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Tytuł pozycji:

Rationale and strategies for chemoprevention of cancer in humans.

Tytuł :
Rationale and strategies for chemoprevention of cancer in humans.
Autorzy :
Bertram, J S
Pokaż więcej
Index Terms :
Anti-Inflammatory Agents: therapeutic use
Ascorbic Acid: therapeutic use
Biotransformation: drug effects
Carcinogens: antagonists & inhibitors
Carotenoids: therapeutic use
Cost-Benefit Analysis
Humans
Neoplasms: prevention & control
Nitrosamines: antagonists & inhibitors
Protease Inhibitors: therapeutic use
Research Design
Retinoids: therapeutic use
Risk
Selenium: antagonists & inhibitors
Sulfhydryl Compounds: therapeutic use
Vitamin E: therapeutic use
retinoid
cancer
cancer chemotherapy
carcinogenesis
human
prevention
priority journal
therapy
Anti-Inflammatory Agents
Ascorbic Acid
Biotransformation
Carcinogens
Carotenoids
Human
Neoplasms
Nitrosamines
Protease Inhibitors
Retinoids
Selenium
Sulfhydryl Compounds
Support
U.S. Gov't
P.H.S.
Vitamin E
article
Źródło :
Cancer research vol 47, iss 11, 3012-3031 0008-5472
Wydawca :
eScholarship, University of California 1987-06-01
Dodane szczegóły :
Bertram, J S
Kolonel, L N
Meyskens, F L, Jr
Typ dokumentu :
Zasób elektroniczny
URL :
https://escholarship.org/uc/item/9w2808gz">https://escholarship.org/uc/item/9w2808gz
https://escholarship.org/">https://escholarship.org/
Dostępność :
Open access content. Open access content
public
Pozostałe numery :
CDLER oai:escholarship.org/ark:/13030/qt9w2808gz
qt9w2808gz
https://escholarship.org/uc/item/9w2808gz
https://escholarship.org/
1114714339
Źródło wspomagające :
UC MASS DIGITIZATION
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1114714339
Zasób elektroniczny
The potential for chemical intervention (chemoprevention) as a means of halting or delaying the process of carcinogenesis is assessed as a strategy for reducing the incidence of human cancer. The process of carcinogenesis is dissected into its constituent steps, thereby exposing sites for intervention. These sites are then critically discussed with regard to the existence of chemicals active at these sites using data gained from the laboratory and from epidemiological studies, intrinsic problems or advantages associated with intervention at specific sites in the carcinogenic process, and practical aspects of intervention in humans. The design and potential long-term positive and negative consequences of chemoprevention clinical trials are critically discussed, with the objective of exposing the major differences that exist between clinical trials in cancer chemoprevention and those in cancer chemotherapy. Results of completed prevention trials and details of ongoing trials are presented and discussed. Based on the laboratory, epidemiological, and clinical evidence presented, it is concluded that chemoprevention offers excellent prospects as a means of reducing cancer incidence. Among currently available agents, the retinoids possess the best combination of properties. However, much more research is needed to optimize drugs and protocols and to develop interim end points for assessing response. The authors finally caution that overambitious claims for the prospects for chemoprevention may lead to reduced emphasis on the need for changes in life-style (principally in smoking and diet) that are viewed as having the greatest potential for reducing cancer incidence.

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