Temat: "5-HT3 receptor" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Effects of adding a neurokinin-1 receptor antagonist to 5 mg olanzapine, a 5-hydroxytryptamine-3 receptor antagonist, and dexamethasone for preventing carboplatin-induced nausea and vomiting: a propensity score-matched analysis.
Autorzy:: Yamamoto S; Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Iihara H; Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan. .; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, 1-25-4 Daigakunishi, Gifu, 501-1196, Japan. .
Uozumi R; Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Kawazoe H; Division of Pharmaceutical Care Sciences, Center for Social Pharmacy and Pharmaceutical Care Sciences, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.; Division of Pharmaceutical Care Sciences, Keio University Graduate School of Pharmaceutical Sciences, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Tanaka K; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Fujita Y; Division of Pharmacy, Gunma Prefectural Cancer Center, 617-1 Takahayashi-nishi, Ohta, Gunma, 373-8550, Japan.
Abe M; Division of Gynecology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.; Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Imai H; Division of Respiratory Medicine, Gunma Prefectural Cancer Center, 617-1, Takahayashi-nishi, Ohta, Gunma, 373-8550, Japan.; Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.
Karayama M; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.; Department of Clinical Oncology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Hayasaki Y; Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Hirose C; Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Suda T; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Nakamura K; Department of Gynecology, Gunma Prefectural Cancer Center, 617-1 Takahayashi-nishi, Ohta, Gunma, 373-8550, Japan.
Suzuki A; Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, 1-25-4 Daigakunishi, Gifu, 501-1196, Japan.
Ohno Y; Department of Cardiology and Respiratory Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Morishige KI; Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Inui N; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. .; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2022 Mar 23; Vol. 22 (1), pp. 310. Date of Electronic Publication: 2022 Mar 23.
Typ publikacji:: Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms:: Carboplatin*/adverse effects
Nausea*/chemically induced
Nausea*/drug therapy
Nausea*/prevention & control
Neurokinin-1 Receptor Antagonists*/therapeutic use
Serotonin 5-HT3 Receptor Antagonists*/therapeutic use
Vomiting*/chemically induced
Vomiting*/drug therapy
Vomiting*/prevention & control
Dexamethasone/therapeutic use ; Humans ; Olanzapine/therapeutic use ; Propensity Score ; Prospective Studies

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Skocz do pozycji: 2.

Tytuł:: Hydroxy Pentacyclic Triterpene Acid, Kaempferol, Inhibits the Human 5-Hydroxytryptamine Type 3A Receptor Activity.
Autorzy:: Lee S; Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Seol HS; College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 61886, Korea.
Eom S; Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Lee J; Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Kim C; Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Park JH; College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 61886, Korea.
Kim TH; Department of Animal Science, Chonnam National University, Gwangju 61886, Korea.
Lee JH; Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 04; Vol. 23 (1). Date of Electronic Publication: 2022 Jan 04.
Typ publikacji:: Journal Article
MeSH Terms:: Kaempferols/*pharmacology
Pentacyclic Triterpenes/*pharmacology
Receptors, Serotonin, 5-HT3/*metabolism
Serotonin 5-HT3 Receptor Antagonists/*pharmacology
Binding Sites ; Dose-Response Relationship, Drug ; Humans ; Kaempferols/chemistry ; Kinetics ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation ; Pentacyclic Triterpenes/chemistry ; Protein Binding ; Receptors, Serotonin, 5-HT3/chemistry ; Receptors, Serotonin, 5-HT3/genetics ; Serotonin 5-HT3 Receptor Antagonists/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 3.

