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Tytuł:
Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.
Autorzy:
Kuroiwa M; Department of Pharmacology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.
Snyder GL
Shuto T
Fukuda A
Yanagawa Y
Benavides DR
Nairn AC
Bibb JA
Greengard P
Nishi A
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2012 Feb; Vol. 219 (4), pp. 1065-79. Date of Electronic Publication: 2011 Aug 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cyclic AMP-Dependent Protein Kinases/*metabolism
Dopamine and cAMP-Regulated Phosphoprotein 32/*metabolism
Phosphodiesterase 4 Inhibitors/*pharmacology
Receptors, Dopamine D1/*metabolism
Animals ; Cyclic Nucleotide Phosphodiesterases, Type 4/drug effects ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Phosphorylation/drug effects ; Prefrontal Cortex/metabolism ; Pyramidal Cells/metabolism ; Rolipram/pharmacology ; Schizophrenia/physiopathology ; Sensory Gating ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.
Autorzy:
Greenwood TA; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.
Light GA
Swerdlow NR
Radant AD
Braff DL
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (1), pp. e29630. Date of Electronic Publication: 2012 Jan 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Endophenotypes*
Genetic Association Studies*
Genetic Predisposition to Disease*
Schizophrenia/*genetics
Adolescent ; Adult ; Aged ; Black People/genetics ; Case-Control Studies ; Female ; Gene Regulatory Networks/genetics ; Humans ; Male ; Middle Aged ; Signal Transduction/genetics ; White People/genetics ; Young Adult
Czasopismo naukowe
Tytuł:
Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug.
Autorzy:
Vorhees CV; Division of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA. />Morford LR
Graham DL
Skelton MR
Williams MT
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Źródło:
Behavioral and brain functions : BBF [Behav Brain Funct] 2011 Oct 05; Vol. 7, pp. 41. Date of Electronic Publication: 2011 Oct 05.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*drug effects
Exploratory Behavior/*drug effects
Fluoxetine/*pharmacology
Paroxetine/*pharmacology
Reflex, Startle/*drug effects
Selective Serotonin Reuptake Inhibitors/*pharmacology
Acoustic Stimulation ; Age Factors ; Analysis of Variance ; Animals ; Body Weight/drug effects ; Brain/growth & development ; Corticosterone/blood ; Critical Period, Psychological ; Dose-Response Relationship, Drug ; Escape Reaction/drug effects ; Immobility Response, Tonic/drug effects ; Longitudinal Studies ; Male ; Maze Learning/drug effects ; Rats ; Sensory Gating/drug effects
Czasopismo naukowe
Tytuł:
Prenatal stress: role in psychotic and depressive diseases.
Autorzy:
Markham JA; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA.
Koenig JI
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2011 Mar; Vol. 214 (1), pp. 89-106. Date of Electronic Publication: 2010 Oct 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Depressive Disorder/*etiology
Pregnancy Complications/*physiopathology
Psychotic Disorders/*etiology
Stress, Psychological/*complications
Adrenal Cortex Hormones/metabolism ; Animals ; Brain/embryology ; Brain/growth & development ; Cytokines/metabolism ; Depressive Disorder/physiopathology ; Female ; Humans ; Neurons/metabolism ; Pregnancy ; Psychotic Disorders/physiopathology ; Schizophrenia/etiology ; Schizophrenia/physiopathology
Czasopismo naukowe
Tytuł:
Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.
Autorzy:
Jain RA; Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
Wolman MA
Schmidt LA
Burgess HA
Granato M
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Źródło:
PloS one [PLoS One] 2011; Vol. 6 (10), pp. e26510. Date of Electronic Publication: 2011 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Mutation*
Zebrafish/*genetics
Animals ; Phenotype
Czasopismo naukowe
Tytuł:
Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats.
