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Tytuł :
Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Autorzy :
Taylor RS; Institute of Health and Well Being, University of Glasgow, United Kingdom. Electronic address: .
Taylor RJ; R(2) Consultancy, Glasgow, United Kingdom.
Bayliss S; Institute of Applied Health Research, University of Birmingham, United Kingdom.
Hagström H; Unit of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden.
Nasr P; Department of Gastroenterology and Hepatology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Schattenberg JM; University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Ishigami M; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Toyoda H; Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan.
Wai-Sun Wong V; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Peleg N; Department of Gastroenterology and Hepatology, Rabin Medical Center, Beilinson Hospital, Petach-Tikva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medicine D, Rabin Medical Center, Beilinson hospital, Petach-Tikva.
Shlomai A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sebastiani G; Department of Medicine, McGill University Health Centre, Montréal, Quebec, Canada.
Seko Y; Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Bhala N; Institute of Applied Health Research, University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, United Kingdom.
Younossi ZM; Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.
Anstee QM; Institute of Clinical and Translational Research, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom; Newcastle National Institute of Health Research Biomedical Research Centre and Liver Transplant Unit, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.
McPherson S; Liver Transplant Unit, The Newcastle upon Tyne Hospitals NHS Foundation Trust; Institute of Clinical and Translational Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom; Newcastle National Institute of Health Research Biomedical Research Centre, Newcastle-upon-Tyne, United Kingdom.
Newsome PN; National Institute for Health Research Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, United Kingdom; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
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Źródło :
Gastroenterology [Gastroenterology] 2020 May; Vol. 158 (6), pp. 1611-1625.e12. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Quality of Life*
Severity of Illness Index*
Liver/*pathology
Liver Cirrhosis/*diagnosis
Non-alcoholic Fatty Liver Disease/*mortality
Biopsy ; Confounding Factors, Epidemiologic ; Humans ; Liver Cirrhosis/mortality ; Liver Cirrhosis/pathology ; Non-alcoholic Fatty Liver Disease/pathology ; Prognosis ; Risk Assessment
Czasopismo naukowe
Tytuł :
Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease.
Autorzy :
Scorletti E; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Department of Gastroenterology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: .
Afolabi PR; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Miles EA; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Smith DE; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Almehmadi A; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Alshathry A; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Childs CE; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Del Fabbro S; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Bilson J; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Moyses HE; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Clough GF; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Sethi JK; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
Patel J; Hepatology, Department of Medicine, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.
Wright M; Hepatology, Department of Medicine, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.
Breen DJ; Department of Radiology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.
Peebles C; Department of Radiology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.
Darekar A; Department of Medical Physics, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom.
Aspinall R; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
Fowell AJ; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
Dowman JK; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
Nobili V; Hepatology, Gastroenterology and Nutrition Unit, Istituto di Ricovero e Cura a Carattere Scientifico 'Bambino Gesù' Children's Hospital, Rome, Italy; Department of Pediatric, University 'La Sapienza', Rome, Italy.
Targher G; Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
Delzenne NM; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Bindels LB; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Calder PC; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
Byrne CD; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
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Źródło :
Gastroenterology [Gastroenterology] 2020 May; Vol. 158 (6), pp. 1597-1610.e7. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Dysbiosis/*diet therapy
Gastrointestinal Microbiome/*drug effects
Liver/*drug effects
Non-alcoholic Fatty Liver Disease/*diet therapy
Synbiotics/*administration & dosage
Adult ; Bifidobacterium animalis ; Biomarkers/analysis ; Biopsy ; Double-Blind Method ; Dysbiosis/complications ; Elasticity Imaging Techniques ; Feces/microbiology ; Female ; Humans ; Lipids/analysis ; Liver/chemistry ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/prevention & control ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/microbiology ; Non-alcoholic Fatty Liver Disease/pathology ; Oligosaccharides/administration & dosage ; Proof of Concept Study ; United Kingdom
Czasopismo naukowe
Tytuł :
Unusual Calcified Lesions of the Liver and Lung in a Young Woman.
