- Tytuł:
- The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
- Autorzy:
- Źródło:
- Science (New York, N.Y.) [Science] 2010 Oct 22; Vol. 330 (6003), pp. 521-5.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Epigenesis, Genetic*
Lymphopoiesis/*genetics
Protein Inhibitors of Activated STAT/*physiology
Repressor Proteins/*physiology
T-Lymphocytes, Regulatory/*cytology
Ubiquitin-Protein Ligases/*physiology
Animals ; Binding Sites ; CD4-Positive T-Lymphocytes/cytology ; Chromatin/metabolism ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; DNA Methyltransferase 3A ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Forkhead Transcription Factors/genetics ; Histones/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Promoter Regions, Genetic ; T-Lymphocytes, Regulatory/immunology ; DNA Methyltransferase 3B
Czasopismo naukowe