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Tytuł pozycji:

Dissociation of glutamate and cortical thickness is restricted to regions subserving trait but not state markers in major depressive disorder

Tytuł :
Dissociation of glutamate and cortical thickness is restricted to regions subserving trait but not state markers in major depressive disorder
Autorzy :
MENG LI
METZGER, Coraline D
HEINZE, Hans-Jochen
HUIGUANG HE
WALTER, Martin
WENJING LI
SAFRON, Adam
VAN TOL, Marie-José
LORD, Anton
KRAUSE, Anna Linda
BORCHARDT, Viola
WEIQIANG DOU
GENZ, Axel
Pokaż więcej
Temat :
Aminoacide excitateur
Excitatory aminoacid
Aminoácido excitador
Encéphale
Encephalon
Encéfalo
Neurotransmetteur
Neurotransmitter
Neurotransmisor
Système nerveux central
Central nervous system
Sistema nervioso central
Trouble de l'humeur
Mood disorder
Trastorno humor
Cortex cérébral
Cerebral cortex
Corteza cerebral
Dissociation
Disociación
Epaisseur couche
Layer thickness
Espesor capa
Etat dépressif
Depression
Estado depresivo
Glutamate
Glutamato
Cortical thickness
Major depressive disorder
Sciences biologiques et medicales
Biological and medical sciences
Sciences medicales
Medical sciences
Psychopathologie. Psychiatrie
Psychopathology. Psychiatry
Etude clinique de l'adulte et de l'adolescent
Adult and adolescent clinical studies
Troubles de l'humeur
Mood disorders
Divers
Miscellaneous
Psychologie. Psychanalyse. Psychiatrie
Psychology. Psychoanalysis. Psychiatry
PSYCHOPATHOLOGIE. PSYCHIATRIE
Cognition
Psychology, psychopathology, psychiatry
Psychologie, psychopathologie, psychiatrie
Źródło :
Journal of affective disorders. 169:91-100
Wydawca :
Oxford: Elsevier, 2014.
Rok publikacji :
2014
Opis fizyczny :
print; 10; 1 p.1/4
Materiał oryginalny :
INIST-CNRS
Typ dokumentu :
Article
Opis pliku :
text
Język :
English
Afiliacje autora :
Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany
Leibniz Institute for Neurobiology, Magdeburg, Germany
Center of Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany
State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China
College of Electronic and Control Engineering, Beijing University of Technology, Beijing, China
Department of Psychology, Northwestern University, United States
Neuroimaging Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany
ISSN :
0165-0327
Dostęp URL :
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=28821202
Prawa :
Copyright 2015 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Numer akcesji :
edsfra.28821202
Czasopismo naukowe
Background: The anterior cingulate cortex (ACC) plays an important role in the neuropathology of major depressive disorder (MDD). So far, the effect of local cortical alteration on metabolites in multiple subdivisions of ACC has not been studied. We aimed to investigate structural and biochemical changes and their relationship in the pregenual ACC (pgACC), dorsal ACC (dACC) in MDD. Methods: We obtained magnetic resonance spectroscopy (MRS) in two investigated regions for 24 depressed patients and matched controls. In each region, cortical thickness (CTh) was calculated within a template mask based on its MRS voxel. We investigated neurotransmitter concentrations of Glx, N-acetyl aspartate (NAA), and myo-inositol (m-Ins) in two investigated regions, as well as their relationships with CTh in depressed individuals and healthy controls. Results: Patients showed significantly lower cortical thickness in dACC compared to controls. Glx in dACC significantly correlated with CTh in healthy controls but not MDD patients, while NAA and CTh in dACC significantly correlated in both groups. A marginal decrease of Glx in pgACC was found in the subgroup of more severely depressive patients, compared to the mildly depressed patients. Limitations: Modest sample size and lack of episodes of depression may limit the generalizability of our findings. Conclusion: Our results indicate an abolished CTh-MRS relation in dACC-associated with structural decline-but not in pgACC, where acute MRS alterations prevailed. Our study provides the first evidence of a neurochemical basis explaining some of the inter-individual variability in CTh in MDD.

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