Tytuł:: Effects of 5-HT ₃ receptor antagonists on cisplatin-induced kidney injury.
Autorzy:: Goda M; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.; Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.
Kanda M; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Yoshioka T; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Yoshida A; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Murai Y; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Zamami Y; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Aizawa F; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Niimura T; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Hamano H; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Okada N; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
Yagi K; Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.
Chuma M; Department of Pharmacy, Asahikawa Medical University Hospital, Hokkaido, Japan.
Izawa-Ishizawa Y; Department of Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Ishizawa K; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2021 Sep; Vol. 14 (5), pp. 1906-1916. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acute Kidney Injury/*pathology
Cisplatin/*adverse effects
Nausea/*drug therapy
Serotonin 5-HT3 Receptor Antagonists/*administration & dosage
Vomiting/*drug therapy
Acute Kidney Injury/chemically induced ; Aged ; Animals ; Benzimidazoles/administration & dosage ; Benzimidazoles/adverse effects ; Cisplatin/administration & dosage ; Disease Models, Animal ; Female ; Granisetron/administration & dosage ; Granisetron/adverse effects ; Humans ; Kidney/drug effects ; Kidney/pathology ; Kidney/physiopathology ; Male ; Mice ; Middle Aged ; Nausea/chemically induced ; Ondansetron/administration & dosage ; Ondansetron/adverse effects ; Organic Cation Transport Proteins/metabolism ; Palonosetron/administration & dosage ; Palonosetron/adverse effects ; Renal Elimination/physiology ; Retrospective Studies ; Serotonin 5-HT3 Receptor Antagonists/adverse effects ; Vomiting/chemically induced

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Skocz do pozycji: 4.

Tytuł:: Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Autorzy:: Yang N; Department of Physiology, Capital Medical University, Beijing, China.
Liu SM
Zheng LF
Ji T
Li Y
Mi XL
Xue H
Ren W
Xu JD
Zhang XH
Li LS
Zhang Y
Zhu JX; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2010 Apr; Vol. 159 (8), pp. 1623-5. Date of Electronic Publication: 2010 Mar 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Serotonin 5-HT3 Receptor Agonists*
Colon/*drug effects
Intestinal Mucosa/*drug effects
Somatostatin/*physiology
Amino Acid Sequence ; Animals ; Colon/metabolism ; Cyclic AMP/metabolism ; Fluorescent Antibody Technique ; Intestinal Mucosa/metabolism ; Ions ; Male ; Molecular Sequence Data ; Oligopeptides/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Serotonin, 5-HT3/chemistry ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists/pharmacology ; Tetrodotoxin/pharmacology

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Skocz do pozycji: 5.

Tytuł:: Treatment of irritable bowel syndrome with diarrhoea using titrated ondansetron (TRITON): study protocol for a randomised controlled trial.
Autorzy:: Gunn D; NIHR Nottingham Digestive Diseases Biomedical Research Centre, University of Nottingham, Nottingham, UK.; Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Fried R; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lalani R; Wingate Institute of Neurogastroenterology, Queen Mary University of London, London, UK.
Farrin A; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Holloway I; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Morris T; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Olivier C; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Kearns R; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Corsetti M; Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Scott M; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Farmer A; Royal Stoke Hospital, University Hospitals of North Midlands NHS Trust, Stoke, UK.
Emmanuel A; University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Whorwell P; Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Yiannakou Y; County Durham and Darlington Foundation Trust, University Hospital of North Durham, Durham, UK.
Sanders D; Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Mclaughlin J; Salford Royal NHS Foundation Trust, Salford Royal University Hospital, Manchester, UK.
Kapur K; Barnsley Hospital, Barnsley Hospital NHS Foundation Trust, Barnsley, UK.
Eugenicos M; Western General Hospital Edinburgh, NHS Lothian, Edinburgh, UK.
Akbar A; London North West Healthcare NHS Trust, St Mark's Hospital, London, UK.
Trudgill N; Sandwell General Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Houghton L; St James's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Dinning PG; Discipline of Surgery and Gastroenterology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia.
Ford AC; St James's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Aziz Q; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Spiller R; NIHR Nottingham Digestive Diseases Biomedical Research Centre, University of Nottingham, Nottingham, UK. .; Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. .; Pokaż więcej
Źródło:: Trials [Trials] 2019 Aug 20; Vol. 20 (1), pp. 517. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Antidiarrheals/*therapeutic use
Diarrhea/*drug therapy
Irritable Bowel Syndrome/*drug therapy
Ondansetron/*therapeutic use
Serotonin 5-HT3 Receptor Antagonists/*therapeutic use
Antidiarrheals/adverse effects ; Clinical Trials, Phase III as Topic ; Diarrhea/diagnosis ; Diarrhea/etiology ; Diarrhea/physiopathology ; Double-Blind Method ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/physiopathology ; Multicenter Studies as Topic ; Ondansetron/adverse effects ; Randomized Controlled Trials as Topic ; Serotonin 5-HT3 Receptor Antagonists/adverse effects ; Time Factors ; Treatment Outcome ; United Kingdom

