Temat: "ACETYLCYSTEINE" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Is Two Better Than Three? A Systematic Review of Two-bag Intravenous N-acetylcysteine Regimens for Acetaminophen Poisoning.
Autorzy:: Cole JB; Hennepin Healthcare, Department of Emergency Medicine, Minneapolis, Minnesota.; University of Minnesota Medical School, Department of Emergency Medicine, Minneapolis, Minnesota.; Minnesota Poison Control System, Minneapolis, Minnesota.
Oakland CL; Minnesota Poison Control System, Minneapolis, Minnesota.
Lee SC; Minnesota Poison Control System, Minneapolis, Minnesota.
Considine KA; Hennepin Healthcare, Medical Intensive Care Unit, Department of Pharmacy, Minneapolis, Minnesota.
Rudis MI; Mayo Clinic, Department of Pharmacy, Rochester, Minnesota.; Mayo Clinic, Department of Emergency Medicine, Rochester, Minnesota.
Swanson AL; Children's Hospitals and Clinics of Minnesota, Department of Pharmacy, Minneapolis, Minnesota.
Olives TD; Hennepin Healthcare, Department of Emergency Medicine, Minneapolis, Minnesota.; University of Minnesota Medical School, Department of Emergency Medicine, Minneapolis, Minnesota.; Minnesota Poison Control System, Minneapolis, Minnesota.; Pokaż więcej
Źródło:: The western journal of emergency medicine [West J Emerg Med] 2023 Nov; Vol. 24 (6), pp. 1131-1145.
Typ publikacji:: Systematic Review; Journal Article
MeSH Terms:: Acetaminophen*/poisoning
Acetylcysteine*/therapeutic use
Acetylcysteine*/adverse effects
Drug Overdose*/drug therapy
Drug-Related Side Effects and Adverse Reactions*
Child ; Humans ; Analgesics, Non-Narcotic/therapeutic use ; Antidotes/therapeutic use ; Infusions, Intravenous

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Skocz do pozycji: 2.

Tytuł:: Effects of coenzyme Q10 and N-acetylcysteine on experimental poisoning by paracetamol in Wistar rats.
Autorzy:: da Silva RHS; Veterinary Toxicology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.
de Moura M; Department of Genetics, Laboratory of Mutagenesis, Federal University of Goiás, Goiânia, Goiás, Brazil.
de Paula L; Pathology Sector, Instituto de Patologia Tropical e Saúde Pública, Federal University of Goiás, Goiânia, Goiás, Brazil.
Arantes KC; Veterinary Toxicology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.
da Silva M; Veterinary Clinical Pathology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.
de Amorim J; Veterinary Clinical Pathology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.
Miguel MP; Pathology Sector, Instituto de Patologia Tropical e Saúde Pública, Federal University of Goiás, Goiânia, Goiás, Brazil.
Martins DB; Veterinary Clinical Pathology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.
de Melo E Silva D; Department of Genetics, Laboratory of Mutagenesis, Federal University of Goiás, Goiânia, Goiás, Brazil.
Melo MM; Veterinary Toxicology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Botelho AFM; Veterinary Toxicology Laboratory, Veterinary Hospital, Veterinary and Animal Science School, Federal University of Goiás, Goiânia, Goiás, Brazil.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Aug 22; Vol. 18 (8), pp. e0290268. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetylcysteine*/pharmacology
Acetylcysteine*/therapeutic use
Acetaminophen*
Adult ; Humans ; Rats ; Animals ; Rats, Wistar ; Saline Solution

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Skocz do pozycji: 3.

Tytuł:: In vitro analysis of n-acetylcysteine (NAC) interference with the international normalized ratio (INR).
Autorzy:: Minhaj FS; Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Leonard JB; Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Seung H; University of Maryland School of Pharmacy, Baltimore, MD, USA.
Anderson BD; Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Klein-Schwartz W; Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.
King JD; Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.; University of Maryland School of Medicine, Baltimore, MD, USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 Apr; Vol. 60 (4), pp. 489-492. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen*
Acetylcysteine*/therapeutic use
Administration, Intravenous ; Adult ; Female ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Prothrombin Time

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Skocz do pozycji: 4.

