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Wyświetlanie 61-80 z 141
Tytuł:
Elasticity and tumorigenic characteristics of cells in a monolayer after nanosecond pulsed electric field exposure.
Autorzy:
Steuer A; Leibniz Institute for Plasma Science and Technology, Felix-Hausdorff-Strasse 2, 17489, Greifswald, Germany.
Wende K; Leibniz Institute for Plasma Science and Technology, Felix-Hausdorff-Strasse 2, 17489, Greifswald, Germany.
Babica P; Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic.
Kolb JF; Leibniz Institute for Plasma Science and Technology, Felix-Hausdorff-Strasse 2, 17489, Greifswald, Germany. .
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Źródło:
European biophysics journal : EBJ [Eur Biophys J] 2017 Sep; Vol. 46 (6), pp. 567-580. Date of Electronic Publication: 2017 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*
Elasticity*
Electricity*
Actins/metabolism ; Cell Line ; Cell Movement ; Cell Proliferation ; Neoplasm Metastasis ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis.
Autorzy:
Zhou R; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Republic of Korea.
Yang Y; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Republic of Korea.; Korean Lichen Research Institute, Sunchon National University, Sunchon, Republic of Korea.
Park SY; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Republic of Korea.
Nguyen TT; Korean Lichen Research Institute, Sunchon National University, Sunchon, Republic of Korea.; Faculty of Natural Science and Technology, Tay Nguyen University, Buon Ma Thuot, Vietnam.
Seo YW; Korea Basic Science Institute, Gwangju Center, Gwangju, Republic of Korea.
Lee KH; Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea.
Lee JH; Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea.
Kim KK; Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea.
Hur JS; Korean Lichen Research Institute, Sunchon National University, Sunchon, Republic of Korea.
Kim H; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2017 Aug 15; Vol. 7 (1), pp. 8136. Date of Electronic Publication: 2017 Aug 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Secondary Metabolism*
Antineoplastic Agents/*pharmacology
Cell Movement/*drug effects
Cell Transformation, Neoplastic/*drug effects
Hydroxybenzoates/*pharmacology
Lichens/*metabolism
Antineoplastic Agents/chemistry ; Biological Products/chemistry ; Biological Products/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Hydroxybenzoates/chemistry ; Hydroxybenzoates/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Proto-Oncogene Proteins c-jun/metabolism ; Signal Transduction/drug effects ; Transcription Factor AP-1/metabolism ; beta Catenin/metabolism ; rho GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer.
Autorzy:
Peng HY; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang 330006, China. .
Yu QF; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. .
Shen W; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. .
Guo CM; Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China. .
Li Z; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang 330006, China. .
Zhou XY; Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China. .
Zhou NJ; Institute of Molecular Medicine, Jiangxi Academy of Medical Sciences, Nanchang 330006, China. .
Min WP; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang 330006, China. .
Gao D; Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang 330006, China. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2016 Dec 16; Vol. 17 (12). Date of Electronic Publication: 2016 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Proteins, Signal Transducing/*genetics
Cell Movement/*genetics
Cell Proliferation/*genetics
Colorectal Neoplasms/*genetics
Cytoskeletal Proteins/*genetics
G1 Phase Cell Cycle Checkpoints/*genetics
Actins/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Female ; HCT116 Cells ; Humans ; Lymphatic Metastasis/genetics ; Male ; Middle Aged ; Neoplasm Invasiveness/genetics ; RNA Interference ; RNA, Small Interfering/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration.
Autorzy:
Hong JH; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Kwak Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Woo Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Park C; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Lee SA; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Lee H; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Park SJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Suh Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Suh BK; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Goo BS; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Mun DJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Sanada K; Molecular Genetics Research Laboratory, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Nguyen MD; Hotchkiss Brain Institute, Departments of Clinical Neurosciences, Cell Biology and Anatomy, and Biochemistry and Molecular Biology, University of Calgary, Calgary T2N 4N1, Canada.