Autorzy:
Bubenikova-Valesova V; Department of Brain Pathophysiology and Biochemistry, Prague Psychiatric Centre, Prague, Czech Republic. />Svoboda J
Horacek J
Sumiyoshi T
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2010 Oct; Vol. 212 (2), pp. 267-76. Date of Electronic Publication: 2010 Jul 31.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Isoindoles/*pharmacology
Piperazines/*pharmacology
Pyrimidines/*pharmacology
Schizophrenia/*drug therapy
Serotonin Receptor Agonists/*pharmacology
Animals ; Antipsychotic Agents/pharmacology ; Disease Models, Animal ; Dizocilpine Maleate/toxicity ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/toxicity ; Haloperidol/pharmacology ; Isoindoles/administration & dosage ; Male ; Motor Activity/drug effects ; Piperazines/administration & dosage ; Pyrimidines/administration & dosage ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A/drug effects ; Receptor, Serotonin, 5-HT1A/metabolism ; Schizophrenia/physiopathology ; Sensory Gating/drug effects ; Serotonin Receptor Agonists/administration & dosage
Czasopismo naukowe
Tytuł:
Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model.
Autorzy:
Li Q; Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Cheung C
Wei R
Hui ES
Feldon J
Meyer U
Chung S
Chua SE
Sham PC
Wu EX
McAlonan GM
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Źródło:
PloS one [PLoS One] 2009 Jul 24; Vol. 4 (7), pp. e6354. Date of Electronic Publication: 2009 Jul 24.
Typ publikacji:
Journal Article
MeSH Terms:
Behavior, Animal*
Disease Models, Animal*
Maternal Exposure*
Brain/*pathology
Magnetic Resonance Imaging/*methods
Schizophrenia/*immunology
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Risk Factors ; Schizophrenia/pathology
Czasopismo naukowe
Tytuł:
Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors.
Autorzy:
Ammassari-Teule M; Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. />Sgobio C
Biamonte F
Marrone C
Mercuri NB
Keller F
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2009 Jun; Vol. 204 (3), pp. 511-21. Date of Electronic Publication: 2009 Mar 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal/*physiology
Cell Adhesion Molecules, Neuronal/*genetics
Extracellular Matrix Proteins/*genetics
Neostriatum/*cytology
Neostriatum/*physiology
Nerve Tissue Proteins/*genetics
Neurons/*physiology
Parvalbumins/*genetics
Serine Endopeptidases/*genetics
Acoustic Stimulation ; Animals ; Avoidance Learning/physiology ; Cell Count ; Extinction, Psychological/physiology ; Fear/physiology ; Female ; Haplotypes ; Heterozygote ; Immunohistochemistry ; Interneurons/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Neurologic Mutants ; Nerve Net/cytology ; Nerve Net/physiology ; Psychomotor Performance/physiology ; Reelin Protein ; gamma-Aminobutyric Acid/physiology
Czasopismo naukowe
Tytuł:
Transcription factor SP4 is a susceptibility gene for bipolar disorder.
Autorzy:
Zhou X; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.
Tang W
Greenwood TA
Guo S
He L
Geyer MA
Kelsoe JR
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Źródło:
PloS one [PLoS One] 2009; Vol. 4 (4), pp. e5196. Date of Electronic Publication: 2009 Apr 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Bipolar Disorder/*genetics
Sp4 Transcription Factor/*genetics
Adolescent ; Adult ; Animals ; Antimanic Agents/therapeutic use ; Asian People/genetics ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Carbamazepine/therapeutic use ; Case-Control Studies ; Dopamine Antagonists/therapeutic use ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Haplotypes ; Hippocampus/physiopathology ; Humans ; Linkage Disequilibrium ; Male ; Mice ; Mice, Mutant Strains ; Middle Aged ; Polymorphism, Single Nucleotide ; Raclopride/therapeutic use ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Schizophrenia/physiopathology ; Sensory Gating/genetics ; Sp4 Transcription Factor/physiology ; White People/genetics ; Young Adult
Czasopismo naukowe
Tytuł:
Realistic expectations of prepulse inhibition in translational models for schizophrenia research.
Autorzy:
Swerdlow NR; Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, 92093-0804, USA, .
