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Tytuł:
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Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
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Autorzy:
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Guxens, Mònica
Ghassabian, Akhgar
Gong, Tong
Garcia-Esteban, Raquel
Porta, Daniela
Giorgis-Allemand, Lise
Almqvist, Catarina
Aranbarri, Aritz
Beelen, Rob
Badaloni, Chiara
Cesaroni, Giulia
Nazelle, Audrey de
Estarlich, Marisa
Forastiere, Francesco
Forns, Joan
Gehring, Ulrike
Ibarluzea, Jesus
Jaddoe, Vincent W.V.
Korek, Michal
Lichtenstein, Paul
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Temat:
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AUTISM risk factors
AIR pollution
CONFIDENCE intervals
DEMOGRAPHY
NITROGEN compounds
PROBABILITY theory
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
STATISTICAL hypothesis testing
LOGISTIC regression analysis
STATISTICAL power analysis
ENVIRONMENTAL exposure
RETROSPECTIVE studies
DATA analysis software
DESCRIPTIVE statistics
PRENATAL exposure delayed effects
ODDS ratio
PREGNANCY
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Źródło:
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Environmental Health Perspectives. Jan2016, Vol. 124 Issue 1, p133-140. 8p. 3 Charts, 2 Graphs.
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Terminy geograficzne:
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ITALY
NETHERLANDS
SPAIN
SWEDEN
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BACKGROUND: Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder. OBJECTIVES: We aimed to assess whether prenatal air pollution exposure is associated with childhood autistic traits in the general population. METHODS: Ours was a collaborative study of four European population-based birth/child cohorts-- CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) and particulate matter (PM) with diameters of ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10), and between 2.5 and 10 μm (PMcoarse), and PM2.5 absorbance were estimated for birth addresses by land-use regression models based on monitoring campaigns performed between 2008 and 2011. Levels were extrapolated back in time to exact pregnancy periods. We quantitatively assessed autistic traits when the child was between 4 and 10 years of age. Children were classified with autistic traits within the borderline/clinical range and within the clinical range using validated cut-offs. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. RESULTS: A total of 8,079 children were included. Prenatal air pollution exposure was not associated with autistic traits within the borderline/clinical range (odds ratio = 0.94; 95% CI: 0.81, 1.10 per each 10-μg/m³ increase in NO2 pregnancy levels). Similar results were observed in the different cohorts, for the other pollutants, and in assessments of children with autistic traits within the clinical range or children with autistic traits as a quantitative score. CONCLUSIONS: Prenatal exposure to NO2 and PM was not associated with autistic traits in children from 4 to 10 years of age in four European population-based birth/child cohort studies. [ABSTRACT FROM AUTHOR]
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