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Title of the item:

Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Title :
Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Index Terms :
Aged
Biomarkers/blood
Cardiovascular Diseases/blood/diagnosis/mortality
Cohort Studies
Death
Female
Follow-Up Studies
Germany/epidemiology
Health Status
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Thrombin/metabolism
Cardiovascular death
Endogenous thrombin potential
Thrombin
info:eu-repo/semantics/article
Publisher :
2014
Added Details :
Luxembourg Centre for Systems Biomedicine (LCSB): Medical Translational Research (J. Schneider Group) [research center]
Schneider, Jochen
Isermann, Berend
Kleber, Marcus E.
Wang, Hongjie
Boehm, Bernhard O.
Grammer, Tanja B.
Prueller, Florian
Nawroth, Peter P.
Maerz, Winfried
Document Type :
Electronic Resource
URL :
http://orbilu.uni.lu/handle/10993/27267
http://orbilu.uni.lu/bitstream/10993/27267/1/Schneider%20Inverse%20Association%20...%20Jochen%20Schneider....pdf
Availability :
Open access content. Open access content
info:eu-repo/semantics/openAccess
Other Numbers :
LULUX oai:orbilu.uni.lu:10993/27267
SCOPUS_ID:84906317654
PMID:25085378
WOS:000341040900031
DOI:10.1016/j.ijcard.2014.07.026
952957434
Contributing Source :
UNIV OF LUXEMBOURG
From OAIster®, provided by the OCLC Cooperative.
Accession Number :
edsoai.ocn952957434
Electronic Resource
BACKGROUND: Coagulation and prothrombotic potential have genuinely been associated with increased cardiovascular risk. However, not all studies in this regard are conclusive. Some clinical trials have shown an increased frequency of cardiovascular complications in patients receiving direct thrombin inhibitors. Previous data from human subjects after acute cardiovascular events showed an inverse association between the thrombin generation marker F1+2 and cardiovascular endpoints indicating that not the lowest, but a slightly elevated propensity for thrombin generation is associated with a lower risk of cardiovascular events. This observation has been supported by findings in animal models of atherosclerosis. Hence, we evaluated the association between the endogenous thrombin potential (ETP) and cardiovascular death (CVD) and markers of vascular dysfunction in a large prospective study with long-term follow up. METHOD: After excluding patients receiving anticoagulants we tested ETP in 2196 participants (median follow-up 10 years) for its ability to predict vascular death (CVD). In addition, the association between ETP and sVCAM-1, sICAM-1, LpPLA2, hsCRP and SAA was determined. RESULTS: We observed an inverse association between ETP and CVD with the lowest hazard ratio in the 4th ETP quartile. The nadirs of sICAM-1 or sVCAM-1 were observed in the 3rd, for LpPLA2 in the 4th ETP quartile. Conversely, hsCRP and SAA were highest in the 4th quartile. CONCLUSIONS: These results demonstrate that not the lowest ETP possible, but slightly higher levels are associated with a reduced risk of CVD and lower markers of endothelial dysfunction, suggesting a more complex role of thrombin in cardiovascular disease.

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