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Tytuł :
Impact TMPRSS2-ERG Molecular Subtype on Prostate Cancer Recurrence.
Autorzy :
Kobelyatskaya AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Pudova EA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Snezhkina AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Fedorova MS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Pavlov VS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Guvatova ZG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Savvateeva MV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Melnikova NV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Dmitriev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Trofimov DY; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
Sukhikh GT; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
Nyushko KM; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
Alekseev BY; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
Razin SV; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Krasnov GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło :
Life (Basel, Switzerland) [Life (Basel)] 2021 Jun 21; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
Autorzy :
Afshari A; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Janfeshan S; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Yaghobi R; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Roozbeh J; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: .
Azarpira N; Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2021 Mar; Vol. 88, pp. 104669. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*genetics
Oncogene Proteins, Fusion/*genetics
Prostatic Neoplasms/*genetics
Serine Endopeptidases/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Aged ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Dihydrotestosterone/metabolism ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Humans ; Male ; Oncogene Proteins, Fusion/metabolism ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/virology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Serine Endopeptidases/metabolism ; Signal Transduction ; Spike Glycoprotein, Coronavirus/metabolism ; Transcription, Genetic ; Virus Internalization
Czasopismo naukowe
Tytuł :
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
Autorzy :
Bernasocchi T; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
El Tekle G; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Bolis M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Mutti A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Vallerga A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Brandt LP; Department of Biomedical Research, University of Bern, 3008, Bern, Switzerland.
Spriano F; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Svinkina T; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Zoma M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Ceserani V; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Janouskova H; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Bossi D; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Cavalli M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Mosole S; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Geiger R; Institute for Research in Biomedicine, 6500, Bellinzona, TI, Switzerland.
Dong Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Yang CG; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Albino D; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Schraml P; Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, ZH, Switzerland.
Linder S; The Netherlands Cancer Institute, Oncode Institute, 1066 CX, Amsterdam, The Netherlands.
Carbone GM; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Alimonti A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, ZH, Switzerland.
Carr SA; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Zwart W; The Netherlands Cancer Institute, Oncode Institute, 1066 CX, Amsterdam, The Netherlands.
Kruithof-de Julio M; Department of Biomedical Research, Urology Research Laboratory, University of Bern, 3010, Bern, Switzerland.; Department of Urology, Inselspital, Bern, Switzerland.
Rubin MA; Department of Biomedical Research, University of Bern, 3008, Bern, Switzerland.
Udeshi ND; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Theurillat JP; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 02; Vol. 12 (1), pp. 734. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Proteins/*metabolism
Oncogene Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Repressor Proteins/*metabolism
Transcriptional Regulator ERG/*metabolism
Ubiquitin-Protein Ligase Complexes/*metabolism
Animals ; Biomarkers, Tumor/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Male ; Mice ; Mice, Nude ; Mutation/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins/genetics ; Prostatic Neoplasms/genetics ; Protein Binding ; Proteomics ; Receptors, Androgen/metabolism ; Repressor Proteins/genetics ; Signal Transduction/physiology ; Transcriptional Regulator ERG/genetics ; Ubiquitin-Protein Ligase Complexes/genetics
Czasopismo naukowe
Tytuł :
Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy.
Autorzy :
Navaei AH; Translational Surgical Pathology, Laboratory of Pathology.
Walter BA; Translational Surgical Pathology, Laboratory of Pathology.
Moreno V; Translational Surgical Pathology, Laboratory of Pathology.
Pack SD; Translational Surgical Pathology, Laboratory of Pathology.
Pinto P; Urologic Oncology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Merino MJ; Translational Surgical Pathology, Laboratory of Pathology.
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Źródło :
Journal of Cancer [J Cancer] 2017 Aug 05; Vol. 8 (13), pp. 2604-2613. Date of Electronic Publication: 2017 Aug 05 (Print Publication: 2017).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.
