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Wyszukujesz frazę ""4-Nitroquinoline-1-oxide"" wg kryterium: Temat


Tytuł :
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium.
Autorzy :
Horiuchi M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Hirose W; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Tsuchida K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University, Sendai, Japan.
Taniyama Y; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kamei T; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Yamamoto M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan .; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
4-Nitroquinoline-1-oxide/*pharmacology
Carcinogenesis/*genetics
Carcinogens/*pharmacology
Esophageal Neoplasms/*genetics
NF-E2-Related Factor 2/*genetics
Alleles ; Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; DNA Damage ; Epithelium/drug effects ; Epithelium/metabolism ; Epithelium/pathology ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophagus/drug effects ; Esophagus/metabolism ; Esophagus/pathology ; Genes, Reporter ; Integrases/genetics ; Integrases/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; Oxidative Stress ; Signal Transduction ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Dietary fat and male sex increase histopathological changes in a mouse model of oral cancer.
Autorzy :
Green JM; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Ciancio MJ; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Goral J; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Pytynia M; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Pitstick L; Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Meyer A; Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Nguyen A; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.; College of Dental Medicine-Illinois, Midwestern University, Downers Grove, IL, USA.
Lee K; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.; College of Dental Medicine-Illinois, Midwestern University, Downers Grove, IL, USA.
Barakat A; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.
Jham BC; College of Dental Medicine-Illinois, Midwestern University, Downers Grove, IL, USA.
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Źródło :
Oral diseases [Oral Dis] 2021 Mar; Vol. 27 (2), pp. 215-225. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Squamous Cell*
Mouth Neoplasms*/chemically induced
Tongue Neoplasms*
4-Nitroquinoline-1-oxide/toxicity ; Animals ; Dietary Fats/adverse effects ; Female ; Male ; Mice
Czasopismo naukowe
Tytuł :
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts.
Autorzy :
Piberger AL; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. .
Bowry A; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Kelly RDW; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Walker AK; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
González-Acosta D; Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain.
Bailey LJ; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.
Doherty AJ; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.
Méndez J; Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain.
Morris JR; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Bryant HE; Department of Oncology & Metabolism, The Medical School, University of Sheffield, Sheffield, S10 2RX, UK.
Petermann E; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5863. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Adducts/*genetics
DNA Primase/*metabolism
DNA-Directed DNA Polymerase/*metabolism
Homologous Recombination/*physiology
Multifunctional Enzymes/*metabolism
4-Nitroquinoline-1-oxide/toxicity ; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/metabolism ; Benz(a)Anthracenes/administration & dosage ; Benz(a)Anthracenes/toxicity ; Cell Line ; DNA Adducts/metabolism ; DNA Primase/genetics ; DNA, Single-Stranded ; DNA-Directed DNA Polymerase/genetics ; Humans ; Multifunctional Enzymes/genetics ; Quinolones/toxicity ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Single Molecule Imaging ; Sister Chromatid Exchange
Czasopismo naukowe
Tytuł :
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
Autorzy :
Sequeira I; Centre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.; Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
Rashid M; Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.
Tomás IM; Centre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
Williams MJ; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Graham TA; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Adams DJ; Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.
Vigilante A; Centre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
Watt FM; Centre for Stem Cells & Regenerative Medicine, King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 09; Vol. 11 (1), pp. 5671. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genomics*
Carcinoma, Squamous Cell/*genetics
Mouth Neoplasms/*genetics
4-Nitroquinoline-1-oxide/adverse effects ; Animals ; Cadherins/genetics ; Carcinogenesis/chemically induced ; Carcinoma, Squamous Cell/pathology ; Disease Models, Animal ; Disease Progression ; Exome/genetics ; Genes, Neoplasm ; Genes, p53/genetics ; Mice ; Mice, Inbred C57BL ; Mouth Neoplasms/pathology ; Mutation ; Neoplasm Invasiveness ; Receptor, Notch1/genetics
Czasopismo naukowe
Tytuł :
Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.
