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Wyszukujesz frazę ""ADAPTOR proteins"" wg kryterium: Temat


Tytuł :
Stable and EGF-Induced Temporal Interactome Profiling of CBL and CBLB Highlights Their Signaling Complex Diversity.
Autorzy :
Liu J; Department of Oncology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China.; The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
Yang L; Department of Oncology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China.; The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
He A; Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
Ke M; Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
Fu C; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China.
Gao W; Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
Xu R; Department of Oncology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China.; The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
Tian R; Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 Jul 02; Vol. 20 (7), pp. 3709-3719. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing*/genetics
Epidermal Growth Factor*/metabolism
Proto-Oncogene Proteins c-cbl*/genetics
Proto-Oncogene Proteins c-cbl*/metabolism
Adaptor Proteins, Vesicular Transport ; Cell Line ; Humans ; Protein-Tyrosine Kinases ; Signal Transduction ; Ubiquitination
Czasopismo naukowe
Tytuł :
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.
Autorzy :
Ciesielska A; Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur St., 02-093, Warsaw, Poland. .
Matyjek M; Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur St., 02-093, Warsaw, Poland.
Kwiatkowska K; Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur St., 02-093, Warsaw, Poland.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (4), pp. 1233-1261. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adaptor Proteins, Vesicular Transport/*genetics
Inflammation/*genetics
Lipopolysaccharide Receptors/*genetics
Toll-Like Receptor 4/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Humans ; Inflammation/chemically induced ; Inflammation/pathology ; Lipopolysaccharides/toxicity ; Membrane Glycoproteins/genetics ; Myeloid Differentiation Factor 88/genetics ; Phagocytosis/genetics ; Receptors, Interleukin-1/genetics
Czasopismo naukowe
Tytuł :
The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.
Autorzy :
Salemme V; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Angelini C; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Chapelle J; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Centonze G; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Natalini D; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Morellato A; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Taverna D; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Turco E; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
Ala U; Department of Veterinary Sciences, Università degli Studi di Torino, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy. .
Defilippi P; Department of Molecular Biotechnology and Health Science, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (4), pp. 1355-1367. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adaptor Proteins, Vesicular Transport/*genetics
Breast Neoplasms/*genetics
Carcinogenesis/*genetics
Neuroblastoma/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Breast Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Mice ; Neoplasm Metastasis ; Neuroblastoma/pathology ; Receptor, ErbB-2/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Proper E-cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer.
Autorzy :
Vazquez-Carretero MD; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
García-Miranda P; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
Balda MS; Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK.
Matter K; Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK.
Ilundáin AA; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
Peral MJ; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Feb; Vol. 236 (2), pp. 1083-1093. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Adenocarcinoma/*genetics
Apoptosis Regulatory Proteins/*genetics
Cadherins/*genetics
Colonic Neoplasms/*genetics
Adaptor Proteins, Vesicular Transport/genetics ; Adenocarcinoma/pathology ; Aged ; Animals ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/genetics ; Colitis/pathology ; Colon/metabolism ; Colon/pathology ; Colonic Neoplasms/pathology ; Dextran Sulfate/toxicity ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mice ; Middle Aged ; Polyps/genetics ; Polyps/pathology ; Rats
Czasopismo naukowe
Tytuł :
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Autorzy :
Robert Hollingsworth L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
David L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Li Y; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Griswold AR; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Ruan J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
Sharif H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Orth-He EL; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Biological Chemistry and Pharmacology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Bachovchin DA; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. .; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. .; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 189. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Ankyrins/*metabolism
Apoptosis Regulatory Proteins/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Ankyrins/chemistry ; Apoptosis ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; CARD Signaling Adaptor Proteins/chemistry ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Caspase Activation and Recruitment Domain ; Cryoelectron Microscopy ; Death Domain Receptor Signaling Adaptor Proteins/chemistry ; Death Domain Receptor Signaling Adaptor Proteins/metabolism ; HEK293 Cells ; Humans ; Inflammasomes/chemistry ; Inflammasomes/ultrastructure ; Models, Molecular ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Interaction Domains and Motifs ; Signal Transduction
Czasopismo naukowe
Tytuł :
REIC/Dkk-3 Gene Therapy Induces Immunogenic Cell Death in a Mouse Model of Malignant Mesothelioma.
