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Tytuł pozycji:

Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest

Tytuł :
Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest
Index Terms :
Adult
Aged
Aged, 80 and over
Biomarkers/blood
Brain Diseases/epidemiology
Female
Humans
Male
MicroRNAs/blood
Middle Aged
Out-of-Hospital Cardiac Arrest/diagnosis
Prognosis
Serum/chemistry
Survival Analysis
Treatment Outcome
Young Adult
dk/atira/pure/researchoutput/pubmedpublicationtype/D016428
Journal Article
dk/atira/pure/researchoutput/pubmedpublicationtype/D013485
Research Support, Non-U.S. Gov't
article
Wydawca :
2017
Dodane szczegóły :
Devaux, Yvan
Salgado-Somoza, Antonio
Dankiewicz, Josef
Boileau, Adeline
Stammet, Pascal
Schritz, Anna
Zhang, Lu
Vausort, Mélanie
Gilje, Patrik
Erlinge, David
Hassager, Christian
Wise, Matthew P
Kuiper, Michael
Friberg, Hans
Nielsen, Niklas
Typ dokumentu :
Zasób elektroniczny
Dostępność :
Open access content. Open access content
info:eu-repo/semantics/openAccess
Pozostałe numery :
DAV oai:pure.atira.dk:publications/c07c5531-873a-4460-a8c2-fdc6ac615ab8
https://curis.ku.dk/portal/da/publications/incremental-value-of-circulating-mir1225p-to-predict-outcome-after-out-of-hospital-cardiac-arrest(c07c5531-873a-4460-a8c2-fdc6ac615ab8).html
https://doi.org/10.7150/thno.19851
https://curis.ku.dk/ws/files/195958685/v07p2555.pdf
1048266712
Źródło wspomagające :
UNIV OF COPENHAGEN
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1048266712
Zasób elektroniczny
Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest. Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation. The primary end-point was poor neurological outcome at 6 months evaluated by the cerebral performance category score. The secondary end-point was survival at the end of the trial. Results. Forty-eight percent of patients had a poor neurological outcome at 6 months and 43% were dead at the end of the trial. Levels of miR-122-5p were lower in patients with poor neurological outcome compared to patients with good neurological outcome (p<0.001), independently of targeted temperature management regimen. Levels of miR-122-5p were significant univariate predictors of neurological outcome (odds ratios (OR), 95% confidence intervals (CI): 0.71 [0.57-0.88]). In multivariable analyses, miR-122-5p was an independent predictor of neurological outcome and improved the predictive value of a clinical model including miR-124-3p (integrated discrimination improvement of 0.03 [0.02-0.04]). In Cox proportional hazards models, miR-122-5p was a significant predictor of survival at the end of the trial. Conclusion. Circulating levels of miR-122-5p improve the prediction of outcome after out-of-hospital cardiac arrest.

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