Autorzy :
Hafız AM; Department of Otorhinolaryngology, Koc University, Istanbul, Turkey.
Doğan R; Department of Otorhinolaryngology, Bezmialem Vakif University, Istanbul, Turkey.
Gucin Z; Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey.
Ozer OF; Department of Biochemistry, Bezmialem Vakif University, Istanbul, Turkey.
Yenigun A; Department of Otorhinolaryngology, Bezmialem Vakif University, Istanbul, Turkey.
Ozturan O; Department of Otorhinolaryngology, Bezmialem Vakif University, Istanbul, Turkey.
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Źródło :
Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2020 Nov; Vol. 29 (11), pp. 1249-1254.
Typ publikacji :
Journal Article
MeSH Terms :
Tongue Neoplasms*/chemically induced
Tongue Neoplasms*/drug therapy
Tongue Neoplasms*/prevention & control
4-Nitroquinoline-1-oxide/toxicity ; Animals ; Pyrrolidines ; Rats ; Thiocarbamates
Czasopismo naukowe
Tytuł :
Characterization of CD103 tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade.
Autorzy :
Han L; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Gao QL; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Zhou XM; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Shi C; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Chen GY; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China.
Song YP; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Yao YJ; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Zhao YM; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Wen XY; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Liu SL; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Qi YM; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Gao YF; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China. .; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Aug; Vol. 69 (8), pp. 1493-1504. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Esophageal Neoplasms/*immunology
Esophageal Neoplasms/*metabolism
Integrin alpha Chains/*metabolism
Lymphocytes, Tumor-Infiltrating/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Tumor Microenvironment/*immunology
4-Nitroquinoline-1-oxide/toxicity ; Adult ; Aged ; Animals ; Antibodies, Monoclonal/pharmacology ; Antigens, CD/immunology ; Biomarkers, Tumor ; Carcinogens/toxicity ; Cohort Studies ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/chemically induced ; Esophageal Squamous Cell Carcinoma/immunology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Follow-Up Studies ; Humans ; Integrin alpha Chains/immunology ; Male ; Mice, Inbred C57BL ; Middle Aged ; Prognosis ; Programmed Cell Death 1 Receptor/immunology ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Tumor-derived exosomes promote carcinogenesis of murine oral squamous cell carcinoma.
Autorzy :
Razzo BM; Department of Medicine, NYU Langone Medical Center, New York, NY, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ludwig N; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Hong CS; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sharma P; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Fabian KP; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Fecek RJ; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Storkus WJ; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Whiteside TL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 625-633.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Carcinogenesis/*pathology
Carcinoma, Squamous Cell/*pathology
Exosomes/*pathology
Mouth Neoplasms/*pathology
4-Nitroquinoline-1-oxide/toxicity ; Animals ; Apoptosis ; B7-H1 Antigen/metabolism ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Carcinogens/toxicity ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/metabolism ; Exosomes/drug effects ; Exosomes/metabolism ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Mutations induced by Bleomycin, 4-nitroquinoline-1-oxide, and hydrogen peroxide in the rpoB gene of Escherichia coli: Perspective on Mutational Hotspots.
Autorzy :
Fernandez K; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
D'Souza S; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Ahn JJ; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Singh S; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Bacasen EM; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Mashiach D; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Mishail D; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Kao T; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Thai J; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Hwang S; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Yaramada L; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States.
Miller JH; Department of Microbiology, Immunology, and Molecular Genetics, and the Molecular Biology Institute, University of California, and the David Geffen School of Medicine, Los Angeles, CA 90095, United States. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2020 May - Dec; Vol. 821, pp. 111702. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
4-Nitroquinoline-1-oxide/*toxicity
Bleomycin/*toxicity
DNA-Directed RNA Polymerases/*genetics
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
Gene Expression Regulation, Bacterial/*radiation effects
Hydrogen Peroxide/*toxicity
Antibiotics, Antineoplastic/toxicity ; DNA-Directed RNA Polymerases/radiation effects ; Escherichia coli/radiation effects ; Escherichia coli Proteins/radiation effects ; Mutagens/toxicity ; Oxidants/toxicity
Czasopismo naukowe
Tytuł :
Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells.
