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Wyszukujesz frazę ""A549 Cells"" wg kryterium: Temat


Tytuł :
Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.
Autorzy :
Lai C; Department of General Surgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Hunan Key Laboratory of Precise Diagnosis and Treatment of Gastrointestinal Tumor, Changsha 410008, Hunan, China.
Zhang J; Department of Oncology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Tan Z; Department of Oncology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Shen LF; Department of Oncology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.
Zhou RR; Department of Oncology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhang YY; Department of Oncology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Feb 26; Vol. 13 (5), pp. 7300-7313. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
A549 Cells/*metabolism
Activating Transcription Factors/*metabolism
Radiation Tolerance/*drug effects
Radiation-Sensitizing Agents/*pharmacology
Repressor Proteins/*metabolism
Sirolimus/*pharmacology
Unfolded Protein Response/*drug effects
A549 Cells/drug effects ; A549 Cells/radiation effects ; Blotting, Western ; Flow Cytometry ; Humans ; Lung Neoplasms/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/radiation effects ; Phosphorylation ; Real-Time Polymerase Chain Reaction ; Unfolded Protein Response/radiation effects
Czasopismo naukowe
Tytuł :
iTRAQ‑based proteomic analysis of the interaction of A549 human lung epithelial cells with Aspergillus fumigatus conidia.
Autorzy :
Zhang X; Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
He D; Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Gao S; Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Wei Y; Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Wang L; Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Dec; Vol. 22 (6), pp. 4601-4610. Date of Electronic Publication: 2020 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
A549 Cells/*metabolism
Aspergillosis/*immunology
Aspergillus fumigatus/*metabolism
A549 Cells/microbiology ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/pathogenicity ; Cell Line ; Epithelial Cells/metabolism ; Gene Expression Profiling ; Gene Ontology ; Humans ; Lung/metabolism ; Proteome/metabolism ; Proteomics ; Respiratory Mucosa/metabolism ; Spores, Fungal/immunology ; Spores, Fungal/metabolism
Czasopismo naukowe
Tytuł :
Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells.
Autorzy :
Sasaki M; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan. Electronic address: .
Kishimoto M; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Itakura Y; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Tabata K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Intaruck K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Uemura K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; Shionogi & Co., Ltd., Osaka, 541-0045, Japan; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060-0812, Japan.
Toba S; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; Shionogi & Co., Ltd., Osaka, 541-0045, Japan.
Sanaki T; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; Shionogi & Co., Ltd., Osaka, 541-0045, Japan.
Sato A; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; Shionogi & Co., Ltd., Osaka, 541-0045, Japan.
Hall WW; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; National Virus Reference Laboratory, University College Dublin, Belfield, Dublin, 4, Ireland; Global Virus Network, Baltimore, MD, 21201, USA.
Orba Y; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Sawa H; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan; Global Virus Network, Baltimore, MD, 21201, USA; One Health Research Center, Hokkaido University, Sapporo, 060-0818, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 146-151. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alveolar Epithelial Cells/*virology
COVID-19/*virology
Cell Culture Techniques/*methods
SARS-CoV-2/*physiology
A549 Cells ; Alveolar Epithelial Cells/pathology ; Cells, Cultured ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Humans ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors.
Autorzy :
Ibrahim AIM; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Ikhmais B; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Batlle E; Faculty of Life Sciences, Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford BD7 1DP, UK.; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.
AbuHarb WK; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Jha V; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Jaradat KT; College of Engineering and Technology, American University of the Middle East, Kuwait City 54200, Kuwait.
Jiménez R; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.
Pequerul R; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.
Parés X; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.
Farrés J; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain.
Pors K; Faculty of Life Sciences, Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford BD7 1DP, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 23; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehyde Oxidoreductases/*antagonists & inhibitors
Benzaldehydes/*chemical synthesis
Enzyme Inhibitors/*chemical synthesis
Neoplasms/*enzymology
A549 Cells ; Benzaldehydes/chemistry ; Benzaldehydes/pharmacology ; Cell Line, Tumor ; Computer Simulation ; Drug Discovery ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Molecular Structure ; Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
[Effects of Magnolol combined with Gefitinib on A549 non-small cell lung cancer cells].
Autorzy :
Ren JL; Department of Medical Laboratory, Fenyang College, Shanxi Medical University, Fenyang 032200.
Cui LZ; Department of Cadre Diagnosis and Treatment, Shanxi Cancer Hospital, Taiyuan 030013.
Hao XX; Department of Medical Laboratory, Fenyang College, Shanxi Medical University, Fenyang 032200.