Autorzy :
Butler MS; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Roshan-Moniri M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Hsing M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Lau D; Department of Biochemistry and Molecular Biology, Department of Chemistry, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Kim A; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Yen P; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Mroczek M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Nouri M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Lien S; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Axerio-Cilies P; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Dalal K; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Yau C; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Ghaidi F; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Guo Y; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Yamazaki T; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Lawn S; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Gleave ME; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Gregory-Evans CY; Department of Ophthalmology and Visual Sciences, Eye Care Centre, University of British Columbia, Vancouver, BC V5Z 3N9, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, Department of Chemistry, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Cox ME; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Rennie PS; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Cherkasov A; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
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Źródło :
Oncotarget [Oncotarget] 2017 Jun 27; Vol. 8 (26), pp. 42438-42454.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*/methods
ETS Motif*
Protein Interaction Domains and Motifs*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Prostatic Neoplasms/*metabolism
Transcriptional Regulator ERG/*chemistry
Transcriptional Regulator ERG/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Models, Molecular ; Molecular Conformation ; Oncogene Proteins, Fusion/chemistry ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Protein Binding ; Structure-Activity Relationship ; Transcriptional Regulator ERG/genetics ; Zebrafish
Czasopismo naukowe
Tytuł :
Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer.
Autorzy :
Todorova K; Institute of Biology and Immunology of Reproduction 'Acad. Kiril Bratanov', Laboratory of Reproductive OMICs Technologies, Bulgarian Academy of Sciences, 73 Tsarigradsko shosse blvd, 1113, Sofia, Bulgaria.
Metodiev MV; School of Biological Sciences, University of Essex, Colchester, UK.
Metodieva G; School of Biological Sciences, University of Essex, Colchester, UK.
Mincheff M; Cellular and Gene Therapy Ward, National Specialized Hematology Hospital, Sofia, Bulgaria.
Fernández N; School of Biological Sciences, University of Essex, Colchester, UK.
Hayrabedyan S; Institute of Biology and Immunology of Reproduction 'Acad. Kiril Bratanov', Laboratory of Reproductive OMICs Technologies, Bulgarian Academy of Sciences, 73 Tsarigradsko shosse blvd, 1113, Sofia, Bulgaria. .
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Źródło :
Hormones & cancer [Horm Cancer] 2017 Feb; Vol. 8 (1), pp. 28-48. Date of Electronic Publication: 2017 Jan 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
MicroRNAs/*metabolism
Oncogene Proteins, Fusion/*metabolism
Prostatic Neoplasms/*genetics
Receptors, Androgen/*metabolism
Cell Line, Tumor ; Core Binding Factor Alpha 1 Subunit/metabolism ; DNA Methylation ; Gene Rearrangement ; Humans ; Male ; Promoter Regions, Genetic/genetics ; Prostatic Neoplasms/metabolism ; Proteomics ; Proto-Oncogene Protein c-ets-1/metabolism ; Serine Endopeptidases/genetics ; Signal Transduction ; Transcriptional Regulator ERG/genetics
Czasopismo naukowe
Tytuł :
Autoantibodies against oncogenic ERG protein in prostate cancer: potential use in diagnosis and prognosis in a panel with C-MYC, AMACR and HERV-K Gag.
Autorzy :
Rastogi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Ali A; Urology Service, Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Tan SH; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Banerjee S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Chen Y; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Cullen J; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Xavier CP; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Mohamed AA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Ravindranath L; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Srivastav J; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Young D; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Sesterhenn IA; The Joint Pathology Center, Silver Spring, MD, USA.
Kagan J; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
McLeod DG; Urology Service, Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Rosner IL; Urology Service, Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Petrovics G; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Dobi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Srivastava S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Srinivasan A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
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Źródło :
Genes & cancer [Genes Cancer] 2016 Nov; Vol. 7 (11-12), pp. 394-413.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG.
Autorzy :
Shah AV; Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Birdsey GM; Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Randi AM; Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: .