Autorzy :
Tan HH; Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Thomas NF; Methodist College Kuala Lumpur, Kuala Lumpur, Malaysia.
Inayat-Hussain SH; Product Stewardship and Toxicology, Group Health, Safety, Security and Environment, Petroliam Nasional Berhad (PETRONAS), Kuala Lumpur, Malaysia.; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United States of America.
Chan KM; Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
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Źródło :
PloS one [PLoS One] 2020 May 04; Vol. 15 (5), pp. e0223344. Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoprotection*
4-Nitroquinoline-1-oxide/*toxicity
Colon/*drug effects
DNA Damage/*drug effects
Furans/*pharmacology
Mutagens/*toxicity
Stilbenes/*pharmacology
Cell Line ; Colon/cytology ; DNA Repair/drug effects ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Furans/chemistry ; Humans ; Mitochondria/drug effects ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Stilbenes/chemistry
Czasopismo naukowe
Tytuł :
Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma.
Autorzy :
Kalish JM; Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.; Department of Pharmacology, Weill Cornell Graduate School of Biomedical Sciences, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Tang XH; Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Scognamiglio T; Department of Pathology, Weill Cornell Medical College, New York, NY, USA.
Zhang T; Weill Cornell Genomics Core Facility, Weill Cornell Medical College, New York, NY, USA.
Gudas LJ; Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.; Department of Pharmacology, Weill Cornell Graduate School of Biomedical Sciences, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
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Źródło :
Cancer biology & therapy [Cancer Biol Ther] 2020 May 03; Vol. 21 (5), pp. 400-411. Date of Electronic Publication: 2020 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
4-Nitroquinoline-1-oxide/*toxicity
Doxycycline/*toxicity
Head and Neck Neoplasms/*pathology
Polycomb Repressive Complex 1/*metabolism
Proto-Oncogene Proteins/*metabolism
Squamous Cell Carcinoma of Head and Neck/*pathology
Animals ; Anti-Bacterial Agents/toxicity ; Carcinogenesis ; Carcinogens/toxicity ; Disease Models, Animal ; Head and Neck Neoplasms/etiology ; Head and Neck Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Polycomb Repressive Complex 1/genetics ; Proto-Oncogene Proteins/genetics ; Squamous Cell Carcinoma of Head and Neck/etiology ; Squamous Cell Carcinoma of Head and Neck/metabolism
Czasopismo naukowe
Tytuł :
Impact of dietary vitamin D on initiation and progression of oral cancer.
Autorzy :
Verma A; Center for Oral Oncology, United States.
Vincent-Chong VK; Center for Oral Oncology, United States.
DeJong H; Center for Oral Oncology, United States.
Hershberger PA; Department of Pharmacology and Therapeutics, United States.
Seshadri M; Center for Oral Oncology, United States; Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 May; Vol. 199, pp. 105603. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Squamous Cell/*diet therapy
Mouth Neoplasms/*diet therapy
Receptors, Calcitriol/*genetics
Vitamin D/*genetics
Vitamin D3 24-Hydroxylase/*genetics
4-Nitroquinoline-1-oxide/toxicity ; Animals ; Body Weight ; Calcitriol/pharmacology ; Carcinogenesis/drug effects ; Carcinoma, Squamous Cell/blood ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/pathology ; Dietary Supplements/adverse effects ; Disease Models, Animal ; Disease Progression ; Humans ; Mice ; Mouth Neoplasms/blood ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/pathology ; Vitamin D/blood ; Vitamin D Deficiency/diet therapy ; Vitamin D Deficiency/genetics ; Vitamin D Deficiency/pathology
Czasopismo naukowe
Tytuł :
A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Autorzy :
Tan MT; Department of Bioengineering, Rice University, Houston, TX, USA.