Autorzy :
Thévenot T; Service d'Hépatologie et de Soins Intensifs Digestifs, Centre Hospitalier Universitaire Jean Minjoz, Besançon cedex, France. Electronic address: .
Charon-Barra C; Centre Georges-François Leclerc, Laboratoire d'anatomie et de cytologie pathologiques, Dijon Cedex, France.
Calame P; Service de Radiologie, Centre Hospitalier Universitaire Jean Minjoz, Besançon cedex, France.
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Źródło :
Gastroenterology [Gastroenterology] 2020 Apr; Vol. 158 (5), pp. 1222-1223. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Calcinosis/*diagnosis
Hemangioendothelioma, Epithelioid/*diagnosis
Liver/*pathology
Liver Neoplasms/*diagnosis
Lung Neoplasms/*diagnosis
Adult ; Biopsy ; Calcinosis/pathology ; Calcium-Binding Proteins/analysis ; Female ; Hemangioendothelioma, Epithelioid/pathology ; Hemangioendothelioma, Epithelioid/secondary ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/pathology ; Lung/diagnostic imaging ; Lung Neoplasms/secondary ; Tomography, X-Ray Computed ; Trans-Activators/analysis ; Ultrasonography
Czasopismo naukowe
Tytuł :
A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice.
Autorzy :
Zahm AM; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Wang AW; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Wang YJ; Department of Biomedical Sciences, Florida State University, Tallahassee, Florida.
Schug J; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.
Wangensteen KJ; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: .
Kaestner KH; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2020 Mar; Vol. 158 (4), pp. 1044-1057.e17. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
High-Throughput Nucleotide Sequencing/*methods
Liver/*injuries
Liver Regeneration/*genetics
MicroRNAs/*analysis
Animals ; Chromosome Mapping ; Hepatocytes/physiology ; Hydrolases/deficiency ; Liver/physiopathology ; Mice ; MicroRNAs/antagonists & inhibitors ; Plasmids ; RNA-Binding Proteins/analysis
Czasopismo naukowe
Tytuł :
A Rapidly Progressing Polycystic Liver Disease?
Autorzy :
Dong ZR; Department of general surgery, Qilu Hospital, Shandong University, Jinan 250012, PR China.
Zhi XT; Department of general surgery, Qilu Hospital, Shandong University, Jinan 250012, PR China.
Li T; Department of general surgery, Qilu Hospital, Shandong University, Jinan 250012, PR China. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2020 Jan; Vol. 158 (1), pp. e9-e11. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*pathology
Liver Neoplasms/*diagnosis
Nasopharyngeal Carcinoma/*pathology
Nasopharyngeal Neoplasms/*pathology
Biopsy ; Cysts/diagnosis ; Diagnosis, Differential ; Disease Progression ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Liver/diagnostic imaging ; Liver Diseases/diagnosis ; Liver Neoplasms/secondary ; Lymph Nodes/diagnostic imaging ; Male ; Middle Aged ; Nasal Cavity/diagnostic imaging ; Nasopharyngeal Carcinoma/diagnosis ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharynx/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals/administration & dosage ; Time Factors
SCR Disease Name :
Polycystic liver disease
Czasopismo naukowe
Tytuł :
Multiple Low-Density Areas in the Liver.
Autorzy :
Yanai M; Department of Pathology, KKR Sapporo Medical Center, Sapporo, Japan. Electronic address: .
Yamamoto A; Department of Pathology, KKR Sapporo Medical Center, Sapporo, Japan.
Itou S; Department of Internal Medicine, KKR Sapporo Medical Center, Sapporo, Japan.
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Źródło :
Gastroenterology [Gastroenterology] 2020 Jan; Vol. 158 (1), pp. e7-e8. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Churg-Strauss Syndrome/*complications
Hepatomegaly/*diagnosis
Liver/*diagnostic imaging
Biopsy ; Churg-Strauss Syndrome/diagnosis ; Churg-Strauss Syndrome/drug therapy ; Hepatomegaly/drug therapy ; Hepatomegaly/etiology ; Hepatomegaly/pathology ; Humans ; Liver/pathology ; Male ; Middle Aged ; Prednisolone/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome
Czasopismo naukowe
Tytuł :
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
Autorzy :
Fan W; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Liu T; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Chen W; CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Hammad S; Sektion Molecular Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Germany; Department of Forensic Medicine and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Longerich T; Sektion Translational Gastrointestinal Pathology, Institute of Pathology, Heidelberg University, Heidelberg, Germany.