Tytuł:: Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia.
Autorzy:: Mészáros P; Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Pécs, Rókus utca 4, 7624 Pecs, Hungary.
Kovács S; Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Pécs, Rókus utca 4, 7624 Pecs, Hungary.
Kulcsár G; Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Pécs, Rókus utca 4, 7624 Pecs, Hungary.
Páskuj M; Sandoz Novartis Division, 018953 Targu Mures, Romania.
Almási A; Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Pécs, Rókus utca 4, 7624 Pecs, Hungary.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 07; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 07.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen*/pharmacology
Hyperglycemia*
Acetylcysteine/metabolism ; Animals ; Cytochrome P-450 CYP2E1/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Glucuronides ; Glutathione/metabolism ; Intestinal Absorption ; Prostaglandin-Endoperoxide Synthases/metabolism ; Rats ; Streptozocin ; Sulfates

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Skocz do pozycji: 5.

Tytuł:: Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020.
Autorzy:: Filip AB; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Berg SE; The Toxikon Consortium, Department of Emergency Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Mullins ME; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Schwarz ES; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.; Pokaż więcej
Corporate Authors:: Toxicology Investigators Consortium (ToxIC); American College of Medical Toxicology, Phoenix, AZ, USA.
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 Sep; Vol. 60 (9), pp. 1006-1011. Date of Electronic Publication: 2022 May 05.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen*
Chemical and Drug Induced Liver Injury*/drug therapy
Chemical and Drug Induced Liver Injury*/etiology
Acetylcysteine/therapeutic use ; Databases, Factual ; Fomepizole ; Humans

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Skocz do pozycji: 6.

Tytuł:: The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.
Autorzy:: Zhang L; College of Pharmacy, Jinan University, Guangzhou, China.
Zhang F; Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiao Y; Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Du J; School of Medicine, Jinan University, Guangzhou, China.
Zhang X; College of Pharmacy, Jinan University, Guangzhou, China.
Chen M; College of Pharmacy, Jinan University, Guangzhou, China.; Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wu B; Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Jun; Vol. 52 (6), pp. 633-643. Date of Electronic Publication: 2022 Oct 05.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen*/metabolism
Acetaminophen*/toxicity
Chemical and Drug Induced Liver Injury*/metabolism
Acetylcysteine/metabolism ; Animals ; Cytochrome P-450 CYP2E1/metabolism ; Liver/metabolism ; Luciferases/metabolism ; Luciferases/pharmacology ; Mice ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism

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Skocz do pozycji: 7.

Tytuł:: Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Autorzy:: Mohan S; Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Mahonski S; Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Hoffman RS; Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 May; Vol. 60 (5), pp. 666. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:: Letter; Comment
MeSH Terms:: Acetaminophen*/poisoning
Analgesics, Non-Narcotic*/poisoning
Acetylcysteine/therapeutic use ; Antidotes/therapeutic use ; Fomepizole/therapeutic use ; Humans

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Skocz do pozycji: 8.

Tytuł:: Reply to Comments on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Autorzy:: Link SL; Saint Louis University Pulmonary and Critical Care Medicine, St. Louis, MO, USA.
Rampon G; University of Kansas Pulmonary and Critical Care Medicine, Kansas City, MO, USA.
Osmon S; Former Saint Louis University Pulmonary and Critical Care Medicine, St. Louis, MO, USA.
Scalzo AJ; Saint Louis University Division of Toxicology, St. Louis, MO, USA.
Rumack BH; Departments of Emergency Medicine and Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 May; Vol. 60 (5), pp. 668-669. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:: Letter; Comment
MeSH Terms:: Acetaminophen*/poisoning
Analgesics, Non-Narcotic*/poisoning
Acetylcysteine/therapeutic use ; Antidotes/therapeutic use ; Fomepizole/therapeutic use ; Humans

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Skocz do pozycji: 9.

Tytuł:: Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Autorzy:: Lebin JA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Mudan A; Department of Emergency Medicine, Columbia University Medical Center, New York, NY, USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 May; Vol. 60 (5), pp. 665. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji:: Letter; Comment
MeSH Terms:: Acetaminophen*/poisoning
Analgesics, Non-Narcotic*/poisoning
Acetylcysteine/therapeutic use ; Antidotes/therapeutic use ; Fomepizole/therapeutic use ; Humans

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Skocz do pozycji: 10.