Wu JG; Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry, Houston, TX, USA.
Callejas-Valera JL; Cancer Biology Research Center, Sanford Research, Sioux Falls, SD, USA.
Schwarz RA; Department of Bioengineering, Rice University, Houston, TX, USA.
Gillenwater AM; Department of Head and Neck Surgery, M.D. Anderson Cancer Center, University of Texas, Houston, TX, USA.
Richards-Kortum RR; Department of Bioengineering, Rice University, Houston, TX, USA.
Vigneswaran N; Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry, Houston, TX, USA.
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Źródło :
International journal of experimental pathology [Int J Exp Pathol] 2020 Feb; Vol. 101 (1-2), pp. 45-54. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
Quinolones*
Cell Transformation, Neoplastic/*chemically induced
Cell Transformation, Neoplastic/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Squamous Cell Carcinoma of Head and Neck/*chemically induced
Squamous Cell Carcinoma of Head and Neck/*genetics
Tongue Neoplasms/*chemically induced
Tongue Neoplasms/*genetics
4-Nitroquinoline-1-oxide ; Animals ; Cell Proliferation ; Cell Transformation, Neoplastic/pathology ; Disease Models, Animal ; Disease Progression ; Lymphocytes/pathology ; Mice, Inbred CBA ; Mice, Transgenic ; Oncogene Proteins, Viral/genetics ; Squamous Cell Carcinoma of Head and Neck/pathology ; Time Factors ; Tongue Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.
Autorzy :
Smart DJ; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland. Electronic address: .
Helbling FR; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Verardo M; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Huber A; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
McHugh D; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Vanscheeuwijck P; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
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Źródło :
Mutation research [Mutat Res] 2020 Jan; Vol. 849, pp. 503129. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutagenesis*
Mutation*
Lymphocytes/*drug effects
Mutagenicity Tests/*standards
Thymidine Kinase/*genetics
4-Nitroquinoline-1-oxide/toxicity ; Benzo(a)pyrene/toxicity ; Cell Line, Tumor ; Cyclophosphamide/toxicity ; DNA/genetics ; DNA/metabolism ; DNA Damage ; Diclofenac/toxicity ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation ; Humans ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Methyl Methanesulfonate/toxicity ; Micronuclei, Chromosome-Defective/drug effects ; Mitomycin/toxicity ; Thymidine Kinase/metabolism ; Vinblastine/toxicity
Czasopismo naukowe
Tytuł :
CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma.
Autorzy :
Ludwig N; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA. Electronic address: .
Szczepanski MJ; Chair and Department of Biochemistry, Medical University of Warsaw, Poland; Department of Otolaryngology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Gluszko A; Chair and Department of Biochemistry, Medical University of Warsaw, Poland.
Szafarowski T; Department of Otolaryngology, Faculty of Medicine and Dentistry, Czerniakowski Hospital, Medical University of Warsaw, 19/25 Stępińska Str., 00-739, Warsaw, Poland.
Azambuja JH; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Programa de Pós-Graduação Em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
Dolg L; Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.
Gellrich NC; Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.
Kampmann A; Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.
Whiteside TL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Departments of Immunology and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Zimmerer RM; Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.
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Źródło :
Cancer letters [Cancer Lett] 2019 Dec 28; Vol. 467, pp. 85-95. Date of Electronic Publication: 2019 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Head and Neck Neoplasms/*blood supply
Hyaluronan Receptors/*genetics
Hyaluronan Receptors/*metabolism
Squamous Cell Carcinoma of Head and Neck/*blood supply
4-Nitroquinoline-1-oxide/adverse effects ; Animals ; Case-Control Studies ; Cell Line, Tumor ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasms, Experimental ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
Participation of UV-regulated Genes in the Response to Helix-distorting DNA Damage in the Thermoacidophilic Crenarchaeon Sulfolobus acidocaldarius.
