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Tytuł pozycji:

A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.

Tytuł :
A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.
Index Terms :
Animals
Animals, Congenic/genetics
Animals, Genetically Modified/genetics
Breeding
Crosses, Genetic
Female
Genetic Markers
Genome
Genotype
Japan
Male
Phenotype
Phylogeny
Polymorphism, Genetic/genetics
Rats
Rats, Inbred Strains/classification
Rats, Inbred Strains/genetics
Rats, Mutant Strains/classification
Rats, Mutant Strains/genetics
Specific Pathogen-Free Organisms
Journal Article
Wydawca :
BioMed Central Ltd. 2012-10-09T07:39:14Z 2012-10-09T07:39:14Z 2006-04-04
Dodane szczegóły :
芹川, 忠夫
Mashimo, Tomoji
Voigt, Birger
Tsurumi, Toshiko
Naoi, Kuniko
Nakanishi, Satoshi
Yamasaki, Ken-ichi
Kuramoto, Takashi
Serikawa, Tadao
Typ dokumentu :
Zasób elektroniczny
URL :
http://hdl.handle.net/2433/159733
10.1186/1471-2156-7-19
Dostępność :
Open access content. Open access content
© 2006 Mashimo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pozostałe numery :
YJ@ oai:repository.kulib.kyoto-u.ac.jp:2433/159733
1471-2156
AA12034956
BMC genetics
7
19
16584579
1141593049
Źródło wspomagające :
KYOTO UNIV
From OAIster®, provided by the OCLC Cooperative.
Numer akcesji :
edsoai.on1141593049
Zasób elektroniczny
[Background]The National Bio Resource Project for the Rat in Japan (NBRP-Rat) is focusing on collecting, preserving and distributing various rat strains, including spontaneous mutant, transgenic, congenic, and recombinant inbred (RI) strains. To evaluate their value as models of human diseases, we are characterizing them using 109 phenotypic parameters, such as clinical measurements, internal anatomy, metabolic parameters, and behavioral tests, as part of the Rat Phenome Project. Here, we report on a set of 357 simple sequence length polymorphism (SSLP) markers and 122 rat strains, which were genotyped by the marker set. [Results]The SSLP markers were selected according to their distribution patterns throughout the whole rat genome with an average spacing of 7.59 Mb. The average number of informative markers between all possible pairs of strains was 259 (72.5% of 357 markers), showing their high degree of polymorphism. From the genetic profile of these rat inbred strains, we constructed a rat family tree to clarify their genetic background. [Conclusion]These highly informative SSLP markers as well as genetically and phenotypically defined rat strains are useful for designing experiments for quantitative trait loci (QTL) analysis and to choose strategies for developing new genetic resources. The data and resources are freely available at the NBRP-Rat web site [1].

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