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Tytuł pozycji:

Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures

Tytuł :
Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures
Index Terms :
Sciences biomédicales
Biotechnologie
Adult
Cells, Cultured
Chemokines -- blood
Endothelial Cells -- cytology -- metabolism
Female
Fractures, Ununited -- blood -- metabolism
Humans
Male
Mesenchymal Stromal Cells -- cytology -- metabolism
Young Adult
Bone healing
Chemokines
Endothelial progenitor cells
Mesenchymal stem cells
Nonunion
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2013
Dodane szczegóły :
Mathieu, Myrielle
Rigutto, Sabrina
Ingels, Aude
Spruyt, Delphine
Stricwant, Nadia
Kharroubi, Ilham
Albarani, Valentina
Jayankura, Marc
Rasschaert, Joanne
Bastianelli, Enrico
Gangji, Valérie
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/137771">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/137771
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
4 full-text file(s): info:eu-repo/semantics/restrictedAccess | info:eu-repo/semantics/closedAccess | info:eu-repo/semantics/closedAccess | info:eu-repo/semantics/restrictedAccess
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/137771
837142065
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn837142065
Zasób elektroniczny
Nonunion fractures can cause severe dysfunction and are often difficult to treat mainly due to a poor understanding of their physiopathology. Although many aspects of impaired fracture healing have been extensively studied, little is known about the cellular and molecular mechanisms leading to atrophic nonunion. Therefore, the aim of the present study was to assess the pools and biological functions of bone marrow-derived mesenchymal stem cells (hMSCs) and circulating endothelial progenitor cells (EPCs) in atrophic nonunion patients compared to healthy subjects, and the systemic levels of growth factors involved in the recruitment, proliferation and differentiation of these cells. In nonunions, the pool of hMSCs was decreased and their proliferation delayed. However, once committed, hMSCs from nonunions were able to proliferate, differentiate into osteoblastic cells and mineralize in vitro as efficiently as hMSCs from healthy subjects. In parallel, we found altered serum levels of chemokines and growth factors involved in the chemotaxis and proliferation of hMSCs such as leptin, interleukin-6 (IL-6) and its soluble receptor, platelet-derived growth factor-BB (PDGF-BB), stem cell factor (SCF) and insulin-like growth factor-1 (IGF-1). Moreover, we showed that the number of EPCs and their regulating growth factors were not affected in nonunion patients. If nonunion is generally attributed to a vascular defect, our results also support a role for a systemic mesenchymal and osteogenic cell pool defect that might be related to alterations in systemic levels of factors implicated in their chemotaxis and proliferation.
SCOPUS: ar.j
info:eu-repo/semantics/published

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