Temat: "5-Lipoxygenase-Activating Proteins" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: ALOX5AP suppresses osteosarcoma progression via Wnt/β-catenin/EMT pathway and associates with clinical prognosis and immune infiltration.
Autorzy:: Han GD; Department of Orthopedics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Dai J; Department of Orthopedics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Hui HX; Department of Medical Oncology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Zhu J; Department of Medical Oncology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China. .; Pokaż więcej
Źródło:: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 Jun 22; Vol. 18 (1), pp. 446. Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Bone Neoplasms*/pathology
Osteosarcoma*/pathology
Adolescent ; Child ; Humans ; beta Catenin/genetics ; beta Catenin/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Prognosis ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Tumor Microenvironment/genetics ; 5-Lipoxygenase-Activating Proteins/genetics ; 5-Lipoxygenase-Activating Proteins/metabolism

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Skocz do pozycji: 2.

Tytuł:: Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
Autorzy:: Kumar RB; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Purhonen P; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Hebert H; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.
Jegerschöld C; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.; Division of Structural Biotechnology, Department of Biomedical Engineering and Health Systems, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Stockholm, Sweden.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jul 09; Vol. 15 (7), pp. e0228607. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*metabolism
Arachidonate 5-Lipoxygenase/*metabolism
Arachidonic Acid/*metabolism
Calcium/*metabolism
5-Lipoxygenase-Activating Proteins/chemistry ; Arachidonic Acid/chemistry ; Centrifugation, Density Gradient ; Electrophoresis, Polyacrylamide Gel ; Humans ; Mass Spectrometry ; Microscopy, Electron, Transmission ; Models, Molecular ; Nanostructures/ultrastructure ; Protein Binding ; Protein Conformation ; Sucrose

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Tytuł:: Synthesis and structure-activity relationships for some novel diflapolin derivatives with benzimidazole subunit.
Autorzy:: Vieider L; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Zoeller E; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Romp E; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Jena, Germany.
Schoenthaler M; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Hernández-Olmos V; Branch for Translation Medicine and Pharmacology TMP, Frauenhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.
Temml V; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria.
Hasenoehrl T; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
Schuster D; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Jena, Germany.
Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany.
Matuszczak B; Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1752-1764.
Typ publikacji:: Journal Article
MeSH Terms:: Benzimidazoles*/pharmacology
Epoxide Hydrolases*
5-Lipoxygenase-Activating Proteins/metabolism ; Enzyme Inhibitors/pharmacology ; Lipoxygenase Inhibitors/pharmacology ; Structure-Activity Relationship

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Skocz do pozycji: 4.

Tytuł:: The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses.
Autorzy:: Schmider AB; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
Vaught M; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
Bauer NC; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
Elliott HL; Image and Data Analysis Core, Department of Cell Biology, Harvard Medical School, Boston, MA, United States of America.
Godin MD; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
Ellis GE; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
Nigrovic PA; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.
Soberman RJ; Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Feb 08; Vol. 14 (2), pp. e0211943. Date of Electronic Publication: 2019 Feb 08 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*metabolism
Arachidonate 5-Lipoxygenase/*metabolism
Basophils/*metabolism
Leukotriene C4/*biosynthesis
Nuclear Envelope/*metabolism
5-Lipoxygenase-Activating Proteins/chemistry ; 5-Lipoxygenase-Activating Proteins/genetics ; Animals ; Arachidonate 5-Lipoxygenase/chemistry ; Arachidonate 5-Lipoxygenase/genetics ; Basophils/cytology ; Basophils/drug effects ; Cell Line, Tumor ; Cluster Analysis ; Gene Expression Regulation ; Immunoglobulin E/genetics ; Immunoglobulin E/metabolism ; Immunoglobulin E/pharmacology ; Nuclear Envelope/drug effects ; Nuclear Envelope/genetics ; Nuclear Envelope/ultrastructure ; Protein Binding ; Rats ; Receptors, IgE/genetics ; Receptors, IgE/metabolism ; Signal Transduction ; Single Molecule Imaging

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Skocz do pozycji: 5.

