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Tytuł pozycji:

Inhibition of restenosis with beta-emitting radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT)

Tytuł :
Inhibition of restenosis with beta-emitting radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT)
Index Terms :
Angioplasty, Transluminal, Percutaneous Coronary/instrumentation
Aspirin/therapeutic use
Automation
Beta Rays
Combined Modality Therapy
Coronary Angiography
Coronary Disease/prevention & control/radiotherapy/*therapy
Coronary Vessels/pathology/radiation effects
Dose-Response Relationship, Radiation
Drug Delivery Systems
Humans
Phosphorus Radioisotopes/administration & dosage/*therapeutic use
Platelet Aggregation Inhibitors/therapeutic use
Radiopharmaceuticals/*therapeutic use
Research Support, Non-U.S. Gov't
Stents
Ticlopidine/therapeutic use
Time Factors
Treatment Outcome
info:eu-repo/semantics/article
Źródło :
Circulation (Baltimore) vol. 102 no. 9, pp. 951-958
Wydawca :
2000-01-01
Dodane szczegóły :
Raizner, A.E. (Albert)
Colombo, A. (Antonio)
Lim, Y.L.
Yeung, A.C. (Alan)
Ali, N.M. (Nadir)
Vandertie, L. (Lynn)
Kaluza, G.L. (Grzegorz)
Chiu, J.K.
Fitzgerald, P.J. (Peter)
White, L.R. (Larry)
Oesterle, S.N.
Waksman, R. (Ron)
Serruys, P.W.J.C. (Patrick)
Giessen, W.J. (Wim) van der
Typ dokumentu :
Zasób elektroniczny
URL :
http://repub.eur.nl/pub/9443
Dostępność :
Open access content. Open access content
info:eu-repo/semantics/openAccess
Pozostałe numery :
QGQ oai:repub.eur.nl:9443
urn:hdl:1765/9443
929969046
Źródło wspomagające :
ERASMUS UNIVERSITEIT ROTTERDAM
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn929969046
Zasób elektroniczny
BACKGROUND: Intracoronary gamma- and beta-radiation have reduced restenosis in animal models. In the clinical setting, the effectiveness of beta-emitters has not been studied in a broad spectrum of patients, particularly those receiving stents. METHODS AND RESULTS: A prospective, randomized, sham-controlled study of intracoronary radiotherapy with the beta-emitting (32)P source wire, using a centering catheter and automated source delivery unit, was conducted. A total of 105 patients with de novo (70%) or restenotic (30%) lesions who were treated by stenting (61%) or balloon angioplasty (39%) received 0 (control), 16, 20, or 24 Gy to a depth of 1 mm in the artery wall. Angiography at 6 months showed a target site late loss index of 11+/-36% in radiotherapy patients versus 55+/-30% in controls (P:<0.0001). A low late loss index was seen in stented and balloon-treated patients and was similar across the 16, 20, and 24 Gy radiotherapy groups. Restenosis (>/=50%) rates were significantly lower in radiotherapy patients at the target site (8% versus 39%; P:=0.012) and at target site plus adjacent segments (22% versus 50%; P:=0.018). Target lesion revascularization was needed in 5 radiotherapy patients (6%) and 6 controls (24%; P:<0.05). Stenosis adjacent to the target site and late thrombotic events reduced the overall clinical benefit of radiotherapy. CONCLUSIONS: beta-radiotherapy with a centered (32)P source is safe and highly effective in inhibiting restenosis at the target site after stent or balloon angioplasty. However, minimizing edge narrowing and late thrombotic events must be accomplished to maximize the clinical benefit of this modality.

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