Park SK; Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
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Źródło:
Scientific reports [Sci Rep] 2016 Aug 22; Vol. 6, pp. 31827. Date of Electronic Publication: 2016 Aug 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Actin Cytoskeleton/*metabolism
Carrier Proteins/*metabolism
Microfilament Proteins/*metabolism
Actins/metabolism ; Carrier Proteins/genetics ; Cell Line ; Cell Movement ; Gene Deletion ; Humans ; Microfilament Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identifying Reproducible Molecular Biomarkers for Gastric Cancer Metastasis with the Aid of Recurrence Information.
Autorzy:
Li M; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Hong G; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Cheng J; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Li J; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Cai H; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Li X; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Guan Q; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Tong M; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Li H; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
Guo Z; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24869. Date of Electronic Publication: 2016 Apr 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers/*analysis
Neoplasm Metastasis/*diagnosis
Neoplasm Metastasis/*pathology
Pathology, Molecular/*methods
Stomach Neoplasms/*pathology
Stomach Neoplasms/*secondary
Humans ; Recurrence ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices.
Autorzy:
Staunton JR; Department of Physics, Arizona State University, Tempe, AZ 85287.; Center for Biological Physics, Arizona State University, Tempe, AZ 85287.
Doss BL; Department of Physics, Arizona State University, Tempe, AZ 85287.; Center for Biological Physics, Arizona State University, Tempe, AZ 85287.
Lindsay S; Department of Physics, Arizona State University, Tempe, AZ 85287.; Center for Biological Physics, Arizona State University, Tempe, AZ 85287.; Biodesign Institute, Arizona State University, Tempe, AZ 85287.; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287.
Ros R; Department of Physics, Arizona State University, Tempe, AZ 85287.; Center for Biological Physics, Arizona State University, Tempe, AZ 85287.; Biodesign Institute, Arizona State University, Tempe, AZ 85287.
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Źródło:
Scientific reports [Sci Rep] 2016 Jan 27; Vol. 6, pp. 19686. Date of Electronic Publication: 2016 Jan 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Collagen Type I/*metabolism
Extracellular Matrix/*metabolism
Neoplasms/*metabolism
Neoplasms/*pathology
Algorithms ; Cell Line, Tumor ; Elastic Modulus ; Humans ; Mechanical Phenomena ; Microscopy, Atomic Force ; Microscopy, Confocal ; Models, Theoretical ; Neoplasm Metastasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reactive oxygen species and hydrogen peroxide generation in cell migration.
Autorzy:
Rudzka DA; Cancer Research UK Beatson Institute ; Garscube Estate; Switchback Road ; Glasgow, UK.
Cameron JM; Cancer Research UK Beatson Institute ; Garscube Estate; Switchback Road ; Glasgow, UK.
Olson MF; Cancer Research UK Beatson Institute ; Garscube Estate; Switchback Road ; Glasgow, UK.
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Źródło:
Communicative & integrative biology [Commun Integr Biol] 2015 Dec 30; Vol. 8 (5), pp. e1074360. Date of Electronic Publication: 2015 Dec 30 (Print Publication: 2015).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells.
Autorzy:
Chen ZY; Department of Life Sciences, National Chung-Hsing University, Taichung, 40227, Taiwan. .
Wang PW; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, 701, Taiwan. .
Shieh DB; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, 701, Taiwan. .; Institute of Oral Medicine, National Cheng Kung University, Tainan, 701, Taiwan. .
Chiu KY; Department of Life Sciences, National Chung-Hsing University, Taichung, 40227, Taiwan. .
Liou YM; Department of Life Sciences, National Chung-Hsing University, Taichung, 40227, Taiwan. .; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, 40227, Taiwan. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2015 Oct 20; Vol. 22, pp. 90. Date of Electronic Publication: 2015 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Breast Neoplasms/*metabolism
Gelsolin/*metabolism
Neoplasm Proteins/*metabolism
Transforming Growth Factor beta1/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Cycle ; Epigenesis, Genetic ; Female ; Gelsolin/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Transforming Growth Factor beta1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1.