Tytuł:: Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Autorzy:: Bateman DN; Pharmacology, Toxicology & Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Dear JW; Pharmacology, Toxicology & Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Eddleston M; Pharmacology, Toxicology & Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Vale JA; City Hospital, Birmingham and University of Birmingham, Birmingham, UK.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 May; Vol. 60 (5), pp. 666-667. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:: Letter; Comment
MeSH Terms:: Acetaminophen*/poisoning
Analgesics, Non-Narcotic*/poisoning
Acetylcysteine/therapeutic use ; Antidotes/therapeutic use ; Fomepizole/therapeutic use ; Humans

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Skocz do pozycji: 11.

Tytuł:: Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Autorzy:: Chomchai S; Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Mekavuthikul P; Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Phuditshinnapatra J; Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chomchai C; Division of Science, Mahidol University International College, Nakhon Pathom, Thailand.; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Feb; Vol. 10 (1), pp. e00920.
Typ publikacji:: Journal Article
MeSH Terms:: Nomograms*
Acetaminophen/*poisoning
Antidotes/*administration & dosage
Chemical and Drug Induced Liver Injury/*etiology
Acetaminophen/administration & dosage ; Acetylcysteine/administration & dosage ; Adolescent ; Adult ; Aged ; Charcoal/administration & dosage ; Dose-Response Relationship, Drug ; Drug Overdose ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult

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Skocz do pozycji: 12.

Tytuł:: Two-bag intravenous N-acetylcysteine, antihistamine pretreatment and high plasma paracetamol levels are associated with a lower incidence of anaphylactoid reactions to N-acetylcysteine.
Autorzy:: Daoud A; Department of Clinical Medicine, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark.
Dalhoff KP; Department of Clinical Medicine, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark.; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Christensen MB; Department of Clinical Medicine, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark.; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Bøgevig S; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Petersen TS; Department of Clinical Medicine, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark.; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2020 Jul; Vol. 58 (7), pp. 698-704. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen/*poisoning
Acetylcysteine/*adverse effects
Anaphylaxis/*prevention & control
Antidotes/*adverse effects
Histamine Antagonists/*administration & dosage
Acetaminophen/pharmacokinetics ; Acetylcysteine/administration & dosage ; Administration, Intravenous ; Adolescent ; Adult ; Analgesics, Non-Narcotic/pharmacokinetics ; Analgesics, Non-Narcotic/poisoning ; Anaphylaxis/chemically induced ; Antidotes/administration & dosage ; Child ; Cohort Studies ; Drug Overdose/drug therapy ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Young Adult

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Skocz do pozycji: 13.

Tytuł:: What is the most appropriate dose of N -acetylcysteine after massive acetaminophen overdose?
Autorzy:: Hendrickson RG; a Department of Emergency Medicine , Oregon Health and Science University , Portland , OR , USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2019 Aug; Vol. 57 (8), pp. 686-691. Date of Electronic Publication: 2019 Feb 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Acetaminophen/*administration & dosage
Acetylcysteine/*administration & dosage
Analgesics, Non-Narcotic/*administration & dosage
Chemical and Drug Induced Liver Injury/*prevention & control
Drug Overdose/*drug therapy
Acetaminophen/blood ; Acetaminophen/toxicity ; Acetylcysteine/blood ; Acetylcysteine/therapeutic use ; Analgesics, Non-Narcotic/blood ; Analgesics, Non-Narcotic/toxicity ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/etiology ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Overdose/blood ; Drug Overdose/etiology ; Humans

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Skocz do pozycji: 14.

