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Tytuł pozycji:

Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study

Tytuł :
Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study
Index Terms :
Acute Disease
Aged
Atrial Fibrillation/blood/metabolism/urine
Brain Ischemia/*blood/*metabolism/urine
Cerebrovascular Disorders/*blood/*metabolism/urine
Cyclooxygenase Inhibitors/therapeutic use
Dinoprost/urine
Female
Humans
Lipid Peroxides/*metabolism
Male
Middle Aged
Platelet Activation
Reference Values
Thromboxane B2/analogs & derivatives/urine
atherosclerosis
risk factors
ultrasonics
info:eu-repo/semantics/article
Źródło :
Circulation (Baltimore) vol. 96 no. 5, pp. 1432-1437
Wydawca :
1997-09-01
Dodane szczegóły :
Bots, M.L. (Michiel)
Hoes, A.W. (Arno)
Koudstaal, P.J. (Peter)
Hofman, A. (Albert)
Grobbee, D.E. (Diederick)
Typ dokumentu :
Zasób elektroniczny
URL :
http://repub.eur.nl/pub/22517">http://repub.eur.nl/pub/22517
Dostępność :
Open access content. Open access content
info:eu-repo/semantics/openAccess
Pozostałe numery :
QGQ oai:repub.eur.nl:22517
929959954
Źródło wspomagające :
ERASMUS UNIVERSITEIT ROTTERDAM
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn929959954
Zasób elektroniczny
BACKGROUND: Noninvasive assessment of intima-media thickness (IMT) is widely used in observational studies and trials as an intermediate or proxy end point for cardiovascular disease. However, data showing that IMT predicts cardiovascular disease are limited. We studied whether common carotid IMT is related to future stroke and myocardial infarction. METHODS AND RESULTS: We used a nested case-control approach among 7983 subjects aged > or =55 years participating in the Rotterdam Study. At baseline (March 1990 through July 1993), ultrasound images of the common carotid artery were stored on videotape. Determination of incident myocardial infarction and stroke was predominantly based on hospital discharge records. Analysis (logistic regression) was based on 98 myocardial infarctions and 95 strokes that were registered before December 31, 1994. IMT was measured from videotape for all case subjects and a sample of 1373 subjects who remained free from myocardial infarction and stroke during follow-up. The mean duration of follow-up was 2.7 years. Results were adjusted for age and sex. Stroke risk increased gradually with increasing IMT. The odds ratio for stroke per standard deviation increase (0.163 mm) was 1.41 (95% CI, 1.25 to 1.82). For myocardial infarction, an odds ratio of 1.43 (95% CI, 1.16 to 1.78) was found. When subjects with a previous myocardial infarction or stroke were excluded, odds ratios were 1.57 (95% CI, 1.27 to 1.94) for stroke and 1.51 (95% CI, 1.18 to 1.92) for myocardial infarction. Additional adjustment for several cardiovascular risk factors attenuated these associations: 1.34 (95% CI, 1.08 to 1.67) and 1.25 (95% CI, 0.98 to 1.58), respectively. CONCLUSIONS: The present study, based on a short follow-up period, provides evidence that an increased common carotid IMT is associated with future cerebrovascular and cardiovascular events.

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