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Tytuł pozycji:

Increased Angiogenesis and Lymphangiogenesis in Metastatic Sentinel Lymph Nodes Is Associated With Nonsentinel Lymph Node Involvement and Distant Metastasis in Patients With Melanoma.

Tytuł :
Increased Angiogenesis and Lymphangiogenesis in Metastatic Sentinel Lymph Nodes Is Associated With Nonsentinel Lymph Node Involvement and Distant Metastasis in Patients With Melanoma.
Index Terms :
Sciences bio-médicales et agricoles
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor -- analysis
Biopsy
Cell Proliferation
Chi-Square Distribution
Female
Humans
Hyaluronan Receptors -- analysis
Immunohistochemistry
Kaplan-Meier Estimate
Ki-67 Antigen -- analysis
Logistic Models
Lymph Nodes -- chemistry -- pathology
Lymphangiogenesis
Lymphatic Metastasis
Lymphatic Vessels -- chemistry -- pathology
Male
Melanoma -- blood supply -- chemistry -- mortality -- secondary
Microvessels -- chemistry -- pathology
Middle Aged
Multivariate Analysis
Neovascularization, Pathologic
Prognosis
Proportional Hazards Models
Skin Neoplasms -- blood supply -- chemistry -- mortality -- pathology
Spain
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
Wydawca :
2016-05
Dodane szczegóły :
Pastushenko, Ievgenia
Van den Eynden, Gert
Vicente-Arregui, Sandra
Prieto-Torres, Lucía
Alvarez-Alegret, Ramiro
Querol, Ignacio
Dirix, Luc Y
Carapeto, Francisco FJ
Vermeulen, Peter B.
Van Laere, S J
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/265053">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/265053
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Dostępność :
Open access content. Open access content
Pozostałe numery :
EQY oai:dipot.ulb.ac.be:2013/265053
1021241631
Źródło wspomagające :
UNIV LIBR DE BRUXELLES
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1021241631
Zasób elektroniczny
Lymph node angio- and lymphangio-genesis have been shown to play an important role in the premetastatic niche of sentinel lymph nodes. In the current study we have investigated the association of angio- and lympangio-genesis related parameters in metastatic sentinel lymph nodes of patients with melanoma with the presence of nonsentinel and distant organ metastasis. Peritumoral and intratumoral relative blood and lymphatic vessel areas (evaluated by Chalkley method), blood and lymphatic microvessel densities, and the rates of blood and lymphatic vessel proliferation were assessed in primary tumors and sentinel lymph node metastasis of 44 patients with melanoma using CD34/Ki-67 and D240/Ki-67 immunohistochemical double staining. Primary melanoma exhibited significantly higher rate of lymphatic proliferation compared with its lymph node metastasis (P < 0.05), while lymph node metastasis showed significantly higher rate of blood vessel proliferation (P < 0.05). Using multivariate logistic regression model, the rate of peritumoral lymphatic proliferation was inversely associated with positive nonsentinel lymph node status (P < 0.05), whereas the rate of intratumoral blood vessel proliferation was associated with distant organ metastasis (P < 0.05). Using multivariate Cox regression analysis, the rate of intratumoral blood vessel proliferation was also inversely associated with overall survival of patients with melanoma (P < 0.05).
info:eu-repo/semantics/published

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