Autorzy :
Suzuki S; Department of Science and Engineering for Sustainable Development, Faculty of Science and Engineering, Soka University.
Kurosawa N; Department of Science and Engineering for Sustainable Development, Faculty of Science and Engineering, Soka University.
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Źródło :
Microbes and environments [Microbes Environ] 2019 Dec 27; Vol. 34 (4), pp. 363-373. Date of Electronic Publication: 2019 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Ultraviolet Rays*
DNA Damage/*genetics
Genes, Archaeal/*physiology
Sulfolobus acidocaldarius/*genetics
4-Nitroquinoline-1-oxide/pharmacology ; Archaeal Proteins/genetics ; Archaeal Proteins/metabolism ; Cisplatin/pharmacology ; DNA Repair/genetics ; Gene Knockout Techniques ; Genes, Archaeal/genetics ; Metronidazole/pharmacology ; Sulfolobus acidocaldarius/drug effects ; Sulfolobus acidocaldarius/growth & development ; Sulfolobus acidocaldarius/radiation effects
Czasopismo naukowe
Tytuł :
Oxidation and alkylation stresses activate ribosome-quality control.
Autorzy :
Yan LL; Department of Biology, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Simms CL; Department of Biology, Washington University in St. Louis, St. Louis, MO, 63130, USA.
McLoughlin F; Department of Biology, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Vierstra RD; Department of Biology, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Zaher HS; Department of Biology, Washington University in St. Louis, St. Louis, MO, 63130, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Dec 09; Vol. 10 (1), pp. 5611. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Oxidative Stress*
Ribosomes/*metabolism
4-Nitroquinoline-1-oxide/metabolism ; Alkylation ; DNA Adducts/metabolism ; DNA Damage ; HEK293 Cells ; Humans ; Methyl Methanesulfonate/pharmacology ; Mutation/genetics ; Oxidation-Reduction ; Peptides/metabolism ; Polyribosomes/metabolism ; Protein Aggregates ; Quinolones/metabolism ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomal Proteins/metabolism ; Ribosomes/drug effects ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Investigation of comet assays under conditions mimicking ocular instillation administration in a three-dimensional reconstructed human corneal epithelial model.
Autorzy :
Tahara H; Research and Development Division, Senju Pharmaceutical Co., Ltd , Kobe , Hyogo , Japan.
Sadamoto K; Research and Development Division, Senju Pharmaceutical Co., Ltd , Kobe , Hyogo , Japan.
Yamagiwa Y; Research and Development Division, Senju Pharmaceutical Co., Ltd , Kobe , Hyogo , Japan.
Nemoto S; Research and Development Division, Senju Pharmaceutical Co., Ltd , Kobe , Hyogo , Japan.
Kurata M; Research and Development Division, Senju Pharmaceutical Co., Ltd , Kobe , Hyogo , Japan.
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Źródło :
Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2019 Dec; Vol. 38 (4), pp. 375-383. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Comet Assay/*methods
Epithelium, Corneal/*drug effects
Ophthalmic Solutions/*toxicity
4-Nitroquinoline-1-oxide/toxicity ; Acridine Orange/toxicity ; Acrylamide/toxicity ; Administration, Ophthalmic ; Cell Line ; Cornea ; DNA Damage ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelium, Corneal/cytology ; Epithelium, Corneal/metabolism ; Ethidium/toxicity ; Humans ; Hydrogen Peroxide/toxicity ; In Vitro Techniques ; Methyl Methanesulfonate/toxicity ; Paraquat/toxicity ; Quinolones/toxicity
Czasopismo naukowe
Tytuł :
Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to 4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure.
Autorzy :
Viarisio D; Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Robitaille A; International Agency for Research on Cancer (IARC), World Health Organization, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France.
Müller-Decker K; Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Flechtenmacher C; Department of Pathology, University Hospital of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany.
