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Tytuł pozycji:

Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy.

Tytuł :
Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy.
Index Terms :
Anatomopathologie
Médecine pathologie humaine
Angiogenesis Inhibitors -- administration & dosage
Animals
Antigens, CD95 -- metabolism
Antimetabolites, Antineoplastic -- administration & dosage
Antineoplastic Combined Chemotherapy Protocols -- pharmacology
Apoptosis -- drug effects
Caspase 3 -- metabolism
Cell Line, Tumor
Chemotherapy, Adjuvant
Deoxycytidine -- administration & dosage -- analogs & derivatives
Epidermal Growth Factor -- metabolism
Indoles -- administration & dosage
Male
Mice
Microvessels -- drug effects
Neovascularization, Pathologic -- drug therapy -- enzymology -- pathology
Pancreatic Neoplasms -- blood supply -- drug therapy -- enzymology -- pathology -- radiotherapy
Pregnancy Proteins -- metabolism
Protein Kinase Inhibitors -- administration & dosage
Pyrroles -- administration & dosage
Radiotherapy, Adjuvant
Time Factors
Vascular Endothelial Growth Factor A -- metabolism
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2009-07
Dodane szczegóły :
Casneuf, Veerle F
Demetter, Pieter
Boterberg, Tom
Delrue, Louke
Peeters, Marc
Van Damme, Nancy
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/110136">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/110136
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/110136
uri/info:pmid/19513511
803485786
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn803485786
Zasób elektroniczny
This work evaluated SU11248 (sunitinib) as a potential therapeutic agent, alone or in combination with the cytotoxic agent gemcitabine or radiotherapy in a murine model of pancreatic cancer. Panc02 cells were injected subcutaneously into HsdOla/MF1 mice (n=222). Treatment was administered during 1 week: sunitinib (SUN), gemcitabine (GEM), radiotherapy (RT), RT+SUN and GEM+SUN. Mice were sacrificed 14 days after treatment. The effect on microvessel density (MVD) was measured by CD31 staining. Apoptosis (sFAS, cleaved caspase-3) and proangiogenic proteins (VEGF, PlGF, EGF) were measured with ELISA and immunohistochemistry. At day 14, tumors in all groups increased significantly despite treatment. Only after RT/SUN treatment tumor growth slowed down, although the accretion was still significant (P=0.033). Highest levels of apoptosis were seen in GEM/SUN, RT/SUN and RT treated mice (respectively P<0.001, P<0.01 and P<0.05 compared to placebo). MVD was lowest in RT/SUN treated mice [compared to placebo (P<0.05), GEM (P<0.05) and GEM/SUN (P<0.01)]. Highest VEGF levels were seen after RT and RT/SUN treatment [vs. placebo (P<0.001) and vs. other treatments (P<0.01 for all comparisons)]. GEM and SUN in monotherapy lead to an up-regulation of PlGF and EGF, respectively. In conclusion, the combination treatments RT/SUN and GEM/SUN result in a more potent anti-angiogenic and antitumor effect when compared to either treatment alone. Multitargeted angiogenesis inhibitor therapy with sunitinib combined with either radiotherapy or gemcitabine may be a novel approach for human pancreatic cancer.
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published

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