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Tytuł pozycji:

Synthesis, characterization and cytotoxicity evaluation of carboxylated carbon nanotubes functionalized with silibinin, betulinic acid and levodopa for drug delivery

Tytuł :
Synthesis, characterization and cytotoxicity evaluation of carboxylated carbon nanotubes functionalized with silibinin, betulinic acid and levodopa for drug delivery
Index Terms :
Drug delivery systems
Pharmaceutical technology
Drug Delivery Systems - methods
Thesis
NonPeerReviewed
Wydawca :
2015-08
Dodane szczegóły :
Tan, Julia Meihua
Typ dokumentu :
Zasób elektroniczny
URL :
http://psasir.upm.edu.my/id/eprint/57998/1/ITMA%202015%206RR.pdf">http://psasir.upm.edu.my/id/eprint/57998/1/ITMA%202015%206RR.pdf
http://psasir.upm.edu.my/id/eprint/57998">http://psasir.upm.edu.my/id/eprint/57998
Dostępność :
Open access content. Open access content
Pozostałe numery :
MYPUT oai:psasir.upm.edu.my:57998
1029839790
Źródło wspomagające :
UNIVERSITI PUTRA MALAYSIA
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1029839790
Zasób elektroniczny
Current methods of conventional drugs administered via liquids or tablets are often faced with problems like inefficient biodistribution, low solubility, poor bioavailability,long term toxicity and limited drug efficacy. As a result, many efforts have been carried out in the past to overcome the above mentioned limitations. This has led to the development of nanomaterial-based carrier as novel drug delivery system. In this study, commercially available carboxylated carbon nanotubes (CNTs) were used as the nano drug carrier due to their attractive physico-chemical properties which facilitate functionalization of therapeutic molecules onto their external walls or being encapsulated inside the nanotubes. Therefore, the main objective of the present work was to develop drug delivery formulation for silibinin (SB), betulinic acid (BA) and levodopa (LD) with carboxylated single walled (SWCNTs-COOH) and multiwalled carbon nanotubes (MWCNTs-COOH) separately for enhanced delivery efficiency into targeted cells with sustained-release effect. The resulting five nanohybrids, namely SWCNTs-SB, MWCNTs-SB, SWCNTs-BA,MWCNTs-BA and SWCNTs-LD, were prepared by non-covalent method via - and hydrogen bonds as well as hydrophobic interactions without the use of any cross-linker agent. The physico-chemical properties of the resulting nanohybrids, i.e. chemical interaction, elemental composition, crystallinity, thermal property, surface morphology,drug loading capacity and drug releasing characteristic were studied using Fourier transform infrared (FTIR) and Raman spectroscopies, elemental analysis (CHN-S),powder X-ray diffractometry (PXRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM) and ultraviolet-visibile spectrophotometry (UV-Vis). In order to assess the cytotoxicity characteristic of the synthesized nanohybrids, human cancer cell lines HepG2 (human liver hepatocellular carcinoma cell lines) and A549

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