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2016 Nov; Vol. 86, pp. 3-13. Date of Electronic Publication: 2016 May 18.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*physiology
Neovascularization, Physiologic/*physiology
Animals ; Gene Expression Regulation ; Homeostasis ; Humans ; Neovascularization, Physiologic/genetics ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
The oncogene ERG: a key factor in prostate cancer.
Autorzy :
Adamo P; Department of Cancer Studies and Molecular Medicine, Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, Leicester, UK.
Ladomery MR; Faculty of Health and Applied Sciences, Department of Biological, Biomedical and Analytical Sciences, University of the West of England, Frenchay Campus, Bristol, UK.
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Źródło :
Oncogene [Oncogene] 2016 Jan 28; Vol. 35 (4), pp. 403-14. Date of Electronic Publication: 2015 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Prostatic Neoplasms/*genetics
Trans-Activators/*chemistry
Trans-Activators/*physiology
Alternative Splicing ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Promoter Regions, Genetic ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation.
Autorzy :
Mounir Z; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Lin F; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Lin VG; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Korn JM; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Yu Y; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Valdez R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Aina OH; Center for Comparative Medicine, University of California, Davis, CA, USA.
Buchwalter G; 1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA [2] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Jaffe AB; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Korpal M; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Zhu P; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Brown M; 1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA [2] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Cardiff RD; Center for Comparative Medicine, University of California, Davis, CA, USA.
Rocnik JL; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Yang Y; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Pagliarini R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
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Źródło :
Oncogene [Oncogene] 2015 Jul; Vol. 34 (29), pp. 3815-25. Date of Electronic Publication: 2014 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation/*genetics
Cell Proliferation/*genetics
Prostatic Neoplasms/*genetics
Serine Endopeptidases/*genetics
Trans-Activators/*genetics
Animals ; Antibiotics, Antineoplastic/pharmacology ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Doxorubicin/pharmacology ; Epithelial Cells/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Mice, Transgenic ; Microscopy, Confocal ; Neuroendocrine Cells/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA Interference ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Serine Endopeptidases/metabolism ; Trans-Activators/metabolism ; Transcriptional Regulator ERG ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods.
Autorzy :
He J; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Schepmoes AA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Wu C; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Fillmore TL; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA. .
Gao Y; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Rodland KD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Camp DG 2nd; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
Rastogi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Tan SH; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Yan W; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Mohamed AA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Huang W; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Banerjee S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Kagan J; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. .
Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. .
McLeod DG; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .; Urology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA. .
Srivastava S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Petrovics G; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Dobi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
Srinivasan A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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Źródło :
Journal of translational medicine [J Transl Med] 2015 Feb 12; Vol. 13, pp. 54. Date of Electronic Publication: 2015 Feb 12.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Mass Spectrometry/*methods
Prostatic Neoplasms/*genetics
Real-Time Polymerase Chain Reaction/*methods
Trans-Activators/*genetics
Amino Acid Sequence ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Female ; HEK293 Cells ; Humans ; Male ; Molecular Sequence Data ; Peptides/chemistry ; Peptides/metabolism ; Prostatic Neoplasms/urine ; RNA, Messenger ; Recombinant Proteins/metabolism ; Trans-Activators/metabolism ; Trans-Activators/urine ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
Autorzy :
Obinata D; Department of Urology, Nihon University School of Medicine, Tokyo, Japan; Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ito A
Fujiwara K
Takayama K
Ashikari D
Murata Y
Yamaguchi K
Urano T
Fujimura T
Fukuda N
Soma M
Watanabe T
Nagase H
Inoue S
Takahashi S
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Źródło :
Cancer science [Cancer Sci] 2014 Oct; Vol. 105 (10), pp. 1272-8. Date of Electronic Publication: 2014 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Fusion*
Imidazoles/*pharmacology
Nylons/*pharmacology
Prostatic Neoplasms/*drug therapy
Pyrroles/*pharmacology
Serine Endopeptidases/*genetics
Trans-Activators/*genetics
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Humans ; Male ; Mice ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer.
