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Tytuł :
Epigenetic strategies to boost CAR T cell therapy.
Autorzy :
Akbari B; Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Ghahri-Saremi N; Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Soltantoyeh T; Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Hadjati J; Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Ghassemi S; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mirzaei HR; Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Sep 01; Vol. 29 (9), pp. 2640-2659. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies.
Autorzy :
Scourzic L; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, United States.
Salataj E; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, United States.
Apostolou E; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 May 14; Vol. 12, pp. 669881. Date of Electronic Publication: 2021 May 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
The Toolbox for Untangling Chromosome Architecture in Immune Cells.
Autorzy :
Liu S; Laboratory of Epigenome Biology, Systems Biology Center, NHLBI, NIH, Bethesda, MD, United States.
Zhao K; Laboratory of Epigenome Biology, Systems Biology Center, NHLBI, NIH, Bethesda, MD, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 29; Vol. 12, pp. 670884. Date of Electronic Publication: 2021 Apr 29 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Intramural
Czasopismo naukowe
Tytuł :
SATB1-mediated chromatin landscape in T cells.
Autorzy :
Zelenka T; Department of Biology, University of Crete , Heraklion, Crete, Greece.; Gene Regulation & Genomics, Institute of Molecular Biology and Biotechnology-Foundation for Research and Technology Hellas , Heraklion, Crete, Greece.
Spilianakis C; Department of Biology, University of Crete , Heraklion, Crete, Greece.; Gene Regulation & Genomics, Institute of Molecular Biology and Biotechnology-Foundation for Research and Technology Hellas , Heraklion, Crete, Greece.
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Źródło :
Nucleus (Austin, Tex.) [Nucleus] 2020 Dec; Vol. 11 (1), pp. 117-131.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review; Video-Audio Media
MeSH Terms :
Autoimmune Diseases/*metabolism
Biomarkers, Tumor/*metabolism
CD4-Positive T-Lymphocytes/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Chromatin/*metabolism
Matrix Attachment Region Binding Proteins/*metabolism
Neoplasm Proteins/*metabolism
Neoplasms/*metabolism
Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/pathology ; Biomarkers, Tumor/genetics ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; Chromatin/genetics ; Chromatin/pathology ; Humans ; Matrix Attachment Region Binding Proteins/genetics ; Mice ; Neoplasm Proteins/genetics ; Neoplasms/genetics ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.
Autorzy :
Rodríguez-Caparrós A; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Álvarez-Santiago J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Del Valle-Pastor MJ; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Suñé C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
López-Ros J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Hernández-Munain C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 11; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enhancer Elements, Genetic/*genetics
Gene Expression Regulation/*genetics
Genes, T-Cell Receptor/*genetics
T-Lymphocytes/*immunology
Animals ; Chromatin/genetics ; Chromatin/immunology ; Enhancer Elements, Genetic/immunology ; Gene Expression Regulation/immunology ; Genes, T-Cell Receptor/immunology ; Humans ; Signal Transduction/genetics ; Signal Transduction/immunology ; Transcription, Genetic/genetics ; Transcription, Genetic/immunology ; V(D)J Recombination/genetics ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
Autorzy :
Zhao H; Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Li Z; Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Zhu Y; Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Bian S; Henan Medical Genetics Institute, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
Zhang Y; Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Qin L; Henan Medical Genetics Institute, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
Naik AK; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
He J; State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhang Z; State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.; Center for Biomedical Informatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou 510515, China.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Hao B; Guangdong Provincial Key Laboratory of Tumor Immunotherapy, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.; Henan Medical Genetics Institute, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9621-9636.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
CCCTC-Binding Factor/*metabolism
Chromatin/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Receptors, Antigen, T-Cell, gamma-delta/*genetics
Animals ; Apoptosis Regulatory Proteins/genetics ; Binding Sites ; CCCTC-Binding Factor/genetics ; Chromatin/genetics ; Gene Expression Regulation ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Homeodomain Proteins/genetics ; Membrane Proteins/genetics ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Thymus Gland/cytology
Czasopismo naukowe
Tytuł :
Genome Topology Control of Antigen Receptor Gene Assembly.
Autorzy :
Allyn BM; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lee KD; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Bassing CH; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and .; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 May 15; Vol. 204 (10), pp. 2617-2626.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
B-Lymphocytes/*immunology
Receptors, Antigen/*genetics
T-Lymphocytes/*immunology
V(D)J Recombination/*genetics
Animals ; CCCTC-Binding Factor/metabolism ; Cell Cycle Proteins/metabolism ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Structures ; Genetic Loci ; Humans ; Molecular Conformation ; Receptors, Antigen/metabolism
Czasopismo naukowe
Tytuł :
Enhancers as regulators of antigen receptor loci three-dimensional chromatin structure.
