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Tytuł:
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Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study.
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Autorzy:
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Yamagishi, Yuko
Suzuki, Hidekazu
Sonoo, Masahiro
Kuwabara, Satoshi
Yokota, Takanori
Nomura, Kyoichi
Chiba, Atsuro
Kaji, Ryuji
Kanda, Takashi
Kaida, Kenichi
Ikeda, Shu‐ichi
Mutoh, Tatsuro
Yamasaki, Ryo
Takashima, Hiroshi
Matsui, Makoto
Nishiyama, Kazutoshi
Sobue, Gen
Kusunoki, Susumu
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Temat:
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THERAPEUTIC use of immunoglobulins
GUILLAIN-Barre syndrome
ACADEMIC medical centers
BIOMARKERS
IMMUNOGLOBULINS
MEDICAL cooperation
RESEARCH
TREATMENT effectiveness
RETROSPECTIVE studies
PROGNOSIS
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Źródło:
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Journal of the Peripheral Nervous System. Dec2017, Vol. 22 Issue 4, p433-439. 7p.
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Terminy geograficzne:
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JAPAN
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Guillain-Barré syndrome (GBS) is an acute monophasic neuropathy. Prognostic tools include the modified Erasmus GBS outcome score (mEGOS), Erasmus GBS respiratory insufficiency score (EGRIS), and the increase in serum IgG levels (ΔIgG) 2 weeks after intravenous immunoglobulin (IVIg) treatment. Given that proportions of GBS subtypes differ between Western countries and Japan, the usefulness of these tools in Japan or other countries remains unknown. We enrolled 177 Japanese patients with GBS from 15 university hospitals and retrospectively obtained mEGOS and EGRIS for all and ΔIgG status for 79 of them. High mEGOS scores on admission or on day 7 were significantly associated with poorer outcomes (unable to walk independently at 6 months). High EGRIS scores (≥5 points) were associated with an increased risk for mechanical ventilation. Patients with ΔIgG <1,108 mg/dl had significantly poorer outcomes. We suggest that mEGOS, EGRIS, and ΔIgG in GBS are clinically relevant in Japan. [ABSTRACT FROM AUTHOR]
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