Autorzy :
Araki K; Innovation Center Okayama for Nanobio-targeted Therapy, Okayama University, Okayama, Japan; .; Watarase Research Center, Kyorin Pharmaceutical Co., Ltd., Nogi-machi, Japan.
Yamamuro N; Watarase Research Center, Kyorin Pharmaceutical Co., Ltd., Nogi-machi, Japan.
Tomonobu N; Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kumon H; Innovation Center Okayama for Nanobio-targeted Therapy, Okayama University, Okayama, Japan.; Niimi University, Niimi, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Oct; Vol. 41 (10), pp. 4837-4855.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*administration & dosage
Cancer Vaccines/*administration & dosage
Immunogenic Cell Death/*drug effects
Mesothelioma, Malignant/*therapy
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Adenosine Triphosphate/metabolism ; Adenoviridae/genetics ; Animals ; Apoptosis/drug effects ; CD8 Antigens/metabolism ; Calreticulin/metabolism ; Cancer Vaccines/genetics ; Cancer Vaccines/immunology ; Combined Modality Therapy ; Genetic Therapy ; Genetic Vectors ; HMGB1 Protein/metabolism ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/therapeutic use ; Mesothelioma, Malignant/immunology ; Mice ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Autorzy :
Shen C; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.; The Sheila and David Fuente Graduate Program in Cancer Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Nayak A; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Neitzel LR; Department of Medicine, University of Maryland, Baltimore, MD, USA.
Adams AA; Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Silver-Isenstadt M; Department of Medicine, University of Maryland, Baltimore, MD, USA.
Sawyer LM; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Benchabane H; Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Wang H; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Bunnag N; Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Li B; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Wynn DT; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Yang F; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.; The Sheila and David Fuente Graduate Program in Cancer Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Garcia-Contreras M; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Williams CH; Department of Medicine, University of Maryland, Baltimore, MD, USA.
Dakshanamurthy S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Hong CC; Department of Medicine, University of Maryland, Baltimore, MD, USA.
Ayad NG; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.; Center for Therapeutic Innovation, Department of Neurological Surgery, Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
Capobianco AJ; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ahmed Y; Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Lee E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Robbins DJ; Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA. .; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. .; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5263. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Peptide Hydrolases/*genetics
Ubiquitin-Protein Ligases/*metabolism
Wnt Signaling Pathway/*physiology
Zebrafish Proteins/*genetics
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Casein Kinase Ialpha/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Embryo, Nonmammalian ; Evolution, Molecular ; HEK293 Cells ; Humans ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Lenalidomide/chemistry ; Lenalidomide/pharmacology ; Mice ; Organoids ; Peptide Hydrolases/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Autorzy :
Decout A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Katz JD; IFM Therapeutics, Boston, MA, USA.
Venkatraman S; IFM Therapeutics, Boston, MA, USA.
Ablasser A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland. .
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2021 Sep; Vol. 21 (9), pp. 548-569. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adaptor Proteins, Signal Transducing/*antagonists & inhibitors
Inflammation/*therapy
Membrane Proteins/*antagonists & inhibitors
Nucleotidyltransferases/*antagonists & inhibitors
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Animals ; Autophagy ; Cell Death ; Cell Proliferation ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/therapeutic use ; Gain of Function Mutation ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Models, Biological ; Models, Molecular ; Nucleotides, Cyclic/immunology ; Nucleotides, Cyclic/metabolism ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/immunology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
ELMO1 signaling is a promoter of osteoclast function and bone loss.
Autorzy :
Arandjelovic S; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia, Charlottesville, VA, USA. .
Perry JSA; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Zhou M; Inova Schar Cancer Institute, Inova Center for Personalized Health, Fairfax, VA, USA.
Ceroi A; Inflammation Research Centre, VIB, and the Department of Biomedical Molecular Biology, Ghent Univeristy, Ghent, Belgium.
Smirnov I; Brain Inflammation and Glia Center and Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Walk SF; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Shankman LS; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Cambré I; Inflammation Research Centre, VIB, and the Department of Biomedical Molecular Biology, Ghent Univeristy, Ghent, Belgium.
Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Elewaut D; Inflammation Research Centre, VIB, and the Department of Biomedical Molecular Biology, Ghent Univeristy, Ghent, Belgium.
Conrads TP; Inova Schar Cancer Institute, Inova Center for Personalized Health, Fairfax, VA, USA.
Ravichandran KS; Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia, Charlottesville, VA, USA. .; Inflammation Research Centre, VIB, and the Department of Biomedical Molecular Biology, Ghent Univeristy, Ghent, Belgium. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 17; Vol. 12 (1), pp. 4974. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Adaptor Proteins, Signal Transducing/*genetics
Adaptor Proteins, Signal Transducing/*metabolism
Bone Diseases, Metabolic/*metabolism
Osteoclasts/*metabolism
Osteoporosis/*metabolism
Adaptor Proteins, Signal Transducing/deficiency ; Animals ; Arthritis/pathology ; Bone Resorption/metabolism ; CRISPR-Cas Systems ; Female ; Mice ; Mice, Knockout ; Osteoprotegerin/deficiency ; Ovariectomy ; Transcriptome ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
Autorzy :
Zhu J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Li X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Cai X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Zha H; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Zhou Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Sun X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Rong F; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Tang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Zhu C; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Liu X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Fan S; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Wang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Liao Q; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Ouyang G; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Xiao W; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China; Hubei Hongshan Laboratory, Wuhan 430070, P.R. China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Aug 05; Vol. 81 (15), pp. 3171-3186.e8. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Arginine/*metabolism
Host-Pathogen Interactions/*physiology
Immunity, Innate/*physiology
Protein-Arginine N-Methyltransferases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Animals ; DEAD Box Protein 58/metabolism ; Fibroblasts/virology ; HEK293 Cells ; Herpes Simplex/immunology ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Humans ; Methylation ; Mice ; Mice, Knockout ; Polyunsaturated Alkamides ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/immunology ; Receptors, Immunologic/metabolism ; Respirovirus Infections/immunology ; Respirovirus Infections/metabolism ; Respirovirus Infections/virology ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier.
Autorzy :
Zhang H; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Lin L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Liu J; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Pan L; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Lin Z; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zhang M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Zhang J; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Cao Y; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Zhu J; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China .
Zhang R; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2021 Aug; Vol. 32 (8), pp. 1946-1960.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*chemistry
Glomerular Filtration Barrier/*chemistry
Guanylate Kinases/*chemistry
Membrane Proteins/*chemistry
Podocytes/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Biophysical Phenomena ; Cell Adhesion Molecules/genetics ; Cytoskeletal Proteins/chemistry ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Fluorescence Recovery After Photobleaching ; Glomerular Filtration Barrier/metabolism ; Glomerular Filtration Barrier/physiology ; Green Fluorescent Proteins ; Guanylate Kinases/genetics ; Humans ; Membrane Proteins/genetics ; Mice ; Molecular Structure ; Mutation ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Phase Transition ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Tytuł :
The detection of specific hypermethylated WIF1 and NPY genes in circulating DNA by crystal digital PCR™ is a powerful new tool for colorectal cancer diagnosis and screening.
Autorzy :
Overs A; Department of Oncobiology, University Hospital of Besançon, Besançon, France.; INSERM, UMR1098, UFC, Besançon, France.
Flammang M; Department of Oncobiology, University Hospital of Besançon, Besançon, France.
Hervouet E; INSERM, UMR1098, UFC, Besançon, France.
Bermont L; Department of Oncobiology, University Hospital of Besançon, Besançon, France.
Pretet JL; Department of Oncobiology, University Hospital of Besançon, Besançon, France.; EA3181, UBFC, UFC, Besançon, France.
Christophe B; INSERM, UMR1098, UFC, Besançon, France.; Department of Medical Oncology, University Hospital of Besançon, Besançon, France.
