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Tytuł :
Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function.
Autorzy :
Swerdlow NR; Departments of Psychiatry, School of Medicine, University of California-San Diego, La Jolla, CA 92093, USA. />Light GA
Cadenhead KS
Sprock J
Hsieh MH
Braff DL
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Źródło :
Archives of general psychiatry [Arch Gen Psychiatry] 2006 Dec; Vol. 63 (12), pp. 1325-35.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Schizophrenic Psychology*
Auditory Perception/*physiology
Cognition Disorders/*diagnosis
Neural Inhibition/*physiology
Reflex, Startle/*physiology
Schizophrenia/*diagnosis
Acoustic Stimulation ; Adolescent ; Adult ; Aged ; Antipsychotic Agents/therapeutic use ; Cognition Disorders/physiopathology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests/statistics & numerical data ; Psychiatric Status Rating Scales/statistics & numerical data ; Reaction Time/physiology ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology ; Sex Factors ; Smoking/epidemiology
Czasopismo naukowe
Tytuł :
Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.
Autorzy :
Turetsky BI; Department of Psychiatry, 10th floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. />Calkins ME
Light GA
Olincy A
Radant AD
Swerdlow NR
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Źródło :
Schizophrenia bulletin [Schizophr Bull] 2007 Jan; Vol. 33 (1), pp. 69-94. Date of Electronic Publication: 2006 Nov 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Phenotype*
Brain/*physiopathology
Evoked Potentials, Auditory/*physiology
Genetic Predisposition to Disease/*genetics
Neural Inhibition/*physiology
Reflex, Startle/*physiology
Saccades/*physiology
Schizophrenia/*physiopathology
Arousal/genetics ; Arousal/physiology ; Attention/physiology ; Contingent Negative Variation/physiology ; Discrimination Learning/physiology ; Event-Related Potentials, P300/physiology ; Genotype ; Humans ; Schizophrenia/diagnosis ; Schizophrenia/genetics ; Twin Studies as Topic
Czasopismo naukowe
Tytuł :
Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia.
Autorzy :
Swerdlow NR; Department of Psychiatry, University of California San Diego, San Diego, California, USA. />Sprock J
Light GA
Cadenhead K
Calkins ME
Dobie DJ
Freedman R
Green MF
Greenwood TA
Gur RE
Mintz J
Olincy A
Nuechterlein KH
Radant AD
Schork NJ
Seidman LJ
Siever LJ
Silverman JM
Stone WS
Tsuang DW
Tsuang MT
Turetsky BI
Braff DL
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Źródło :
Schizophrenia research [Schizophr Res] 2007 May; Vol. 92 (1-3), pp. 237-51. Date of Electronic Publication: 2007 Mar 08.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Acoustic Stimulation*
Inhibition, Psychological*
Mental Processes*
Psychology/*methods
Reflex, Startle/*physiology
Schizophrenia/*genetics
Schizophrenia/*physiopathology
Adolescent ; Adult ; Brain/physiopathology ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Consensus ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Schizophrenia/epidemiology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats.
Autorzy :
Auclair AL; Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106, Castres, France. />Galinier A
Besnard J
Newman-Tancredi A
Depoortère R
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2007 Jul; Vol. 193 (1), pp. 45-54. Date of Electronic Publication: 2007 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Serotonin 5-HT1 Receptor Agonists*
Antipsychotic Agents/*pharmacology
Receptors, Dopamine D2/*agonists
Reflex, Startle/*drug effects
Animals ; Dopamine D2 Receptor Antagonists ; Dose-Response Relationship, Drug ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial.
