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Wyszukujesz frazę ""A549 Cells"" wg kryterium: Temat


Tytuł :
Trichinella spiralis muscle larvae excretory/secretory products trigger apoptosis and S-phase arrest of the non-small-cell lung cancer line A549.
Autorzy :
Wu H; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Li M; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Shao X; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
An Z; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Du J; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Yin H; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Pan J; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Li S; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Zhang Y; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China.
Du L; Department of Pathogenic Biology, Chengde Medical University, Chengde, 067000, Hebei, China. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2020 Nov; Vol. 218, pp. 107983. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
A549 Cells/*drug effects
Antigens, Helminth/*pharmacology
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
Helminth Proteins/*pharmacology
S Phase/*drug effects
Trichinella spiralis/*chemistry
A549 Cells/cytology ; Analysis of Variance ; Animals ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation/drug effects ; Culture Media, Serum-Free ; Female ; Humans ; Larva/chemistry ; Mice ; Trichinella spiralis/immunology
Czasopismo naukowe
Tytuł :
MiR-424 overexpression protects alveolar epithelial cells from LPS-induced apoptosis and inflammation by targeting FGF2 via the NF-κB pathway.
Autorzy :
Cheng D; Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China; Department of Pediatric, Henan Provincial People's Hospital, Zhengzhou 450000, PR China; Department of Pediatric, People's Hospital of Zhengzhou University, Zhengzhou 450000, PR China.
Zhu C; Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China. Electronic address: .
Liang Y; Department of Hematology, Children's Hospital of Kaifeng City, Kaifeng 475000, PR China.
Xing Y; Department of Pediatric, Henan Provincial People's Hospital, Zhengzhou 450000, PR China; Department of Pediatric, People's Hospital of Zhengzhou University, Zhengzhou 450000, PR China.
Shi C; Department of Pediatric, Henan Provincial People's Hospital, Zhengzhou 450000, PR China; Department of Pediatric, People's Hospital of Zhengzhou University, Zhengzhou 450000, PR China.
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Źródło :
Life sciences [Life Sci] 2020 Feb 01; Vol. 242, pp. 117213. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/physiology
A549 Cells/*metabolism
Apoptosis/*drug effects
Fibroblast Growth Factor 2/*physiology
Inflammation/*physiopathology
Lipopolysaccharides/*pharmacology
MicroRNAs/*metabolism
NF-kappa B/*metabolism
Pulmonary Alveoli/*metabolism
Respiratory Mucosa/*metabolism
A549 Cells/physiology ; Apoptosis/physiology ; Blotting, Western ; Fibroblast Growth Factor 2/metabolism ; Fluorescent Antibody Technique ; Humans ; Inflammation/metabolism ; MicroRNAs/physiology ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/physiology ; Real-Time Polymerase Chain Reaction ; Respiratory Mucosa/cytology ; Respiratory Mucosa/physiology
Czasopismo naukowe
Tytuł :
E-cigarette aerosol induced cytotoxicity, DNA damages and late apoptosis in dynamically exposed A549 cells.
Autorzy :
Khalil C; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University (LAU), Byblos, Lebanon; Department of Natural Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon. Electronic address: .
Chahine JB; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University (LAU), Byblos, Lebanon.
Haykal T; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University (LAU), Byblos, Lebanon.
Al Hageh C; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University (LAU), Byblos, Lebanon.
Rizk S; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University (LAU), Byblos, Lebanon.
Khnayzer RS; Department of Natural Sciences, Lebanese American University, Chouran, Beirut, 1102-2801, Lebanon.
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 263, pp. 127874. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Electronic Nicotine Delivery Systems*
A549 Cells ; Aerosols/toxicity ; Apoptosis ; DNA Damage
Czasopismo naukowe
Tytuł :
Nano nickel oxide promotes epithelial-mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells.
Autorzy :
Chang X; Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.
Tian M; Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.
Zhang Q; Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.
Gao J; Institute of Occupational Disease Control and Prevention, Lanzhou Municipal Center for Disease Control, Lanzhou, China.
