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Tytuł pozycji:

The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10.

Tytuł :
The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10.
Index Terms :
Sciences bio-médicales et agricoles
Animals
Brain -- drug effects
Brain -- metabolism
Conditioning (Psychology) -- drug effects
Conditioning (Psychology) -- physiology
Disease Models, Animal
Drug Synergism
Drug Tolerance -- physiology
Hyperalgesia -- chemically induced
Hyperalgesia -- metabolism
Hyperalgesia -- physiopathology
Hypothalamic Hormones -- metabolism
Hypothalamic Hormones -- pharmacology
Injections, Intraventricular
Mice
Mice, Knockout
Morphine -- agonists
Narcotic Antagonists -- pharmacology
Neural Pathways -- metabolism
Neuropeptides -- metabolism
Neuropeptides -- pharmacology
Opioid Peptides -- metabolism
Pain -- chemically induced
Pain -- metabolism
Pain -- physiopathology
Pain Threshold -- drug effects
Pain Threshold -- physiology
Prolactin-Releasing Hormone
Receptors, G-Protein-Coupled -- genetics
Receptors, G-Protein-Coupled -- physiology
Substance Withdrawal Syndrome -- genetics
Substance Withdrawal Syndrome -- metabolism
Substance Withdrawal Syndrome -- physiopathology
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2005-12
Dodane szczegóły :
Laurent, Patrick
Becker, Jérôme
Valverde, Olga
Ledent, Catherine
de Kerchove d'Exaerde, Alban
Schiffmann, Serge N.
Maldonado, Rafael
Vassart, Gilbert
Parmentier, Marc
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50711">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50711
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
1 full-text file(s): info:eu-repo/semantics/openAccess
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/50711
778634432
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn778634432
Zasób elektroniczny
Prolactin-releasing peptide (PrRP) and its receptor G protein-coupled receptor 10 (GPR10) are expressed in brain areas involved in the processing of nociceptive signals. We investigated the role of this new neuropeptidergic system in GPR10-knockout mice. These mice had higher nociceptive thresholds and stronger stress-induced analgesia than wild-type mice, differences that were suppressed by naloxone treatment. In addition, potentiation of morphine-induced antinociception and reduction of morphine tolerance were observed in mutants. Intracerebroventricular administration of PrRP in wild-type mice promoted hyperalgesia and reversed morphine-induced antinociception. PrRP administration had no effect on GPR10-mutant mice, showing that its effects are mediated by GPR10. Anti-opioid effects of neuropeptide FF were found to require a functional PrRP-GPR10 system. Finally, GPR10 deficiency enhanced the acquisition of morphine-induced conditioned place preference and decreased the severity of naloxone-precipitated morphine withdrawal syndrome. Altogether, our data identify the PrRP-GPR10 system as a new and potent negative modulator of the opioid system.
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published

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