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Tytuł :
The mycotoxin beauvericin impairs development, fertility and life span in the nematode Caenorhabditis elegans accompanied by increased germ cell apoptosis and lipofuscin accumulation.
Autorzy :
Büchter C; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany.
Koch K; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany.
Freyer M; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany.
Baier S; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany.
Saier C; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany.
Honnen S; Heinrich Heine University, Medical Faculty, Institute of Toxicology, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Wätjen W; Martin-Luther-University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Weinbergweg 22, 06120 Halle/Saale, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Nov 01; Vol. 334, pp. 102-109. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Caenorhabditis elegans/*drug effects
Depsipeptides/*toxicity
Germ Cells/*drug effects
Lipofuscin/*metabolism
Longevity/*drug effects
Mycotoxins/*toxicity
Animals ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Dose-Response Relationship, Drug ; Fertility/drug effects ; Food Contamination ; Germ Cells/pathology ; Motor Activity/drug effects ; Toxicity Tests, Acute
Czasopismo naukowe
Tytuł :
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis.
Autorzy :
Chen S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Tan S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Yang S; School of Medicine, Hunan Normal University, Changsha, Hunan Province 410013, PR China.
Chen G; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Zhu L; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Sun Z; Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners, Qinhuangdao, Hebei Province 066104, PR China.
Li H; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yao S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Nov 01; Vol. 334, pp. 94-101. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Macrophages, Alveolar/*drug effects
Nicotine/*toxicity
Silicosis/*pathology
Adenine/analogs & derivatives ; Adenine/pharmacology ; Caspase 3/metabolism ; Cells, Cultured ; Humans ; In Situ Nick-End Labeling ; Lysosomes/drug effects ; Lysosomes/metabolism ; Lysosomes/pathology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/pathology ; Male ; Microtubule-Associated Proteins/metabolism ; Silicon Dioxide/toxicity ; Silicosis/metabolism
Czasopismo naukowe
Tytuł :
Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice.
Autorzy :
Zhao J; Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Academy of Chinses Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China; School of Pharmaceutical Science, Hebei Medical University, Shijiazhuang, Hebei, China; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Xie C; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wang K; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Takahashi S; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Krausz KW; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Lu D; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Wang Q; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Luo Y; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Gong X; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Mu X; School of Pharmaceutical Science, Hebei Medical University, Shijiazhuang, Hebei, China.
Wang Q; School of Pharmaceutical Science, Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address: .
Su S; Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address: .
Gonzalez FJ; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 290-302. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury*/genetics
Chemical and Drug Induced Liver Injury*/metabolism
Chemical and Drug Induced Liver Injury*/pathology
Apoptosis/*drug effects
Diterpenes/*toxicity
Metabolome/*drug effects
Necroptosis/*drug effects
Phenanthrenes/*toxicity
Transcriptome/*drug effects
Animals ; Apoptosis/genetics ; Dose-Response Relationship, Drug ; Epoxy Compounds/toxicity ; Gene Expression Profiling ; Metabolome/genetics ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Necroptosis/genetics
Czasopismo naukowe
Tytuł :
Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage.
Autorzy :
Higgs EB; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Godschalk R; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Coltman NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: .
Stewart GS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: .
van Schooten FJ; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Hodges NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 10; Vol. 332, pp. 27-35. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Apoptosis/*drug effects
DNA Glycosylases/*genetics
Fibroblasts/*drug effects
Glutathione/*metabolism
Adenosine Triphosphate/biosynthesis ; Animals ; Buthionine Sulfoximine/pharmacology ; DNA Repair/drug effects ; DNA Repair/genetics ; Enzyme Inhibitors/pharmacology ; Hydrogen Peroxide/pharmacology ; Mice ; Mice, Knockout ; Mitochondria/drug effects ; Oxidants/pharmacology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Autorzy :
Gao Z; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Dlamini MB; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Ge H; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Jiang L; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Geng C; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Li Q; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Shi X; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Liu Y; School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China.