Gissmann L; Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany; Department of Botany and Microbiology (honorary MMember), King Saud University, Riyadh, Saudi Arabia.
Tommasino M; International Agency for Research on Cancer (IARC), World Health Organization, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France. Electronic address: .
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Źródło :
Virology [Virology] 2019 Dec; Vol. 538, pp. 53-60. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Nitroquinoline-1-oxide/*toxicity
Betapapillomavirus/*metabolism
Neoplasms/*genetics
Oncogene Proteins, Viral/*metabolism
Papillomavirus E7 Proteins/*metabolism
Papillomavirus Infections/*virology
Tobacco/*adverse effects
Animals ; Betapapillomavirus/genetics ; Disease Susceptibility ; Female ; Humans ; Mice ; Mice, Transgenic ; Mutation/drug effects ; Neoplasms/etiology ; Oncogene Proteins, Viral/genetics ; Papillomavirus E7 Proteins/genetics ; Papillomavirus Infections/genetics
Czasopismo naukowe
Tytuł :
Role of Electron Microscopy in Early Detection of Altered Epithelium During Experimental Oral Carcinogenesis.
Autorzy :
Sawant S; Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, Maharashtra, India.
Dongre H; Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, Maharashtra, India.; Department of Clinical Medicine and Centre for Cancer Biomarkers, Haukeland University Hospital, University of Bergen, N-5021, Norway.
Kanojia D; Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, Maharashtra, India.; Department of Neurological Surgery, Northwestern University, 303 E. Superior St., Chicago, IL 60611, USA.
Jamghare S; Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, Maharashtra, India.
Borges A; Department of Histopathology, Asian Institute of Oncology, S. L. Raheja Hospital, Mahim, Mumbai-4000116, Maharashtra, India.
Vaidya M; Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, Maharashtra, India.
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Źródło :
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada [Microsc Microanal] 2019 Dec; Vol. 25 (6), pp. 1367-1375.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Carcinoma/*diagnosis
Epithelium/*pathology
Microscopy, Electron/*methods
Mouth Mucosa/*pathology
Mouth Neoplasms/*diagnosis
4-Nitroquinoline-1-oxide/administration & dosage ; Animals ; Carcinogens/administration & dosage ; Disease Models, Animal ; Early Diagnosis ; Rats
Czasopismo naukowe
Tytuł :
Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model.
Autorzy :
Cabrera Ortega AA; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Univ Estadual Paulista (UNESP), Araraquara, Brazil.
Gonçalves Vde P; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Univ Estadual Paulista (UNESP), Araraquara, Brazil.
Guimarães MR; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Univ Estadual Paulista (UNESP), Araraquara, Brazil.; Department of Stomatology, School of Dentistry, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Rossa Junior C; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Univ Estadual Paulista (UNESP), Araraquara, Brazil.
Spolidorio LC; Department of Physiology and Pathology, School of Dentistry at Araraquara, Univ Estadual Paulista (UNESP), Araraquara, Brazil.
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Źródło :
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2016 Sep; Vol. 45 (8), pp. 573-80. Date of Electronic Publication: 2016 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
4-Nitroquinoline-1-oxide*
Carcinogens*
Biomarkers, Tumor/*biosynthesis
Mouth Neoplasms/*chemically induced
Mouth Neoplasms/*metabolism
Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cadherins/biosynthesis ; Cadherins/genetics ; Disease Models, Animal ; Epithelial-Mesenchymal Transition ; Male ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/genetics ; Proliferating Cell Nuclear Antigen/biosynthesis ; Proliferating Cell Nuclear Antigen/genetics ; Proto-Oncogene Proteins c-bcl-2/biosynthesis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Rats ; Suppressor of Cytokine Signaling 1 Protein/biosynthesis ; Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/biosynthesis ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Twist-Related Protein 1/biosynthesis ; Twist-Related Protein 1/genetics ; Vimentin/biosynthesis ; Vimentin/genetics
Czasopismo naukowe

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