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Tytuł pozycji:

ENTERALNA PREHRANA – GDJE SMO DANAS U FARMAKONUTRICIJI?

Tytuł :
ENTERALNA PREHRANA – GDJE SMO DANAS U FARMAKONUTRICIJI?
Index Terms :
Enteralna prehrana – metode; Pripravci za enteralnu prehranu – analiza; Farmakonutricija – metode; Omega-3 masne kiseline – farmakologija, terapijska primjena; Eikozapentaenska kiselina – farmakologija, terapijska primjena; Kaheksija – dijetoterapija; Leucin – metabolizam; Skeletni mišići – djelovanje lijeka, metabolizam; Mišićna atrofi ja – dijetoterapija; Kritični bolesnci – liječenje; Glutamin – farmakologija, terapijska primjena; Arginin – terapijska primjena
Entaral nutrition – methods; Food, formulated – analysis; Nutrition therapy – methods; Fatty acids, omega-3 – pharmacology, therapeutic use; Eicosapentaenoic acid – pharmacology, therapeutic use; Cachexia – diet therapy; Leucine – metabolism; Muscle, skeletal – drug effects, metabolism; Muscular atrophy – diet therapy; Critical illness – therapy; Glutamine – pharmacology, therapeutic use; Arginine – pharmacology, therapeutic use
text
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Tytuły dodatkowe :
ENTERAL NUTRITION – WHERE ARE WE TODAY IN PHARMACONUTRITION?
Wydawca :
Croatian medical association 2018
Dodane szczegóły :
Pavić, Tajana
Tomek-Roksandić, Spomenka
Vranešić Bender, Darija
Krznarić, Željko
Typ dokumentu :
Zasób elektroniczny
URL :
info:eu-repo/semantics/altIdentifier/doi/10.26800/LV-140-1-2-6
Dostępność :
Open access content. Open access content
info:eu-repo/semantics/openAccess
The Medical Journal is an open access journal. The content of the magazine is available in its entirety free of charge. The contents of the Medical Journal may be reproduced with the quotation "taken from the Medical Journal". Users may not use the materials for commercial purposes, may not modify, redesign or rework the material.
Pozostałe numery :
HRCAK oai:hrcak.srce.hr:201048
https://hrcak.srce.hr/201048
https://hrcak.srce.hr/file/296022
1046457772
Źródło wspomagające :
HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1046457772
Zasób elektroniczny
U posljednjih nekoliko desetljeća dostupan nam je velik izbor enteralnih formula za različite indikacije. Koncept kliničke prehrane s vremenom je evoluirao od nutritivne potpore koja ima cilj samo zadovoljiti energetske potrebe bolesnika do one koja može utjecati i na sam tijek bolesti. Iako za određene farmakološki aktivne tvari u enteralnim pripravcima, kao što su različite aminokiseline i njihovi metaboliti, ω-3 masne kiseline, nukleotidi i antioksidansi, postoje dokazi da mogu utjecati na upalne i imunološke funkcije, pozitivan utjecaj imunomodulirajućih nutrijenata na klinički ishod u određenim je uvjetima bilo vrlo teško dokazati, usprkos velikom broju kliničkih istraživanja u ovom području. Moguća objašnjenja za ove proturječnosti kriju se u nedovoljno precizno utvrđenim mehanizmima djelovanja, vremenu i načinu davanja, dozi, a napose vrsti i tijeku bolesti u kojoj su se primjenjivali. Svrha je ovog pregleda objasniti potencijalno korisne fiziološke mehanizme djelovanja najčešće upotrebljavanih farmakonutrijenata i prezentirati kliničke dokaze o njihovoj uporabi.
Enteral nutrition formulas have been created over the past several decades with a variety of intended uses. Over the past two decades, the focus has shifted to the administration of pharmacologically active substances, such as different amino acids and their metabolites, ω-3 fatty acids, nucleotides and antioxidants in an attempt to modulate the inflammatory or immune response and affect clinical outcomes. Although some pharmaconutrients have clearly demonstrated the ability to potentiate, antagonize, or otherwise modify metabolic functions, despite the large volume of clinical research in this area, undoubted benefit of immunomodulating diets in certain clinical settings was difficult to prove. Potential explanations for discrepancies include variable effects of individual nutrients dependent on dose, nutrient interactions, timing of delivery and different metabolic needs of heterogeneous patient population. The purpose of this review is to cover potential beneficial physiological mechanisms for some common individual pharmaconutrients and briefly describe some of the current clinical data regarding their use.

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