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    Wyświetlanie 1-11 z 11
    Tytuł:
    5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.
    Autorzy:
    Zammarchi F; Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
    Boutsalis G
    Cartegni L
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    Źródło:
    PloS one [PLoS One] 2013; Vol. 8 (3), pp. e49721. Date of Electronic Publication: 2013 Mar 05.
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    5' Untranslated Regions*
    Gene Expression Regulation, Neoplastic*
    Prostatic Neoplasms/*genetics
    Prostatic Neoplasms/*metabolism
    Serine Endopeptidases/*genetics
    Trans-Activators/*genetics
    Alternative Splicing ; Animals ; Cell Death ; Cell Line, Tumor ; Genetic Variation ; HeLa Cells ; Humans ; Male ; Mice ; NIH 3T3 Cells ; Open Reading Frames ; Promoter Regions, Genetic ; Protein Biosynthesis ; Protein Isoforms/genetics ; Transcriptional Regulator ERG
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Differentially methylated loci distinguish ovarian carcinoma histological types: evaluation of a DNA methylation assay in FFPE tissue.
    Autorzy:
    Kelemen LE; Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, AB, Canada T2S 3C3 ; Departments of Medical Genetics and Oncology, University of Calgary, Calgary, AB, Canada T2N 4N2.
    Köbel M
    Chan A
    Taghaddos S
    Dinu I
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    Źródło:
    BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 815894. Date of Electronic Publication: 2013 Sep 24.
    Typ publikacji:
    Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    DNA Methylation*
    Gene Expression Regulation, Neoplastic*
    Genetic Loci*
    DNA, Neoplasm/*metabolism
    Ovarian Neoplasms/*metabolism
    Ovarian Neoplasms/*pathology
    Female ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells.
    Autorzy:
    Farooqi AA; Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, 35 Km Ferozepur Road, Lahore, Pakistan.
    Hou MF; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ; Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
    Chen CC; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
    Wang CL; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
    Chang HW; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan ; Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan.
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    Źródło:
    Cancer cell international [Cancer Cell Int] 2014 Apr 17; Vol. 14, pp. 34. Date of Electronic Publication: 2014 Apr 17 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods.
    Autorzy:
    He J; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Schepmoes AA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Wu C; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Fillmore TL; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Gao Y; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Rodland KD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Camp DG 2nd; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. .
    Rastogi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Tan SH; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Yan W; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Mohamed AA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Huang W; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Banerjee S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Kagan J; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. .
    Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. .
    McLeod DG; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .; Urology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA. .
    Srivastava S; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Petrovics G; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Dobi A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
    Srinivasan A; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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    Źródło:
    Journal of translational medicine [J Transl Med] 2015 Feb 12; Vol. 13, pp. 54. Date of Electronic Publication: 2015 Feb 12.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Mass Spectrometry/*methods
    Prostatic Neoplasms/*genetics
    Real-Time Polymerase Chain Reaction/*methods
    Trans-Activators/*genetics
    Amino Acid Sequence ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Female ; HEK293 Cells ; Humans ; Male ; Molecular Sequence Data ; Peptides/chemistry ; Peptides/metabolism ; Prostatic Neoplasms/urine ; RNA, Messenger ; Recombinant Proteins/metabolism ; Trans-Activators/metabolism ; Trans-Activators/urine ; Transcriptional Regulator ERG
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer.
    Autorzy:
    Urbinati G; Université Paris-Sud 11, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; CNRS, Villejuif, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; Gustave Roussy, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805.
    Ali HM; Université Paris-Sud 11, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; CNRS, Villejuif, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; Gustave Roussy, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805.
    Rousseau Q; Université Paris-Sud 11, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; CNRS, Villejuif, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; Gustave Roussy, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; Laboratory of Experimental Cancer Research, Ghent University Hospital Building P7, De Pintelaan 185, B-9000 Gent, Belgium.
    Chapuis H; Institut Galien, UMR CNRS 8612, Université Paris-Sud 11, Faculté de pharmacie, 5 rue J. B. Clément, 92296 Châtenay-Malabry, France.
    Desmaële D; Institut Galien, UMR CNRS 8612, Université Paris-Sud 11, Faculté de pharmacie, 5 rue J. B. Clément, 92296 Châtenay-Malabry, France.
    Couvreur P; Institut Galien, UMR CNRS 8612, Université Paris-Sud 11, Faculté de pharmacie, 5 rue J. B. Clément, 92296 Châtenay-Malabry, France.