Hausser I; Sektion Translational Gastrointestinal Pathology, Institute of Pathology, Heidelberg University, Heidelberg, Germany.
Fu Y; Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li N; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
He Y; Department of Infectious Diseases, Institute of Hepatology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liu C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Zhang Y; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Lian Q; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Zhao X; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Yan C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Li L; CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
Yi C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Ling Z; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Ma L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Zhao X; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Xu H; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Wang P; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Cong M; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
You H; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Liu Z; Department of Infectious Diseases, Institute of Hepatology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang Y; Department of Infectious Diseases, Institute of Hepatology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen J; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Li D; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Hui L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Dooley S; Sektion Molecular Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address: .
Hou J; Department of Infectious Diseases, Institute of Hepatology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
Jia J; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China. Electronic address: .
Sun B; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, Shanghai, China. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Nov; Vol. 157 (5), pp. 1352-1367.e13. Date of Electronic Publication: 2019 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemical and Drug Induced Liver Injury/*prevention & control
Extracellular Matrix Proteins/*metabolism
Hepatic Stellate Cells/*metabolism
Liver/*metabolism
Liver Cirrhosis, Experimental/*prevention & control
Transforming Growth Factor beta/*metabolism
ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Carbon Tetrachloride ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Extracellular Matrix Proteins/deficiency ; Extracellular Matrix Proteins/genetics ; Hepatic Stellate Cells/pathology ; Hepatitis, Alcoholic/metabolism ; Hepatitis, Alcoholic/pathology ; Hepatitis, Viral, Human/metabolism ; Hepatitis, Viral, Human/pathology ; Humans ; Liver/pathology ; Liver Cirrhosis, Alcoholic/metabolism ; Liver Cirrhosis, Alcoholic/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction
Czasopismo naukowe
Tytuł :
Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury.
Autorzy :
Panel M; INSERM U955, Team 3, Créteil, France; Université Paris-Est, UMR S955, DHU A-TVB, UPEC, Créteil, France.
Ruiz I; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France.
Brillet R; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France.
Lafdil F; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France; Institut Universitaire de France (IUF), Paris, France.
Teixeira-Clerc F; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France.
Nguyen CT; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France; Department of Pathology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Calderaro J; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France; Department of Pathology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Gelin M; Centre de Biochimie Structurale (CBS), INSERM U1054, CNRS UMR5048, Université de Montpellier, Montpellier, France.
Allemand F; Centre de Biochimie Structurale (CBS), INSERM U1054, CNRS UMR5048, Université de Montpellier, Montpellier, France.
Guichou JF; Centre de Biochimie Structurale (CBS), INSERM U1054, CNRS UMR5048, Université de Montpellier, Montpellier, France.
Ghaleh B; INSERM U955, Team 3, Créteil, France; Université Paris-Est, UMR S955, DHU A-TVB, UPEC, Créteil, France.
Ahmed-Belkacem A; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France.
Morin D; INSERM U955, Team 3, Créteil, France; Université Paris-Est, UMR S955, DHU A-TVB, UPEC, Créteil, France. Electronic address: .