Li S; Institute of Public Health, The First People's Hospital of Lanzhou City, Lanzhou, China.
Sun Y; Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Dec; Vol. 35 (12), pp. 1308-1317. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition/*drug effects
Nanoparticles/*toxicity
Nickel/*toxicity
Smad2 Protein/*metabolism
Smad3 Protein/*metabolism
Transforming Growth Factor beta1/*metabolism
A549 Cells ; Cell Culture Techniques ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mitophagy-lysosomal pathway is involved in silver nanoparticle-induced apoptosis in A549 cells.
Autorzy :
Li J; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Chang X; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Shang M; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Niu S; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Zhang W; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Zhang B; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Huang W; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Wu T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Zhang T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Tang M; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Xue Y; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111463. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Metal Nanoparticles/*toxicity
Mitophagy/*physiology
Silver/*toxicity
A549 Cells ; Apoptosis/drug effects ; Autophagy/drug effects ; Caspase 9 ; Cell Death/drug effects ; Humans ; Lysosomes/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Mitophagy/drug effects ; Reactive Oxygen Species/metabolism ; Ubiquitin-Protein Ligases
Czasopismo naukowe
Tytuł :
Artesunate exhibits synergistic anti-cancer effects with cisplatin on lung cancer A549 cells by inhibiting MAPK pathway.
Autorzy :
Li W; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Ma G; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Deng Y; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Wu Q; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Wang Z; Laboratory of Molecular Diagnosis of Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
Zhou Q; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 15; Vol. 766, pp. 145134. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Artesunate/*pharmacology
Cisplatin/*pharmacology
Lung Neoplasms/*drug therapy
MAP Kinase Signaling System/*drug effects
Signal Transduction/*drug effects
A549 Cells ; Animals ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Synergism ; Female ; Humans ; Lung Neoplasms/metabolism ; Mice ; Mice, Nude ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks.
Autorzy :
Schneider WM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Luna JM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Sánchez-Rivera FJ; Cancer Biology and Genetics, MSKCC, New York, NY 10065, USA.
Leal AA; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA.
Ashbrook AW; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Le Pen J; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Ricardo-Lax I; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Michailidis E; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Peace A; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Stenzel AF; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Lowe SW; Cancer Biology and Genetics, MSKCC, New York, NY 10065, USA.
MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: .
Poirier JT; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 07; Vol. 184 (1), pp. 120-132.e14. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Coronavirus Infections/*genetics
SARS-CoV-2/*physiology
A549 Cells ; Cell Line ; Clustered Regularly Interspaced Short Palindromic Repeats ; Coronavirus 229E, Human/physiology ; Coronavirus Infections/virology ; Coronavirus NL63, Human/physiology ; Coronavirus OC43, Human/physiology ; Gene Knockout Techniques ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Humans ; Membrane Proteins/metabolism ; Metabolic Networks and Pathways/drug effects ; Protein Interaction Mapping
Czasopismo naukowe
Tytuł :
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
Autorzy :
Wang R; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Simoneau CR; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Kulsuptrakul J; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Bouhaddou M; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Travisano KA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Hayashi JM; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA.
Carlson-Stevermer J; Synthego Corporation, Menlo Park, CA 94025, USA.
Zengel JR; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Richards CM; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Fozouni P; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Oki J; Synthego Corporation, Menlo Park, CA 94025, USA.
Rodriguez L; UCSF CoLabs, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Joehnk B; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Walcott K; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Holden K; Synthego Corporation, Menlo Park, CA 94025, USA.
Sil A; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Carette JE; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Krogan NJ; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Ott M; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: .
