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Wyświetlanie 1-20 z 167
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Tytuł :
Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis.
Autorzy :
El-Sahar AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
Rastanawi AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
El-Yamany MF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
Saad MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt; School of Pharmacy, Newgiza University, Cairo, Egypt. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118076. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Benzhydryl Compounds/*pharmacology
Glucosides/*pharmacology
Glycolysis/*drug effects
Huntington Disease/*drug therapy
Sodium-Glucose Transporter 2 Inhibitors/*pharmacology
Animals ; Autophagy/drug effects ; Behavior, Animal/drug effects ; Disease Models, Animal ; Huntington Disease/physiopathology ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Maze Learning/drug effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.
Autorzy :
Saba J; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Turati J; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ramírez D; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Carniglia L; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Durand D; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Lasaga M; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Caruso C; Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Paraguay 2155, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
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Źródło :
Journal of neurochemistry [J Neurochem] 2018 Sep; Vol. 146 (6), pp. 686-702. Date of Electronic Publication: 2018 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Astrocytes/*drug effects
Astrocytes/*metabolism
Brain-Derived Neurotrophic Factor/*pharmacology
Membrane Glycoproteins/*metabolism
Neuroprotective Agents/*pharmacology
Receptor, trkB/*metabolism
Signal Transduction/*drug effects
Animals ; Apoptosis/genetics ; Azepines/pharmacology ; Benzamides/pharmacology ; Carbazoles/pharmacology ; Cell Cycle/drug effects ; Cells, Cultured ; Culture Media, Serum-Free/toxicity ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Indole Alkaloids/pharmacology ; Membrane Glycoproteins/genetics ; PC12 Cells ; Protein-Tyrosine Kinases/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Receptor, trkB/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats.
Autorzy :
Wahdan SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abbasia, Cairo, Egypt.
Tadros MG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abbasia, Cairo, Egypt. .
Khalifa AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abbasia, Cairo, Egypt.
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Źródło :
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2017 Sep; Vol. 390 (9), pp. 905-917. Date of Electronic Publication: 2017 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Apoptosis/*drug effects
Neuroprotective Agents/*pharmacology
Selegiline/*pharmacology
Animals ; Antioxidants/administration & dosage ; Catalase/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Gene Expression Regulation/drug effects ; Glutathione/metabolism ; Lipid Peroxidation/drug effects ; Male ; Neuroprotective Agents/administration & dosage ; Nitro Compounds/toxicity ; Prepulse Inhibition/drug effects ; Propionates/toxicity ; Rats ; Rats, Wistar ; Selegiline/administration & dosage
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy.
Autorzy :
Chen SD; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan. .; Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan. .; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. .
Wu CL; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 11221, Taiwan. .; Institute of Brain Science and Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan. .
Hwang WC; Department of Neurology, Taipei City Hospital, Taipei 11221, Taiwan. .
Yang DI; Institute of Brain Science and Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2017 Mar 03; Vol. 18 (3). Date of Electronic Publication: 2017 Mar 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis*/drug effects
Autophagy*/drug effects
Oxidative Stress*/drug effects
Brain-Derived Neurotrophic Factor/*metabolism
Neurodegenerative Diseases/*metabolism
Neurons/*metabolism
Animals ; Brain-Derived Neurotrophic Factor/pharmacology ; Cells, Cultured ; Disease Models, Animal ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neurons/drug effects ; Neuroprotective Agents/pharmacology ; Nitro Compounds/pharmacology ; Nitro Compounds/toxicity ; Nuclear Proteins/metabolism ; Propionates/pharmacology ; Propionates/toxicity ; RNA-Binding Proteins/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair-Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax-Bad genes in male wistar rats.
Autorzy :
Thangarajan S; Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113,Tamil Nadu, India. Electronic address: .
Ramachandran S; Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113,Tamil Nadu, India.
Krishnamurthy P; Department of Biotechnology, Rajalakshmi Engineering College, Rajalakshmi Nagar, Thandalam, Chennai, 602 105, Tamil Nadu, India.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2016 Dec; Vol. 84, pp. 514-525. Date of Electronic Publication: 2016 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Nitro Compounds*
Propionates*
Apoptosis/*drug effects
Basal Ganglia/*drug effects
Behavior, Animal/*drug effects
Flavonoids/*pharmacology
Huntington Disease/*prevention & control
Mitochondrial Diseases/*prevention & control
Neuroprotective Agents/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*metabolism
bcl-2-Associated X Protein/*metabolism
bcl-Associated Death Protein/*metabolism
Animals ; Basal Ganglia/metabolism ; Basal Ganglia/pathology ; Biomarkers/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Down-Regulation ; Huntington Disease/metabolism ; Huntington Disease/physiopathology ; Huntington Disease/psychology ; Male ; Maze Learning/drug effects ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/physiopathology ; Mitochondrial Diseases/psychology ; Mitochondrial Swelling/drug effects ; Motor Activity/drug effects ; Nerve Degeneration ; Oxidative Stress/drug effects ; Postural Balance/drug effects ; Proto-Oncogene Proteins c-bcl-2/genetics ; Rats, Wistar ; Signal Transduction/drug effects ; Time Factors ; Up-Regulation ; bcl-2-Associated X Protein/genetics ; bcl-Associated Death Protein/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms.
Autorzy :
Jang M; Department of Convergence Medical Science, College of Oriental Medicine, and Institute of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Cancer Preventive Material Development, Kyung Hee University, Seoul 130-701, Republic of Korea.
Lee MJ; Department of Convergence Medical Science, College of Oriental Medicine, and Institute of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Cancer Preventive Material Development, Kyung Hee University, Seoul 130-701, Republic of Korea.
Cho IH; Department of Convergence Medical Science, College of Oriental Medicine, and Institute of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2014 May; Vol. 38, pp. 151-65. Date of Electronic Publication: 2014 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Anti-Inflammatory Agents/*pharmacology
Corpus Striatum/*drug effects
Neuroprotective Agents/*pharmacology
Nitro Compounds/*toxicity
Propionates/*toxicity
Pyruvates/*pharmacology
Animals ; Behavior, Animal/drug effects ; Corpus Striatum/metabolism ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells
Autorzy :
Kulasekaran, Gopinath
Ganapasam, Sudhandiran
Pokaż więcej
Źródło :
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease. November 2015 409(1-2):199-211
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 167

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