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Skocz do pozycji: 6.

Tytuł:: Enhanced alcohol-seeking behavior by nicotine in the posterior ventral tegmental area of female alcohol-preferring (P) rats: modulation by serotonin-3 and nicotinic cholinergic receptors.
Autorzy:: Hauser SR; Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN, 46202-4887, USA, .
Deehan GA Jr
Toalston JE
Bell RL
McBride WJ
Rodd ZA; Pokaż więcej
Źródło:: Psychopharmacology [Psychopharmacology (Berl)] 2014 Sep; Vol. 231 (18), pp. 3745-55. Date of Electronic Publication: 2014 Mar 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Drug-Seeking Behavior/*drug effects
Ethanol/*administration & dosage
Nicotine/*pharmacology
Nicotinic Antagonists/*pharmacology
Serotonin 5-HT3 Receptor Antagonists/*pharmacology
Ventral Tegmental Area/*drug effects
Animals ; Benzamides/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Female ; Mecamylamine/pharmacology ; Rats ; Self Administration ; Serotonin/pharmacology ; Serotonin 5-HT3 Receptor Agonists/pharmacology

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Skocz do pozycji: 7.

Tytuł:: Natural Negative Allosteric Modulators of 5-HT₃ Receptors.
Autorzy:: Al Kury LT; Department of Health Sciences, College of Natural and Health Sciences, Zayed University, 144534 Abu Dhabi, United Arab Emirates. .
Mahgoub M; Departments of Pharmacology, College of Medicine and Health Sciences, UAE University, 15551 Al Ain, United Arab Emirates. mahjoub_.
Howarth FC; Departments of Physiology, College of Medicine and Health Sciences, UAE University, 15551 Al Ain, United Arab Emirates. .
Oz M; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, 13060 Kuwait. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Dec 03; Vol. 23 (12). Date of Electronic Publication: 2018 Dec 03.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Nausea/*metabolism
Receptors, Serotonin, 5-HT3/*metabolism
Serotonin 5-HT3 Receptor Antagonists/*pharmacology
Vomiting/*metabolism
Allosteric Regulation ; Antineoplastic Agents/adverse effects ; Binding Sites ; Cannabidiol/pharmacology ; Zingiber officinale/chemistry ; Humans ; Nausea/chemically induced ; Serotonin 5-HT3 Receptor Antagonists/chemistry ; Terpenes/pharmacology ; Vomiting/chemically induced

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Skocz do pozycji: 8.

