Mechanism of odorant adaptation in the olfactory receptor cell.

Investigates the nature of the adaptational mechanism in intact olfactory cells by using a combination of odorant stimulation and caged cyclase/cyclic AMP (cAMP) photolysis. The production of current responses that bypass the early stages of signal transduction; The involvement of the receptor, G protein and adenylyl cyclase; The demonstration that phosphodiesterase activity remains constant during adaptation.