Autorzy :
Wynn JK; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. />Green MF
Sprock J
Light GA
Widmark C
Reist C
Erhart S
Marder SR
Mintz J
Braff DL
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Źródło :
Schizophrenia research [Schizophr Res] 2007 Sep; Vol. 95 (1-3), pp. 134-42. Date of Electronic Publication: 2007 Jul 26.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antipsychotic Agents/*therapeutic use
Habituation, Psychophysiologic/*drug effects
Reflex, Startle/*drug effects
Schizophrenia/*drug therapy
Acoustic Stimulation ; Benzodiazepines/pharmacology ; Benzodiazepines/therapeutic use ; Double-Blind Method ; Electromyography ; Female ; Haloperidol/pharmacology ; Haloperidol/therapeutic use ; Humans ; Male ; Middle Aged ; Olanzapine ; Psychotic Disorders/drug therapy ; Psychotic Disorders/psychology ; Risperidone/pharmacology ; Risperidone/therapeutic use ; Schizophrenic Psychology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Acute or subchronic clozapine treatment does not ameliorate prepulse inhibition (PPI) deficits in CPB-K mice with low levels of hippocampal NMDA receptor density.
Autorzy :
Wolf R; Department of Psychiatry, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany. />Paelchen K
Matzke K
Dobrowolny H
Bogerts B
Schwegler H
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2007 Sep; Vol. 194 (1), pp. 93-102. Date of Electronic Publication: 2007 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acoustic Stimulation/*methods
Clozapine/*pharmacology
Neural Inhibition/*drug effects
Reflex, Startle/*drug effects
Analysis of Variance ; Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/pharmacology ; Clozapine/administration & dosage ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred Strains ; Neural Inhibition/physiology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Reflex, Startle/physiology ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Time Factors
Czasopismo naukowe
Tytuł :
Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults.
Autorzy :
Light GA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0804, USA. />Swerdlow NR
Braff DL
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Źródło :
Journal of cognitive neuroscience [J Cogn Neurosci] 2007 Oct; Vol. 19 (10), pp. 1624-32.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Field Dependence-Independence*
Attention/*physiology
Discrimination, Psychological/*physiology
Evoked Potentials, Auditory/*physiology
Orientation/*physiology
Acoustic Stimulation ; Adult ; Female ; Humans ; Male ; Mental Recall/physiology ; Reference Values
Czasopismo naukowe
Tytuł :
Neurophysiological biomarkers for drug development in schizophrenia.
Autorzy :
Javitt DC; Nathan Kline Institute for Schizophrenia Research/New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA.
Spencer KM
Thaker GK
Winterer G
Hajós M
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2008 Jan; Vol. 7 (1), pp. 68-83.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Design*
Antipsychotic Agents/*therapeutic use
Brain/*physiopathology
Neurophysiology/*methods
Schizophrenia/*drug therapy
Schizophrenia/*physiopathology
Auditory Perception ; Brain/pathology ; Brain Mapping ; Humans
Czasopismo naukowe
Tytuł :
Advances in endophenotyping schizophrenia.
Autorzy :
Braff DL; Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA.
Greenwood TA
Swerdlow NR
Light GA
Schork NJ
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Corporate Authors :
Investigators of the Consortium on the Genetics of Schizophrenia
Źródło :
World psychiatry : official journal of the World Psychiatric Association (WPA) [World Psychiatry] 2008 Feb; Vol. 7 (1), pp. 11-8.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.
Autorzy :
Koda K; Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Ago Y
Kawasaki T
Hashimoto H
Baba A
Matsuda T
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2008 Feb; Vol. 196 (2), pp. 293-301. Date of Electronic Publication: 2007 Oct 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Galantamine/*pharmacology
Indans/*pharmacology
Neural Inhibition/*drug effects
Piperidines/*pharmacology
Social Isolation/*psychology
Aconitine/analogs & derivatives ; Aconitine/pharmacology ; Acoustic Stimulation ; Analysis of Variance ; Animals ; Animals, Outbred Strains ; Apomorphine/pharmacology ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Cholinesterase Inhibitors/pharmacology ; Dizocilpine Maleate/pharmacology ; Donepezil ; Dose-Response Relationship, Drug ; Male ; Mecamylamine/pharmacology ; Mice ; Neural Inhibition/physiology ; Nicotinic Antagonists/pharmacology ; Receptors, Nicotinic/physiology ; Reflex, Startle/drug effects ; Risperidone/pharmacology ; alpha7 Nicotinic Acetylcholine Receptor
Czasopismo naukowe
Tytuł :
Uncontrollable voices and their relationship to gating deficits in schizophrenia.
