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Tytuł :
The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.
Autorzy :
Dong W; Department of Biosciences and Nutrition, Karolinska Institutet NEO, 141 83 Huddinge, Sweden.
Prasad P; Cancer Biology Group, Institute of Life Sciences, NALCO Square, Bhubaneswar, Odhisa 751023, India.
Lennartsson A; Department of Biosciences and Nutrition, Karolinska Institutet NEO, 141 83 Huddinge, Sweden.
Ekwall K; Department of Biosciences and Nutrition, Karolinska Institutet NEO, 141 83 Huddinge, Sweden.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 11; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphatases/*metabolism
DNA-Binding Proteins/*metabolism
Nucleosomes/*metabolism
Schizosaccharomyces/*metabolism
Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/genetics ; Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Catalytic Domain ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Histones/chemistry ; Histones/genetics ; Histones/metabolism ; Nucleosomes/chemistry ; Nucleosomes/genetics ; Schizosaccharomyces/chemistry ; Schizosaccharomyces/genetics ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Implications of Adenylate Metabolism in Hygiene Assessment: A Review.
Autorzy :
Mildenhall KB; Department of Food Science, University of Wisconsin-Madison, Madison, Wisconsin 53528, USA (ORCID: https://orcid.org/0000-0001-6784-6770 [S.A.R.]).
Rankin SA; Department of Food Science, University of Wisconsin-Madison, Madison, Wisconsin 53528, USA (ORCID: https://orcid.org/0000-0001-6784-6770 [S.A.R.]).
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Źródło :
Journal of food protection [J Food Prot] 2020 Sep 01; Vol. 83 (9), pp. 1619-1631.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adenosine Triphosphate*/analysis
Food Microbiology*
Adenosine Monophosphate ; Colony Count, Microbial ; Humans ; Hygiene
Czasopismo naukowe
Tytuł :
Targeting adenosinergic pathway and adenosine A 2A receptor signaling for the treatment of COVID-19: A hypothesis.
Autorzy :
Abouelkhair MA; Department of Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, 2407 River Dr, Knoxville, TN 37996, USA. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2020 Nov; Vol. 144, pp. 110012. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
Adenosine A2 Receptor Antagonists/*therapeutic use
COVID-19/*drug therapy
Receptor, Adenosine A2A/*physiology
5'-Nucleotidase/metabolism ; Adaptive Immunity/drug effects ; Adenosine A2 Receptor Antagonists/pharmacology ; Adenosine Triphosphate/metabolism ; Apyrase/metabolism ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/metabolism ; GPI-Linked Proteins/metabolism ; Humans ; Immunity, Innate/drug effects ; Interferon-beta/physiology ; Models, Immunological ; Molecular Targeted Therapy ; SARS Virus/immunology ; SARS-CoV-2/immunology ; Signal Transduction/drug effects ; Virus Replication/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System.
Autorzy :
Rijo-Ferreira F; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
Bjorness TE; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.; Research Service, VA North Texas Health Care System, Dallas, Texas 75216-7167.
Cox KH; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
Sonneborn A; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
Greene RW; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
Takahashi JS; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111 .; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Nov 25; Vol. 40 (48), pp. 9306-9316. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Sleep*
Adenosine/*physiology
Trypanosomiasis, African/*physiopathology
Adenosine A2 Receptor Antagonists/pharmacology ; Animals ; Electroencephalography ; Electromyography ; Electrophysiological Phenomena ; Gene Expression ; Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Adenosine A2A/genetics ; Receptor, Adenosine A2A/metabolism ; Sleep Deprivation ; Trypanosoma brucei brucei
Czasopismo naukowe
Tytuł :
Identification and rescue of a tRNA wobble inosine deficiency causing intellectual disability disorder.
Autorzy :
Ramos J; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
Proven M; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
Halvardson J; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 08 Uppsala, Sweden.
Hagelskamp F; LMU Munich, Department of Chemistry, 81377 Munich, Germany.
Kuchinskaya E; Department of Clinical Genetics, and Department of Clinical Medicine, Linköping University, 581 83 Linköping, Sweden.
Phelan B; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
Bell R; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
Kellner SM; LMU Munich, Department of Chemistry, 81377 Munich, Germany.
Feuk L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 08 Uppsala, Sweden.
Thuresson AC; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 08 Uppsala, Sweden.