Autorzy:
Zhu KC; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China ; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Sun JM; Department of Neonatology, Tongji Hospital, Tongji University, Shanghai 200065, P.R. China.
Shen JG; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Jin JZ; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Liu F; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Xu XL; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Chen L; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Liu LT; Department of Urology, Shanghai Jiaotong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, P.R. China.
Lv JJ; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.
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Źródło:
Oncology letters [Oncol Lett] 2015 Oct; Vol. 10 (4), pp. 2359-2365. Date of Electronic Publication: 2015 Aug 18.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling.
Autorzy:
Rastetter RH; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.; Present address: Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.
Blömacher M; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Drebber U; Institute of Pathology, University Hospital of Cologne, 50931, Cologne, Germany.
Marko M; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Behrens J; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Solga R; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Hojeili S; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Bhattacharya K; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Wunderlich CM; Institute for Genetics, University of Cologne, 50674, Cologne, Germany.
Wunderlich FT; Max Planck Institute for Neurological Research, 50931, Cologne, Germany.
Odenthal M; Institute of Pathology, University Hospital of Cologne, 50931, Cologne, Germany.
Ziemann A; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Eichinger L; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany.
Clemen CS; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Street 52, 50931, Cologne, Germany. .
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Źródło:
BMC cancer [BMC Cancer] 2015 Sep 15; Vol. 15, pp. 638. Date of Electronic Publication: 2015 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Adenocarcinoma/*genetics
Adenocarcinoma/*metabolism
Adenoma/*genetics
Adenoma/*metabolism
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Microfilament Proteins/*genetics
Adenocarcinoma/pathology ; Adenoma/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Colorectal Neoplasms/pathology ; Humans ; Microfilament Proteins/metabolism ; Mitogen-Activated Protein Kinase 14/metabolism ; Phosphorylation ; Protein Transport ; Protein-Arginine N-Methyltransferases/metabolism ; Pseudopodia/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Stress Fibers/metabolism ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1.
Autorzy:
Biondini M; 1] Institut Curie, Centre de Recherche, Paris Sciences et Lettres University, 75248 Paris, France [2] ART group, Inserm U830.
Duclos G; 1] Institut Curie, Centre de Recherche, Paris Sciences et Lettres University, 75248 Paris, France [2] UMR168, CNRS, UPMC Equipe labellisée Ligue contre le Cancer.
Meyer-Schaller N; Department of Biomedicine, University of Basel, Switzerland.
Silberzan P; 1] Institut Curie, Centre de Recherche, Paris Sciences et Lettres University, 75248 Paris, France [2] UMR168, CNRS, UPMC Equipe labellisée Ligue contre le Cancer.
Camonis J; 1] Institut Curie, Centre de Recherche, Paris Sciences et Lettres University, 75248 Paris, France [2] ART group, Inserm U830.
Parrini MC; 1] Institut Curie, Centre de Recherche, Paris Sciences et Lettres University, 75248 Paris, France [2] ART group, Inserm U830.
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Źródło:
Scientific reports [Sci Rep] 2015 Jul 08; Vol. 5, pp. 11759. Date of Electronic Publication: 2015 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition/*drug effects
Rho Guanine Nucleotide Exchange Factors/*metabolism
Transforming Growth Factor beta/*pharmacology
ral GTP-Binding Proteins/*metabolism
Amides/pharmacology ; Cell Line, Tumor ; Humans ; Microscopy, Atomic Force ; Pyridines/pharmacology ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction/drug effects ; rac1 GTP-Binding Protein/metabolism ; ral GTP-Binding Proteins/antagonists & inhibitors ; ral GTP-Binding Proteins/genetics ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization.