Autorzy :
Kumari V; Department of Psychology, Institute of Psychiatry, King's College London, London, UK. />Peters ER
Fannon D
Premkumar P
Aasen I
Cooke MA
Anilkumar AP
Kuipers E
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Źródło :
Schizophrenia research [Schizophr Res] 2008 Apr; Vol. 101 (1-3), pp. 185-94. Date of Electronic Publication: 2008 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Schizophrenic Psychology*
Perceptual Disorders/*etiology
Schizophrenia/*complications
Voice/*physiology
Acoustic Stimulation ; Adult ; Auditory Perception ; Blinking ; Case-Control Studies ; Female ; Humans ; Inhibition, Psychological ; Male ; Middle Aged ; Psychophysics ; Reaction Time ; Reflex, Startle ; Time Factors
Czasopismo naukowe
Tytuł :
Strain differences in the gating-disruptive effects of apomorphine: relationship to gene expression in nucleus accumbens signaling pathways.
Autorzy :
Shilling PD; Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA.
Saint Marie RL
Shoemaker JM
Swerdlow NR
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Źródło :
Biological psychiatry [Biol Psychiatry] 2008 Apr 15; Vol. 63 (8), pp. 748-58. Date of Electronic Publication: 2008 Feb 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cues*
Apomorphine/*pharmacology
Dopamine Agonists/*pharmacology
Gene Expression/*drug effects
Neural Inhibition/*drug effects
Nucleus Accumbens/*drug effects
RNA, Messenger/*genetics
Receptors, Dopamine/*drug effects
Receptors, Dopamine/*genetics
Reflex, Startle/*drug effects
Signal Transduction/*drug effects
Acoustic Stimulation ; Animals ; Attention/drug effects ; Dopamine/metabolism ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Rats ; Rats, Long-Evans ; Rats, Sprague-Dawley ; Species Specificity ; Transcription, Genetic/drug effects
Czasopismo naukowe
Tytuł :
Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients.
Autorzy :
Hong LE; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA. />Wonodi I
Lewis J
Thaker GK
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Źródło :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2008 Aug; Vol. 33 (9), pp. 2167-74. Date of Electronic Publication: 2007 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Inhibition, Psychological*
Schizophrenic Psychology*
Nicotine/*pharmacology
Nicotinic Agonists/*pharmacology
Schizophrenia/*physiopathology
Acoustic Stimulation/methods ; Adult ; Analysis of Variance ; Chi-Square Distribution ; Female ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Reaction Time/drug effects ; Reflex, Acoustic/drug effects ; Reflex, Acoustic/radiation effects ; Reflex, Startle/drug effects
Czasopismo naukowe
Tytuł :
Realistic expectations of prepulse inhibition in translational models for schizophrenia research.
Autorzy :
Swerdlow NR; Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, 92093-0804, USA, .
Weber M
Qu Y
Light GA
Braff DL
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2008 Aug; Vol. 199 (3), pp. 331-88. Date of Electronic Publication: 2008 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Models, Psychological*
Schizophrenic Psychology*
Antipsychotic Agents/*therapeutic use
Reflex, Startle/*drug effects
Reflex, Startle/*physiology
Schizophrenia/*drug therapy
Animals ; Disease Models, Animal ; Humans ; Reflex, Startle/genetics ; Schizophrenia/genetics
Czasopismo naukowe
Tytuł :
Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating.