Fu D; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Nov; Vol. 26 (11), pp. 1654-1666. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mutation, Missense*
Adenosine Deaminase/*genetics
Adenosine Deaminase/*metabolism
Intellectual Disability/*genetics
RNA, Transfer/*chemistry
RNA-Binding Proteins/*genetics
RNA-Binding Proteins/*metabolism
Active Transport, Cell Nucleus ; Adenosine/metabolism ; Adenosine Deaminase/chemistry ; Adolescent ; Binding Sites ; Cells, Cultured ; Child ; Child, Preschool ; Codon, Terminator ; Female ; Genetic Predisposition to Disease ; Humans ; Inosine/metabolism ; Intellectual Disability/metabolism ; Male ; Pedigree ; Protein Domains ; RNA-Binding Proteins/chemistry ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
"Adenosine an old player with new possibilities in kidney diseases": Preclinical evidences and clinical perspectives.
Autorzy :
Pandey S; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Aggarwal D; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Gupta K; Department of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India.
Kumari A; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Sen P; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Singh R; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Joshi JC; Department of Pharmacology, College of Medicine, University of Illinois at Chicago, USA.
Sharma VV; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Mehra K; Department of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India.
Singh G; Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118834. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adenosine/*metabolism
Kidney Diseases/*physiopathology
Receptors, Purinergic P1/*metabolism
Acute Kidney Injury/drug therapy ; Acute Kidney Injury/physiopathology ; Adenosine Kinase/antagonists & inhibitors ; Adenosine Kinase/metabolism ; Animals ; Humans ; Kidney Diseases/drug therapy ; Reperfusion Injury/physiopathology
Czasopismo naukowe
Tytuł :
NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV.
Autorzy :
Zhao B; Department of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Section of Computational and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Rm. 5428, Los Angeles, CA 90089, USA.
Naila T; Department of Internal Medicine and Molecular Genetics and Microbiology, and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, 915 Camino de Salud, Albuquerque, NM 87131, USA.
Lieber MR; Department of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Section of Computational and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Rm. 5428, Los Angeles, CA 90089, USA.
Tomkinson AE; Department of Internal Medicine and Molecular Genetics and Microbiology, and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, 915 Camino de Salud, Albuquerque, NM 87131, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. 12746-12750.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adenosine Diphosphate Ribose/*genetics
DNA/*genetics
DNA Ligase ATP/*genetics
NAD/*genetics
Adenosine Monophosphate/genetics ; Adenosine Triphosphate/genetics ; Amino Acid Sequence/genetics ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; Humans
Czasopismo naukowe
Tytuł :
Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2.
Autorzy :
Dos Anjos F; Medical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Simões JLB; Medical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Assmann CE; Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Carvalho FB; Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Bagatini MD; Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
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Źródło :
Journal of immunology research [J Immunol Res] 2020 Dec 01; Vol. 2020, pp. 8632048. Date of Electronic Publication: 2020 Dec 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2*
Adenosine Triphosphate/*metabolism
COVID-19/*immunology
Cardiovascular Diseases/*virology
Receptors, Purinergic/*metabolism
Adenosine A2 Receptor Agonists/pharmacology ; COVID-19/drug therapy ; COVID-19/metabolism ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/physiopathology ; Cytokines/metabolism ; Humans ; Myocardial Ischemia/immunology ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/virology ; Pandemics ; Purinergic Antagonists/pharmacology ; Receptor, Adenosine A2A/metabolism ; Receptor, Adenosine A3/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Pharmacological characterisation of novel adenosine A 3 receptor antagonists.
Autorzy :
Barkan K; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
Lagarias P; Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Stampelou M; Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Stamatis D; Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Hoare S; Pharmechanics LLC, 14 Sunnyside Drive South, Owego, NY, 13827, USA.
Safitri D; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.; Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung, 40534, Indonesia.
Klotz KN; Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
Vrontaki E; Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Kolocouris A; Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece. .
Ladds G; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 27; Vol. 10 (1), pp. 20781. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine A3 Receptor Antagonists/*chemistry
Adenosine A3 Receptor Antagonists/*pharmacology
Adenosine A3 Receptor Antagonists/pharmacokinetics ; Animals ; Binding Sites/genetics ; Binding, Competitive ; CHO Cells ; Cricetulus ; Cyclic AMP/metabolism ; Drug Evaluation, Preclinical ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Radioligand Assay ; Rats ; Receptor, Adenosine A3/chemistry ; Receptor, Adenosine A3/genetics ; Receptor, Adenosine A3/metabolism ; Receptors, Purinergic P1/chemistry ; Receptors, Purinergic P1/genetics ; Receptors, Purinergic P1/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Species Specificity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Adenosine A 2A Receptor Antagonists for Cancer Immunotherapy.
