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Tytuł pozycji:

Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG).

Tytuł :
Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG).
Index Terms :
Sciences bio-médicales et agricoles
Adult
Aged
Antineoplastic Agents -- administration & dosage
Antineoplastic Agents -- adverse effects
Antineoplastic Agents -- therapeutic use
Benzofurans -- administration & dosage
Benzofurans -- adverse effects
Benzofurans -- therapeutic use
Breast Neoplasms -- drug therapy
Colorectal Neoplasms -- drug therapy
Female
Head and Neck Neoplasms -- drug therapy
Humans
Indoles -- administration & dosage
Indoles -- adverse effects
Indoles -- therapeutic use
Infusions, Intravenous
Lymphoma, Non-Hodgkin -- drug therapy
Male
Melanoma -- drug therapy
Middle Aged
Neoplasm Staging
Neoplasms -- drug therapy
Neoplasms -- pathology
Ovarian Neoplasms -- drug therapy
Prodrugs -- adverse effects
Prodrugs -- therapeutic use
Stomach Neoplasms -- drug therapy
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2000
Dodane szczegóły :
Pavlidis, N
Aamdal, S
Awada, Ahmad
Calvert, H
Fumoleau, Pierre
Sorio, R
Punt, Cornelis
Verweij, Jaap
van Oosterom, A
Morant, Rudolf
Wanders, Jantien
Hanauske, Axel-R
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53675">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53675
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/53675
uri/info:pmid/10972487
764595394
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn764595394
Zasób elektroniczny
PURPOSE: In a phase II trial, the activity of carzelesin, a cyclopropylpyrroloindole prodrug analog, was assessed. PATIENTS AND METHODS: Carzelesin was used as second- or third-line chemotherapy in patients with breast, ovarian, head and neck cancer and non-Hodgkin's lymphoma, and as first-line chemotherapy in patients with colorectal and gastric cancer and melanoma. The drug was given as a bolus infusion at a 4-weekly dose of 150 microg/m2. A total of 140 patients were entered and a total of 285 courses were administered. RESULTS: In general, the compound was well tolerated. Myelotoxicity was the most common toxicity. Grade 3 and 4 leukopenia was observed in 18.6% of the courses, neutropenia in 20.3%, thrombocytopenia in 16.2% and anemia in 8.7%. Double nadirs were seen in a total of 41 courses for neutrophils, in 40 for leukocytes and in 3 for platelets. Non-hematological toxicity was very mild. Only one partial response in a patient with melanoma was seen. CONCLUSIONS: At this dose and schedule carzelesin did not yield activity in the types of tumors studied.
Clinical Trial
Clinical Trial, Phase II
Journal Article
Multicenter Study
info:eu-repo/semantics/published

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