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Tytuł:
The interactions that shape amyloid fibrils in disease.
Autorzy:
Joachimiak LA; Department of Biochemistry, Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1045-1047.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid*/chemistry
Czasopismo naukowe
Tytuł:
Homologues not needed: Structure prediction from a protein language model.
Autorzy:
Ben-Tal N; Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: .
Kolodny R; Department of Computer Science, University of Haifa, Mount Carmel, Haifa, 3498838, Israel. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1047-1049.
Typ publikacji:
Journal Article
MeSH Terms:
Computational Biology*
Deep Learning*
Amino Acid Sequence ; Language ; Proteins/chemistry
Czasopismo naukowe
Tytuł:
Structural insights from G-protein-coupled receptor complexes enable the rational engineering of improved light-activated designer receptors.
Autorzy:
Kapolka NJ; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: bryan_.
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1043-1045.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*
Czasopismo naukowe
Tytuł:
Triangulating variation in the population to define mechanisms for precision management of genetic disease.
Autorzy:
Wang C; Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA.
Anglès F; Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA.
Balch WE; Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1190-1207.e5. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Cystic Fibrosis*/drug therapy
Cystic Fibrosis*/genetics
Cystic Fibrosis Transmembrane Conductance Regulator/chemistry ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Ion Transport ; Mutation ; Proteins/metabolism
Czasopismo naukowe
Tytuł:
Structures of an active type III-A CRISPR effector complex.
Autorzy:
Smith EM; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Ferrell S; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Tokars VL; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Mondragón A; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1109-1128.e6. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
CRISPR-Associated Proteins*/chemistry
CRISPR-Associated Proteins*/genetics
CRISPR-Associated Proteins*/metabolism
Adenosine Triphosphate/metabolism ; CRISPR-Cas Systems ; RNA/metabolism ; Staphylococcus epidermidis/genetics ; Staphylococcus epidermidis/metabolism
Czasopismo naukowe
Tytuł:
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Autorzy:
Dejmek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Šála M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Brazdova A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Vanekova L; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic; Faculty of Science, Charles University, 128 00 Prague, Czech Republic.
Smola M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Klíma M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Břehová P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Buděšínský M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Dračínský M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Procházková E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Zavřel M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Šimák O; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Páv O; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Boura E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Birkuš G; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Nencka R; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1146-1156.e11. Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Nucleotides, Cyclic*/metabolism
Nucleotides, Cyclic*/pharmacology
Prodrugs*
Cytosol/metabolism ; Leukocytes, Mononuclear/metabolism ; Membrane Proteins/chemistry
Czasopismo naukowe
Tytuł:
Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a G protein-coupled receptor.
Autorzy:
Morra G; Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, Room LC-501C, New York, NY 10065, USA; Istituto di Scienze e Tecnologie Chimiche SCITEC, CNR, Via Mario Bianco 9, 20131 Milano, Italy.
Razavi AM; Roivant Sciences, New York, NY 10036, USA.
Menon AK; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Khelashvili G; Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, Room LC-501C, New York, NY 10065, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1208-1217.e2. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Phospholipid Transfer Proteins*/genetics
Phospholipid Transfer Proteins*/metabolism
Receptors, G-Protein-Coupled*/metabolism
Animals ; Biological Transport ; Cholesterol ; Lipid Bilayers ; Mammals/metabolism ; Opsins/metabolism ; Phospholipids/metabolism
Czasopismo naukowe
Tytuł:
Crystal structure of the lipid flippase MurJ in a "squeezed" form distinct from its inward- and outward-facing forms.
Autorzy:
Kohga H; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Mori T; Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Tanaka Y; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Yoshikaie K; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Taniguchi K; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Fujimoto K; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.
Fritz L; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Schneider T; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
Tsukazaki T; Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1088-1097.e3. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Escherichia coli Proteins*/chemistry
Bacterial Proteins/chemistry ; Escherichia coli/chemistry ; Escherichia coli/genetics ; Lipids ; Peptidoglycan/chemistry ; Phospholipid Transfer Proteins/chemistry ; Protein Conformation
Czasopismo naukowe
Tytuł:
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Autorzy:
Ling EM; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Baslé A; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Cowell IG; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
van den Berg B; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Blower TR; Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK. Electronic address: .