Pawlotsky JM; INSERM U955, Team Viruses, Hepatology, Cancer, Créteil, France; National Reference Center for Viral Hepatitis B, C and Delta, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Nov; Vol. 157 (5), pp. 1368-1382. Date of Electronic Publication: 2019 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclophilin D/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Liver/*drug effects
Liver Diseases/*prevention & control
Mitochondria, Liver/*drug effects
Mitochondrial Membrane Transport Proteins/*antagonists & inhibitors
Reperfusion Injury/*prevention & control
Animals ; Calcium Signaling/drug effects ; Cells, Cultured ; Cyclophilin D/genetics ; Cyclophilin D/metabolism ; Cytoprotection ; Disease Models, Animal ; Humans ; Liver/enzymology ; Liver/pathology ; Liver Diseases/enzymology ; Liver Diseases/genetics ; Liver Diseases/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria, Liver/enzymology ; Mitochondria, Liver/pathology ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Permeability Transition Pore ; Mitochondrial Swelling/drug effects ; Reperfusion Injury/enzymology ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
A Rare Cause of Multiple Hepatic Masses.
Autorzy :
Kim SB; Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Kim JW; Department of Radiology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Choi JH; Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
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Źródło :
Gastroenterology [Gastroenterology] 2019 Sep; Vol. 157 (3), pp. e12-e13. Date of Electronic Publication: 2019 Apr 14.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actinomyces/*isolation & purification
Actinomycosis/*microbiology
Liver/*microbiology
Actinomyces/drug effects ; Actinomycosis/diagnosis ; Actinomycosis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Biopsy ; Female ; Humans ; Liver/diagnostic imaging ; Liver/drug effects ; Middle Aged ; Tomography, X-Ray Computed ; Ultrasonography
Czasopismo naukowe
Tytuł :
Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation.
Autorzy :
Hamesch K; Coordinating Center for Alpha1-Antitrypsin Deficiency-Related Liver Disease of the European Reference Network 'Rare Liver' and the European Association for the Study of the Liver Registry Group 'Alpha1-Liver,' University Hospital Aachen, Aachen, Germany; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Mandorfer M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.
Pereira VM; Department of Gastroenterology, Centro Hospitalar do Funchal, Madeira, Portugal.
Moeller LS; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
Pons M; Liver Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Dolman GE; Department of Hepatology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.
Reichert MC; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Schneider CV; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Woditsch V; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Voss J; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Lindhauer C; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Fromme M; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Spivak I; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Guldiken N; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Zhou B; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Arslanow A; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany; Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Schaefer B; Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria.
Zoller H; Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria.
Aigner E; Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria.
Reiberger T; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.
Wetzel M; Department of Medicine I, Charité-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Siegmund B; Department of Medicine I, Charité-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Simões C; Gastroenterology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
Gaspar R; Gastroenterology Department, Centro Hospitalar de São João, Faculty of Medicine of Porto University, Porto, Portugal.
Maia L; Gastroenterology Department, Centro Hospitalar do Porto, Porto, Portugal.
Costa D; Gastroenterology Department, Hospital de Braga, Braga, Portugal.
Bento-Miranda M; Gastroenterology Department, Hospital Universitário de Coimbra, Coimbra, Portugal.
van Helden J; Medical Care Centre, Dr Stein and Colleagues, Moenchengladbach, Germany.
Yagmur E; Medical Care Centre, Dr Stein and Colleagues, Moenchengladbach, Germany.
Bzdok D; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany; Jülich Aachen Research Alliance-Brain, Aachen, Germany.
Stolk J; Clinic for Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Gleiber W; Clinic for Pulmonology, University Hospital Frankfurt, Frankfurt, Germany.
Knipel V; Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany.
Windisch W; Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany.
Mahadeva R; Department of Respiratory Medicine, Cambridge National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Bals R; Department of Medicine V, Saarland University Medical Center, Saarland University, Homburg, Germany.
Koczulla R; Clinic for Pneumology, Marburg University Hospital, Marburg, Germany; Institute for Pulmonary Rehabilitation Research, Schoen Clinic Berchtesgadener Land, Member of the Deutsches Zentrum für Lungenforschung, Schönau am Königssee, Germany.
Barrecheguren M; Department of Pneumology, Vall d'Hebron University Hospital, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Barcelona, Spain.
Miravitlles M; Department of Pneumology, Vall d'Hebron University Hospital, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Barcelona, Spain.
Janciauskiene S; Clinic for Pneumology, German Center for Lung Research, Medical University Hannover, Hannover, Germany.
Stickel F; Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.