Weber M
Qu Y
Light GA
Braff DL
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2008 Aug; Vol. 199 (3), pp. 331-88. Date of Electronic Publication: 2008 Jun 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Models, Psychological*
Schizophrenic Psychology*
Antipsychotic Agents/*therapeutic use
Reflex, Startle/*drug effects
Reflex, Startle/*physiology
Schizophrenia/*drug therapy
Animals ; Disease Models, Animal ; Humans ; Reflex, Startle/genetics ; Schizophrenia/genetics
Czasopismo naukowe
Tytuł:
Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.
Autorzy:
Koda K; Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Ago Y
Kawasaki T
Hashimoto H
Baba A
Matsuda T
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2008 Feb; Vol. 196 (2), pp. 293-301. Date of Electronic Publication: 2007 Oct 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Galantamine/*pharmacology
Indans/*pharmacology
Neural Inhibition/*drug effects
Piperidines/*pharmacology
Social Isolation/*psychology
Aconitine/analogs & derivatives ; Aconitine/pharmacology ; Acoustic Stimulation ; Analysis of Variance ; Animals ; Animals, Outbred Strains ; Apomorphine/pharmacology ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Cholinesterase Inhibitors/pharmacology ; Dizocilpine Maleate/pharmacology ; Donepezil ; Dose-Response Relationship, Drug ; Male ; Mecamylamine/pharmacology ; Mice ; Neural Inhibition/physiology ; Nicotinic Antagonists/pharmacology ; Receptors, Nicotinic/physiology ; Reflex, Startle/drug effects ; Risperidone/pharmacology ; alpha7 Nicotinic Acetylcholine Receptor
Czasopismo naukowe
Tytuł:
Neurophysiological biomarkers for drug development in schizophrenia.
Autorzy:
Javitt DC; Nathan Kline Institute for Schizophrenia Research/New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA.
Spencer KM
Thaker GK
Winterer G
Hajós M
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Źródło:
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2008 Jan; Vol. 7 (1), pp. 68-83.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Design*
Antipsychotic Agents/*therapeutic use
Brain/*physiopathology
Neurophysiology/*methods
Schizophrenia/*drug therapy
Schizophrenia/*physiopathology
Auditory Perception ; Brain/pathology ; Brain Mapping ; Humans
Czasopismo naukowe
Tytuł:
Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults.
Autorzy:
Light GA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0804, USA. />Swerdlow NR
Braff DL
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Źródło:
Journal of cognitive neuroscience [J Cogn Neurosci] 2007 Oct; Vol. 19 (10), pp. 1624-32.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Field Dependence-Independence*
Attention/*physiology
Discrimination, Psychological/*physiology
Evoked Potentials, Auditory/*physiology
Orientation/*physiology
Acoustic Stimulation ; Adult ; Female ; Humans ; Male ; Mental Recall/physiology ; Reference Values
Czasopismo naukowe
Tytuł:
Acute or subchronic clozapine treatment does not ameliorate prepulse inhibition (PPI) deficits in CPB-K mice with low levels of hippocampal NMDA receptor density.
Autorzy:
Wolf R; Department of Psychiatry, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany. />Paelchen K
Matzke K
Dobrowolny H
Bogerts B
Schwegler H
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2007 Sep; Vol. 194 (1), pp. 93-102. Date of Electronic Publication: 2007 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acoustic Stimulation/*methods
Clozapine/*pharmacology
Neural Inhibition/*drug effects
Reflex, Startle/*drug effects
Analysis of Variance ; Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/pharmacology ; Clozapine/administration & dosage ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred Strains ; Neural Inhibition/physiology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Reflex, Startle/physiology ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Time Factors
Czasopismo naukowe
Tytuł:
Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats.
Autorzy:
Auclair AL; Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106, Castres, France. />Galinier A
Besnard J
Newman-Tancredi A
Depoortère R
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2007 Jul; Vol. 193 (1), pp. 45-54. Date of Electronic Publication: 2007 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin 5-HT1 Receptor Agonists*
Antipsychotic Agents/*pharmacology
Receptors, Dopamine D2/*agonists
Reflex, Startle/*drug effects
Animals ; Dopamine D2 Receptor Antagonists ; Dose-Response Relationship, Drug ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

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