Autorzy:
Seong BK; 1] Departments of Pediatrics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada [2] Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Lau J; Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Adderley T; Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Kee L; Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Chaukos D; Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Pienkowska M; Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
Malkin D; 1] Departments of Pediatrics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada [2] Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada [3] Division of Hematology-Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Thorner P; 1] Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Irwin MS; 1] Departments of Pediatrics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada [2] Cell Biology Program, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada [3] Division of Hematology-Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada [4] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
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Źródło:
Oncogene [Oncogene] 2015 Jul; Vol. 34 (27), pp. 3582-92. Date of Electronic Publication: 2014 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Neoplasms/*pathology
Cell Movement/*genetics
Cytoskeleton/*genetics
Cytoskeleton/*metabolism
Matrix Attachment Region Binding Proteins/*physiology
Osteosarcoma/*pathology
Transcription Factors/*physiology
Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Cytoskeletal Proteins/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Mice ; Microarray Analysis ; Neoplasm Invasiveness ; Osteosarcoma/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Three-dimensional cage-like microscaffolds for cell invasion studies.
Autorzy:
Spagnolo B; 1] Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy [2] Dipartimento di Ingegneria dell'Innovazione, Università del Salento, via per Monteroni, 73100 Lecce, Italy.
Brunetti V; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
Leménager G; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
De Luca E; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
Sileo L; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
Pellegrino T; Nanochemistry Department, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy.
Paolo Pompa P; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
De Vittorio M; 1] Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy [2] Dipartimento di Ingegneria dell'Innovazione, Università del Salento, via per Monteroni, 73100 Lecce, Italy.
Pisanello F; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy.
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Źródło:
Scientific reports [Sci Rep] 2015 May 27; Vol. 5, pp. 10531. Date of Electronic Publication: 2015 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Microscopy, Confocal*
Time-Lapse Imaging*
Cell Line, Tumor ; Cell Movement ; Coculture Techniques ; Humans ; Nonmuscle Myosin Type IIA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.
Autorzy:
Lim HC; Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark. hooi_.; Current address: Stem Cell Center, Lund University, Lund, Sweden. hooi_.
Multhaupt HA; Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark. .
Couchman JR; Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark. .
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Źródło:
Molecular cancer [Mol Cancer] 2015 Jan 27; Vol. 14, pp. 15. Date of Electronic Publication: 2015 Jan 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Cell Membrane/*metabolism
Heparan Sulfate Proteoglycans/*metabolism
Breast Neoplasms/genetics ; Caveolin 2/genetics ; Caveolin 2/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Extracellular Matrix/metabolism ; Female ; Gene Expression ; Heparin/metabolism ; Humans ; Matrix Metalloproteinase 14/metabolism ; Neoplasm Invasiveness ; Phenotype ; Receptor, PAR-1/metabolism ; Signal Transduction ; Syndecan-2/genetics ; Syndecan-2/metabolism ; Syndecan-4/genetics ; Syndecan-4/metabolism ; Thrombin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility.
Autorzy:
Menhofer MH; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Kubisch R; Department of Pharmacy, Pharmaceutical Biotechnology, University of Munich, Munich, Germany.
Schreiner L; Department of Pharmacy, Pharmaceutical Biotechnology, University of Munich, Munich, Germany.
Zorn M; Department of Physics, Soft Matter Physics and Biophysics, University of Munich, Munich, Germany.
Foerster F; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Mueller R; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Raedler JO; Department of Physics, Soft Matter Physics and Biophysics, University of Munich, Munich, Germany.
Wagner E; Department of Pharmacy, Pharmaceutical Biotechnology, University of Munich, Munich, Germany.
