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Tytuł pozycji:

Part 2: influence of 2-euryfuryl-1,4-naphthoquinone and its peri-hydroxy derivatives on both cell death and metabolism of TLT cells, a murine hepatoma cell line. modulation of cytotoxicity by vitamin C.

Tytuł :
Part 2: influence of 2-euryfuryl-1,4-naphthoquinone and its peri-hydroxy derivatives on both cell death and metabolism of TLT cells, a murine hepatoma cell line. modulation of cytotoxicity by vitamin C.
Index Terms :
Adenosine Triphosphate - metabolism
Animals
Glutathione - metabolism
Hydrogen Bonding
L-Lactate Dehydrogenase - metabolism
Liver Neoplasms, Experimental - drug therapy, metabolism
Mice
Naphthoquinones - chemical synthesis, pharmacology
Neoplasm Transplantation
Antineoplastic Agents - chemical synthesis, pharmacology
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Caspase 3 - metabolism
Cell Death - drug effects
Cell Line, Tumor
Electrochemistry
Free Radicals - chemistry
info:eu-repo/semantics/article
Wydawca :
Pharmaceutical Society of Japan 2009
Dodane szczegóły :
UCL - MD/FARM - Ecole de pharmacie
Benites, Julio
Valderrama, Jaime Adolfo
Taper, Henryk
Buc Calderon, Pedro
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2078.1/106610">http://hdl.handle.net/2078.1/106610
Dostępność :
Open access content. Open access content
Pozostałe numery :
UCDLC oai:dial.uclouvain.be:boreal:106610
960560599
Źródło wspomagające :
UNIVERSITE CATHOLIQUE DE LOUVAIN
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.ocn960560599
Zasób elektroniczny
2-Euryfuryl-1,4-naphthoquinone C(1) and its 5- and 5,8-hydroxy derivatives C(2) and C(3), were tested for their cytotoxicity towards transplantable liver tumor (TLT) cells (a murine hepatoma cell line) in the absence and in the presence of vitamin C. Cell death, caspase-3 activity and two metabolic end-points, namely the intracellular content of ATP and glutathione (GSH), were employed to evaluate their cytotoxicity. In a range of concentration from 0 to 10 microg/ml C(1) and C(3) were non toxic against TLT cells, while compound C(2) killed about 50% of cells by necrosis. Interestingly, the presence of vitamin C did not enhance the cytolysis of C(2), but its addition exacerbated the effects of the three compounds on both ATP and GSH contents, the two metabolic end points selected in our study. Our assumption is that the electron donor effect of the peri-hydroxyl substituents on euryfurylnaphthoquinones and the hydrogen bond between the peri-hydroxy and quinone carbonyl groups influence the electron-acceptor capability of the quinone nucleus and thus modifies the electron transfer from ascorbate to the electroactive quinone nucleus. The combination of euryfurylnaphthoquinones with vitamin C may be of potential clinical interest, because cancer cells accumulate vitamin C, they are sensitive to an oxidant insult and they depend on glycolysis (ATP formation) for their survival.

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