Lammert F; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Liberal R; Gastroenterology Department, Centro Hospitalar de São João, Faculty of Medicine of Porto University, Porto, Portugal.
Genesca J; Liver Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Griffiths WJ; Department of Hepatology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.
Trauner M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.
Krag A; Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
Trautwein C; Coordinating Center for Alpha1-Antitrypsin Deficiency-Related Liver Disease of the European Reference Network 'Rare Liver' and the European Association for the Study of the Liver Registry Group 'Alpha1-Liver,' University Hospital Aachen, Aachen, Germany; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
Strnad P; Coordinating Center for Alpha1-Antitrypsin Deficiency-Related Liver Disease of the European Reference Network 'Rare Liver' and the European Association for the Study of the Liver Registry Group 'Alpha1-Liver,' University Hospital Aachen, Aachen, Germany; Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany. Electronic address: .
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Corporate Authors :
European Alpha1-Liver Study Group
Źródło :
Gastroenterology [Gastroenterology] 2019 Sep; Vol. 157 (3), pp. 705-719.e18. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Metabolism*
Mutation*
Fatty Liver/*etiology
Liver/*metabolism
Liver Cirrhosis/*etiology
alpha 1-Antitrypsin/*genetics
alpha 1-Antitrypsin Deficiency/*complications
Adult ; Age Factors ; Aged ; Animals ; Case-Control Studies ; Elasticity Imaging Techniques ; Europe ; Fatty Liver/blood ; Fatty Liver/diagnosis ; Female ; Genetic Predisposition to Disease ; Homozygote ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Function Tests ; Male ; Mice, Transgenic ; Middle Aged ; Phenotype ; Risk Factors ; Sex Factors ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/enzymology ; alpha 1-Antitrypsin Deficiency/genetics
Czasopismo naukowe
Tytuł :
An Incidentally Identified Liver Mass.
Autorzy :
Zhang XF; Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi'an Jiaotong University. Xi'an, Shaanxi Province, China.
Liu XM; Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi'an Jiaotong University. Xi'an, Shaanxi Province, China.
Lv Y; Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi'an Jiaotong University. Xi'an, Shaanxi Province, China.
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Źródło :
Gastroenterology [Gastroenterology] 2019 Sep; Vol. 157 (3), pp. e10-e11. Date of Electronic Publication: 2019 Apr 06.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Incidental Findings*
Liver*/diagnostic imaging
Liver*/physiology
Liver*/surgery
Splenosis/*diagnosis
Biopsy ; Humans ; Male ; Splenosis/surgery ; Tomography, X-Ray Computed ; Young Adult
Czasopismo naukowe
Tytuł :
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
Autorzy :
Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Singh BK; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
D'Agostino GA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Ng B; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Lim WW; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Tan J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Paleja BS; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore.
Tripathi M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Lim SY; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Shekeran SG; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Rabes A; Department of Tropical Medicine and Infectious Diseases, University Medical Center, Rostock, Germany.
Sombetzki M; Department of Tropical Medicine and Infectious Diseases, University Medical Center, Rostock, Germany.
Bruinstroop E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Min LP; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Sinha RA; Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Albani S; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore.
Yen PM; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; National Heart and Lung Institute, Imperial College London, London, UK; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Sep; Vol. 157 (3), pp. 777-792.e14. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*pharmacology
Hepatitis/*prevention & control
Interleukin-11/*antagonists & inhibitors
Interleukin-11 Receptor alpha Subunit/*metabolism
Liver/*drug effects
Liver Cirrhosis, Experimental/*prevention & control
Non-alcoholic Fatty Liver Disease/*prevention & control
Animals ; Cell Death/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Hepatitis/genetics ; Hepatitis/metabolism ; Hepatitis/pathology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Inflammation Mediators/metabolism ; Interleukin-11/metabolism ; Interleukin-11 Receptor alpha Subunit/deficiency ; Interleukin-11 Receptor alpha Subunit/genetics ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Signal Transduction/drug effects ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice.
