- Tytuł:
- Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
- Autorzy:
- Źródło:
- Science (New York, N.Y.) [Science] 1998 Dec 11; Vol. 282 (5396), pp. 2085-8.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Drosophila Proteins*
Signal Transduction*
Lipopolysaccharides/*metabolism
Membrane Glycoproteins/*genetics
Receptors, Cell Surface/*genetics
Amino Acid Sequence ; Animals ; Chromosome Mapping ; Cloning, Molecular ; Genes, Dominant ; Gram-Negative Bacterial Infections/immunology ; Homozygote ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Membrane Glycoproteins/chemistry ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Molecular Sequence Data ; Mutation, Missense ; Point Mutation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/metabolism ; Toll-Like Receptor 4 ; Toll-Like Receptors
Czasopismo naukowe