Tytuł:: In vivo electrophysiological study of the targeting of 5-HT 3 receptor-expressing cortical interneurons by the multimodal antidepressant, vortioxetine.
Autorzy:: Schweimer JV; Department of Pharmacology, University of Oxford, Oxford, UK.; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.
Brouard JT; Department of Pharmacology, University of Oxford, Oxford, UK.
Li Y; Lundbeck A/S, Valby, Denmark.; Discovery, Apellis Pharmaceuticals, Inc, Waltham, Massachusetts, USA.
Sánchez C; Lundbeck A/S, Valby, Denmark.; Translational Medicine, Alkermes, Inc, Waltham, Massachusetts, USA.; Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
Sharp T; Department of Pharmacology, University of Oxford, Oxford, UK.; Pokaż więcej
Źródło:: The European journal of neuroscience [Eur J Neurosci] 2022 Mar; Vol. 55 (6), pp. 1409-1423. Date of Electronic Publication: 2022 Mar 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ondansetron*
Serotonin*/metabolism
Animals ; Antidepressive Agents/pharmacology ; Interneurons/metabolism ; Piperazines/pharmacology ; Rats ; Serotonin 5-HT3 Receptor Antagonists/pharmacology ; Sulfides/pharmacology ; Vortioxetine/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Tapping into 5-HT 3 Receptors to Modify Metabolic and Immune Responses.
Autorzy:: Irving H; Department of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3550, Australia.
Turek I; Department of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3550, Australia.
Kettle C; Department of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3550, Australia.
Yaakob N; Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 02; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 02.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Immunity/*immunology
Inflammation/*drug therapy
Metabolic Diseases/*drug therapy
Receptors, Serotonin, 5-HT3/*chemistry
Serotonin 5-HT3 Receptor Antagonists/*pharmacology
Animals ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology

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Skocz do pozycji: 10.

Tytuł:: 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells.
Autorzy:: Yasuda M; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Kato S
Yamanaka N
Iimori M
Matsumoto K
Utsumi D
Kitahara Y
Amagase K
Horie S
Takeuchi K; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2013 Mar; Vol. 168 (6), pp. 1388-400.
Typ publikacji:: Journal Article
MeSH Terms:: Antimetabolites, Antineoplastic/*adverse effects
Apoptosis/*drug effects
Fluorouracil/*adverse effects
Immunosuppressive Agents/*adverse effects
Intestinal Mucosa/*drug effects
Mucositis/*prevention & control
Serotonin 5-HT3 Receptor Antagonists/*therapeutic use
Animals ; Antimetabolites, Antineoplastic/therapeutic use ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Benzimidazoles/administration & dosage ; Benzimidazoles/adverse effects ; Benzimidazoles/therapeutic use ; Colonic Neoplasms/drug therapy ; Cytokines/genetics ; Cytokines/metabolism ; Diarrhea/etiology ; Diarrhea/prevention & control ; Dose-Response Relationship, Drug ; Drug Interactions ; Fluorouracil/antagonists & inhibitors ; Fluorouracil/therapeutic use ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/therapeutic use ; Gene Expression Regulation/drug effects ; Immunosuppressive Agents/antagonists & inhibitors ; Immunosuppressive Agents/therapeutic use ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mucositis/chemically induced ; Mucositis/metabolism ; Mucositis/pathology ; Ondansetron/adverse effects ; Ondansetron/therapeutic use ; Serotonin 5-HT3 Receptor Agonists/adverse effects ; Serotonin 5-HT3 Receptor Agonists/therapeutic use ; Serotonin 5-HT3 Receptor Antagonists/administration & dosage ; Serotonin 5-HT3 Receptor Antagonists/adverse effects

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Skocz do pozycji: 11.

Tytuł:: Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials.
Autorzy:: Qi Q; Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
Zhang Y; Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
Chen F; Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
Zuo X; Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
Li Y; Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China. .; Pokaż więcej
Źródło:: BMC gastroenterology [BMC Gastroenterol] 2018 Jan 08; Vol. 18 (1), pp. 5. Date of Electronic Publication: 2018 Jan 08.
Typ publikacji:: Journal Article; Meta-Analysis; Review; Systematic Review
MeSH Terms:: Benzimidazoles/*therapeutic use
Diarrhea/*drug therapy
Irritable Bowel Syndrome/*drug therapy
Serotonin 5-HT3 Receptor Antagonists/*therapeutic use
Abdominal Pain/drug therapy ; Benzimidazoles/adverse effects ; Constipation/chemically induced ; Diarrhea/etiology ; Humans ; Irritable Bowel Syndrome/complications ; Serotonin 5-HT3 Receptor Antagonists/adverse effects

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Skocz do pozycji: 12.