Puschnik AS; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 07; Vol. 184 (1), pp. 106-119.e14. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Host-Pathogen Interactions*/drug effects
COVID-19/*genetics
Coronavirus/*physiology
Coronavirus Infections/*genetics
SARS-CoV-2/*physiology
A549 Cells ; Animals ; Biosynthetic Pathways/drug effects ; COVID-19/virology ; Cell Line ; Chlorocebus aethiops ; Cholesterol/biosynthesis ; Cholesterol/metabolism ; Cluster Analysis ; Clustered Regularly Interspaced Short Palindromic Repeats ; Common Cold/genetics ; Common Cold/virology ; Coronavirus/classification ; Coronavirus Infections/virology ; Gene Knockout Techniques ; Humans ; Mice ; Phosphatidylinositols/biosynthesis ; Vero Cells ; Virus Internalization/drug effects ; Virus Replication
Czasopismo naukowe
Tytuł :
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Autorzy :
Daniloski Z; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.
Jordan TX; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wessels HH; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.
Hoagland DA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kasela S; New York Genome Center, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA.
Legut M; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.
Maniatis S; New York Genome Center, New York, NY, USA.
Mimitou EP; Technology Innovation Lab, New York Genome Center, New York, NY, USA.
Lu L; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.
Geller E; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.
Danziger O; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Phatnani H; New York Genome Center, New York, NY, USA; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Smibert P; Technology Innovation Lab, New York Genome Center, New York, NY, USA.
Lappalainen T; New York Genome Center, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA.
tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: .
Sanjana NE; New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 07; Vol. 184 (1), pp. 92-105.e16. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions*/drug effects
COVID-19/*genetics
COVID-19/*virology
SARS-CoV-2/*physiology
A549 Cells ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/virology ; Angiotensin-Converting Enzyme 2/metabolism ; Biosynthetic Pathways ; COVID-19/metabolism ; Cholesterol/biosynthesis ; Clustered Regularly Interspaced Short Palindromic Repeats ; Endosomes/metabolism ; Gene Expression Profiling ; Gene Knockdown Techniques ; Gene Knockout Techniques/methods ; Genome-Wide Association Study ; Humans ; RNA Interference ; SARS-CoV-2/growth & development ; Single-Cell Analysis ; Viral Load/drug effects ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2.
Autorzy :
Chow RD; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Systems Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; M.D.-Ph.D. Program, Yale University, New Haven, CT, USA.
Majety M; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Systems Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; The College, Yale University, New Haven, CT, 06520, USA.
Chen S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. .; Systems Biology Institute, Yale University, West Haven, CT, USA. .; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA. .; M.D.-Ph.D. Program, Yale University, New Haven, CT, USA. .; Immunobiology Program, Yale University, New Haven, CT, USA. .; Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA. .; Combined Program in the Biological and Biomedical Sciences, Yale University, New Haven, CT, USA. .; Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT, USA. .; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA. .; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA. .; Yale Liver Center, Yale University School of Medicine, New Haven, CT, USA. .; Yale Center for Biomedical Data Science, Yale University School of Medicine, New Haven, CT, USA. .; Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 4. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aging/*genetics
COVID-19/*genetics
Lung/*physiology
A549 Cells ; Adult ; Aged ; Aging/metabolism ; Aging/pathology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Endothelial Cells/pathology ; Female ; Fibroblasts/pathology ; Gene Expression ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Male ; Middle Aged ; Pericytes/pathology ; RNA-Seq ; SARS-CoV-2/isolation & purification ; Transcriptome ; Young Adult
Czasopismo naukowe
Tytuł :
Phosphorylation of levan by microwave-assisted synthesis enhanced anticancer ability.
Autorzy :
Huang TY; Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Huang MY; Fisheries Research Institute, Council of Agriculture, Keelung 20246, Taiwan.
Tsai CK; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Su WT; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2021 Jan; Vol. 131 (1), pp. 98-106. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Microwaves*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Fructans/*chemistry
Fructans/*pharmacology
A549 Cells ; Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Chemistry Techniques, Synthetic ; Fructans/chemical synthesis ; HCT116 Cells ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells.
Autorzy :
Zhang BD; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Zhu WF; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Akihisa T; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China; Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Kikuchi T; Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.
Ukiya M; College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
Maya F; College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
Xu J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Liu WY; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Feng F; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China; Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu, 223003, China. Electronic address: .