Tytuł:: Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol .
Autorzy:: Egan H; a Prince of Wales Hospital Clinical School , University of NSW , NSW , Australia.
Isbister GK; b Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Clinical Toxicology Research Group , University of Newcastle , Callaghan , NSW , Australia.
Robinson J; b Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Clinical Toxicology Research Group , University of Newcastle , Callaghan , NSW , Australia.
Downes M; b Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Clinical Toxicology Research Group , University of Newcastle , Callaghan , NSW , Australia.
Chan BS; c Department of Clinical Toxicology , Prince of Wales Hospital , Randwick , NSW , Australia.
Vecellio E; d NSW Health Pathology , Prince of Wales Hospital, Randwick , NSW , Australia.
Chiew AL; c Department of Clinical Toxicology , Prince of Wales Hospital , Randwick , NSW , Australia.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2019 Aug; Vol. 57 (8), pp. 703-711. Date of Electronic Publication: 2019 Feb 21.
Typ publikacji:: Journal Article; Observational Study
MeSH Terms:: Acetaminophen/*administration & dosage
Acetylcysteine/*therapeutic use
Alanine Transaminase/*blood
Analgesics, Non-Narcotic/*administration & dosage
Chemical and Drug Induced Liver Injury/*blood
Drug Overdose/*blood
Acetaminophen/blood ; Acetaminophen/therapeutic use ; Acetylcysteine/administration & dosage ; Adult ; Analgesics, Non-Narcotic/blood ; Analgesics, Non-Narcotic/therapeutic use ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/epidemiology ; Drug Overdose/drug therapy ; Drug Overdose/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies

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Skocz do pozycji: 15.

Tytuł:: Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine.
Autorzy:: Downs JW; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.
Cumpston KL; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.
Kershner EK; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.
Troendle MM; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.
Rose SR; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.
Wills BK; Department of Emergency Medicine, Division of Medical Toxicology, Virginia Commonwealth University Health System, Richmond, VA, USA.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Oct; Vol. 59 (10), pp. 932-936. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:: Journal Article; Observational Study
MeSH Terms:: Acetaminophen/*poisoning
Acetylcysteine/*administration & dosage
Analgesics, Non-Narcotic/*poisoning
Antidotes/*administration & dosage
Chemical and Drug Induced Liver Injury/*prevention & control
Drug Overdose/*drug therapy
Adolescent ; Adult ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Drug Administration Schedule ; Drug Overdose/diagnosis ; Female ; Humans ; Infusions, Intravenous ; Male ; Poison Control Centers ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Young Adult

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Skocz do pozycji: 16.

Tytuł:: Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Autorzy:: Wong A; a Monash Toxicology Unit and Emergency Medicine Service , Monash Health , Victoria , Australia.; b Department of Medicine, School of Clinical Sciences , Monash University , Victoria , Australia.; c Austin Toxicology Service , Austin Health , Victoria , Australia.
Homer N; d Edinburgh Clinical Research Facility , Queen's Medical Research Institute , Edinburgh , UK.
Dear JW; e Pharmacology, Toxicology and Therapeutics, University/BHF Centre for Cardiovascular Sciences , University of Edinburgh , Edinburgh , UK.
Choy KW; f Monash Pathology , Monash Health , Victoria , Australia.
Doery J; b Department of Medicine, School of Clinical Sciences , Monash University , Victoria , Australia.; f Monash Pathology , Monash Health , Victoria , Australia.
Graudins A; a Monash Toxicology Unit and Emergency Medicine Service , Monash Health , Victoria , Australia.; b Department of Medicine, School of Clinical Sciences , Monash University , Victoria , Australia.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2019 May; Vol. 57 (5), pp. 312-317. Date of Electronic Publication: 2018 Nov 19.
Typ publikacji:: Controlled Clinical Trial; Journal Article
MeSH Terms:: Drug Overdose*
Acetaminophen/*poisoning
Acetylcysteine/*administration & dosage
Analgesics, Non-Narcotic/*poisoning
Antidotes/*administration & dosage
Chemical and Drug Induced Liver Injury/*prevention & control
Poisoning/*drug therapy
Acetaminophen/blood ; Acetaminophen/pharmacokinetics ; Acetylcysteine/adverse effects ; Adolescent ; Adult ; Analgesics, Non-Narcotic/blood ; Analgesics, Non-Narcotic/pharmacokinetics ; Antidotes/adverse effects ; Biotransformation ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/diagnosis ; Female ; Humans ; Infusions, Intravenous ; Male ; Poisoning/blood ; Poisoning/diagnosis ; Treatment Outcome ; Victoria ; Young Adult

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Skocz do pozycji: 17.

