- Tytuł:
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.
- Autorzy:
- Źródło:
- Nature [Nature] 2013 Oct 24; Vol. 502 (7472), pp. 575-579. Date of Electronic Publication: 2013 Sep 22.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms:
-
Protein Engineering*
Adrenergic beta-2 Receptor Agonists/*pharmacology
Epinephrine/*pharmacology
Receptors, Adrenergic, beta-2/*chemistry
Receptors, Adrenergic, beta-2/*metabolism
Single-Chain Antibodies/*pharmacology
Benzoxazines/pharmacology ; Binding Sites/drug effects ; Crystallography, X-Ray ; Directed Molecular Evolution ; Humans ; Hydrogen Bonding/drug effects ; Isoproterenol/analogs & derivatives ; Isoproterenol/pharmacology ; Ligands ; Models, Molecular ; Protein Stability/drug effects ; Receptors, Adrenergic, beta-2/drug effects ; Single-Chain Antibodies/genetics ; Tyrosine/chemistry ; Tyrosine/metabolism ; Water/chemistry ; Water/pharmacology
Czasopismo naukowe