Tytuł:: Genetic Variants in the Transcriptional Regulatory Region of the ALOX5AP gene and Susceptibility to Ischemic Stroke in Chinese Populations.
Autorzy:: Yang D; School of life sciences of Zhengzhou University, Zhengzhou, 450052, China.
Huang X; School of life sciences of Zhengzhou University, Zhengzhou, 450052, China.
Cui C; Department of Neurology, The First People's Hospital of Zhengzhou, Zhengzhou, 450000, China.
Zhang Y; Department of Medical Genetics &Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.
Li Y; Department of Medical Genetics &Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.
Zang X; School of life sciences of Zhengzhou University, Zhengzhou, 450052, China.
He Y; Department of Medical Genetics &Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.
Zheng H; Department of Medical Genetics &Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Jul 15; Vol. 6, pp. 29513. Date of Electronic Publication: 2016 Jul 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription, Genetic*
5-Lipoxygenase-Activating Proteins/*genetics
Ischemia/*genetics
Stroke/*genetics
5-Lipoxygenase-Activating Proteins/metabolism ; Aged ; Alleles ; Case-Control Studies ; China ; Female ; Gene Frequency ; Gene Regulatory Networks ; Haplotypes ; Humans ; Ischemia/ethnology ; Linkage Disequilibrium ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Risk Factors ; Stroke/ethnology

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Skocz do pozycji: 6.

Tytuł:: Fingerprint-based computational models of 5-lipo-oxygenase activating protein inhibitors: Activity prediction and structure clustering.
Autorzy:: Tu G; State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
Qin Z; State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
Huo D; State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
Zhang S; State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.
Yan A; State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, Beijing University of Chemical Technology, Beijing, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2020 Sep; Vol. 96 (3), pp. 931-947.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computer Simulation*
5-Lipoxygenase-Activating Proteins/*drug effects
Algorithms ; Cluster Analysis ; Datasets as Topic ; Machine Learning ; Molecular Structure ; Support Vector Machine

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Skocz do pozycji: 7.

Tytuł:: Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice.
Autorzy:: Michael J; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Unger MS; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Poupardin R; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.; Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria.
Schernthaner P; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Mrowetz H; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Attems J; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria. .; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria. .; Austrian Cluster for Tissue Regeneration, Vienna, Austria. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Aug 08; Vol. 8 (1), pp. 129. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*metabolism
Brain/*metabolism
Leukotrienes/*biosynthesis
Microglia/*metabolism
5-Lipoxygenase-Activating Proteins/biosynthesis ; Animals ; Arachidonate 5-Lipoxygenase/biosynthesis ; Female ; Humans ; Male ; Mice ; Neurons/metabolism

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Skocz do pozycji: 8.

Tytuł:: Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis.
Autorzy:: Li M; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Jin X; Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wu G; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang S; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yang C; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .
Deng S; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2020 Jan 28; Vol. 20 (1), pp. 65. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji:: Journal Article
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*genetics
Antigens, Differentiation, B-Lymphocyte/*genetics
Bone Neoplasms/*mortality
Gene Expression Profiling/*methods
Histocompatibility Antigens Class II/*genetics
Osteosarcoma/*mortality
Receptors, IgG/*genetics
Bone Neoplasms/genetics ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Neoplasm Metastasis ; Osteosarcoma/genetics ; Prognosis ; Survival Analysis ; Tumor Microenvironment

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Skocz do pozycji: 9.

Tytuł:: Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract.
Autorzy:: Schütz B; Institute of Anatomy and Cell Biology, Philipps-University, Marburg, Germany.
Ruppert AL; Institute of Anatomy and Cell Biology, Philipps-University, Marburg, Germany.
Strobel O; Department of General Surgery, University of Heidelberg, Heidelberg, Germany.; European Pancreas Center, University of Heidelberg, Heidelberg, Germany.
Lazarus M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Urade Y; Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.; Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Büchler MW; Department of General Surgery, University of Heidelberg, Heidelberg, Germany.; European Pancreas Center, University of Heidelberg, Heidelberg, Germany.
Weihe E; Institute of Anatomy and Cell Biology, Philipps-University, Marburg, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Nov 25; Vol. 9 (1), pp. 17466. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Biliary Tract/*cytology
Intestines/*cytology
Pancreas/*cytology
5-Lipoxygenase-Activating Proteins/metabolism ; Adolescent ; Adult ; Aged ; Biliary Tract/metabolism ; Child ; Cyclooxygenase 1/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Female ; Humans ; Intestinal Mucosa/metabolism ; Intramolecular Oxidoreductases/metabolism ; Keratin-18/metabolism ; Male ; Microfilament Proteins/metabolism ; Middle Aged ; Pancreas/metabolism ; Young Adult

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Skocz do pozycji: 10.