Autorzy :
Hazlett EA; Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, New York, NY 10029, USA. />Buchsbaum MS
Zhang J
Newmark RE
Glanton CF
Zelmanova Y
Haznedar MM
Chu KW
Nenadic I
Kemether EM
Tang CY
New AS
Siever LJ
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Źródło :
NeuroImage [Neuroimage] 2008 Sep 01; Vol. 42 (3), pp. 1164-77. Date of Electronic Publication: 2008 Jul 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Mapping*
Brain/*physiopathology
Schizophrenia/*physiopathology
Adult ; Attention/physiology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male
Czasopismo naukowe
Tytuł :
Cortical grey matter volume and sensorimotor gating in schizophrenia.
Autorzy :
Kumari V; Department of Psychology, Institute of Psychiatry, King's College London, London, UK. />Fannon D
Geyer MA
Premkumar P
Antonova E
Simmons A
Kuipers E
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Źródło :
Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2008 Oct; Vol. 44 (9), pp. 1206-14. Date of Electronic Publication: 2008 Jan 20.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cerebral Cortex/*physiopathology
Habituation, Psychophysiologic/*physiology
Reflex, Startle/*physiology
Schizophrenia/*physiopathology
Acoustic Stimulation/methods ; Adult ; Blinking/physiology ; Cerebral Cortex/pathology ; Dominance, Cerebral/physiology ; Electromyography/methods ; Facial Muscles/physiology ; Frontal Lobe/pathology ; Frontal Lobe/physiopathology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology ; Reaction Time/physiology ; Statistics as Topic
Czasopismo naukowe
Tytuł :
Brief subjective durations contract with repetition.
Autorzy :
Pariyadath V; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. />Eagleman DM
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Źródło :
Journal of vision [J Vis] 2008 Dec 22; Vol. 8 (16), pp. 11.1-6. Date of Electronic Publication: 2008 Dec 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Time Perception*
Photic Stimulation/*methods
Adolescent ; Adult ; Flicker Fusion ; Humans ; Judgment ; Middle Aged ; Perceptual Masking ; Sensory Thresholds ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Transcription factor SP4 is a susceptibility gene for bipolar disorder.
Autorzy :
Zhou X; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.
Tang W
Greenwood TA
Guo S
He L
Geyer MA
Kelsoe JR
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Źródło :
PloS one [PLoS One] 2009; Vol. 4 (4), pp. e5196. Date of Electronic Publication: 2009 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bipolar Disorder/*genetics
Sp4 Transcription Factor/*genetics
Adolescent ; Adult ; Animals ; Antimanic Agents/therapeutic use ; Asian Continental Ancestry Group/genetics ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Carbamazepine/therapeutic use ; Case-Control Studies ; Dopamine Antagonists/therapeutic use ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Haplotypes ; Hippocampus/physiopathology ; Humans ; Linkage Disequilibrium ; Male ; Mice ; Mice, Mutant Strains ; Middle Aged ; Polymorphism, Single Nucleotide ; Raclopride/therapeutic use ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Schizophrenia/physiopathology ; Sensory Gating/genetics ; Sp4 Transcription Factor/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients.
Autorzy :
Csomor PA; University Hospital of Psychiatry, Zurich Switzerland. />Yee BK
Feldon J
Theodoridou A
Studerus E
Vollenweider FX
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Źródło :
Schizophrenia bulletin [Schizophr Bull] 2009 Jan; Vol. 35 (1), pp. 244-55. Date of Electronic Publication: 2008 Jan 31.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Health Status*
Reaction Time*
Reflex, Startle*
Antipsychotic Agents/*therapeutic use
Nerve Net/*physiology
Neural Inhibition/*physiology
Reflex/*physiology
Schizophrenia/*drug therapy
Schizophrenia/*physiopathology
Adult ; Electromyography ; Female ; Habituation, Psychophysiologic ; Humans ; Male ; Schizophrenia/epidemiology ; Withholding Treatment/statistics & numerical data
Czasopismo naukowe

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