Austin CA; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1129-1145.e3. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Adenosine Triphosphatases*/chemistry
Adenosine Triphosphate*/metabolism
DNA Topoisomerases, Type II*/chemistry
DNA Topoisomerases, Type II*/genetics
Adenosine Diphosphate/metabolism ; Adenylyl Imidodiphosphate ; Humans ; Hydrolysis ; Poly-ADP-Ribose Binding Proteins
Czasopismo naukowe
Tytuł:
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Autorzy:
Xu Y; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Margetts MB; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia.
Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC 3800, Australia.
Menting JG; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Kirk NS; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia.
Croll TI; Cambridge Institute for Medical Research, University of Cambridge, Keith Peters Building, Cambridge CB2 0XY, UK.
Delaine C; Discipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, SA 5042, Australia.
Forbes BE; Discipline of Medical Biochemistry, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, SA 5042, Australia.
Lawrence MC; WEHI, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1098-1108.e6. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Like Growth Factor I*/metabolism
Receptor, Insulin*/chemistry
Receptor, Insulin*/metabolism
Cryoelectron Microscopy ; Cysteine ; Insulin/metabolism ; Ligands ; Receptor, IGF Type 1/chemistry ; Receptors, Somatomedin
Czasopismo naukowe
Tytuł:
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein.
Autorzy:
Zuzic L; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore; Department of Chemistry, Faculty of Science and Engineering, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK.
Samsudin F; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore.
Shivgan AT; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore.
Raghuvamsi PV; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.
Marzinek JK; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore.
Boags A; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore; School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.
Pedebos C; School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Tulsian NK; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117546, Singapore.
Warwicker J; School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK.
MacAry P; Life Sciences Institute, Centre for Life Sciences, National University of Singapore, Singapore 117546, Singapore.
Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Khalid S; School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: .
Anand GS; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore; Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: .
Bond PJ; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1062-1074.e4. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
SARS-CoV-2*
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/genetics
Benzene ; Cryoelectron Microscopy ; Molecular Dynamics Simulation ; Protein Binding
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Dusquetide modulates innate immune response through binding to p62.
Autorzy:
Zhang Y; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: .
Towers CG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA; The Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Singh UK; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Liu J; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Håkansson M; SARomics Biostructures AB, Medicon Village, Lund 223 63, Sweden.
Logan DT; SARomics Biostructures AB, Medicon Village, Lund 223 63, Sweden.
Donini O; Soligenix Inc., 29 Emmons Drive, Suite C-10, Princeton, NJ 08540, USA. Electronic address: .
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1055-1061.e7. Date of Electronic Publication: 2022 May 30.
Typ publikacji:
Journal Article
MeSH Terms:
Immunity, Innate*
Oligopeptides*/metabolism
Autophagy ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism
Czasopismo naukowe
Tytuł:
Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs.
Autorzy:
van der Kant R; Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Department for Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Louros N; Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Department for Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Schymkowitz J; Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Department for Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
Rousseau F; Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Department for Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1178-1189.e3. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid*/chemistry
Amyloid beta-Peptides*/chemistry
Protein Conformation ; Thermodynamics
Czasopismo naukowe
Tytuł:
Protein language-model embeddings for fast, accurate, and alignment-free protein structure prediction.
Autorzy:
Weissenow K; TUM (Technical University of Munich), Department of Informatics, Bioinformatics and Computational Biology - i12, Boltzmannstr. 3, 85748 Garching/Munich, Germany; TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), Boltzmannstr. 11, 85748 Garching, Germany. Electronic address: .
Heinzinger M; TUM (Technical University of Munich), Department of Informatics, Bioinformatics and Computational Biology - i12, Boltzmannstr. 3, 85748 Garching/Munich, Germany; TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), Boltzmannstr. 11, 85748 Garching, Germany.
Rost B; TUM (Technical University of Munich), Department of Informatics, Bioinformatics and Computational Biology - i12, Boltzmannstr. 3, 85748 Garching/Munich, Germany; Institute for Advanced Study (TUM-IAS), Lichtenbergstr. 2a, 85748 Garching/Munich, Germany & TUM School of Life Sciences Weihenstephan (WZW), Alte Akademie 8, Freising, Germany.
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1169-1177.e4. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Computational Biology*/methods
Language*
Artificial Intelligence ; Proteins/chemistry ; Sequence Alignment
Czasopismo naukowe
Tytuł:
Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Autorzy:
Czarna A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Plewka J; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Kresik L; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Matsuda A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Karim A; Department of Biology, College of Science, Salahaddin University-Erbil, Kirkuk Road, 44002 Erbil, Kurdistan Region, Iraq; Department of Community Health, College of Health Technology, Cihan University-Erbil, 100 Street, 44001 Erbil, Kurdistan Region, Iraq.