Tytuł:: Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.
Autorzy:: Shi Y; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Xu L; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Feng Q; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Li A; Department of Neurology, The First People's Hospital of Zhengzhou, Zhengzhou, 450004, China.
Jia J; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Xu Y; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Yang D; School of Life Sciences of Zhengzhou University, Zhengzhou, 450001, China.
Zhang Y; Department of Eugenic Genetics, The First People's Hospital of Zhengzhou, Zhengzhou, 450004, China.
Zhang X; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Zhao H; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Wang J; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
He Y; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. .
Zheng H; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. .; Pokaż więcej
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2018 Oct; Vol. 39 (10), pp. 1717-1724. Date of Electronic Publication: 2018 Jul 12.
Typ publikacji:: Journal Article
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*genetics
5-Lipoxygenase-Activating Proteins/*metabolism
Brain Ischemia/*genetics
Brain Ischemia/*metabolism
Stroke/*genetics
Stroke/*metabolism
Alleles ; CpG Islands ; DNA Methylation ; Epigenesis, Genetic ; Female ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Genetic Association Studies ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; RNA, Messenger/metabolism

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Skocz do pozycji: 11.

Tytuł:: Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.
Autorzy:: Chu J; Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street MRB, 706A, Philadelphia, PA 19140, USA.
Praticò D; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2012 Jun 14; Vol. 9, pp. 127. Date of Electronic Publication: 2012 Jun 14.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Disease Models, Animal*
Phenotype*
5-Lipoxygenase-Activating Proteins/*physiology
Alzheimer Disease/*enzymology
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*genetics
Amyloid beta-Protein Precursor/*genetics
5-Lipoxygenase-Activating Protein Inhibitors/pharmacology ; 5-Lipoxygenase-Activating Protein Inhibitors/therapeutic use ; 5-Lipoxygenase-Activating Proteins/metabolism ; Alzheimer Disease/etiology ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Peptides/biosynthesis ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Arachidonate 5-Lipoxygenase/metabolism ; Cells, Cultured ; Female ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Mice ; Mice, Transgenic ; Quinolines/pharmacology ; Quinolines/therapeutic use ; RNA, Messenger/antagonists & inhibitors ; Random Allocation

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Skocz do pozycji: 12.

Tytuł:: The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
Autorzy:: Tulah AS; Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
Parker SG
Moffatt MF
Wardlaw AJ
Connolly MJ
Sayers I; Pokaż więcej
Źródło:: BMC medical genetics [BMC Med Genet] 2011 Dec 29; Vol. 12, pp. 173. Date of Electronic Publication: 2011 Dec 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Polymorphism, Single Nucleotide*
5-Lipoxygenase-Activating Proteins/*genetics
Epoxide Hydrolases/*genetics
Lung/*physiopathology
Pulmonary Disease, Chronic Obstructive/*genetics
Receptors, Leukotriene B4/*genetics
White People/*genetics
5-Lipoxygenase-Activating Proteins/metabolism ; Adult ; Aged ; Cohort Studies ; Epoxide Hydrolases/metabolism ; Female ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Male ; Middle Aged ; Receptors, Leukotriene B4/metabolism ; Respiratory Function Tests ; Smoking/genetics ; United Kingdom

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Skocz do pozycji: 13.

Tytuł:: Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.
Autorzy:: Li Y; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, China.
Xu X; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, China.
Zhang D; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, China.
Cheng W; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Zhang Y; Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, 150001, China.
Yu B; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, China.
Zhang Y; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. yaozhang_.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, China. yaozhang_.; Pokaż więcej
Źródło:: Lipids in health and disease [Lipids Health Dis] 2019 Jan 24; Vol. 18 (1), pp. 25. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:: Journal Article
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*genetics
Arachidonate 5-Lipoxygenase/*genetics
Atherosclerosis/*genetics
Epoxide Hydrolases/*genetics
Myocardial Infarction/*genetics
Alcohol Drinking/genetics ; Alcohol Drinking/physiopathology ; Atherosclerosis/physiopathology ; China ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Haplotypes/genetics ; Humans ; Inflammation/genetics ; Inflammation/physiopathology ; Leukotriene B4/genetics ; Leukotriene B4/metabolism ; Male ; Metabolic Networks and Pathways/genetics ; Middle Aged ; Myocardial Infarction/physiopathology ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; White People

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Skocz do pozycji: 14.