Autorzy :
Yu F; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Zhu C; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
Wang Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12196-12212. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunotherapy*
Adenosine A2 Receptor Antagonists/*chemistry
Neoplasms/*therapy
Adenosine A2 Receptor Antagonists/pharmacology ; Adenosine A2 Receptor Antagonists/therapeutic use ; Humans ; Neoplasms/pathology ; Receptor, Adenosine A2A/chemistry ; Receptor, Adenosine A2A/metabolism ; Receptor, Adenosine A2B/chemistry ; Receptor, Adenosine A2B/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Structure-Activity Relationship ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Suppression of adenosine A 2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1.
Autorzy :
Yang Y; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Zhang H; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Lu Q; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Liu X; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Fan Y; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Zhu J; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Sun B; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Zhao J; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.
Dong X; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China. Electronic address: .
Li L; Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114340. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine A2 Receptor Antagonists/*therapeutic use
Cyclophosphamide/*toxicity
Cystitis/*drug therapy
Hyperalgesia/*drug therapy
TRPV Cation Channels/*antagonists & inhibitors
Urinary Bladder, Overactive/*drug therapy
Adenosine A2 Receptor Antagonists/pharmacology ; Animals ; Antineoplastic Agents, Alkylating/toxicity ; Cystitis/chemically induced ; Cystitis/metabolism ; Female ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, Adenosine A2A/biosynthesis ; TRPV Cation Channels/biosynthesis ; Triazines/pharmacology ; Triazoles/pharmacology ; Urinary Bladder/drug effects ; Urinary Bladder/metabolism ; Urinary Bladder, Overactive/chemically induced ; Urinary Bladder, Overactive/metabolism
Czasopismo naukowe
Tytuł :
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?
Autorzy :
Russell FM; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland DD1 5EH, UK.
Hardie DG; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland DD1 5EH, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 27; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
AMP-Activated Protein Kinases/*antagonists & inhibitors
AMP-Activated Protein Kinases/*metabolism
Adenosine Monophosphate/*pharmacology
Energy Metabolism/*physiology
Neoplasms/*metabolism
Protein Kinase Inhibitors/*pharmacology
Signal Transduction/*drug effects
AMP-Activated Protein Kinases/chemistry ; AMP-Activated Protein Kinases/genetics ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Triphosphate/biosynthesis ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; DNA Damage/genetics ; DNA Damage/physiology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Phosphorylation/drug effects ; Signal Transduction/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Probing Cooperativity of N-Terminal Domain Orientations in the p97 Molecular Machine: Synergy Between NMR Spectroscopy and Cryo-EM.
Autorzy :
Huang R; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Program in Molecular Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.; Department of Molecular Genetics and Chemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Chemistry, University of Guelph, Guelph, Ontario, N1G 1Y4, Canada.
Ripstein ZA; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Program in Molecular Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
Rubinstein JL; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Program in Molecular Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
Kay LE; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Program in Molecular Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.; Department of Molecular Genetics and Chemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Dec 07; Vol. 59 (50), pp. 22423-22426. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphatases/*metabolism
Nuclear Proteins/*metabolism
Adenosine Triphosphatases/chemistry ; Adenosine Triphosphate/metabolism ; Cryoelectron Microscopy ; Homeostasis ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Nuclear Proteins/chemistry
Czasopismo naukowe
Tytuł :
Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis.
Autorzy :
Gao S
Thompson EJ
Barrow SL
Zhang W; David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Iavarone AT
Klinman JP
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Nov 25; Vol. 142 (47), pp. 19936-19949. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hydrogen Deuterium Exchange-Mass Spectrometry*
Adenosine Deaminase/*metabolism
Adenosine/metabolism ; Adenosine Deaminase/chemistry ; Adenosine Deaminase/genetics ; Animals ; Binding Sites ; Biocatalysis ; Deamination ; Kinetics ; Mice ; Mutagenesis, Site-Directed ; Protein Structure, Tertiary ; Substrate Specificity ; Temperature
Czasopismo naukowe
Tytuł :
Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter.
Autorzy :
Xavier BM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Zein AA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Venes A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Biomedical Sciences Program, Department of Biology, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Wang J; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15206, USA.
