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Tytuł pozycji:

Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes.

Tytuł :
Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes.
Index Terms :
Sciences bio-médicales et agricoles
Animals
Avoidance Learning -- drug effects
Avoidance Learning -- physiology
Cognition -- drug effects
Cognition -- physiology
Male
Mice
Mice, Knockout
Nicotine -- pharmacology
Physostigmine -- pharmacology
Piperidines -- pharmacology
Pyrazoles -- pharmacology
Receptor, Cannabinoid, CB1 -- deficiency
Receptor, Cannabinoid, CB1 -- drug effects
Receptor, Cannabinoid, CB1 -- genetics
Receptor, Cannabinoid, CB1 -- physiology
Receptors, Nicotinic -- drug effects
Receptors, Nicotinic -- physiology
Scopolamine -- pharmacology
Active avoidance
Cannabinoid
CB1 knockout mice
Cholinergic system
Cognition
Nicotine
Object recognition test
Rimonabant
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2007-03
Dodane szczegóły :
Bura, S Andreea
Castañé, Anna
Ledent, Catherine
Valverde, Olga
Maldonado, Rafael
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/54683
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
2 full-text file(s): info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/restrictedAccess
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/54683
uri/info:doi/10.1038/sj.bjp.0707152
uri/info:pii/0707152
uri/info:pmid/17279087
uri/info:scp/33947323723
uri/info:pmcid/PMC2013866
https://dipot.ulb.ac.be/dspace/bitstream/2013/54683/6/PMC2013866.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/54683/5/54683.pdf
764630076
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn764630076
Zasób elektroniczny
BACKGROUND AND PURPOSE: The objective of this study was to investigate the possible interactions between the cannabinoid and cholinergic systems in memory and learning processes by using genetic and pharmacological approaches in two different behavioural models, the active avoidance and the object recognition test. EXPERIMENTAL APPROACH: The effects induced by nicotine, physostigmine and scopolamine were studied in CB(1) receptor knockout and wild-type mice in the active avoidance paradigm. In addition, the effects of pretreatment with the CB(1) receptor antagonist rimonabant were evaluated on the responses induced by nicotine in the active avoidance and the object recognition tasks in wild-type mice. KEY RESULTS: Nicotine (0.5 mg kg(-1) s.c.) did not modify the performance of CB(1) knockout and wild-type mice in this model, whereas scopolamine (0.5 mgkg(-1) i.p.) impaired the performance in both genotypes. Physostigmine (0.1 mg kg(-1) i.p.) increased the active avoidance performance in wild-type but not in CB(1) knockout mice. Rimonabant (0.3, 1, 3, and 10 mg kg(-1)) did not modify the performance in the active avoidance test, given alone or co-administered with nicotine. In contrast, nicotine enhanced the performance in the object recognition task but this response was attenuated by rimonabant co-administration. CONCLUSIONS AND IMPLICATIONS: The present findings revealed that the cognitive effects of nicotine and physostigmine were attenuated in the absence of CB(1) receptor activity. Scopolamine effects were independent from CB(1) receptors.
Journal Article
Research Support, N.I.H. Extramural
Research Support, Non-U.S. Gov't
FLWIN
info:eu-repo/semantics/published

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