Li XY; Department of Laboratory Medicine, Fenyang Hospital, Shanxi Province, Fenyang 032200.
Chang YX; The First Affiliated Hospital of Xi'an Medical College, Xi'an 710077, China.
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Źródło :
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2021 Sep; Vol. 37 (5), pp. 506-510.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
A549 Cells ; Apoptosis ; Biphenyl Compounds ; Cell Line, Tumor ; Cell Proliferation ; Gefitinib/pharmacology ; Humans ; Lignans
Czasopismo naukowe
Tytuł :
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Autorzy :
Ding Z; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Xi J; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhong M; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Chen F; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhao H; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhang B; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Fang J; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Nov 17; Vol. 69 (45), pp. 13557-13567. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Pyruvate Kinase*/genetics
Sesquiterpenes*/pharmacology
A549 Cells ; Apoptosis ; Cell Cycle Checkpoints ; DNA Damage ; Humans ; Lactones/pharmacology ; Mitochondrial Dynamics
Czasopismo naukowe
Tytuł :
Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses.
Autorzy :
Paidi RK; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Jana M; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Mishra RK; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL; and.
Dutta D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Pahan K; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL; .; Division of Research and Development, Jesse Brown VA Medical Center, Chicago, IL.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Nov 15; Vol. 207 (10), pp. 2521-2533. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Anti-Inflammatory Agents/*therapeutic use
COVID-19/*therapy
Lung/*immunology
Peptides/*metabolism
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; COVID-19/immunology ; Cytokines/metabolism ; Female ; HEK293 Cells ; Humans ; Inflammation Mediators/metabolism ; Locomotion ; Male ; Mice ; Molecular Targeted Therapy ; NF-kappa B/metabolism ; Peptides/genetics ; Peptides/therapeutic use ; Signal Transduction ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells.
Autorzy :
Caohuy H; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Eidelman O; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Chen T; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Consortium for Health and Military Performance (CHAMP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Liu S; Laboratory of Vector-Borne Viral Diseases, Division of Viral Products, Center for Biologics Evaluation (CBER), U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.
Yang Q; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Center for the Study of Traumatic Stress (CSTS), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Bera A; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Walton NI; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; Consortium for Health and Military Performance (CHAMP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Wang TT; Laboratory of Vector-Borne Viral Diseases, Division of Viral Products, Center for Biologics Evaluation (CBER), U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.
Pollard HB; Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. .; Collaborative Health Initiative Research Program (CHIRP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. .; Consortium for Health and Military Performance (CHAMP), Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Nov 12; Vol. 11 (1), pp. 22195. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*drug therapy
Cardiotonic Agents/*pharmacology
SARS-CoV-2/*drug effects
Spike Glycoprotein, Coronavirus/*metabolism
Virus Internalization/*drug effects
A549 Cells ; Animals ; COVID-19/metabolism ; Chlorocebus aethiops ; Digitoxin/pharmacology ; Digoxin/pharmacology ; Humans ; Lung/drug effects ; Lung/metabolism ; Ouabain/pharmacology ; Protein Binding/drug effects ; SARS-CoV-2/physiology ; Vero Cells
Czasopismo naukowe
Tytuł :
The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication.
Autorzy :
Nilsson-Payant BE; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Uhl S; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Grimont A; Department of Surgery, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Doane AS; Department of Physiology and Biophysics, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Higgins CA; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Acklin JA; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Chandar V; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Blanco-Melo D; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Panis M; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Schwartz RE; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Chandwani R; Department of Surgery, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
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Źródło :
Journal of virology [J Virol] 2021 Nov 09; Vol. 95 (23), pp. e0125721. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Transcriptome*
Virus Replication*
COVID-19/*metabolism
Cytokines/*metabolism
Interferon Type I/*metabolism
Transcription Factor RelA/*metabolism
A549 Cells ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; Epigenomics ; Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Host Microbial Interactions ; Humans ; Signal Transduction ; Single-Cell Analysis ; Transcription Factor RelA/antagonists & inhibitors ; Transcription Factor RelA/genetics ; Transcription Factors/metabolism ; Vero Cells
Czasopismo naukowe
Tytuł :
Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma.
Autorzy :
You Q; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.; Department of Pharmacy, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, People's Republic of China.
Li D; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Ding H; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Chen H; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Hu Y; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Liu Y; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Nov 03; Vol. 69 (43), pp. 12705-12716. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Flavones*/pharmacokinetics
A549 Cells ; Animals ; HCT116 Cells ; HeLa Cells ; Hep G2 Cells ; Humans ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF.