Selmani Z; Department of Oncobiology, University Hospital of Besançon, Besançon, France. .; INSERM, UMR1098, UFC, Besançon, France. .; Department of Medical Oncology, University Hospital of Besançon, Besançon, France. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 10; Vol. 21 (1), pp. 1092. Date of Electronic Publication: 2021 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Adaptor Proteins, Signal Transducing/*genetics
Circulating Tumor DNA/*genetics
Colorectal Neoplasms/*genetics
Neuropeptide Y/*genetics
Polymerase Chain Reaction/*methods
Adaptor Proteins, Signal Transducing/metabolism ; Adult ; Aged ; Aged, 80 and over ; Circulating Tumor DNA/blood ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Confidence Intervals ; Female ; Genetic Markers ; Humans ; Liquid Biopsy ; Male ; Middle Aged ; Neuropeptide Y/metabolism ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Association of GCKR Gene Polymorphisms with Metabolic Syndrome in a Han Population from Northeast China.
Autorzy :
Yu X
Duan R
Niu Y
Ding Y
Zhu B
Xu W
Bai W
Wu Y
Yu Y
Du H
Kou C
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Źródło :
Clinical laboratory [Clin Lab] 2021 Oct 01; Vol. 67 (10).
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing*/genetics
Metabolic Syndrome*/diagnosis
Metabolic Syndrome*/genetics
Asian Continental Ancestry Group/genetics ; Case-Control Studies ; China/epidemiology ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
Autorzy :
Nakatani K; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Bio Science and Engineering Laboratory, Research and Development Management Headquarters, FujiFilm Corporation, Kanagawa, Japan.
Maehama T; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Nishio M; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Otani J; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yamaguchi K; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Fukumoto M; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hikasa H; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Hagiwara S; Bio Science and Engineering Laboratory, Research and Development Management Headquarters, FujiFilm Corporation, Kanagawa, Japan.
Nishina H; Medical Research Institute, Department of Developmental and Regenerative Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Mak TW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.
Honma T; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Kondoh Y; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
Osada H; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
Yoshida M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.; Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Suzuki A; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Oct; Vol. 112 (10), pp. 4303-4316. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Acyltransferases/*antagonists & inhibitors
Adaptor Proteins, Signal Transducing/*antagonists & inhibitors
Antineoplastic Agents, Phytogenic/*pharmacology
Biological Products/*pharmacology
Lactones/*pharmacology
Reactive Oxygen Species/*metabolism
Sesquiterpenes, Eudesmane/*pharmacology
Acyltransferases/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Auranofin/pharmacology ; Cell Movement ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Self Renewal ; DNA-Binding Proteins/metabolism ; Drug Discovery ; Female ; Inula/chemistry ; Luciferases ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Nuclear Proteins/metabolism ; Phosphorylation/drug effects ; Proteolysis/drug effects ; Small Molecule Libraries ; Tongue Neoplasms/chemically induced ; Tongue Neoplasms/prevention & control ; Transcription Factors/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Dact1 is expressed during chicken and mouse skeletal myogenesis and modulated in human muscle diseases.
Autorzy :
Contriciani RE; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
da Veiga FC; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
do Amaral MJ; Faculty of Pharmacy, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brazil.
Castelucci BG; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
de Sousa LM; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
de Jesus MB; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Consonni SR; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Collares-Buzato CB; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Mermelstein C; Biomedical Sciences Institute, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brazil.
Dietrich S; Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, UK.
Alvares LE; Department of Biochemistry and Tissue Biology, University of Campinas - UNICAMP, Campinas, SP, Brazil. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2021 Oct-Dec; Vol. 256, pp. 110645. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Developmental*
Muscle Development*
Adaptor Proteins, Signal Transducing/*metabolism
Muscle, Skeletal/*metabolism
Muscular Diseases/*metabolism
Myoblasts/*metabolism
Nuclear Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Differentiation ; Cell Nucleus/metabolism ; Cell Proliferation ; Chickens ; Female ; Humans ; Mice ; Muscle, Skeletal/cytology ; Muscular Diseases/pathology ; Myoblasts/cytology ; Nuclear Proteins/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ.
Autorzy :
Günay KA; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Silver JS; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Chang TL; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Bednarski OJ; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Bannister KL; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Rogowski CJ; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Olwin BB; BioFrontiers Institute, University of Colorado, Boulder, CO, USA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA. Electronic address: .