Tytuł:: Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor.
Autorzy:: Ericsson H; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Nelander K; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Lagerstrom-Fermer M; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Balendran C; Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
Bhat M; Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
Chialda L; PAREXEL International, Northwick Park Hospital, Harrow, UK.
Gan LM; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Heijer M; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Kjaer M; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.
Lambert J; PAREXEL International, Northwick Park Hospital, Harrow, UK.
Lindstedt EL; Cardiovascular and Metabolic Diseases, AstraZeneca, Gothenburg, Sweden.
Forsberg GB; Cardiovascular and Metabolic Diseases, AstraZeneca, Gothenburg, Sweden.
Whatling C; Cardiovascular and Metabolic Diseases, AstraZeneca, Gothenburg, Sweden.
Skrtic S; Early Clinical Development, AstraZeneca, Gothenburg, Sweden.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2018 May; Vol. 11 (3), pp. 330-338. Date of Electronic Publication: 2018 Mar 08.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: 5-Lipoxygenase-Activating Protein Inhibitors/*pharmacology
5-Lipoxygenase-Activating Proteins/*metabolism
Coronary Artery Disease/*drug therapy
Pyrazoles/*pharmacology
5-Lipoxygenase-Activating Protein Inhibitors/therapeutic use ; Administration, Oral ; Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Healthy Volunteers ; Humans ; Inhibitory Concentration 50 ; Leukotriene B4/blood ; Leukotriene B4/metabolism ; Leukotriene E4/metabolism ; Leukotriene E4/urine ; Male ; Placebos ; Pyrazoles/therapeutic use ; Single-Blind Method

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Skocz do pozycji: 15.

Tytuł:: Down-regulation of NF-κB expression by n-3 fatty acid-rich linseed oil is modulated by PPARγ activation, eicosanoid cascade and secretion of cytokines by macrophages in rats fed partially hydrogenated vegetable fat.
Autorzy:: Rao YPC; Department of Lipid Science, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, 570 020, India.
Lokesh BR; Department of Lipid Science, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, 570 020, India. lokesh_.; Pokaż więcej
Źródło:: European journal of nutrition [Eur J Nutr] 2017 Apr; Vol. 56 (3), pp. 1135-1147. Date of Electronic Publication: 2016 Jan 30.
Typ publikacji:: Journal Article
MeSH Terms:: Eicosanoids/*pharmacology
Fatty Acids, Omega-3/*pharmacology
Linseed Oil/*pharmacology
Macrophages/*drug effects
NF-kappa B/*metabolism
PPAR gamma/*metabolism
5-Lipoxygenase-Activating Proteins/genetics ; 5-Lipoxygenase-Activating Proteins/metabolism ; Animals ; Cells, Cultured ; Cholesterol/blood ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Cytokines/blood ; Cytokines/metabolism ; Diet ; Down-Regulation ; Fatty Acids/analysis ; Macrophages/metabolism ; Male ; NF-kappa B/genetics ; PPAR gamma/genetics ; Rats ; Rats, Wistar ; Triglycerides/blood ; Up-Regulation

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Skocz do pozycji: 16.

Tytuł:: The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects.
Autorzy:: Chen Z; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China.
Zheng J; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China.
Liu W; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China.
Yang K; Department of Neurosurgery, Nanjing Brain Hospital Affiliated with Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Li K; Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
Huang B; Department of Neurosurgery, Sir Shaw Hospital, Nanjing Medical University, Nanjing, 211100, Jiangsu, China.
Zhu R; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Lu X; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Li L; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. .; Pokaż więcej
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2017 Apr; Vol. 38 (4), pp. 579-587. Date of Electronic Publication: 2017 Jan 18.
Typ publikacji:: Journal Article; Meta-Analysis
MeSH Terms:: Genetic Predisposition to Disease*
Polymorphism, Genetic*
5-Lipoxygenase-Activating Proteins/*genetics
Brain Ischemia/*genetics
Stroke/*genetics
White People/*genetics
Brain Ischemia/ethnology ; Europe ; Humans ; Stroke/ethnology

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Skocz do pozycji: 17.

