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Tytuł pozycji:

Digestion Assays in Allergenicity Assessment of Transgenic Proteins.

Tytuł :
Digestion Assays in Allergenicity Assessment of Transgenic Proteins.
Autorzy :
Herman, Rod A.
Storer, Nicholas P.
Yong Gao
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Temat :
ALLERGIES
IMMUNOLOGIC diseases
DIGESTION
RISK assessment
PROTEINS
ALLERGENS
GASTRIC juice
BODY fluids
MEDICAL research
Źródło :
Environmental Health Perspectives. Aug2006, Vol. 114 Issue 8, p1154-1157. 4p.
Czasopismo naukowe
The food-allergy risk assessment for transgenic proteins expressed in crops is currently based on a weight-of-evidence approach that holistically considers multiple lines of evidence. This approach recognizes that no single test or property is known to distinguish allergens from nonallergens. The stability of a protein to digestion, as predicted by an in vitro simulated gastric fluid assay, currently is used as one element in the risk assessment process. A review of the literature on the use of the simulated gastric fluid assay to predict the allergenic status of proteins suggests that more extensive kinetic studies with well-characterized reference proteins are required before the predictive value of this assay can be adequately judged. [ABSTRACT FROM AUTHOR]
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