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Tytuł pozycji:

Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1

Tytuł :
Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1
Index Terms :
Cell Migration Inhibition
Receptors, Immunologic
Animals
Cell Movement/*drug effects/immunology
Cytokines/antagonists & inhibitors/biosynthesis
Dendritic Cells/cytology/*drug effects/*immunology
Down-Regulation/drug effects/immunology
Epitopes, T-Lymphocyte/administration & dosage/immunology
Hydantoins/administration & dosage
Intubation, Intratracheal
Lung/*cytology/drug effects/*immunology/metabolism
Lymph Nodes/cytology/drug effects/immunology/metabolism
Lymphocyte Activation/drug effects
Mice
Mice, Inbred BALB C
Mice, Transgenic
Ovalbumin/administration & dosage/immunology
Prostaglandin D2/*administration & dosage/metabolism
Receptors, Prostaglandin/agonists/*metabolism/physiology
Research Support, Non-U.S. Gov't
T-Lymphocyte Subsets/drug effects/immunology
Thorax
info:eu-repo/semantics/article
Źródło :
Journal of Immunology
Wydawca :
2003-01-01
Dodane szczegóły :
Hammad, H. (Hamida)
Heer, H.J. de
Soullié, T. (Thomas)
Hoogsteden, H.C. (Henk)
Trottein, F.
Lambrecht, B.N.M. (Bart)
Typ dokumentu :
Zasób elektroniczny
URL :
http://repub.eur.nl/pub/10233">http://repub.eur.nl/pub/10233
Dostępność :
Open access content. Open access content
info:eu-repo/semantics/openAccess
Pozostałe numery :
QGQ oai:repub.eur.nl:10233
urn:hdl:1765/10233
929978144
Źródło wspomagające :
ERASMUS UNIVERSITEIT ROTTERDAM
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn929978144
Zasób elektroniczny
PGD(2) is the major mediator released by mast cells during allergic responses, and it acts through two different receptors, the D prostanoid receptor 1 (DP1) and DP2, also known as CRTH2. Recently, it has been shown that PGD(2) inhibits the migration of epidermal Langerhans cells to the skin draining lymph nodes (LNs) and affects the subsequent cutaneous inflammatory reaction. However, the role of PGD(2) in the pulmonary immune response remains unclear. Here, we show that the intratracheal instillation of FITC-OVA together with PGD(2) inhibits the migration of FITC(+) lung DC to draining LNs. This process is mimicked by the DP1 agonist BW245C, but not by the DP2 agonist DK-PGD(2). The ligation of DP1 inhibits the migration of FITC-OVA(+) DCs only temporarily, but still inhibits the proliferation of adoptively transferred, OVA-specific, CFSE-labeled, naive T cells in draining LNs. These T cells produced lower amounts of the T cell cytokines IL-4, IL-10, and IFN-gamma compared with T cells from mice that received FITC-OVA alone. Taken together, our data suggest that the activation of DP receptor by PGD(2) may represent a pathway to control airway DC migration and to limit the activation of T cells in the LNs under steady state conditions, possibly contributing to homeostasis in the lung.

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