Tytuł:: Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
Autorzy:: Temml V; Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
Garscha U; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Romp E; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Schubert G; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Gerstmeier J; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Kutil Z; Laboratory of Plant Biotechnologies, Institute of Experimental Botany AS CR, Rozvojova 263, Prague 6 - Lysolaje, Czech Republic.
Matuszczak B; Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
Waltenberger B; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
Stuppner H; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
Werz O; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Schuster D; Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Feb 20; Vol. 7, pp. 42751. Date of Electronic Publication: 2017 Feb 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 5-Lipoxygenase-Activating Proteins/*metabolism
Anti-Inflammatory Agents/*chemistry
Enzyme Inhibitors/*chemistry
Epoxide Hydrolases/*antagonists & inhibitors
5-Lipoxygenase-Activating Protein Inhibitors/chemistry ; 5-Lipoxygenase-Activating Protein Inhibitors/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Cell-Free System ; Computer Simulation ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/pharmacology ; Humans ; Leukotrienes/biosynthesis ; Models, Molecular ; Molecular Structure

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Skocz do pozycji: 18.

Tytuł:: Synthesis of [(3) H] and [(2) H6 ]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP).
Autorzy:: Lindelöf Å; Isotope Chemistry, Enabling Services, Drug Safety and Metabolism iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.
Ericsson C; Isotope Chemistry, Enabling Services, Drug Safety and Metabolism iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.
Simonsson R; Isotope Chemistry, Enabling Services, Drug Safety and Metabolism iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.
Nilsson G; Isotope Chemistry, Enabling Services, Drug Safety and Metabolism iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.
Grönberg G; Structure Analysis & Separation Science, Medicinal Chemistry, Respiratory, Inflammation, and Autoimmune iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.
Elmore CS; Isotope Chemistry, Enabling Services, Drug Safety and Metabolism iMED, AstraZeneca Pharmaceuticals LP, Mölndal, Sweden.; Pokaż więcej
Źródło:: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2016 Jul; Vol. 59 (9), pp. 340-5. Date of Electronic Publication: 2016 Jun 14.
Typ publikacji:: Journal Article
MeSH Terms:: 5-Lipoxygenase-Activating Protein Inhibitors/*chemical synthesis
5-Lipoxygenase-Activating Proteins/*metabolism
Picolinic Acids/*chemical synthesis
Pyrazines/*chemical synthesis
Tritium/*chemistry
5-Lipoxygenase-Activating Protein Inhibitors/chemistry ; 5-Lipoxygenase-Activating Protein Inhibitors/pharmacology ; Acetone/chemistry ; Chemistry Techniques, Synthetic ; Isotope Labeling ; Picolinic Acids/chemistry ; Picolinic Acids/pharmacology ; Pyrazines/chemistry ; Pyrazines/pharmacology

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Skocz do pozycji: 19.

Tytuł:: Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.
Autorzy:: Diakite B; Faculty of Medicine and Pharmacy 14, Department of Genetics and Molecular Pathology Laboratory (LGPM), Hassan II University, 9154 Casablanca, .
Hamzi K
Hmimech W
Nadifi S; Pokaż więcej
Corporate Authors:: GMRAVC
Źródło:: Journal of genetics [J Genet] 2016 Jun; Vol. 95 (2), pp. 303-9.
Typ publikacji:: Journal Article
MeSH Terms:: Genetic Predisposition to Disease*
Polymorphism, Genetic*
5-Lipoxygenase-Activating Proteins/*genetics
Apolipoprotein A-V/*genetics
Hypertension/*genetics
Stroke/*genetics
Alleles ; Case-Control Studies ; Female ; Gene Expression ; Gene Frequency ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Male ; Middle Aged ; Morocco ; Polymerase Chain Reaction ; Risk Factors ; Stroke/diagnosis ; Stroke/physiopathology

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Skocz do pozycji: 20.

Tytuł:: Genetics of ischemic stroke: An Indian scenario.
Autorzy:: Kumar A; Department of Neurology, All Institute of Medical Sciences, New Delhi, India.
Kumar P
Kathuria P
Misra S
Pandit AK
Chakravarty K
Prasad M; Pokaż więcej
Źródło:: Neurology India [Neurol India] 2016 Jan-Feb; Vol. 64 (1), pp. 29-37.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Genetic Predisposition to Disease*
5-Lipoxygenase-Activating Proteins/*genetics
Brain Ischemia/*genetics
Stroke/*genetics
Gene Frequency ; Genetic Linkage ; Genome-Wide Association Study ; Humans

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