Autorzy :
Barajas-Mora EM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
Feeney AJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
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Źródło :
Transcription [Transcription] 2020 Feb; Vol. 11 (1), pp. 37-51. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
The murine IgH locus contains a distinct DNA sequence motif for the chromatin regulatory factor CTCF.
Autorzy :
Ciccone DN; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Namiki Y; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Chen C; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Morshead KB; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Wood AL; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.
Johnston CM; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.
Morris JW; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Wang Y; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Sadreyev R; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.
Corcoran AE; Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.
Matthews AGW; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114.; Department of Biological Sciences and Program in Biochemistry, Wellesley College, Wellesley, Massachusetts 02481.
Oettinger MA; Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Sep 13; Vol. 294 (37), pp. 13580-13592. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CCCTC-Binding Factor/*metabolism
Immunoglobulin Heavy Chains/*genetics
Adaptive Immunity/genetics ; Animals ; Binding Sites ; CCCTC-Binding Factor/genetics ; Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/genetics ; Gene Rearrangement ; Humans ; Immunoglobulin Heavy Chains/metabolism ; Immunoglobulin Variable Region ; K562 Cells ; Mice ; Mice, Knockout ; NIH 3T3 Cells ; Nucleotide Motifs ; Regulatory Sequences, Nucleic Acid ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Diversification of the TCR β Locus V β Repertoire by CTCF.
Autorzy :
Chen S; Department of Immunology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, North Carolina, 27710, USA.
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Źródło :
ImmunoHorizons [Immunohorizons] 2018 Dec; Vol. 2 (11), pp. 377-383.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.
Autorzy :
Chen S; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Luperchio TR; Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA.
Wong X; Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA.
Doan EB; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Byrd AT; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Roy Choudhury K; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA.
Reddy KL; Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2018 Nov 13; Vol. 25 (7), pp. 1729-1740.e6.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Loci*
Transcription, Genetic*
Nuclear Lamina/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Recombination, Genetic/*genetics
Animals ; Cell Line ; Chromatin/metabolism ; Histones/metabolism ; Humans ; Lysine/metabolism ; Mice, Inbred C57BL ; Models, Biological ; Transcriptional Activation/genetics ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Epigenetic control of CD8 T cell differentiation.
Autorzy :
Henning AN; Center for Cell-Based Therapy, National Cancer Institute (NCI).; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.
Roychoudhuri R; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.
Restifo NP; Center for Cell-Based Therapy, National Cancer Institute (NCI).; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2018 May; Vol. 18 (5), pp. 340-356. Date of Electronic Publication: 2018 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
CD8-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*immunology
Cell Differentiation/*genetics
Cell Differentiation/*immunology
Epigenesis, Genetic/*immunology
Animals ; CD8-Positive T-Lymphocytes/metabolism ; Cellular Reprogramming Techniques/methods ; Chromatin Assembly and Disassembly/genetics ; Chromatin Assembly and Disassembly/immunology ; DNA Methylation/immunology ; Enhancer Elements, Genetic ; Histone Code/genetics ; Humans ; Immunotherapy/methods ; Models, Genetic ; Models, Immunological ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.
Autorzy :
Loguercio S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Barajas-Mora EM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.
Shih HY; Department of Immunology, Duke University Medical Center, Durham, NC, United States.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC, United States.
Feeney AJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 Mar 08; Vol. 9, pp. 425. Date of Electronic Publication: 2018 Mar 08 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
B-Lymphocytes/*physiology
CCCTC-Binding Factor/*metabolism
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Immunoglobulins/*genetics
Receptors, Antigen, T-Cell/*genetics
T-Lymphocytes/*physiology
Animals ; CCCTC-Binding Factor/genetics ; Cell Differentiation ; Cell Lineage ; Cells, Cultured ; Chromatin/metabolism ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Developmental ; Genes, RAG-1 ; Genetic Loci/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Organ Specificity ; Protein Binding
Czasopismo naukowe
Tytuł :
Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.
Autorzy :
Carico ZM; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Roy Choudhury K; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA.
Zhang B; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Zhuang Y; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2017 Jun 06; Vol. 19 (10), pp. 2157-2173.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Genetic*
Thymocytes*
V(D)J Recombination*
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Receptors, Antigen, T-Cell, gamma-delta/*genetics
Animals ; Mice ; Mice, Knockout ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/immunology
Czasopismo naukowe
Tytuł :
Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding.