Tytuł:: N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer - a case report.
Autorzy:: McDougall G; Dalhousie University, Halifax, Canada.
Murphy NG; Department of Emergency Medicine, Dalhousie University, Halifax, Canada.; IWK Regional Poison Centre, Halifax, Canada.
Loubani O; Department of Emergency Medicine, Dalhousie University, Halifax, Canada.; Department of Critical Care, Dalhousie University, Halifax, Canada.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Sep; Vol. 59 (9), pp. 840-842. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Maternal-Fetal Exchange*
Acetaminophen/*toxicity
Acetylcysteine/*therapeutic use
Analgesics, Non-Narcotic/*therapeutic use
Brain Diseases/*chemically induced
Chemical and Drug Induced Liver Injury/*drug therapy
Drug-Related Side Effects and Adverse Reactions/*drug therapy
Adult ; Brain Diseases/physiopathology ; Chemical and Drug Induced Liver Injury/physiopathology ; Drug-Related Side Effects and Adverse Reactions/physiopathology ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Risk Factors ; Treatment Outcome

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Skocz do pozycji: 18.

Tytuł:: A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Autorzy:: Dear JW; Pharmacology, Toxicology, and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Ng ML; Cardiovascular Research Institute, National University Health System, Singapore City, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.
Bateman DN; Pharmacology, Toxicology, and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Leroy Sivappiragasam P; Cardiovascular Research Institute, National University Health System, Singapore City, Singapore.
Choi H; Cardiovascular Research Institute, National University Health System, Singapore City, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research, Singapore City, Singapore.
Khoo BBJ; Cardiovascular Research Institute, National University Health System, Singapore City, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Ibrahim B; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Kepala Batas, Malaysia.
Drum CL; Cardiovascular Research Institute, National University Health System, Singapore City, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1476-1489. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji:: Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetaminophen/*poisoning
Acetylcysteine/*administration & dosage
Antidotes/*administration & dosage
Chemical and Drug Induced Liver Injury/*prevention & control
Drug Overdose/*drug therapy
Acetaminophen/pharmacokinetics ; Adult ; Biomarkers/blood ; Biomarkers/metabolism ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Drug Administration Schedule ; Drug Monitoring/methods ; Drug Overdose/blood ; Drug Overdose/etiology ; Female ; Humans ; Infusions, Intravenous ; Male ; Metabolomics ; Middle Aged ; Oxidation-Reduction/drug effects ; ROC Curve ; Sulfhydryl Compounds/blood ; Sulfhydryl Compounds/metabolism

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Skocz do pozycji: 19.

Tytuł:: Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomised controlled trial.
Autorzy:: Dear J; The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. .; Pokaż więcej
Corporate Authors:: POP Trial Investigators
Źródło:: Trials [Trials] 2019 Jan 08; Vol. 20 (1), pp. 27. Date of Electronic Publication: 2019 Jan 08.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Acetaminophen/*poisoning
Acetylcysteine/*therapeutic use
Chemical and Drug Induced Liver Injury/*drug therapy
Edetic Acid/*analogs & derivatives
Pyridoxal Phosphate/*analogs & derivatives
Acetylcysteine/administration & dosage ; Clinical Trials Data Monitoring Committees ; Clinical Trials, Phase I as Topic ; Data Interpretation, Statistical ; Drug Overdose ; Drug Therapy, Combination ; Edetic Acid/administration & dosage ; Edetic Acid/adverse effects ; Female ; Humans ; Male ; Outcome Assessment, Health Care ; Pyridoxal Phosphate/administration & dosage ; Pyridoxal Phosphate/adverse effects ; Randomized Controlled Trials as Topic ; Research Design

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Skocz do pozycji: 20.

Tytuł:: Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Autorzy:: McNulty R; a Western Sydney Toxicology Service , Westmead , Australia.; b School of Medicine , Western Sydney University , Sydney , Australia.
Lim JME; c Sydney Medical School , University of Sydney , Sydney , Australia.
Chandru P; a Western Sydney Toxicology Service , Westmead , Australia.
Gunja N; a Western Sydney Toxicology Service , Westmead , Australia.; c Sydney Medical School , University of Sydney , Sydney , Australia.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2018 Jul; Vol. 56 (7), pp. 618-621. Date of Electronic Publication: 2017 Dec 08.
Typ publikacji:: Journal Article
MeSH Terms:: Acetaminophen/*poisoning
Acetylcysteine/*adverse effects
Drug Overdose/*drug therapy
Acetylcysteine/administration & dosage ; Adult ; Anaphylaxis/chemically induced ; Chemical and Drug Induced Liver Injury/prevention & control ; Female ; Humans ; Male ; Middle Aged

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