Tytuł:: Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects.
Autorzy:: Sarapultsev A; Institute of Immunology and Physiology of the Ural Branch of RAS, Pervomayskaya 106, 620049 Ekaterinburg, Russia.; School of Medical Biology, South Ural State University, Lenina 76, 454080 Chelyabinsk, Russia.
Vassiliev P; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Square 1, 400131 Volgograd, Russia.
Grinchii D; Center of Biosciences, Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dúbravská Cesta 9, 840 05 Bratislava, Slovakia.
Kiss A; Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.
Mach M; Center of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 840 04 Bratislava, Slovakia.
Osacka J; Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.
Balloova A; Center of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 840 04 Bratislava, Slovakia.
Paliokha R; Center of Biosciences, Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dúbravská Cesta 9, 840 05 Bratislava, Slovakia.
Kochetkov A; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Square 1, 400131 Volgograd, Russia.
Sidorova L; Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 Mira Street, 620002 Ekaterinburg, Russia.
Sarapultsev P; Institute of Immunology and Physiology of the Ural Branch of RAS, Pervomayskaya 106, 620049 Ekaterinburg, Russia.
Chupakhin O; Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 Mira Street, 620002 Ekaterinburg, Russia.; The IJ Postovsky Institute of Organic Synthesis of the Ural Branch of RAS, Akademicheskaya/S. Kovalevskoi, 22/20, 620990 Ekaterinburg, Russia.
Rantsev M; Ural State Medical University, Repina 3, 620014 Ekaterinburg, Russia.
Spasov A; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Square 1, 400131 Volgograd, Russia.
Dremencov E; Center of Biosciences, Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Dúbravská Cesta 9, 840 05 Bratislava, Slovakia.; Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:: Journal Article
MeSH Terms:: Antidepressive Agents/*pharmacology
Depression/*drug therapy
Hydrazines/*pharmacology
Myocardial Infarction/*complications
Stroke/*complications
Animals ; Antidepressive Agents/therapeutic use ; Computer Simulation ; Depression/etiology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hydrazines/therapeutic use ; Male ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A/drug effects ; Receptors, Serotonin, 5-HT3/drug effects ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Plasma Membrane Transport Proteins/drug effects ; Selective Serotonin Reuptake Inhibitors/pharmacology

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Skocz do pozycji: 13.

Tytuł:: Ameliorative effects of tropisetron on liver injury in streptozotocin-induced diabetic rats.
Autorzy:: Gholizadeh-Ghaleh Aziz S; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Naderi R; Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran.; Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Mahmodian N; Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.; Pokaż więcej
Źródło:: Archives of physiology and biochemistry [Arch Physiol Biochem] 2021 Aug; Vol. 127 (4), pp. 367-372. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Complications/*prevention & control
Diabetes Mellitus, Experimental/*complications
Liver Diseases/*prevention & control
Oxidative Stress/*drug effects
Tropisetron/*pharmacology
Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/metabolism ; Blood Glucose/analysis ; Diabetes Complications/etiology ; Diabetes Complications/pathology ; Liver Diseases/etiology ; Liver Diseases/pathology ; Male ; Rats ; Rats, Wistar ; Serotonin 5-HT3 Receptor Antagonists/pharmacology

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Skocz do pozycji: 14.

