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Tytuł:
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.
Autorzy:
Taha HB; Department of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, California, USA.
Ati SS; Department of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, California, USA.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Dec; Vol. 29 (12), pp. 3741-3755. Date of Electronic Publication: 2023 Jul 07.
Typ publikacji:
Meta-Analysis; Systematic Review; Journal Article; Review
MeSH Terms:
Extracellular Vesicles*
Multiple System Atrophy*/diagnosis
Parkinson Disease*/diagnosis
Parkinsonian Disorders*/diagnosis
Humans ; alpha-Synuclein ; Biomarkers ; Central Nervous System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathological substrate of memory impairment in multiple system atrophy.
Autorzy:
Miki Y; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Tanji K; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Shinnai K; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Tanaka MT; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.; Faculty of Science and Engineering, Graduate School of Science and Engineering, Iwate University, Morioka, Japan.
Altay F; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Foti SC; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Strand C; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Sasaki T; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kon T; Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Shimoyama S; Department of Neurophysiology, Institute of Brain Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Furukawa T; Department of Neurophysiology, Institute of Brain Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Nishijima H; Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yamazaki H; Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University, Hirosaki, Japan.; Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Asi YT; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Bettencourt C; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jaunmuktane Z; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Tada M; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Mori F; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Mizukami H; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Tomiyama M; Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Lashley T; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Ling H; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology, University College London, London, UK.
Lees AJ; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Holton JL; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Warner TT; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology, University College London, London, UK.
Wakabayashi K; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Dec; Vol. 48 (7), pp. e12844. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/pathology
Parkinson Disease*/pathology
Humans ; alpha-Synuclein/metabolism ; Inclusion Bodies/pathology ; Neurons/pathology ; Brain/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.
Autorzy:
Wang P; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.; National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, 310002, China.
Lan G; Department of Pathology, Peking University Health Science Center, Beijing, 100191, China.
Xu B; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Yu Z; Department of Neurology, Center for Movement Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China.
Tian C; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Lei X; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Meissner WG; CNRS, IMN, UMR 5293, University of Bordeaux, 33000, Bordeaux, France.; CHU Bordeaux, Service de Neurologie des Maladies Neurodégénératives, IMNc, 33000, Bordeaux, France.; Department of Medicine, New Zealand Brain Research Institute, University of Otago, Christchurch, Christchurch, New Zealand.
Feng T; Department of Neurology, Center for Movement Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. .; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China. .
Yang Y; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China. rebecca_.; Department of Pathology, Peking University Health Science Center, Beijing, 100191, China. rebecca_.
Zhang J; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China. .; National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, 310002, China. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2023 Aug 25; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/diagnosis
Multiple System Atrophy*
Extracellular Vesicles*
Humans ; alpha-Synuclein/genetics ; Astrocytes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.
Autorzy:
Graves NJ; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
Gambin Y; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
Sierecki E; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 28; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Lewy Body Disease*/metabolism
Multiple System Atrophy*
Parkinson Disease*/metabolism
Synucleinopathies*
Humans ; alpha-Synuclein/metabolism ; Protein Aggregates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Autorzy:
Lau HHC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
So RWL; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Mehra S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Silver NRG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Mao A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Stuart E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Schmitt-Ulms C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Hyman BT; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.; Neuroscience Program, Harvard Medical School, Boston, MA, USA.
Ingelsson M; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.
Kovacs GG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Watts JC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada. .; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 May 03; Vol. 11 (1), pp. 72. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/genetics
Parkinson Disease*/pathology
Multiple System Atrophy*/genetics
Multiple System Atrophy*/pathology
Synucleinopathies*/genetics
Humans ; Mice ; Animals ; alpha-Synuclein/genetics ; alpha-Synuclein/chemistry ; Mutation/genetics ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.
Autorzy:
Schmitz M; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany. .
Candelise N; National Center for Drug Research and Evaluation, Institute Superiore di Sanità, Rome, Italy.
Canaslan S; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.
Altmeppen HC; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Matschke J; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Younas N; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.
Zafar S; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.
Hermann P; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.
Zerr I; Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2023 Mar 14; Vol. 12 (1), pp. 12. Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Synucleinopathies*/diagnosis
Synucleinopathies*/genetics
Synucleinopathies*/metabolism
Parkinson Disease*/diagnosis
Parkinson Disease*/genetics
Parkinson Disease*/metabolism
Multiple System Atrophy*/diagnosis
Multiple System Atrophy*/genetics
Multiple System Atrophy*/pathology
Humans ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Lewy Bodies/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The morphological substrate of memory impairment in multiple system atrophy.
Autorzy:
Jellinger KA; Institute of Clinical Neurobiology, Vienna, Austria.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2023 Feb; Vol. 49 (1), pp. e12854. Date of Electronic Publication: 2022 Oct 24.
Typ publikacji:
Letter
MeSH Terms:
Multiple System Atrophy*
Humans ; alpha-Synuclein/metabolism ; Neuroglia/metabolism ; Brain/metabolism
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
Autorzy:
De Nuccio F; Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy.
Kashyrina M; Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy.
Serinelli F; Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy.
Laferrière F; Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, UMR 5293, 33076 Bordeaux, France.
Lofrumento DD; Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy.
De Giorgi F; Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, UMR 5293, 33076 Bordeaux, France.
Ichas F; Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, UMR 5293, 33076 Bordeaux, France.