Lee JY; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 19; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 5/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 8/*metabolism
Adenosine Triphosphatases/*metabolism
Cholesterol/*metabolism
Cholesterol Esters/*metabolism
Cholic Acid/*metabolism
Lipoproteins/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 5/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 8/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 8/genetics ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Binding Sites ; Biological Transport ; Cholesterol/chemistry ; Cholesterol Esters/chemistry ; Cholic Acid/chemistry ; Gene Expression ; Humans ; Hypercholesterolemia/genetics ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/pathology ; Intestinal Diseases/genetics ; Intestinal Diseases/metabolism ; Intestinal Diseases/pathology ; Kinetics ; Lipid Metabolism, Inborn Errors/genetics ; Lipid Metabolism, Inborn Errors/metabolism ; Lipid Metabolism, Inborn Errors/pathology ; Lipoproteins/chemistry ; Lipoproteins/genetics ; Models, Molecular ; Mutation ; Phytosterols/adverse effects ; Phytosterols/genetics ; Phytosterols/metabolism ; Pichia/chemistry ; Pichia/genetics ; Pichia/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thermodynamics
SCR Disease Name :
Sitosterolemia
Czasopismo naukowe
Tytuł :
ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter.
Autorzy :
Lacabanne D; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.; Medical Research Council Mitochondrial Biology Unit University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Hills Road, Cambridge CB2 0XY, UK.
Wiegand T; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Wili N; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Kozlova MI; Department of Physics, Osnabrueck University, 49069 Osnabrueck, Germany.
Cadalbert R; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Klose D; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Mulkidjanian AY; Department of Physics, Osnabrueck University, 49069 Osnabrueck, Germany.; School of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Meier BH; Laboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Böckmann A; Molecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, 69367 Lyon, France.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 12; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
ATP-Binding Cassette Transporters/*metabolism
Adenosine Triphosphate/*chemistry
Bacillus subtilis/*enzymology
DnaB Helicases/*metabolism
Helicobacter pylori/*enzymology
Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/analogs & derivatives ; Adenylyl Imidodiphosphate/chemistry ; Aluminum Compounds/chemistry ; Bacterial Proteins/metabolism ; Electron Spin Resonance Spectroscopy ; Electrons ; Fluorides/chemistry ; Hydrolysis ; Magnetic Resonance Spectroscopy ; Protein Conformation
Czasopismo naukowe
Tytuł :
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling.
Autorzy :
Chang D; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Whiteley AT; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309.
Bugda Gwilt K; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Lencer WI; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115.
Mekalanos JJ; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115; .; Department of Microbiology, Harvard Medical School, Boston, MA 02115.
Thiagarajah JR; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115; .; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27502-27508. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Immunity, Mucosal*
Adenosine/*metabolism
Epithelial Cells/*metabolism
Nucleotides, Cyclic/*metabolism
5'-Nucleotidase/metabolism ; Cell Line, Tumor ; Chlorides/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelial Cells/immunology ; GPI-Linked Proteins/metabolism ; Humans ; Interferon-beta/metabolism ; Intestinal Mucosa/cytology ; Phosphoric Diester Hydrolases/metabolism ; Poly I-C/immunology ; Pyrophosphatases/metabolism ; Receptor, Adenosine A2B/metabolism ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification.
Autorzy :
Zhu M; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, No. 1 Shizishan Street, Wuhan, 430070, P. R. China.
Wang L; Key Laboratory of Tropical Marine Bio-resources and Ecology RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
He J; State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, No. 1 Shizishan Street, Wuhan, 430070, P. R. China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jan 25; Vol. 60 (4), pp. 2030-2035. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Monophosphate/*metabolism
Butyric Acid/*metabolism
Enzymes/*metabolism
Adenosine Triphosphate/metabolism ; Catalysis ; Enzyme Stability ; Esterification ; Streptomyces/enzymology ; Streptomyces/metabolism ; Substrate Specificity ; Sulfhydryl Compounds/metabolism
SCR Organism :
Streptomyces thioluteus
Czasopismo naukowe
Tytuł :
Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.
Autorzy :
Province HS; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Xiao C; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Mogul AS; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Sahoo A; Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Jacobson KA; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Piñol RA; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Gavrilova O; Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
Reitman ML; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 16; Vol. 15 (12), pp. e0243986. Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Hypothermia/*metabolism
Receptor, Adenosine A1/*metabolism
Adenosine A1 Receptor Agonists/pharmacology ; Animals ; Hypothalamus/metabolism ; Hypothalamus/physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Peripheral Nerves/metabolism ; Peripheral Nerves/physiopathology
Czasopismo naukowe

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