Cao J; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 01; Vol. 331, pp. 178-187. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Activating Transcription Factor 4/*metabolism
Apoptosis/*drug effects
Autophagy/*drug effects
Chromium/*toxicity
Endoplasmic Reticulum Stress/*drug effects
Environmental Pollutants/*toxicity
Glycolysis/*drug effects
A549 Cells ; Activating Transcription Factor 4/genetics ; Apoptosis/genetics ; Autophagy/genetics ; Endoplasmic Reticulum Stress/genetics ; Gene Knockdown Techniques ; Glycolysis/genetics ; Humans
Czasopismo naukowe
Tytuł :
The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells.
Autorzy :
Vaz I; UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa, Praça Nove de Abril, 349, 4249-004, Porto, Portugal.
Carvalho T; UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa, Praça Nove de Abril, 349, 4249-004, Porto, Portugal.
Valente MJ; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. Electronic address: .
Castro A; UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa, Praça Nove de Abril, 349, 4249-004, Porto, Portugal.
Araújo AM; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Bastos ML; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
Carvalho M; UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa, Praça Nove de Abril, 349, 4249-004, Porto, Portugal; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 01; Vol. 331, pp. 42-52. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*toxicity
Apoptosis/*drug effects
Autophagy/*drug effects
Illicit Drugs/*toxicity
Kidney/*drug effects
Alkaloids/chemistry ; Benzodioxoles/chemistry ; Benzodioxoles/toxicity ; Cell Culture Techniques ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Humans ; Kidney/metabolism ; Kidney/pathology ; Methamphetamine/analogs & derivatives ; Methamphetamine/chemistry ; Methamphetamine/toxicity ; Methylamines/chemistry ; Methylamines/toxicity ; Pentanones/chemistry ; Pentanones/toxicity ; Pyrrolidines/chemistry ; Pyrrolidines/toxicity ; Reactive Nitrogen Species/metabolism ; Reactive Oxygen Species/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Excessive fluoride exposure induces thymocyte apoptosis and impairs cell division: Roles of the PERK and IRE1 pathways.
Autorzy :
Wei W; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin, Heilongjiang, 150081, China; Institution of Environmentally Related Diseases, Harbin Medical University, Harbin, Heilongjiang, 150081, China. Electronic address: .
Wang Q; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Pang S; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China; Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser hospital), Qingdao, Shandong Province, 266033, China.
Tan S; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Sun J; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Li M; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Wang S; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Sun D; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Aug 01; Vol. 328, pp. 35-44. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cell Division/*drug effects
Fluorides/*toxicity
Membrane Proteins/*drug effects
Protein-Serine-Threonine Kinases/*drug effects
Signal Transduction/*drug effects
Thymocytes/*drug effects
eIF-2 Kinase/*drug effects
Animals ; B-Lymphocytes/drug effects ; CD3 Complex ; Cells, Cultured ; Gene Knockdown Techniques ; In Situ Nick-End Labeling ; Male ; Membrane Proteins/genetics ; Protein-Serine-Threonine Kinases/genetics ; Rats ; Rats, Wistar ; Thymus Gland/cytology ; Thymus Gland/drug effects ; eIF-2 Kinase/genetics
Czasopismo naukowe
Tytuł :
Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro.
Autorzy :
Chen Y; Research Center of Endocrinology and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Chen K; Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Zhou Y; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China.
Li X; Research Center of Endocrinology and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Mao X; Research Center of Endocrinology and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Wei X; Research Center of Endocrinology and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Xu Y; Research Center of Endocrinology and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Yang W; Clinical Laboratory, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China.
Chen G; Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China. Electronic address: .
Liu C; Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 15; Vol. 326, pp. 106-113. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cell Survival/*drug effects
Cyanobacteria/*chemistry
Glucose/*metabolism
Insulin-Secreting Cells/*drug effects
Microcystins/*toxicity
Pancreas/*drug effects
Animals ; Male ; Mice
Czasopismo naukowe
Tytuł :
Impaired activation of Notch-1 signaling hinders repair processes of bronchial epithelial cells exposed to cigarette smoke.