Autorzy :
Yan J; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Tung HC; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Li S; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Niu Y; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Garbacz WG; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lu P; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Bi Y; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Li Y; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
He J; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xu M; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Ren S; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Monga SP; Department of Pathology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Schwabe RF; Department of Medicine, Columbia University, New York, New York.
Yang D; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Xie W; Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Sep; Vol. 157 (3), pp. 793-806.e14. Date of Electronic Publication: 2019 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cellular Senescence*/drug effects
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Chemical and Drug Induced Liver Injury/*prevention & control
Hepatic Stellate Cells/*metabolism
Liver/*metabolism
Liver Cirrhosis, Experimental/*prevention & control
Receptors, Aryl Hydrocarbon/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/deficiency ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Proliferation ; Cells, Cultured ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Gene Expression Regulation ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/pathology ; Indoles/pharmacology ; Liver/drug effects ; Liver/pathology ; Liver Cirrhosis, Experimental/genetics ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/deficiency ; Receptors, Aryl Hydrocarbon/genetics ; Signal Transduction ; Smad3 Protein/metabolism ; Thiazoles/pharmacology ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
An 8-Year History of Increased Level of Aspartate Aminotransferase.
Autorzy :
Shah-Khan SM; Department of Medicine, West Virginia University, Morgantown, West Virginia.
Hsueh W; Section of Digestive Diseases, West Virginia University, Morgantown, West Virginia.
Reynolds GJ; Section of Digestive Diseases, West Virginia University, Morgantown, West Virginia.
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Źródło :
Gastroenterology [Gastroenterology] 2019 Aug; Vol. 157 (2), pp. 318-319. Date of Electronic Publication: 2019 Jan 04.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Asymptomatic Diseases*
Aspartate Aminotransferases/*blood
Blood Chemical Analysis/*methods
Liver/*metabolism
Liver Diseases/*diagnosis
Aged ; Appalachian Region ; Aspartate Aminotransferases/chemistry ; Aspartate Aminotransferases/metabolism ; Female ; Humans ; Liver Diseases/blood ; Polyethylene Glycols/chemistry ; Rural Population
Czasopismo naukowe
Tytuł :
Lanreotide Reduces Liver Growth In Patients With Autosomal Dominant Polycystic Liver and Kidney Disease.
Autorzy :
van Aerts RMM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Kievit W; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
D'Agnolo HMA; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Blijdorp CJ; Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Casteleijn NF; Department of Urology, University Medical Center Groningen, Groningen, The Netherlands.
Dekker SEI; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
van Gastel M; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Gevers TJ; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
van de Laarschot LFM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Lantinga MA; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Losekoot M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Meijer E; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Messchendorp AL; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Neijenhuis MK; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Pena MJ; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Peters DJM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Salih M; Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Soonawala D; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands; Department of Internal Medicine, Haga teaching hospital, The Hague, The Netherlands.
Spithoven EM; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Visser FW; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands; Department of Internal Medicine, Hospital group Twente, Almelo, The Netherlands.
Wetzels JF; Deptartment of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
Zietse R; Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Gansevoort RT; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Drenth JPH; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: .
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Corporate Authors :
DIPAK-1 Investigators
Źródło :
Gastroenterology [Gastroenterology] 2019 Aug; Vol. 157 (2), pp. 481-491.e7. Date of Electronic Publication: 2019 Apr 22.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysts/*drug therapy
Kidney/*pathology
Liver/*pathology
Liver Diseases/*drug therapy
Peptides, Cyclic/*administration & dosage
Polycystic Kidney, Autosomal Dominant/*drug therapy
Somatostatin/*analogs & derivatives
Adult ; Cysts/diagnostic imaging ; Cysts/etiology ; Cysts/pathology ; Drug Administration Schedule ; Female ; Humans ; Injections, Subcutaneous ; Kidney/diagnostic imaging ; Kidney/drug effects ; Liver/diagnostic imaging ; Liver/drug effects ; Liver Diseases/diagnostic imaging ; Liver Diseases/etiology ; Liver Diseases/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size/drug effects ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Somatostatin/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.
Autorzy :
Lupberger J; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address: .