Autorzy :
Schuliga M; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Kanwal A; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Read J; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Blokland KEC; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Department of Pathology and Medical Biology, Groningen Research Institute of Asthma and COPD and KOLFF Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Burgess JK; Department of Pathology and Medical Biology, Groningen Research Institute of Asthma and COPD and KOLFF Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Prêle CM; Institute for Respiratory Health, University of Western Australia, Nedlands, Western Australia, Australia.; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia, Australia.
Mutsaers SE; Institute for Respiratory Health, University of Western Australia, Nedlands, Western Australia, Australia.; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia, Australia.
Grainge C; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.; John Hunter Hospital, Newcastle, New South Wales, Australia.
Thomson C; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.; St Vincent's Hospital, Sydney, New South Wales, Australia.
James A; John Hunter Hospital, Newcastle, New South Wales, Australia.
Bartlett NW; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Knight DA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.; Priority Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Providence Health Care Research Institute, Vancouver, British Columbia, Canada.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Nov 01; Vol. 321 (5), pp. L859-L871. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alveolar Epithelial Cells/*pathology
Cellular Senescence/*physiology
DNA Damage/*genetics
Idiopathic Pulmonary Fibrosis/*pathology
Nucleotidyltransferases/*metabolism
A549 Cells ; Benzofurans/pharmacology ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cytokines/biosynthesis ; DNA, Mitochondrial/metabolism ; Deoxyribonuclease I/pharmacology ; Epithelial Cell Adhesion Molecule/metabolism ; Etoposide/pharmacology ; Humans ; Mitochondria/genetics ; Mitochondria/pathology ; Nucleotidyltransferases/antagonists & inhibitors ; Nucleotidyltransferases/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
LncRNA AC020978 facilitates non-small cell lung cancer progression by interacting with malate dehydrogenase 2 and activating the AKT pathway.
Autorzy :
Xu F; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Hua Q; Department of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Zhang A; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Di Z; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Wang Y; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Zhao L; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yang H; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Liu J; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Huang G; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4501-4514. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Progression*
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
Malate Dehydrogenase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
RNA, Long Noncoding/*metabolism
A549 Cells ; Animals ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/secondary ; Cell Line, Tumor ; Cell Movement ; Female ; Glutarates/metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Prognosis
Czasopismo naukowe
Tytuł :
FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule-stabilizing effect.
Autorzy :
Yu H; Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.; Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.; College of Basic Medicine, Hebei Medical University, Shijiazhuang, China.
Wang H; College of Basic Medicine, Hebei Medical University, Shijiazhuang, China.
Qie A; College of Basic Medicine, Hebei Medical University, Shijiazhuang, China.; Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Wang J; College of Basic Medicine, Hebei Medical University, Shijiazhuang, China.
Liu Y; Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Gu G; Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yang J; Department of Physiology, Hebei Medical University, Shijiazhuang, China.
Zhang H; College of Basic Medicine, Hebei Medical University, Shijiazhuang, China.
Pan W; Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Tian Z; Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Wang C; Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4655-4668. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*pharmacology
Cisplatin/*pharmacology
Copper Transporter 1/*metabolism
Copper-Transporting ATPases/*metabolism
Fibroblast Growth Factors/*physiology
A549 Cells ; Antineoplastic Agents/metabolism ; Cell Line, Tumor ; Cisplatin/metabolism ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/metabolism ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Microtubules/drug effects ; Platinum Compounds/metabolism ; Platinum Compounds/pharmacology ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Osteopontin improves sensitivity to tyrosine kinase inhibitor in lung adenocarcinoma in vitro by promoting epidermal growth factor receptor phosphorylation.
Autorzy :
Wang YJ; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China.
Wang QW; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China.
Yu DH; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China.
Song CK; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China.
Guo ZX; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China.
Liu XP; Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.
Chen C; Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Human Genetics Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Yao J; Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Human Genetics Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wang AF; Department of Obstetrics and Gynecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, 77 S Changan Road, Zhangjiagang, Jiangsu, China.
Hu WD; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. .; Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, No. 169, East Lake Road, Wuchang, Wuhan, 430071, Hubei, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Nov; Vol. 147 (11), pp. 3245-3254. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*drug therapy
Gefitinib/*pharmacology
Lung Neoplasms/*drug therapy
Osteopontin/*metabolism
Protein Kinase Inhibitors/*pharmacology
A549 Cells ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; ErbB Receptors/metabolism ; Female ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Phosphorylation
Czasopismo naukowe
Tytuł :
Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway.
Autorzy :
Luan X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Yang W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Bai X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Li H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Li H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Fan W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zhang H; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Guangdong, China.