Tytuł:: In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs.
Autorzy:: George B; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Wen X; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Jaimes EA; Renal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Joy MS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.; Cancer Center, University of Colorado, Aurora, CO 80045, USA.; Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Aleksunes LM; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.; Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08854, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 16; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:: Journal Article
MeSH Terms:: Antiemetics/*pharmacology
Kidney/*drug effects
Kidney/*metabolism
Organic Cation Transport Proteins/*biosynthesis
Organic Cation Transporter 2/*biosynthesis
Animals ; Antiemetics/chemistry ; Biological Transport/drug effects ; Cell Line ; Cells, Cultured ; Dogs ; Gene Expression ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Molecular Structure ; Organic Cation Transport Proteins/genetics ; Organic Cation Transport Proteins/metabolism ; Organic Cation Transporter 2/genetics ; Serotonin 5-HT3 Receptor Antagonists/pharmacology

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Skocz do pozycji: 15.

Tytuł:: Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis.
Autorzy:: Tricco AC; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, 6th Floor, 155 College Street, Toronto, Ontario, M5T 3M7, Canada.
Blondal E; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.; Institute for Health Policy Management & Evaluation, University of Toronto, 4th Floor, 155 College Street, Toronto, Ontario, M5T 3M6, Canada.
Veroniki AA; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Soobiah C; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.; Institute for Health Policy Management & Evaluation, University of Toronto, 4th Floor, 155 College Street, Toronto, Ontario, M5T 3M6, Canada.
Vafaei A; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Ivory J; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Strifler L; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Cardoso R; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Reynen E; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Nincic V; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Ashoor H; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Ho J; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Ng C; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Johnson C; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Lillie E; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Antony J; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Roberts DJ; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada.
Hemmelgarn BR; Departments of Medicine and Community Health Sciences, University of Calgary, TRW Building, 3rd Floor, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
Straus SE; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario, M5B 1W8, Canada. .; Department of Geriatric Medicine, University of Toronto, 27 King's College Circle, Toronto, Ontario, M5S 1A1, Canada. .; Pokaż więcej
Źródło:: BMC medicine [BMC Med] 2016 Dec 23; Vol. 14 (1), pp. 216. Date of Electronic Publication: 2016 Dec 23.
Typ publikacji:: Comparative Study; Journal Article; Meta-Analysis; Review; Systematic Review
MeSH Terms:: Antiemetics/*therapeutic use
Antineoplastic Agents/*adverse effects
Serotonin 5-HT3 Receptor Antagonists/*therapeutic use
Adult ; Antiemetics/adverse effects ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Humans ; Nausea/prevention & control ; Network Meta-Analysis ; Serotonin 5-HT3 Receptor Antagonists/adverse effects ; Vomiting/prevention & control

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Skocz do pozycji: 16.

Tytuł:: Antidepressant & anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide: A novel serotonin type 3 receptor antagonist in behavioural animal models.
Autorzy:: Pandey DK; Pharmacology Department, Novel Drug Discovery and Development (NDDD), Lupin Research Park, Pune, India.
Devadoss T; Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.
Modak N; Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India.
Mahesh R; Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India.; Pokaż więcej
Źródło:: The Indian journal of medical research [Indian J Med Res] 2016 Oct; Vol. 144 (4), pp. 614-621.
Typ publikacji:: Journal Article
MeSH Terms:: Antidepressive Agents/*administration & dosage
Quinoxalines/*administration & dosage
Serotonin/*metabolism
Serotonin 5-HT3 Receptor Antagonists/*administration & dosage
Animals ; Anxiety/drug therapy ; Depression/drug therapy ; Depressive Disorder/drug therapy ; Disease Models, Animal ; Feeding and Eating Disorders/drug therapy ; Male ; Mice ; Motor Activity/drug effects ; Obsessive-Compulsive Disorder/drug therapy ; Quinoxalines/chemistry ; Rats ; Rats, Wistar ; Receptors, Serotonin/metabolism ; Schizophrenia/drug therapy ; Serotonin 5-HT3 Receptor Antagonists/chemistry

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Skocz do pozycji: 17.

Tytuł:: 2023 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting
Autorzy:: Rapoport, Bernardo LeonAff1, Aff2, IDs00520023082241_cor1
Herrstedt, JørnAff3, Aff4
Snow, Rebecca Clark
Radhakrishnan, Venkatraman
Saito, Mitsue
Navari, Rudolph M.
Smit, Teresa; Pokaż więcej
Źródło:: Supportive Care in Cancer. 32(1)

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Skocz do pozycji: 18.