Autorzy :
Di Sano C; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
D'Anna C; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Ferraro M; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Chiappara G; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Sangiorgi C; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Di Vincenzo S; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Bertani A; Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy.
Vitulo P; Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy.
Bruno A; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Dino P; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy.
Pace E; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche, Palermo, Italy. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 15; Vol. 326, pp. 61-69. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Bronchi/*drug effects
Cell Proliferation/*drug effects
Epithelial Cells/*drug effects
Receptors, Notch/*drug effects
Signal Transduction/*drug effects
Tobacco Smoke Pollution/*adverse effects
Humans
Czasopismo naukowe
Tytuł :
A reporter cell line for real-time imaging of autophagy and apoptosis.
Autorzy :
Lupitha SS; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Chandrasekhar L; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Varadarajan SN; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Jayaprasad AG; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Chandrasekharan A; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Patil SN; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Mini M; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Pillai PR; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India.
Santhoshkumar TR; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (Research Centre, University of Kerala), Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala, 695014, India. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 15; Vol. 326, pp. 23-30. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Cell Line, Tumor/*drug effects
Drug Evaluation, Preclinical/*methods
Genes, Reporter/*drug effects
Green Fluorescent Proteins/*drug effects
HeLa Cells/*drug effects
Apoptosis/physiology ; Autophagy/physiology ; Cell Line, Tumor/physiology ; Genes, Reporter/physiology ; Green Fluorescent Proteins/physiology ; HeLa Cells/physiology ; Humans
Czasopismo naukowe
Tytuł :
Downregulation of vdac2 inhibits spermatogenesis via JNK and P53 signalling in mice exposed to cadmium.
Autorzy :
Fang Y; Department of Medical Genetics, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Zhang L; Department of Medical Genetics, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Dong X; Department of Medical Genetics, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Wang H; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China.
He L; Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Zhong S; Department of Medical Genetics, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 15; Vol. 326, pp. 114-122. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cadmium/*toxicity
Cell Proliferation/*drug effects
Down-Regulation/*drug effects
Signal Transduction/*drug effects
Spermatogenesis/*drug effects
Voltage-Dependent Anion Channel 2/*drug effects
Animals ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish.
Autorzy :
Shang X; School of Psychology, North China University of Science and Technology, 21 Bohai Road, Tang'shan 063210, Hebei Province, PR China.
Ji X; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China.
Dang J; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China.
Wang L; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China.
Sun C; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China.
Liu K; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China.
Sik A; Institute of Physiology, Medical School, University of Pecs, Pecs H-7624, Hungary; Szentagothai Research Centre, University of Pecs, Pecs H-7624, Hungary; Institute of Clinical Sciences, Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Jin M; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, 28789 East Jingshi Road, Ji'nan 250103, Shandong Province, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 May 15; Vol. 324, pp. 1-11. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Abnormalities, Drug-Induced/*etiology
Anisoles/*toxicity
Apoptosis/*drug effects
Electrocardiography/*drug effects
Heart Defects, Congenital/*chemically induced
Mitochondria, Heart/*drug effects
Animals ; Cardiotoxicity/etiology ; Embryo, Nonmammalian/drug effects ; Mitochondria, Heart/pathology ; Zebrafish
Czasopismo naukowe
Tytuł :
Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells.
Autorzy :
Goswami DG; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Kant R; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Ammar DA; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Agarwal C; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Gomez J; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Agarwal R; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Saba LM; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Fritz KS; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Tewari-Singh N; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, 48824, USA. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Apr 01; Vol. 322, pp. 1-11. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Epithelium, Corneal/*drug effects
Hydrocarbons, Chlorinated/*toxicity
Oxidative Stress/*drug effects
Pesticides/*toxicity
Protein Carbonylation/*drug effects
Caspase 3/metabolism ; Cells, Cultured ; Cyclooxygenase 2/metabolism ; DNA Damage ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Epithelium, Corneal/metabolism ; Epithelium, Corneal/pathology ; Heme Oxygenase-1/metabolism ; Histones/metabolism ; Humans ; Inflammation Mediators/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Lipid Peroxidation ; Phosphorylation ; Poly(ADP-ribose) Polymerases/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo.