Autorzy :
Rastogi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Tan SH; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Mohamed AA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Chen Y; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Hu Y; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Petrovics G; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Sreenath T; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Kagan J; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA;
Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA;
McLeod DG; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; ; Urology Service, Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA;
Sesterhenn IA; The Joint Pathology Center; Silver Spring, MD, USA.
Srivastava S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Dobi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
Srinivasan A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;
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Źródło :
Genes & cancer [Genes Cancer] 2014 Jul; Vol. 5 (7-8), pp. 273-84.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells.
Autorzy :
Farooqi AA; Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, 35 Km Ferozepur Road, Lahore, Pakistan.
Hou MF; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ; Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
Chen CC; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
Wang CL; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
Chang HW; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan ; Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan.
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Źródło :
Cancer cell international [Cancer Cell Int] 2014 Apr 17; Vol. 14, pp. 34. Date of Electronic Publication: 2014 Apr 17 (Print Publication: 2014).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Interleukin-27 gene delivery for modifying malignant interactions between prostate tumor and bone.
Autorzy :
Zolochevska O; 1 Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, TX 77555.
Ellis J
Parelkar S
Chan-Seng D
Emrick T
Wei J
Patrikeev I
Motamedi M
Figueiredo ML
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Źródło :
Human gene therapy [Hum Gene Ther] 2013 Dec; Vol. 24 (12), pp. 970-81. Date of Electronic Publication: 2013 Nov 06.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Transfer Techniques*
Bone Neoplasms/*therapy
Interleukin-27/*therapeutic use
Prostatic Neoplasms/*therapy
Bone Neoplasms/genetics ; Bone Neoplasms/secondary ; Cell Differentiation/drug effects ; Humans ; Interleukin-27/genetics ; Male ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Prostatic Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer.
Autorzy :
Kissick HT; Urology Division, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, E/CLS-447, Boston, MA, 02215, USA.
Sanda MG
Dunn LK
Arredouani MS
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2013 Dec; Vol. 62 (12), pp. 1831-40. Date of Electronic Publication: 2013 Oct 23.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Molecular Targeted Therapy*
Cancer Vaccines/*therapeutic use
HLA-A2 Antigen/*immunology
Oncogene Proteins, Fusion/*antagonists & inhibitors
Peptide Fragments/*immunology
Prostatic Neoplasms/*therapy
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Case-Control Studies ; Epitopes, T-Lymphocyte/immunology ; Flow Cytometry ; Humans ; Immunotherapy ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/immunology ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.
Autorzy :
Zammarchi F; Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Boutsalis G
Cartegni L
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Źródło :
PloS one [PLoS One] 2013; Vol. 8 (3), pp. e49721. Date of Electronic Publication: 2013 Mar 05.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
5' Untranslated Regions*
Gene Expression Regulation, Neoplastic*
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*metabolism
Serine Endopeptidases/*genetics
Trans-Activators/*genetics
Alternative Splicing ; Animals ; Cell Death ; Cell Line, Tumor ; Genetic Variation ; HeLa Cells ; Humans ; Male ; Mice ; NIH 3T3 Cells ; Open Reading Frames ; Promoter Regions, Genetic ; Protein Biosynthesis ; Protein Isoforms/genetics ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
Differentially methylated loci distinguish ovarian carcinoma histological types: evaluation of a DNA methylation assay in FFPE tissue.
Autorzy :
Kelemen LE; Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, AB, Canada T2S 3C3 ; Departments of Medical Genetics and Oncology, University of Calgary, Calgary, AB, Canada T2N 4N2.
Köbel M
Chan A
Taghaddos S
Dinu I
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Źródło :
BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 815894. Date of Electronic Publication: 2013 Sep 24.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Genetic Loci*
DNA, Neoplasm/*metabolism
Ovarian Neoplasms/*metabolism
Ovarian Neoplasms/*pathology
Female ; Humans
Czasopismo naukowe

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