    Massaad-Massade L; Université Paris-Sud 11, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; CNRS, Villejuif, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805; Gustave Roussy, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif, France-94805.
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    Źródło:
    PloS one [PLoS One] 2015 May 01; Vol. 10 (5), pp. e0125277. Date of Electronic Publication: 2015 May 01 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Antineoplastic Agents, Phytogenic/*pharmacology
    Oncogene Proteins, Fusion/*antagonists & inhibitors
    Prostatic Neoplasms/*therapy
    RNA, Messenger/*antagonists & inhibitors
    RNA, Small Interfering/*genetics
    Squalene/*pharmacology
    Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Drug Carriers ; Genetic Therapy/methods ; Humans ; Male ; Mice ; Mice, SCID ; Nanoparticles/chemistry ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; Receptors, Adrenergic, alpha-2/genetics ; Receptors, Adrenergic, alpha-2/metabolism ; Signal Transduction ; Squalene/chemistry ; Squalene/metabolism ; Treatment Outcome ; Tumor Burden ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation.
    Autorzy:
    Mounir Z; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Lin F; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Lin VG; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Korn JM; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Yu Y; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Valdez R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Aina OH; Center for Comparative Medicine, University of California, Davis, CA, USA.
    Buchwalter G; 1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA [2] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
    Jaffe AB; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Korpal M; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Zhu P; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Brown M; 1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA [2] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
    Cardiff RD; Center for Comparative Medicine, University of California, Davis, CA, USA.
    Rocnik JL; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Yang Y; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
    Pagliarini R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
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    Źródło:
    Oncogene [Oncogene] 2015 Jul; Vol. 34 (29), pp. 3815-25. Date of Electronic Publication: 2014 Sep 29.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cell Differentiation/*genetics
    Cell Proliferation/*genetics
    Prostatic Neoplasms/*genetics
    Serine Endopeptidases/*genetics
    Trans-Activators/*genetics
    Animals ; Antibiotics, Antineoplastic/pharmacology ; Benzamides ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Doxorubicin/pharmacology ; Epithelial Cells/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Mice, Transgenic ; Microscopy, Confocal ; Neuroendocrine Cells/metabolism ; Nitriles ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA Interference ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Serine Endopeptidases/metabolism ; Trans-Activators/metabolism ; Transcriptional Regulator ERG ; Translocation, Genetic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    --A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS.
    Autorzy:
    Nicholas TR; Department of Biology, Indiana University, Bloomington, Indiana, United States of America.
    Meng J; Chemical Genomics Core Facility, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
    Greulich BM; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana, United States of America.
    Morris TS; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana, United States of America.
    Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana, United States of America.
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    Źródło:
    PloS one [PLoS One] 2020 Sep 11; Vol. 15 (9), pp. e0238999. Date of Electronic Publication: 2020 Sep 11 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    High-Throughput Screening Assays/*methods
    Prostatic Neoplasms/*drug therapy
    Prostatic Neoplasms/*metabolism
    RNA-Binding Protein EWS/*antagonists & inhibitors
    Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; Feasibility Studies ; Humans ; Male ; Prostatic Neoplasms/genetics ; Protein Interaction Domains and Motifs/drug effects ; RNA-Binding Protein EWS/genetics ; RNA-Binding Protein EWS/metabolism ; Recombinant Proteins/drug effects ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Small Molecule Libraries ; Transcriptional Regulator ERG/antagonists & inhibitors ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Impact TMPRSS2-ERG Molecular Subtype on Prostate Cancer Recurrence.
    Autorzy:
    Kobelyatskaya AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
    Pudova EA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Snezhkina AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Fedorova MS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Pavlov VS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Guvatova ZG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Savvateeva MV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Melnikova NV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Dmitriev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Trofimov DY; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
    Sukhikh GT; Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
    Nyushko KM; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
    Alekseev BY; National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
    Razin SV; Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
    Krasnov GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
    Pokaż więcej
    Źródło:
    Life (Basel, Switzerland) [Life (Basel)] 2021 Jun 21; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 21.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer.
    Autorzy:
    Lorenzin F; Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, 38123 Trento, Italy.
    Demichelis F; Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, 38123 Trento, Italy.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA.; The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
    Pokaż więcej
    Źródło:
    Cancers [Cancers (Basel)] 2022 Feb 22; Vol. 14 (5). Date of Electronic Publication: 2022 Feb 22.
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-11 z 11

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