Autorzy :
Huang M; Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.
Zhong Y; Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.
Lin L; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Liang B; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Liu J; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Jiang J; Faculty of Preventive Medicine, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Hu M; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Huang Y; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Lin X; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Lu L; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Bian Z; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Zhong W; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Wu J; Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Zheng J; Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.
Rong W; Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China.
Zhang Y; Faculty of Preventive Medicine, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Jiang L; Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Wu J; Department of Healthcare, Guangdong Women and Children Hospital, Guangzhou 511442, China.
Zhang X; Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yang X; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Hu Q; Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: .
Huang Z; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Apr 01; Vol. 322, pp. 87-97. Date of Electronic Publication: 2020 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cerebellum/*drug effects
Ethylene Dichlorides/*toxicity
Mitochondria/*drug effects
Neurons/*drug effects
Animals ; Apoptosis Regulatory Proteins/metabolism ; Behavior, Animal/drug effects ; Cells, Cultured ; Cerebellum/metabolism ; Cerebellum/pathology ; Cerebellum/physiopathology ; Humans ; Locomotion/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/metabolism ; Neurons/pathology ; Risk Assessment ; Signal Transduction
Czasopismo naukowe
Tytuł :
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Autorzy :
Lin Y; Institute of Marine Biology, Ocean University of China, Qingdao, 266003, China.
Yu M; Institute of Marine Biology, Ocean University of China, Qingdao, 266003, China.
Fan T; Institute of Marine Biology, Ocean University of China, Qingdao, 266003, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 01; Vol. 320, pp. 9-18. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*toxicity
Apoptosis/*drug effects
Benzopyrans/*toxicity
Corneal Stroma/*drug effects
Necroptosis/*drug effects
Propionates/*toxicity
Stromal Cells/*drug effects
Animals ; Caspases/metabolism ; Cells, Cultured ; Chromatin Assembly and Disassembly/drug effects ; Corneal Stroma/metabolism ; Corneal Stroma/pathology ; Dose-Response Relationship, Drug ; Humans ; Male ; Protein Kinases/metabolism ; Rabbits ; Reactive Oxygen Species/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Time Factors
Czasopismo naukowe
Tytuł :
Continuous gibberellin A3 exposure from weaning to sexual maturity induces ovarian granulosa cell apoptosis by activating Fas-mediated death receptor signaling pathways and changing methylation patterns on caspase-3 gene promoters.
Autorzy :
Guo Y; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Wang W; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. Electronic address: .
Chen Y; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Sun Y; Center for Reproductive Medicine, Teaching Hospital of Fujian Medical University, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China.
Li Y; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Guan F; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Shen Q; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Guo Y; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Zhang W; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Feb 01; Vol. 319, pp. 175-186. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Caspase 3/*drug effects
DNA Methylation/*drug effects
Fas-Associated Death Domain Protein/*biosynthesis
Gibberellins/*toxicity
Granulosa Cells/*drug effects
Ovary/*cytology
Signal Transduction/*drug effects
Animals ; DNA (Cytosine-5-)-Methyltransferases/biosynthesis ; DNA (Cytosine-5-)-Methyltransferases/genetics ; Fas-Associated Death Domain Protein/drug effects ; Female ; Ovarian Follicle/drug effects ; Ovary/drug effects ; Promoter Regions, Genetic/drug effects ; Rats ; Rats, Wistar ; Superovulation/drug effects
Czasopismo naukowe
Tytuł :
Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro.
Autorzy :
Vitoux MA; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France; HORUS PHARMA, F-06700 Saint-Laurent-du-Var, France.
Kessal K; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, IHU Foresight, F-75012 Paris, France.
Melik Parsadaniantz S; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France.
Claret M; HORUS PHARMA, F-06700 Saint-Laurent-du-Var, France.
