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Title of the item:

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.

Title :
Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.
Authors :
Emmett EA ()
Zhang H ()
Shofer FS ()
Freeman D ()
Rodway NV ()
Desai C ()
Shaw LM ()
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Source :
Journal of Occupational & Environmental Medicine. Aug2006, Vol. 48 Issue 8, p771-779. 9p.
Academic Journal
OBJECTIVE: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA. METHODS: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL). RESULTS: No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease. CONCLUSIONS: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed. [ABSTRACT FROM AUTHOR]
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