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Tytuł pozycji:

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Tytuł :
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Index Terms :
Pathologie générale
Médecine légale
Anatomie générale [morphologie humaine]
Biomarkers, Tumor -- analysis
Biopsy
Brain Neoplasms -- immunology -- pathology
Carcinoma, Non-Small-Cell Lung -- immunology -- pathology
Carcinoma, Squamous Cell -- immunology -- pathology
Endometrial Neoplasms -- immunology -- pathology
Female
Gastrointestinal Neoplasms -- immunology -- pathology
Head and Neck Neoplasms -- immunology -- pathology
Humans
Immunohistochemistry
Lung Neoplasms -- immunology -- pathology
Lymphocytes, Tumor-Infiltrating -- immunology -- pathology
Melanoma -- immunology -- pathology
Mesothelioma -- immunology -- pathology
Ovarian Neoplasms -- immunology -- pathology
Pathology -- methods -- standards
Phenotype
Predictive Value of Tests
Skin Neoplasms -- immunology -- pathology
Squamous Cell Carcinoma of Head and Neck
Urogenital Neoplasms -- immunology -- pathology
biomarkers
cancer
immunotherapy
lymphocytes
pathology
tumor-infiltrating
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2017
Dodane szczegóły :
Hendry, Shona
Salgado, Roberto
Sotiriou, Christos
Ignatiadis, Michail
Sirtaine, Nicolas
Larsimont, Denis
De Wind, Roland
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260727">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260727
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
1 full-text file(s): info:eu-repo/semantics/restrictedAccess
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/260727
1012855381
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1012855381
Zasób elektroniczny
Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
0
SCOPUS: re.j
info:eu-repo/semantics/published

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