Guerin C; HORUS PHARMA, F-06700 Saint-Laurent-du-Var, France.
Baudouin C; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, IHU Foresight, F-75012 Paris, France; Université Versailles-Saint-Quentin-en-Yvelines, Hôpital Ambroise Paré, APHP, F-92100 Boulogne-Billancourt, France.
Brignole-Baudouin F; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, IHU Foresight, F-75012 Paris, France; Université de Paris, Faculté de Pharmacie de Paris, F-75006 Paris, France.
Réaux-Le Goazigo A; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de la Vision, F-75012 Paris, France.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Feb 01; Vol. 319, pp. 74-84. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Benzalkonium Compounds/*toxicity
Epithelial Cells/*drug effects
Epithelium, Corneal/*drug effects
Inflammation/*chemically induced
Neurons/*drug effects
Preservatives, Pharmaceutical/*toxicity
Trigeminal Ganglion/*drug effects
Activating Transcription Factor 3/biosynthesis ; Activating Transcription Factor 3/drug effects ; Animals ; Cell Line ; Dry Eye Syndromes/chemically induced ; Dry Eye Syndromes/pathology ; Epithelium, Corneal/cytology ; Gene Expression/drug effects ; Humans ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Trigeminal Ganglion/cytology
Czasopismo naukowe
Tytuł :
Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.
Autorzy :
Almada M; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Alves P; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Fonseca BM; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Carvalho F; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Queirós CR; University of Lisboa, Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016, Lisboa, Portugal.
Gaspar H; University of Lisboa, Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016, Lisboa, Portugal; MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, 2520-641, Peniche, Portugal.
Amaral C; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Teixeira NA; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal.
Correia-da-Silva G; UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal. Electronic address: .
Pokaż więcej
Źródło :
Toxicology letters [Toxicol Lett] 2020 Feb 01; Vol. 319, pp. 129-137. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cannabinoids/*toxicity
Dronabinol/*toxicity
Indoles/*toxicity
Naphthalenes/*toxicity
Placenta/*cytology
Placenta/*drug effects
Adult ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Female ; Humans ; L-Lactate Dehydrogenase/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Pregnancy ; Reactive Oxygen Species/metabolism ; Trophoblasts/drug effects
Czasopismo naukowe
Tytuł :
Keratinocytes apoptosis contributes to crizotinib induced-erythroderma.
Autorzy :
Hu Y; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang X; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhao Z; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Chen X; Department of Oncology, Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Zhou Z; Department of Pharmacy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Yang X; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yang B; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
He Q; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Luo P; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Feb 01; Vol. 319, pp. 102-110. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Apoptosis/*drug effects
Crizotinib/*toxicity
Dermatitis, Exfoliative/*chemically induced
Keratinocytes/*drug effects
Amino Acid Chloromethyl Ketones/pharmacology ; Caspase 8/metabolism ; Caspase Inhibitors/pharmacology ; Cell Line ; DNA Damage ; Dermatitis, Exfoliative/pathology ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Primary Cell Culture ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Involvement of ADAM10 in acrolein-induced astrocytic inflammation.
Autorzy :
Park JH; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Choi JY; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Jo C; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea.
Koh YH; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Toxicology letters [Toxicol Lett] 2020 Jan; Vol. 318, pp. 44-49. Date of Electronic Publication: 2019 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
ADAM10 Protein/*metabolism
Acrolein/*toxicity
Apoptosis/*drug effects
Astrocytes/*drug effects
Brain/*drug effects
Encephalitis/*chemically induced
Inflammasomes/*drug effects
ADAM10 Protein/genetics ; Animals ; Astrocytes/enzymology ; Astrocytes/pathology ; Brain/enzymology ; Brain/pathology ; Cadherins/metabolism ; Caspase 1/metabolism ; Cell Line ; Encephalitis/enzymology ; Encephalitis/pathology ; Excitatory Amino Acid Transporter 1/metabolism ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nerve Tissue Proteins/metabolism ; Rats ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe

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