Croonenborghs T; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
Roca Suarez AA; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Van Renne N; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Jühling F; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Oudot MA; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Virzì A; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Bandiera S; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Jamey C; Université de Strasbourg, Strasbourg, France; Laboratoire de Biochimie et de Biologie Moléculaire, Pôle de biologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Meszaros G; Université de Strasbourg, Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
Brumaru D; Université de Strasbourg, Strasbourg, France; Laboratoire de Biochimie et de Biologie Moléculaire, Pôle de biologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Mukherji A; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Durand SC; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Heydmann L; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Verrier ER; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
El Saghire H; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Hamdane N; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany; Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fereshetian S; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Ramberger E; Proteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Berlin, Germany; Berlin Institute of Health, Berlin, Germany.
Sinha R; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
Nabian M; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
Everaert C; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
Jovanovic M; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Department of Biological Sciences, Columbia University, New York, New York.
Mertins P; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Proteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Berlin, Germany; Berlin Institute of Health, Berlin, Germany.
Carr SA; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Chayama K; Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Liver Research Project Center, Hiroshima University, Hiroshima, Japan.
Dali-Youcef N; Université de Strasbourg, Strasbourg, France; Laboratoire de Biochimie et de Biologie Moléculaire, Pôle de biologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
Ricci R; Université de Strasbourg, Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
Bardeesy NM; Massachusetts General Hospital, Boston, Massachusetts.
Fujiwara N; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Gevaert O; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Stanford Center for Biomedical Informatics Research, Department of Medicine and Biomedical Data Science, Stanford University, Stanford, California.
Zeisel MB; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France.
Hoshida Y; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Pochet N; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Cell Circuits Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: .
Baumert TF; Institut National de la Santé et de la Recherche Médicale, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg (IVH), Strasbourg, France; Université de Strasbourg, Strasbourg, France; Pôle Hépato-digestif, Institut Hopitalo-Universitaire, Strasbourg, France. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Aug; Vol. 157 (2), pp. 537-551.e9. Date of Electronic Publication: 2019 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hepacivirus/*pathogenicity
Hepatitis C, Chronic/*pathology
Hepatocytes/*pathology
Liver/*pathology
Animals ; Cell Line, Tumor ; Datasets as Topic ; Disease Models, Animal ; Gene Expression Profiling ; Glucose/metabolism ; Hepatitis C, Chronic/metabolism ; Hepatitis C, Chronic/virology ; Hepatocytes/transplantation ; Hepatocytes/virology ; Humans ; Liver/cytology ; Liver/virology ; Metabolomics ; Mice ; Peroxisomes/metabolism ; Peroxisomes/pathology ; Proteomics ; STAT3 Transcription Factor/metabolism ; Transplantation Chimera
Czasopismo naukowe
Tytuł :
Gas in the Liver.
Autorzy :
Dasa O; Division of Hospital Medicine, University of Florida, Gainesville, Florida.
Moroi MK; Penn State College of Medicine, Hershey, Pennsylvania.
Ruzieh M; Penn State Heart and Vascular Institute, Hershey, Pennsylvania.
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Źródło :
Gastroenterology [Gastroenterology] 2019 Aug; Vol. 157 (2), pp. 313-314. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gases*
Gastric Mucosa/*injuries
Hydrogen Peroxide/*toxicity
Liver/*diagnostic imaging
Portal Vein/*pathology
Accidents, Home ; Drinking ; Gastric Mucosa/blood supply ; Gastric Mucosa/drug effects ; Humans ; Liver/blood supply ; Liver/pathology ; Male ; Middle Aged ; Portal Vein/diagnostic imaging ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.
Autorzy :
Aziz K; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Limzerwala JF; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hurley E; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.
Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Nelson G; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Bronk S; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Fierro Velasco RO; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
van Deursen EJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
O'Brien DR; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Kocher JA; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Youssef SA; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
van Ree JH; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
de Bruin A; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
van den Bos H; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Spierings DCJ; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Foijer F; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van de Sluis B; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Roberts LR; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Gores GJ; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.
van Deursen JM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Jul; Vol. 157 (1), pp. 210-226.e12. Date of Electronic Publication: 2019 Mar 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adenoma, Liver Cell/*genetics
Carcinoma, Hepatocellular/*genetics
Chromosomal Instability/*genetics
Cyclin E/*genetics
Liver/*metabolism
Liver Neoplasms/*genetics
Oncogene Proteins/*genetics
Adenoma, Liver Cell/pathology ; Adenoma, Liver Cell/virology ; Animals ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Chromosome Structures ; DNA Damage/genetics ; DNA Replication ; Fibroblasts ; Hepatitis B, Chronic ; Hepatocytes ; Liver/pathology ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Liver Neoplasms, Experimental/genetics ; Liver Neoplasms, Experimental/pathology ; Mice ; Oxidative Stress/genetics ; Parvoviridae Infections ; Parvovirinae ; Polyploidy ; S Phase Cell Cycle Checkpoints
SCR Organism :
Adeno-associated virus-2
Czasopismo naukowe
Tytuł :
Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.
Autorzy :
Hilscher MB; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Sehrawat T; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Arab JP; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Zeng Z; Department of Immunology, University of Calgary, Calgary, Alberta, Canada.
Gao J; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Liu M; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Kostallari E; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Gao Y; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Simonetto DA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Yaqoob U; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Cao S; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Revzin A; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Beyder A; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Wang RA; Department of Surgery, University of California at San Francisco, San Francisco, California.
Kamath PS; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Kubes P; Department of Immunology, University of Calgary, Calgary, Alberta, Canada.
Shah VH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Jul; Vol. 157 (1), pp. 193-209.e9. Date of Electronic Publication: 2019 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Neutrophil Infiltration*
Stress, Mechanical*
Capillaries/*metabolism
Chemokine CXCL1/*metabolism
Endothelial Cells/*metabolism
Hypertension, Portal/*metabolism
Liver/*blood supply
Thrombosis/*metabolism
Animals ; Calcium Signaling ; Capillaries/cytology ; Extracellular Traps ; Hydrolases/genetics ; In Vitro Techniques ; Integrins/metabolism ; Leukocyte Elastase/genetics ; Ligation ; Liver/metabolism ; Mechanotransduction, Cellular ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Portal Pressure ; Protein-Arginine Deiminase Type 4 ; Receptor, Notch1/genetics ; Vena Cava, Inferior/surgery
Czasopismo naukowe
Tytuł :
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.
Autorzy :
Chaturantabut S; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Shwartz A; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Evason KJ; Department of Pathology, University of Utah, Salt Lake City, Utah.
Cox AG; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Labella K; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Schepers AG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Yang S; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
Acuña M; Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York.
Houvras Y; Departments of Surgery and Medicine, Weill Cornell Medical College, New York, New York.
Mancio-Silva L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Romano S; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama.
Gorelick DA; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama.
Cohen DE; Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, New York.
Zon LI; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase, Maryland; Harvard Stem Cell Institute, Cambridge, Massachusetts; Dana-Farber Cancer Institute, Boston, Massachusetts.
Bhatia SN; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
North TE; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts.
Goessling W; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts; Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Divison of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 May; Vol. 156 (6), pp. 1788-1804.e13. Date of Electronic Publication: 2019 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Estradiol/*pharmacology
Estrogens/*pharmacology
Liver/*growth & development
Liver Neoplasms/*metabolism
Receptors, Estrogen/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Zebrafish Proteins/*metabolism
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Carcinogenesis/drug effects ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Female ; Gene Expression/drug effects ; Hepatocytes ; Humans ; Liver/metabolism ; Liver Cirrhosis/metabolism ; Liver Neoplasms/pathology ; Liver Regeneration ; Male ; Organ Size/drug effects ; Phosphatidylinositol 3-Kinase/metabolism ; Receptors, G-Protein-Coupled/genetics ; Sex Factors ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tumor Burden/drug effects ; Zebrafish ; Zebrafish Proteins/genetics
Czasopismo naukowe

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