Liu W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Guangdong, China.; Institute of Microbiology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.
Sun L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Nov; Vol. 35 (11), pp. e21958.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclophilin A/*physiology
Interleukin-6/*metabolism
Receptors, Interleukin-6/*metabolism
Suppressor of Cytokine Signaling 1 Protein/*metabolism
A549 Cells ; HEK293 Cells ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition.
Autorzy :
Yang Q; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Yang F; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Dai W; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Meng X; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Wei W; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Cheng Y; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Dong J; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Lu H; Department of Chemistry, School of Chemistry and Bioengineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Dong H; Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.; Department of Chemistry, School of Chemistry and Bioengineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.; Marshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, 518071, P. R. China.
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Źródło :
Advanced healthcare materials [Adv Healthc Mater] 2021 Nov; Vol. 10 (21), pp. e2101130. Date of Electronic Publication: 2021 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computers, Molecular*
MicroRNAs*
A549 Cells ; DNA ; Humans ; Logic ; MCF-7 Cells ; Nanotechnology
Czasopismo naukowe
Tytuł :
Profiling of Aldehyde Dehydrogenase Isoforms in In Vitro Formed Tumorspheres.
Autorzy :
Tsochantaridis I; Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
Voulgaridou GP; Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
Giatromanolaki A; Department of Pathology, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Koukourakis MI; Radiotherapy/Oncology, Department of Medicine, School of Health Sciences, Democritus University of Thrace, Alexandroupolis, Greece.
Panayiotidis MI; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.; School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.
Pappa A; Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Nov; Vol. 41 (11), pp. 5481-5488.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehyde Dehydrogenase/*metabolism
Carcinoma, Hepatocellular/*enzymology
Liver Neoplasms/*enzymology
Lung Neoplasms/*enzymology
Neoplastic Stem Cells/*enzymology
A549 Cells ; Aldehyde Dehydrogenase/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Isoenzymes ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Phenotype ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Spheroids, Cellular
Czasopismo naukowe
Tytuł :
3,3'-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides.
Autorzy :
Gandhi VV; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Gandhi KA; Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Kumbhare LB; Chemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Goda JS; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Gota V; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi, Mumbai, India.
Priyadarsini KI; UM-DAE Centre for Excellence in Basic Sciences, Kalina Campus, Mumbai, 400098, India.
Kunwar A; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India; Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Nov 01; Vol. 175, pp. 1-17. Date of Electronic Publication: 2021 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Tumor Suppressor Protein p53*/genetics
A549 Cells ; Animals ; Cell Line, Tumor ; Endoplasmic Reticulum Stress ; Humans ; Mice ; Mice, SCID ; Propionates ; Reactive Oxygen Species/metabolism ; Selenium Compounds
Czasopismo naukowe
Tytuł :
Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains.
Autorzy :
Binder F; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany.
Gallo G; Department of Virology, Institut Pasteur, Antiviral Strategies, Paris, France.
Bendl E; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany.; University Hospital Freiburg, Institute of Virology, Freiburg, Germany.
Eckerle I; University of Bonn, Medical Centre, Bonn, Germany.; Geneva Centre for Emerging Viral Diseases, Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland.
Ermonval M; Department of Virology, Institut Pasteur, Antiviral Strategies, Paris, France.
Luttermann C; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Immunology, Greifswald-Insel Riems, Germany.
Ulrich RG; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany. .
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Źródło :
Archives of virology [Arch Virol] 2021 Nov; Vol. 166 (11), pp. 2999-3012. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Host-Pathogen Interactions/*physiology
Interferon Type I/*metabolism
Puumala virus/*pathogenicity
Viral Nonstructural Proteins/*metabolism
A549 Cells ; Adaptation, Physiological ; Animals ; Chlorocebus aethiops ; Gene Expression Regulation, Viral ; Germany ; HEK293 Cells ; Hemorrhagic Fever with Renal Syndrome ; Humans ; Interferon Type I/genetics ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Mutation ; Promoter Regions, Genetic ; Puumala virus/isolation & purification ; Puumala virus/physiology ; Vero Cells ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities.
Autorzy :
Cui WY; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Jin Y; School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Liu H; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Zu ML; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Zhai XF; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Yang C; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Gu YL; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Cheng Y; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
Piao XL; Center on Translational Neuroscience and School of Pharmacy, Minzu University of China, Beijing, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (22), pp. 4433-4441. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Saponins*/pharmacology
Triterpenes*/pharmacology
A549 Cells ; Gynostemma ; Humans
Czasopismo naukowe

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