Zhang J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China; Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu, 223003, China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Jan; Vol. 181, pp. 112544. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiac Glycosides*/pharmacology
Moraceae*
A549 Cells ; Apoptosis ; Glycosides/pharmacology
Czasopismo naukowe
Tytuł :
Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin.
Autorzy :
Du X; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.; Institute of Clinical Medicine Research, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, China.
Zuo X; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Meng F; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Han C; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Ouyang W; Department of Infectious Diseases, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Han Y; Department of Infectious Diseases, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Gu Y; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Zhao X; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
Xu F; Department of Infectious Diseases, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Qin FX; Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Suzhou Institute of Systems Medicine, Suzhou, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Jan; Vol. 54 (1), pp. e12953. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Azithromycin/*pharmacology
COVID-19/*metabolism
Influenza A virus/*metabolism
Influenza, Human/*metabolism
SARS-CoV-2/*metabolism
Virus Internalization/*drug effects
A549 Cells ; COVID-19/drug therapy ; COVID-19/genetics ; Caco-2 Cells ; HEK293 Cells ; HeLa Cells ; Humans ; Influenza A virus/genetics ; Influenza, Human/drug therapy ; Influenza, Human/genetics ; Interferons/genetics ; Interferons/metabolism ; SARS-CoV-2/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Reactive oxygen species production and inflammatory effects of ambient PM 2.5 -associated metals on human lung epithelial A549 cells "one year-long study": The Delhi chapter.
Autorzy :
Das A; Department of Civil Engineering, Indian Institute of Technology, Delhi, India. Electronic address: .
Habib G; Department of Civil Engineering, Indian Institute of Technology, Delhi, India. Electronic address: .
Vivekanandan P; Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, India. Electronic address: .
Kumar A; Department of Civil Engineering, Indian Institute of Technology, Delhi, India. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 262, pp. 128305. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Air Pollutants/*toxicity
Environmental Monitoring/*methods
Epithelial Cells/*drug effects
Metals, Heavy/*toxicity
Particulate Matter/*toxicity
Reactive Oxygen Species/*analysis
A549 Cells ; Air Pollutants/analysis ; Cell Survival/drug effects ; Cytokines/analysis ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Humans ; India ; Metals, Heavy/analysis ; Particulate Matter/analysis ; Seasons
Czasopismo naukowe
Tytuł :
Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer.
Autorzy :
Lou JS; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 31121, China. Electronic address: .
Zhao LP; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 31121, China.
Huang ZH; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 31121, China.
Chen XY; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 31121, China.
Xu JT; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Tai WC; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR China.
Tsim KWK; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Chen YT; College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Xie T; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 31121, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153370. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Biflavonoids/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Heme Oxygenase-1/*metabolism
Lung Neoplasms/*drug therapy
NF-E2-Related Factor 2/*metabolism
A549 Cells ; Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Biflavonoids/administration & dosage ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cisplatin/administration & dosage ; ErbB Receptors/genetics ; Ferroptosis/drug effects ; Ginkgo biloba/chemistry ; Heme Oxygenase-1/genetics ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Membrane Potential, Mitochondrial/drug effects ; Mice, Nude ; Plant Leaves/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Diterpenoid and triterpenoid glycosides from Clinopodium chinense .
Autorzy :
Qu LX; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.; Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, China.
Liu YQ; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, China.
Wang Y; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, China.
Wang H; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
Huang XL; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
Zhang ML; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
Mou YX; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
Xu TH; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China.; Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, China.
Zhu YD; School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 25-33. Date of Electronic Publication: 2019 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Diterpenes/*pharmacology
Lamiaceae/*chemistry
Triterpenes/*pharmacology
A549 Cells ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Diterpenes/chemistry ; Drug Evaluation, Preclinical ; Glycosides/chemistry ; Glycosides/pharmacology ; Hep G2 Cells ; Humans ; Insulin Resistance ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Plant Extracts/chemistry ; Triterpenes/chemistry
Czasopismo naukowe
Tytuł :
Indole-based alkaloids from Ophiocordyceps xuefengensis.