Tytuł:: Design, synthesis, and pharmacological evaluation of novel 2-(4-substituted piperazin-1-yl)1, 8 naphthyridine 3-carboxylic acids as 5-HT3 receptor antagonists for the management of depression.
Autorzy:: Dhar AK; Department of Pharmacy, FD-III, Birla Institute of Technology & Science, Pilani, Rajasthan, 333 031, India.
Mahesh R
Jindal A
Devadoss T
Bhatt S; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2014 Dec; Vol. 84 (6), pp. 721-31. Date of Electronic Publication: 2014 Jun 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Design*
Antidepressive Agents/*chemical synthesis
Carboxylic Acids/*chemistry
Receptors, Serotonin, 5-HT3/*chemistry
Serotonin 5-HT3 Receptor Antagonists/*chemical synthesis
Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Carboxylic Acids/pharmacology ; Carboxylic Acids/therapeutic use ; Depression/drug therapy ; Guinea Pigs ; Mice ; Motor Activity/drug effects ; Naphthyridines/chemistry ; Receptors, Serotonin, 5-HT3/metabolism ; Serotonin 5-HT3 Receptor Antagonists/pharmacology ; Serotonin 5-HT3 Receptor Antagonists/therapeutic use ; Structure-Activity Relationship

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Skocz do pozycji: 19.

Tytuł:: Design, synthesis and evaluation of antidepressant activity of novel 2-methoxy 1, 8 naphthyridine 3-carboxamides as 5-HT3 receptor antagonists.
Autorzy:: Mahesh R; Department of Pharmacy, FD-III, Birla Institute of Technology & Science, Pilani, Rajasthan, 333 031, India.
Dhar AK
Jindal A
Bhatt S; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2014 May; Vol. 83 (5), pp. 583-91. Date of Electronic Publication: 2014 Mar 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Design*
Amides/*chemistry
Antidepressive Agents/*chemical synthesis
Naphthyridines/*chemistry
Receptors, Serotonin, 5-HT3/*chemistry
Serotonin 5-HT3 Receptor Antagonists/*chemical synthesis
Amides/chemical synthesis ; Amides/pharmacology ; Animals ; Antidepressive Agents/chemistry ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Guinea Pigs ; Mice ; Motor Activity/drug effects ; Myenteric Plexus/drug effects ; Receptors, Serotonin, 5-HT3/metabolism ; Serotonin 5-HT3 Receptor Antagonists/chemistry ; Serotonin 5-HT3 Receptor Antagonists/pharmacology

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Skocz do pozycji: 20.

Tytuł:: Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT 3A R and 5-HT 3B R Expression in the Rat Brain.
Autorzy:: Li F; Fengtai Maternal and Children's Health Hospital of Beijing, Beijing 100069, China.
Feng J; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Gao D; Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Wang J; Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Song C; Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Wei S; Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Qiao M; Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.; Pokaż więcej
Źródło:: Neural plasticity [Neural Plast] 2016; Vol. 2016, pp. 7950781. Date of Electronic Publication: 2016 Sep 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*metabolism
Depression/*metabolism
Drugs, Chinese Herbal/*therapeutic use
Premenstrual Syndrome/*metabolism
Receptors, Serotonin, 5-HT3/*biosynthesis
Serotonin 5-HT3 Receptor Antagonists/*therapeutic use
Animals ; Brain/drug effects ; Capsules ; Cells, Cultured ; Depression/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Female ; Gene Expression ; Premenstrual Syndrome/drug therapy ; Random Allocation ; Rats ; Rats, Wistar ; Receptors, Serotonin, 5-HT3/genetics ; Serotonin 5-HT3 Receptor Antagonists/pharmacology

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