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Źródło:
Biomolecules [Biomolecules] 2023 Feb 01; Vol. 13 (2). Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/pathology
Synucleinopathies*/metabolism
Humans ; Mice ; Animals ; alpha-Synuclein/metabolism ; Lewy Bodies/metabolism ; Inclusion Bodies/metabolism ; Oligodendroglia/metabolism ; Neurites/metabolism ; Mice, Transgenic ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alzheimer's disease pathology concomitant with memory impairment in late-onset multiple system atrophy.
Autorzy:
Miki Y; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Bettencourt C; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jaunmuktane Z; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Holton JL; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Warner TT; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology, London, UK.
Wakabayashi K; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2023 Feb; Vol. 49 (1), pp. e12878.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/pathology
Multiple System Atrophy*/complications
Lewy Body Disease*/pathology
Humans ; tau Proteins ; Atrophy ; Magnetic Resonance Imaging
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The ‘α-synucleinopathy syndicate’: multiple system atrophy and Parkinson’s disease
Autorzy:
Sian-Hulsmann, Jeswinder
Riederer, PeterAff2, Aff3, IDs00702023026532_cor2
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Źródło:
Journal of Neural Transmission: Translational Neuroscience, Neurology and Preclinical Neurological Studies, Psychiatry and Preclinical Psychiatric Studies. :1-11
Czasopismo naukowe
Szczegóły
Tytuł:
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
Autorzy:
Yang, Yang
Garringer, Holly J.
Shi, YangAff1, Aff8
Lövestam, Sofia
Peak-Chew, Sew
Zhang, Xianjun
Kotecha, Abhay
Bacioglu, Mehtap
Koto, Atsuo
Takao, MasakiAff6, Aff7
Spillantini, Maria Grazia
Ghetti, Bernardino
Vidal, Ruben
Murzin, Alexey G.Aff1, IDs00401023025508_cor14
Scheres, Sjors H. W.Aff1, IDs00401023025508_cor15
Goedert, MichelAff1, IDs00401023025508_cor16
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Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 145(5):561-572
Czasopismo naukowe
Szczegóły
Tytuł:
iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release.
Autorzy:
Henkel LM; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.; Center for Systems Neuroscience, Bünteweg 2, 30559 Hannover, Germany.
Kankowski S; Institute of Neuroanatomy and Cell Biology, Hannover Medical School, 30625 Hanover, Germany.
Moellenkamp TM; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Smandzich NJ; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.; Center for Systems Neuroscience, Bünteweg 2, 30559 Hannover, Germany.
Schwarz S; Curiositas-ad-sanum Studien und Beratungs GmbH, Krankenhausstr. 3, 83527 Haag in Oberbayern, Germany.
Di Fonzo A; Foundation IRCCS Ca' Granda Hospital Maggiore Policlinico, Unità di Neurologia, 20122 Milan, Italy.
Göhring G; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Höglinger G; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.; Center for Systems Neuroscience, Bünteweg 2, 30559 Hannover, Germany.; Department of Neurology, University Hospital of Munich, Marchioninistr. 15, 81377 Munich, Germany.
Wegner F; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.; Center for Systems Neuroscience, Bünteweg 2, 30559 Hannover, Germany.
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Źródło:
Cells [Cells] 2023 Jan 04; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/pathology
Induced Pluripotent Stem Cells*/pathology
Humans ; alpha-Synuclein ; Medium Spiny Neurons ; GABAergic Neurons/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.
Autorzy:
Kinoshita C; Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Kubota N; Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.; Teikyo University Support Center for Women Physicians and Researchers, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Aoyama K; Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 01; Vol. 23 (23). Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Multiple System Atrophy*/genetics
Multiple System Atrophy*/pathology
MicroRNAs*/genetics
Parkinsonian Disorders*
Humans ; Glutathione ; Cerebellum/metabolism ; Antioxidants ; alpha-Synuclein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein
Autorzy:
Holec, Sara A. M.
Lee, Jisoo
Oehler, Abby
Ooi, Felicia K.
Mordes, Daniel A.Aff2, Aff3
Olson, Steven H.Aff2, Aff4, Aff6
Prusiner, Stanley B.Aff2, Aff4, Aff5, IDs00401022024767_cor7
Woerman, Amanda L.Aff1, Aff2, Aff4, IDs00401022024767_cor8
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Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 144(4):677-690
Czasopismo naukowe
Szczegóły
Tytuł:
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.
Autorzy:
Li A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Washington University School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Rastegar C; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Mao X; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Jul 17; Vol. 12 (7). Date of Electronic Publication: 2022 Jul 17.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/pathology
Parkinson Disease*
Prions*
Synucleinopathies*
Animals ; alpha-Synuclein/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein.
Autorzy:
Srivastava A; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Alam P; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Caughey B; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Apr 14; Vol. 12 (4). Date of Electronic Publication: 2022 Apr 14.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Intramural
MeSH Terms:
Lewy Body Disease*/diagnosis
Lewy Body Disease*/metabolism
Multiple System Atrophy*
Parkinson Disease*/diagnosis
Parkinson Disease*/metabolism
Prions*
Synucleinopathies*/diagnosis
Humans ; alpha-Synuclein/metabolism
Czasopismo naukowe
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Tytuł:
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.
Autorzy:
Coughlin DG; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Dryden I; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Goodwill VS; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Pizzo DP; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Wright B; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Lessig S; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Galasko D; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
MacKenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Hiniker A; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Apr; Vol. 48 (3), pp. e12783. Date of Electronic Publication: 2021 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Frontotemporal Lobar Degeneration*/pathology
Multiple System Atrophy*/complications
Multiple System Atrophy*/pathology
Parkinsonian Disorders*/complications
Synucleinopathies*
Humans ; alpha-Synuclein
Czasopismo naukowe
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