Autorzy :
Qin Y; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China; Hunan University of Chinese Medicine, Changsha, 410208, China.
Zhou RR; College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, China.
Jin J; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Cheng F; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Shen BB; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Zeng HL; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Wan D; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Zhong C; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Xie J; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China.
Shu J; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China; Hunan University of Chinese Medicine, Changsha, 410208, China.
Shi SY; College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China. Electronic address: .
Zhang SH; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, 410013, China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Jan; Vol. 181, pp. 112536. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*/pharmacology
Indole Alkaloids*/pharmacology
A549 Cells ; Cell Line, Tumor ; Hypocreales ; Molecular Structure
SCR Organism :
Ophiocordyceps xuefengensis
Czasopismo naukowe
Tytuł :
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism.
Autorzy :
Jiang X; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China. Electronic address: .
Zhao W; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Zhu F; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Wu H; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Ding X; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Bai J; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Zhang X; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
Qian M; Wuxi Fifth People's Hospital, Wuxi 214016, Jiangsu, China.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115336. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Butyrolactone/*analogs & derivatives
Carcinoma, Non-Small-Cell Lung/*metabolism
Cell Proliferation/*drug effects
Glycolysis/*drug effects
Lung Neoplasms/*metabolism
4-Butyrolactone/pharmacology ; 4-Butyrolactone/therapeutic use ; A549 Cells ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cell Proliferation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Glycolysis/physiology ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Random Allocation
Czasopismo naukowe
Tytuł :
Ethyl maltol enhances copper mediated cytotoxicity in lung epithelial cells.
Autorzy :
Durrani K; Department of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore 21205, MD, USA; Environmental Health and Engineering, The Johns Hopkins University, Bloomberg School of Public Health, USA.
El Din SA; Department of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore 21205, MD, USA; Environmental Health and Engineering, The Johns Hopkins University, Bloomberg School of Public Health, USA.
Sun Y; Department of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore 21205, MD, USA; Environmental Health and Engineering, The Johns Hopkins University, Bloomberg School of Public Health, USA.
Rule AM; Environmental Health and Engineering, The Johns Hopkins University, Bloomberg School of Public Health, USA.
Bressler J; Department of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore 21205, MD, USA; Environmental Health and Engineering, The Johns Hopkins University, Bloomberg School of Public Health, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115354. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Copper/*toxicity
Cytotoxins/*toxicity
Lung/*drug effects
Pyrones/*toxicity
Respiratory Mucosa/*drug effects
A549 Cells ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Drug Synergism ; HEK293 Cells ; Humans ; Lung/pathology ; Respiratory Mucosa/pathology
Czasopismo naukowe
Tytuł :
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Autorzy :
Heer CD; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA.; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Sanderson DJ; Department of Chemical Physiology & Biochemistry, Oregon Health Sciences University, Portland, Oregon, USA.
Voth LS; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Alhammad YMO; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Schmidt MS; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Trammell SAJ; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA.
Perlman S; Department of Microbiology & Immunology, University of Iowa, Iowa City, Iowa, USA.
Cohen MS; Department of Chemical Physiology & Biochemistry, Oregon Health Sciences University, Portland, Oregon, USA.
Fehr AR; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA .
Brenner C; Department of Biochemistry, University of Iowa, Iowa City, Iowa, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 17986-17996. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*metabolism
NAD/*immunology
Poly(ADP-ribose) Polymerases/*immunology
SARS-CoV-2/*immunology
A549 Cells ; ADP-Ribosylation ; Adenosine Diphosphate Ribose/metabolism ; Adult ; Animals ; COVID-19/immunology ; Cell Line, Tumor ; Female ; Ferrets ; Humans ; Immunity, Innate ; Male ; Metabolome ; Mice ; Mice, Inbred C57BL ; NAD/metabolism ; Niacinamide/analogs & derivatives ; Niacinamide/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/blood ; SARS-CoV-2/metabolism
Czasopismo naukowe

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