 mapping (modified Look-Locker inversion recovery), cine and late gadolinium enhancement (LGE) imaging. The Query Amyloid Late Enhancement (QALE) score, myocardial native T2, T1 and extra cellular volume fraction (ECV) were calculated for all patients. Results Of the 44 patients, 36 (82%) exhibited enhancement on LGE images. Mean QALE score of AL (7.9 ± 6) and ATTR (10.5 ± 5) patients were similar (p = 0.6). Myocardial native T2 was significantly (p

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