Autorzy :
Rawat P; National Institute of Immunology, New Delhi, India.
Jalan M; National Institute of Immunology, New Delhi, India.
Sadhu A; National Institute of Immunology, New Delhi, India.
Kanaujia A; National Institute of Immunology, New Delhi, India.
Srivastava M; National Institute of Immunology, New Delhi, India .
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2017 Apr 14; Vol. 37 (9). Date of Electronic Publication: 2017 Apr 14 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
Chromatin Assembly and Disassembly/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Repressor Proteins/*metabolism
V(D)J Recombination/*genetics
Animals ; Binding Sites/immunology ; CCCTC-Binding Factor ; Cells, Cultured ; Enhancer Elements, Genetic/genetics ; Genome/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Regulatory Elements, Transcriptional/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases.
Autorzy :
Mirlekar B; Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Pune, India; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Gautam D; Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC , USA.
Chattopadhyay S; Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Pune, India; Cancer Biology and Inflammatory Disorder Division, Indian Institute of Chemical Biology, Kolkata, India.
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Źródło :
Frontiers in immunology [Front Immunol] 2017 Feb 09; Vol. 8, pp. 72. Date of Electronic Publication: 2017 Feb 09 (Print Publication: 2017).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
Autorzy :
Chen L; Department of Immunology, Duke University Medical Center, Durham, NC 27710.
Zhao L; Howard Hughes Medical Institute, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; and.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Alt FW; Howard Hughes Medical Institute, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; and.; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC 27710; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Oct 15; Vol. 197 (8), pp. 3188-3197. Date of Electronic Publication: 2016 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor/*genetics
Repressor Proteins/*immunology
V(D)J Recombination/*genetics
Animals ; Binding Sites ; CCCTC-Binding Factor ; Female ; Gene Rearrangement, delta-Chain T-Cell Antigen Receptor/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements.
Autorzy :
Pugacheva EM; Laboratory of Immunogenetics, NIH, NIAID, Rockville, MD 20852 USA.
Teplyakov E; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Wu Q; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Li J; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Chen C; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Meng C; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Liu J; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Robinson S; Laboratory of Immunogenetics, NIH, NIAID, Rockville, MD 20852 USA.
Loukinov D; Laboratory of Immunogenetics, NIH, NIAID, Rockville, MD 20852 USA.
Boukaba A; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
Hutchins AP; Department of Biology, Southern University of Science and Technology of China, Shenzhen, 518055 Guangdong China.
Lobanenkov V; Laboratory of Immunogenetics, NIH, NIAID, Rockville, MD 20852 USA.
Strunnikov A; Molecular Epigenetics Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 Guangdong China.
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Źródło :
Epigenetics & chromatin [Epigenetics Chromatin] 2016 Aug 31; Vol. 9 (1), pp. 35. Date of Electronic Publication: 2016 Aug 31 (Print Publication: 2016).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.
Autorzy :
Zhao L; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115.
Frock RL; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115.
Du Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115.
Hu J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115.
Chen L; Department of Immunology, Duke University Medical Center, Durham, NC 27710.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC 27710 .
Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115 .
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Źródło :
The Journal of experimental medicine [J Exp Med] 2016 Aug 22; Vol. 213 (9), pp. 1921-36. Date of Electronic Publication: 2016 Aug 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
V(D)J Recombination*
Homeodomain Proteins/*physiology
Receptors, Antigen, T-Cell, gamma-delta/*genetics
T-Lymphocytes/*physiology
Amino Acid Transport Systems, Basic/genetics ; Animals ; Cells, Cultured ; DNA Breaks, Double-Stranded ; Mice
Czasopismo naukowe
Tytuł :
Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.
Autorzy :
Bolland DJ; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Koohy H; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Wood AL; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Matheson LS; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Krueger F; Bioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Stubbington MJ; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Baizan-Edge A; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Chovanec P; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Stubbs BA; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Tabbada K; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Andrews SR; Bioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Spivakov M; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: .
Corcoran AE; Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2016 Jun 14; Vol. 15 (11), pp. 2475-87. Date of Electronic Publication: 2016 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
V(D)J Recombination/*genetics
Algorithms ; Animals ; Epigenesis, Genetic ; Evolution, Molecular ; Gene Expression Regulation ; Genetic Loci ; Homeodomain Proteins/metabolism ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Mice ; Receptors, Antigen ; Sequence Analysis, DNA ; Transcription, Genetic
Czasopismo naukowe

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