Robinson C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, UK.
O'Byrne S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, UK.
Cunningham F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, UK.
Georgiou I; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, UK.
Wilk P; Structural Biology Core Facility, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Pachota M; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.
Popowicz G; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany.
Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, UK. Electronic address: .
Dubin G; Protein Crystallography Research Group, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland. Electronic address: .
Pyrć K; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1050-1054.e2. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Exoribonucleases*/chemistry
Viral Nonstructural Proteins*/chemistry
Viral Regulatory and Accessory Proteins*/chemistry
Exonucleases ; Methyltransferases/chemistry ; Protein Folding ; RNA, Viral/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Structure-guided optimization of light-activated chimeric G-protein-coupled receptors.
Autorzy:
Tichy AM; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 3800 Clayton/Melbourne, VIC, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 3800 Clayton/Melbourne, VIC, Australia.
So WL; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 3800 Clayton/Melbourne, VIC, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 3800 Clayton/Melbourne, VIC, Australia.
Gerrard EJ; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 3800 Clayton/Melbourne, VIC, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 3800 Clayton/Melbourne, VIC, Australia; Commonwealth Scientific and Industrial Research Organisation, Synthetic Biology Future Science Platform, Monash University, 3800 Clayton/Melbourne, VIC, Australia.
Janovjak H; Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, 3800 Clayton/Melbourne, VIC, Australia; European Molecular Biology Laboratory Australia (EMBL Australia), Monash University, 3800 Clayton/Melbourne, VIC, Australia; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, 5042 Bedford Park/Adelaide, SA, Australia. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1075-1087.e4. Date of Electronic Publication: 2022 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
GTP-Binding Proteins*/metabolism
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Humans ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł:
Modeling of protein conformational changes with Rosetta guided by limited experimental data.
Autorzy:
Sala D; Institute for Drug Discovery, Leipzig University, Leipzig, Saxony 04103, Germany.
Del Alamo D; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USA.
Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USA.
Meiler J; Institute for Drug Discovery, Leipzig University, Leipzig, Saxony 04103, Germany; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Aug 04; Vol. 30 (8), pp. 1157-1168.e3. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article
MeSH Terms:
Membrane Proteins*/chemistry
Electron Spin Resonance Spectroscopy ; Protein Conformation
Czasopismo naukowe
Tytuł:
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2.
Autorzy:
Lan J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.
Chen P; Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine and Vanke School of Public Health, Tsinghua University, Beijing, China.
Liu W; Department of Critical Care Medicine, Beijing Boai Hospital, China Rehabilitation Research Centre, No. 10 Jiaomen Beilu, Fengtai District, Beijing 100068, China.
Ren W; Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
Zhang L; Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine and Vanke School of Public Health, Tsinghua University, Beijing, China.
Ding Q; Center for Infectious Disease Research, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
Zhang Q; Comprehensive AIDS Research Center, Beijing Advanced Innovation Center for Structural Biology, School of Medicine and Vanke School of Public Health, Tsinghua University, Beijing, China. Electronic address: .
Wang X; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address: .
Ge J; The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Sciences, Beijing, China. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Jul 31. Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis.
Autorzy:
Armstrong Z; Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, UK.
Meek RW; Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, UK.
Wu L; Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, UK; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0FA, UK.
Blaza JN; Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, UK.
Davies GJ; Department of Chemistry, Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, UK. Electronic address: .
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Źródło:
Structure (London, England : 1993) [Structure] 2022 Jul 19. Date of Electronic Publication: 2022 Jul 19.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Catalytic cycling of human mitochondrial Lon protease.
Autorzy:
Mohammed I; Biozentrum, University of Basel, Basel, Switzerland.
Schmitz KA; Biozentrum, University of Basel, Basel, Switzerland.
Schenck N; Biozentrum, University of Basel, Basel, Switzerland.
Balasopoulos D; Biozentrum, University of Basel, Basel, Switzerland.
Topitsch A; Biozentrum, University of Basel, Basel, Switzerland.
Maier T; Biozentrum, University of Basel, Basel, Switzerland.
Abrahams JP; Biozentrum, University of Basel, Basel, Switzerland; Laboratory of Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland. Electronic address: .
Pokaż więcej
Źródło:
Structure (London, England : 1993) [Structure] 2022 Jul 12. Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article
Czasopismo naukowe

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