Vollmar AM; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Zahler S; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
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Źródło:
PloS one [PLoS One] 2014 Nov 12; Vol. 9 (11), pp. e112542. Date of Electronic Publication: 2014 Nov 12 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Contractile Proteins/*antagonists & inhibitors
Depsipeptides/*pharmacology
Lung Neoplasms/*drug therapy
Mammary Neoplasms, Experimental/*drug therapy
Peptides, Cyclic/*pharmacology
Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cardiac Myosins/genetics ; Cardiac Myosins/metabolism ; Cell Line, Tumor ; Cell Movement ; Contractile Proteins/genetics ; Contractile Proteins/metabolism ; Female ; Humans ; Injections, Intravenous ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mammary Glands, Animal/drug effects ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/pathology ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Myosin Light Chains/genetics ; Myosin Light Chains/metabolism ; Proto-Oncogene Proteins c-vav/genetics ; Proto-Oncogene Proteins c-vav/metabolism ; Signal Transduction ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Autorzy:
Acton SE; 1] Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK [2] Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Farrugia AJ; 1] Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK [2] Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Astarita JL; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Mourão-Sá D; Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Jenkins RP; Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Nye E; Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Hooper S; Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
van Blijswijk J; Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Rogers NC; Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Snelgrove KJ; Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Rosewell I; Transgenics Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
Moita LF; 1] Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal [2] Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Stamp G; Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Turley SJ; Department of Cancer Immunology, Genentech, One DNA Way, South San Francisco, California 94080, USA.
Sahai E; Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Reis e Sousa C; Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
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Źródło:
Nature [Nature] 2014 Oct 23; Vol. 514 (7523), pp. 498-502.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dendritic Cells/*physiology
Fibroblasts/*cytology
Lymph Nodes/*cytology
Stromal Cells/*cytology
Actomyosin/metabolism ; Animals ; Cell Membrane/metabolism ; Cytoskeleton/metabolism ; Dendritic Cells/immunology ; Female ; Fibroblasts/physiology ; Inflammation/immunology ; Lectins, C-Type/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Stromal Cells/physiology ; ras Proteins/metabolism ; rho GTP-Binding Proteins/metabolism ; rhoA GTP-Binding Protein ; rhoC GTP-Binding Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
Autorzy:
Pettee KM; Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, Ohio, United States of America.
Dvorak KM; Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, Ohio, United States of America.
Nestor-Kalinoski AL; Department of Surgery, University of Toledo Health Science Campus, Toledo, Ohio, United States of America.
Eisenmann KM; Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, Ohio, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Feb 28; Vol. 9 (2), pp. e90371. Date of Electronic Publication: 2014 Feb 28 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Carrier Proteins/*metabolism
Neoplasms, Glandular and Epithelial/*metabolism
Ovarian Neoplasms/*metabolism
Spheroids, Cellular/*metabolism
rho-Associated Kinases/*metabolism
Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/metabolism ; Carcinoma, Ovarian Epithelial ; Carrier Proteins/antagonists & inhibitors ; Carrier Proteins/genetics ; Cell Line, Tumor ; Cell Movement ; Female ; Formins ; Humans ; Neoplasms, Glandular and Epithelial/genetics ; Neoplasms, Glandular and Epithelial/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Spheroids, Cellular/pathology ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/genetics ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.
Autorzy:
Patel RA; Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Liu Y; Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Wang B; Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Li R; Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Sebti SM; 1] Drug Discovery Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA [2] Departments of Oncologic Sciences and Molecular Medicine, University of South Florida, Tampa, FL, USA.
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Źródło:
Oncogene [Oncogene] 2014 Jan 30; Vol. 33 (5), pp. 550-5. Date of Electronic Publication: 2013 Feb 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antineoplastic Agents/*isolation & purification
Cell Movement/*drug effects
Protein Kinase Inhibitors/*isolation & purification
rho-Associated Kinases/*antagonists & inhibitors
3T3 Cells ; Actins/metabolism ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cardiac Myosins/metabolism ; Cell Line, Tumor ; Cytoskeleton/drug effects ; Humans ; Mice ; Myosin Light Chains/metabolism ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects ; p21-Activated Kinases/metabolism ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 61-80 z 141

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