Anseth KS; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 Oct; Vol. 277, pp. 121097. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adaptor Proteins, Signal Transducing*/metabolism
Mechanotransduction, Cellular*
Muscle Fibers, Skeletal/metabolism ; Myoblasts/metabolism ; Trans-Activators/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
MiR-145 regulates steroidogenesis in mouse primary granulosa cells through targeting Crkl.
Autorzy :
Wang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Tang W; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ma L; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, Guiyang Maternity and Child Health Care Hospital, Guiyang, Guizhou, People's Republic of China.
Yang J; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Huang K; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Du X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Luo A; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Shen W; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ding T; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Ye S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Zhou S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Yang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: .
Wang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Oct 01; Vol. 282, pp. 119820. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Cell Proliferation*
Down-Regulation*
MAP Kinase Signaling System*
Adaptor Proteins, Signal Transducing/*biosynthesis
Granulosa Cells/*metabolism
MicroRNAs/*biosynthesis
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Female ; Mice ; MicroRNAs/genetics
Czasopismo naukowe
Tytuł :
TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer.
Autorzy :
Demeule M; Theratechnologies Inc., Montréal, QC, Canada.
Charfi C; Theratechnologies Inc., Montréal, QC, Canada.
Currie JC; Theratechnologies Inc., Montréal, QC, Canada.
Larocque A; Theratechnologies Inc., Montréal, QC, Canada.
Zgheib A; Laboratoire d'Oncologie Moléculaire, Université du Québec à Montréal, Montréal, QC, Canada.
Kozelko S; Laboratoire d'Oncologie Moléculaire, Université du Québec à Montréal, Montréal, QC, Canada.
Béliveau R; Laboratoire d'Oncologie Moléculaire, Université du Québec à Montréal, Montréal, QC, Canada.
Marsolais C; Theratechnologies Inc., Montréal, QC, Canada.
Annabi B; Laboratoire d'Oncologie Moléculaire, Université du Québec à Montréal, Montréal, QC, Canada.
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Źródło :
Cancer science [Cancer Sci] 2021 Oct; Vol. 112 (10), pp. 4317-4334. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Vesicular Transport/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
Triple Negative Breast Neoplasms/*metabolism
Adaptor Proteins, Vesicular Transport/genetics ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Down-Regulation ; Drug Combinations ; Drug Discovery ; Female ; Gene Silencing ; Heterografts ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Nude ; Microtubules/drug effects ; Neoplasm Transplantation ; Neurotensin/pharmacology ; Progranulins/pharmacology ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling.
Autorzy :
Lee S; Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.
Kang H; Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.
Shin E; Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.
Jeon J; Department of Radiation Oncology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
Youn H; Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Korea.
Youn B; Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.; Department of Biological Sciences, Pusan National University, Busan 46241, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 11; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Actins/*metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Glioblastoma/*metabolism
Microtubule-Associated Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Oncogene Proteins/*metabolism
Transcription Factors/*metabolism
Actins/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Line, Tumor ; Glioblastoma/genetics ; Glioblastoma/pathology ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microtubule-Associated Proteins/genetics ; Neoplasm Transplantation ; Nerve Tissue Proteins/genetics ; Oncogene Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
TNF-α-mediated m A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis.
Autorzy :
Xie Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Yu W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Zheng G; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Li J; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Cen S; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Ye G; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Li Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Liu W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Li M; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Lin J; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Su Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Che Y; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Ye F; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China.
Wang P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China. .
Wu Y; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China. .
Shen H; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, 518000, P.R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 10; Vol. 12 (1), pp. 5373. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Mesenchymal Stem Cells/*pathology
Osteogenesis/*genetics
Spondylitis, Ankylosing/*pathology
Tumor Necrosis Factor-alpha/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Animals ; Biopsy ; Bone Marrow/pathology ; Case-Control Studies ; Cell Differentiation/genetics ; Cell Movement/genetics ; DNA Methylation ; Disease Models, Animal ; Epigenesis, Genetic ; Female ; HEK293 Cells ; Healthy Volunteers ; Humans ; Male ; Mice ; Primary Cell Culture ; Spondylitis, Ankylosing/chemically induced ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/genetics ; X-Ray Microtomography ; beta-Glucans/administration & dosage ; beta-Glucans/adverse effects
Czasopismo naukowe

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