Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation

Tytuł :
Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation
Autorzy :
Patel, Eshan U
Pokaż więcej
Index Terms :
Acyclovir/therapeutic use Antibodies
Viral/*blood Antiviral Agents/therapeutic use CD4 Lymphocyte Count Cytomegalovirus Infections/*complications/drug therapy/*immunology *Disease Progression Female HIV Infections/*complications HIV-1/isolation & purification Humans Immunoglobulin G/*blood Prospective Studies Uganda/epidemiology Viral Load
Biological Sciences
Medical And Health Sciences
Psychology And Cognitive Sciences
Virology
article
Źródło :
AIDS vol 31, iss 6, 807-813 0269-9370
Wydawca :
eScholarship, University of California 2017-03-01
Dodane szczegóły :
Patel, Eshan U
Gianella, Sara
Newell, Kevin
Tobian, Aaron AR
Kirkpatrick, Allison R
Nalugoda, Fredrick
Grabowski, Mary K
Gray, Ronald H
Serwadda, David
Quinn, Thomas C
Redd, Andrew D
Reynolds, Steven J
Typ dokumentu :
Zasób elektroniczny
URL :
https://escholarship.org/uc/item/4497j515
https://escholarship.org/
Dostępność :
Open access content. Open access content
public
Pozostałe numery :
CDLER oai:escholarship.org/ark:/13030/qt4497j515
qt4497j515
https://escholarship.org/uc/item/4497j515
https://escholarship.org/
1114629402
Źródło wspomagające :
UC MASS DIGITIZATION
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1114629402
Zasób elektroniczny
OBJECTIVE: To assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers. DESIGN: A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. METHODS: The primary endpoints were progression to a CD4 T-cell count less than 250 cells/mul, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART. RESULTS: There were 300 HIV/CMV-coinfected participants who contributed a total of 426.4 person-years with a median follow-up time of 1.81 years. Compared with the lowest CMV IgG tertile group at baseline, the highest CMV IgG tertile group was associated with an increased risk to reach a primary endpoint independent of acyclovir use, age, CD4 T-cell count, and HIV viral load at baseline [adjusted hazard ratio = 1.59; (95% CI = 1.05-2.39); P = 0.027]. Among pre-ART visits (n = 1200), women in the highest baseline CMV IgG tertile had increasing annual rates of soluble CD14 and CRP levels, which was not observed for the low CMV IgG tertile group. Compared with pre-ART visits, CMV IgG antibody levels were higher post-ART initiation, and concurrent levels remained associated with soluble CD14 and CRP during suppressive ART (n = 88 person-visits). CONCLUSION: The magnitude of the immune response to CMV was associated with HIV disease progression and immune activation in sub-Saharan Africa.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies