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Tytuł :
Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
Autorzy :
Zhang L; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Zhang B; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Yu Y; Department of General Practice, Zhongshan Hospital, Fudan University.
Wang J; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Wu J; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Su Y; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Jiang H; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Zou Y; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
Ge J; Department of Cardiology, Zhongshan Hospital, Fudan University.; Shanghai Institute of Cardiovascular Diseases.
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Źródło :
International heart journal [Int Heart J] 2021 Jan 30; Vol. 62 (1), pp. 162-170. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*pharmacology
HMGB1 Protein/*drug effects
Losartan/*pharmacology
Myocardium/*metabolism
Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Aorta/pathology ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Case-Control Studies ; Constriction ; HMGB1 Protein/blood ; HMGB1 Protein/metabolism ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Losartan/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Up-Regulation ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Tytuł :
Differential responses of bone to angiotensin II and angiotensin(1-7): beneficial effects of ANG(1-7) on bone with exposure to high glucose.
Autorzy :
Sha NN; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.
Zhang JL; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Poon CC; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, China.
Li WX; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li Y; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang YF; National TCM Clinical Research Base of Hypertension, the affiliated Hospital of Shandong University of TCM, Jinan, China.
Shi W; National TCM Clinical Research Base of Hypertension, the affiliated Hospital of Shandong University of TCM, Jinan, China.
Lin FH; Department of Orthopaedic, Shenzhen Pingle Orthopaedic Hospital, Shenzhen, China.
Lin WP; Department of Orthopaedic, Shenzhen Pingle Orthopaedic Hospital, Shenzhen, China.
Wang YJ; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.
Zhang Y; Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Jan 01; Vol. 320 (1), pp. E55-E70. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin I/*pharmacology
Angiotensin II/*pharmacology
Bone Density Conservation Agents/*pharmacology
Bone and Bones/*drug effects
Glucose/*adverse effects
Peptide Fragments/*pharmacology
3T3 Cells ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Bone Density/drug effects ; Bone Development/drug effects ; Male ; Mice ; Osteoblasts/drug effects ; Osteoclasts/drug effects ; Osteoporosis/prevention & control ; Phosphorylation/drug effects ; RAW 264.7 Cells ; Rats ; Rats, Inbred SHR
Czasopismo naukowe
Tytuł :
The effect of olmesartan on aortic intimal thickening after balloon injury through Apelin/APJ.
Autorzy :
Li Y; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China. Electronic address: .
Guo J; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Yu H; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Zhou J; Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Chu X; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Hou B; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Ge J; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Li T; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Duan S; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Xu H; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
Yang X; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.
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Źródło :
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2020 Nov - Dec; Vol. 49, pp. 107230. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Neointima*
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Apelin/*metabolism
Apelin Receptors/*metabolism
Imidazoles/*pharmacology
Muscle, Smooth, Vascular/*drug effects
Myocytes, Smooth Muscle/*drug effects
Tetrazoles/*pharmacology
Vascular System Injuries/*drug therapy
Angioplasty, Balloon ; Angiotensin II/metabolism ; Animals ; Aorta/drug effects ; Aorta/injuries ; Aorta/metabolism ; Aorta/pathology ; Cell Proliferation/drug effects ; Constriction, Pathologic ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Male ; Muscle, Smooth, Vascular/injuries ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Phosphorylation ; Rats, Wistar ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; Vascular System Injuries/etiology ; Vascular System Injuries/metabolism ; Vascular System Injuries/pathology
Czasopismo naukowe
Tytuł :
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Autorzy :
Wang Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takeshita H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yamamoto K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Huang Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Wang C; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakajima T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nozato Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Fujimoto T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yokoyama S; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Hongyo K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Nakagami F; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Akasaka H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takami Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Takeya Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Sugimoto K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Rakugi H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Mar; Vol. 35 (3), pp. e21419.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Angiotensin II/*pharmacology
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*metabolism
Losartan/*pharmacology
ADAM17 Protein/genetics ; ADAM17 Protein/metabolism ; Angiotensin II/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Furin/genetics ; Furin/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Losartan/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Vasoconstrictor Agents/pharmacology
Czasopismo naukowe
Tytuł :
Angiotensin II enhances the proliferation of Natural Killer/T-cell lymphoma cells via activating PI3K/Akt signaling pathway.
Autorzy :
Zhang GH; Department of Hematology, The Second Affiliated Hospital of Xuzhou Medical University, General Hospital of Xuzhou Coal Mining Group, Xuzhou, China.
Miao FA; Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xu JG; Department of Hematology, The Second Affiliated Hospital of Xuzhou Medical University, General Hospital of Xuzhou Coal Mining Group, Xuzhou, China.
Zhang Y; Department of Hematology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Oct 30; Vol. 40 (10).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin II/*metabolism
Lymphoma, Extranodal NK-T-Cell/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Aged ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Female ; Heterocyclic Compounds, 3-Ring/pharmacology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Losartan/pharmacology ; Losartan/therapeutic use ; Lymph Nodes/pathology ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Male ; Middle Aged ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-akt/analysis ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Receptor, Angiotensin, Type 1/analysis ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction/drug effects ; Wortmannin/pharmacology ; Wortmannin/therapeutic use ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Apelin-potential therapy for COVID-19?
Autorzy :
Saeedi Saravi SS; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland.
Beer JH; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Aug; Vol. 145, pp. 84-87. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Apelin/*therapeutic use
Apelin Receptors/*therapeutic use
Betacoronavirus/*metabolism
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*drug therapy
Angiotensin I/metabolism ; Angiotensin II/biosynthesis ; Angiotensin II/blood ; Angiotensin-Converting Enzyme 2 ; Animals ; Apelin/metabolism ; Apelin Receptors/agonists ; Apelin Receptors/metabolism ; COVID-19 ; Coronavirus Infections/virology ; Drug Repositioning/methods ; Humans ; Mice ; Pandemics ; Peptide Fragments/metabolism ; Pneumonia, Viral/virology ; Receptor, Angiotensin, Type 1/metabolism ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/immunology ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats.
Autorzy :
Zhan C; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Bai N; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Zheng M; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Wang Y; Department of Digestion, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China.
Wang Y; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Zhang L; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Li J; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Li G; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Zhao H; Department of Cardiology, The People's Hospital of Liaoning Province, Shenyang 110015, China.
Liu G; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Lou Q; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Yang W; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Li T; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Li L; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Li W; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 15; Vol. 267, pp. 118984. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II/*drug effects
Cardiomegaly/*metabolism
Doxorubicin/*adverse effects
ortho-Aminobenzoates/*pharmacology
Angiotensin II/biosynthesis ; Angiotensin II/metabolism ; Animals ; Antioxidants/pharmacology ; Cardiomegaly/drug therapy ; Doxorubicin/pharmacology ; Fibrosis ; Heart Diseases/etiology ; Male ; Mast Cells/drug effects ; Myocardium/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; ortho-Aminobenzoates/metabolism
Czasopismo naukowe
Tytuł :
The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system.
Autorzy :
Offringa A; Microbiology and System Biology, Netherlands Organisation for Applied Scientific Research, The Hague, The Netherlands.
Montijn R; Microbiology and System Biology, Netherlands Organisation for Applied Scientific Research, The Hague, The Netherlands.
Singh S; Vascular Medicine, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.; Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Paul M; Faculty of Health Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands.
Pinto YM; Cardiology, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Pinto-Sietsma SJ; Vascular Medicine, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.; Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
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Źródło :
European heart journal. Cardiovascular pharmacotherapy [Eur Heart J Cardiovasc Pharmacother] 2020 Sep 01; Vol. 6 (5), pp. 317-325.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Antiviral Agents/*therapeutic use
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*drug therapy
Renin-Angiotensin System/*drug effects
Virus Internalization/*drug effects
Angiotensin II/metabolism ; Animals ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Endocytosis/drug effects ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/therapeutic use ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
[Angiotensin Ⅱ inhibits AMPK/SIRT1 pathway by inducing oxidative stress in RAW264.7 macrophages].
Autorzy :
Xiao S; Department of Pharmacy, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Ma Y; Department of Pharmacy, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Li J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 511400, China.
Zhang Y; Department of Traditional Chinese Medicine, Guangzhou First People's Hospital, Guangzhou 511400, China.
He H; Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 511400, China.
Fang C; Department of Pharmacy, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Wang W; General Hospital of the Yangtze River Shipping, Wuhan 430000, China.; Wuhan Brain Hospital, Wuhan 430000, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Mar 25; Vol. 41 (3), pp. 384-390.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II*/pharmacology
Sirtuin 1*/genetics
Sirtuin 1*/metabolism
AMP-Activated Protein Kinases/metabolism ; Macrophages/metabolism ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Preparation and Evaluation of Co-amorphous Formulations of Telmisartan-Amino Acids as a Potential Method for Solubility and Dissolution Enhancement.
Autorzy :
Khanfar M; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. .
Al-Remawi M; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan.
Al-Akayleh F; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan.
Hmouze S; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Mar 21; Vol. 22 (3), pp. 112. Date of Electronic Publication: 2021 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acids/*chemistry
Angiotensin II Type 1 Receptor Blockers/*administration & dosage
Telmisartan/*administration & dosage
Angiotensin II Type 1 Receptor Blockers/chemistry ; Buffers ; Calorimetry, Differential Scanning ; Drug Compounding ; Drug Liberation ; Drug Stability ; Solubility ; Telmisartan/chemistry ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Impact of Sacubitril-Valsartan Treatment on Diastolic Function in Patients with Heart Failure and Reduced Ejection Fraction.
Autorzy :
Pericas P; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain. .; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain. .
Mas-Lladó C; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Ramis-Barceló MF; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Valadrón I; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Noris Mora M; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Pasamar Márquez L; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
González Colino R; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Forteza Albertí JF; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Peral Disdier V; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.
Rossello X; Cardiology Department, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.; Grupo de investigación de Fisiopatología y Terapéutica Cardiovascular, Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
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Źródło :
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension [High Blood Press Cardiovasc Prev] 2021 Mar; Vol. 28 (2), pp. 167-175. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Aminobutyrates/*therapeutic use
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Heart Failure/*drug therapy
Neprilysin/*antagonists & inhibitors
Protease Inhibitors/*therapeutic use
Stroke Volume/*drug effects
Tetrazoles/*therapeutic use
Ventricular Function, Left/*drug effects
Aged ; Aminobutyrates/adverse effects ; Angiotensin II Type 1 Receptor Blockers/adverse effects ; Diastole ; Drug Combinations ; Echocardiography ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Protease Inhibitors/adverse effects ; Recovery of Function ; Tetrazoles/adverse effects ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study.
Autorzy :
Khan AA; Department of Chemistry, University of Gour Banga, Mokdumpur, Malda, 732103, India. Electronic address: .
Baildya N; Department of Chemistry, University of Kalyani, Kalyani, 741235, India. Electronic address: .
Dutta T; Departments of Chemistry, JIS College of Engineering, Kalyani, 741235, India. Electronic address: .
Ghosh NN; Department of Chemistry, University of Gour Banga, Mokdumpur, Malda, 732103, India. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Mar; Vol. 152, pp. 104762. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II Type 2 Receptor Blockers/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drug Evaluation, Preclinical/*methods
SARS-CoV-2/*drug effects
Angiotensin II Type 2 Receptor Blockers/chemistry ; Antiviral Agents/chemistry ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł :
Effects of SET7 on angiotensin II-mediated proliferation and collagen synthesis of myocardial fibroblasts and its mechanisms.
Autorzy :
Ma H; Department of Cardiovascular Medicine, Xi'an NO.1 Hospital, Xi'an 710002, China. .
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Transliterated Title :
SET7对Ang II介导的心肌成纤维细胞增殖和胶原合成的影响及其机制.
Źródło :
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences [Zhong Nan Da Xue Xue Bao Yi Xue Ban] 2021 Feb 28; Vol. 46 (2), pp. 135-141.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin II*/pharmacology
Hedgehog Proteins*
Cell Proliferation ; Cells, Cultured ; Collagen/genetics ; Fibroblasts
Czasopismo naukowe
Tytuł :
Alteration of the Renin-Angiotensin-Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3.
Autorzy :
Picod A; INSERM U942 MASCOT Paris, France and.; University of Paris Paris, France.
Deniau B; INSERM U942 MASCOT Paris, France and.; University of Paris Paris, France.
Vaittinada Ayar P; INSERM U942 MASCOT Paris, France and.; University of Paris Paris, France.
Genest M; INSERM U942 MASCOT Paris, France and.
Julian N; INSERM U942 MASCOT Paris, France and.; University of Paris Paris, France.
Azibani F; INSERM U942 MASCOT Paris, France and.
Mebazaa A; INSERM U942 MASCOT Paris, France and.; University of Paris Paris, France.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Feb 15; Vol. 203 (4), pp. 526-527.
Typ publikacji :
Letter; Comment
MeSH Terms :
Angiotensin II*
Renin*
Catecholamines ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Humans ; Renin-Angiotensin System
Opinia redakcyjna
Tytuł :
Reply to Picod et al. : Alteration of the Renin-Angiotensin-Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3.
Autorzy :
Chawla LS; Veterans Affairs Medical Center San Diego, California and.
Bellomo R; The University of Melbourne Melbourne, Victoria, Australia.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Feb 15; Vol. 203 (4), pp. 527-528.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Angiotensin II*
Renin*
Catecholamines ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Humans ; Renin-Angiotensin System
Raport
Tytuł :
Outside-in Signaling by Adventitial Fibroblasts.
Autorzy :
Schickling BM; Department of Medicine, Duke University, Durham, NC.
Miller FJ Jr; Department of Medicine, Duke University, Durham, NC.; Wake Forest University, Winston-Salem, NC.; Veterans Affairs Medical Center, Salisbury, NC.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Feb; Vol. 41 (2), pp. 711-713.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Comment
MeSH Terms :
Angiotensin II*
Hypertension*
Fibroblasts ; Humans ; Muscle, Smooth, Vascular ; Paracrine Communication ; Vascular Remodeling
Czasopismo naukowe
Tytuł :
Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis.
Autorzy :
Shu J; Department of Gerontology, Shibei Hospital of Jing'an District, Shanghai 200443, P.R. China.
Gu Y; Department of Gerontology, Shibei Hospital of Jing'an District, Shanghai 200443, P.R. China.
Jin L; Department of Gerontology, Shibei Hospital of Jing'an District, Shanghai 200443, P.R. China.
Wang H; Department of Gerontology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2), pp. 1. Date of Electronic Publication: 2020 Dec 20.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Angiotensin II/*pharmacology
Fibrosis/*genetics
Heart/*physiopathology
Matrix Metalloproteinase 3/*metabolism
Angiotensin II/metabolism ; Animals ; Cell Movement ; Cell Survival ; Cells, Cultured ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Fibrosis/physiopathology ; Heart/drug effects ; Myocardium/metabolism ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization.
Autorzy :
Qi Y; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Liang X; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Dai F; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Guan H; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Sun J; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
Yao W; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, Jiangsu, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 29; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Actin Cytoskeleton/*drug effects
Angiotensin II/*pharmacology
Cell Dedifferentiation/*drug effects
Myocytes, Smooth Muscle/*drug effects
Receptor, Angiotensin, Type 1/*genetics
rho-Associated Kinases/*genetics
rhoA GTP-Binding Protein/*genetics
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Actins/genetics ; Actins/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Cell Line ; Cell Movement/drug effects ; Gene Expression Regulation ; Humans ; Irbesartan/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Polymerization/drug effects ; Protein Kinase Inhibitors/pharmacology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; Vasodilator Agents/pharmacology ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/antagonists & inhibitors ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules: Novel Roles of Mitochondrial Ang II/AT 1a /O 2 and Ang II/AT and Ang II/AT 2 /NO Signaling.
Autorzy :
Li XC; From the Tulane Hypertension and Renal Center of Excellence (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.; Department of Physiology (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.; Department of Pharmacology and Toxicology (X.C.L., J.L.Z.), University of Mississippi Medical Center, Jackson.
Zhou X; Department of Pathology (X.Z.), University of Mississippi Medical Center, Jackson.
Zhuo JL; From the Tulane Hypertension and Renal Center of Excellence (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.; Department of Physiology (X.C.L., J.L.Z.), Tulane University School of Medicine, New Orleans, LA.; Department of Pharmacology and Toxicology (X.C.L., J.L.Z.), University of Mississippi Medical Center, Jackson.
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2020 Jul; Vol. 76 (1), pp. 121-132. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Angiotensin II/*physiology
Kidney Tubules, Proximal/*physiology
Mitochondria/*physiology
Receptor, Angiotensin, Type 1/*physiology
Receptor, Angiotensin, Type 2/*physiology
Signal Transduction/*physiology
Angiotensin II Type 2 Receptor Blockers/pharmacology ; Animals ; Cells, Cultured ; Glycolysis ; Hypertension/physiopathology ; Imidazoles/pharmacology ; Kidney Cortex/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NG-Nitroarginine Methyl Ester/pharmacology ; Organophosphorus Compounds/pharmacology ; Piperidines/pharmacology ; Pyridines/pharmacology ; Receptor, Angiotensin, Type 1/deficiency ; Sodium/metabolism ; Sodium-Bicarbonate Symporters/metabolism ; Sodium-Hydrogen Exchanger 1/deficiency ; Sodium-Hydrogen Exchanger 1/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł :
Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats.
Autorzy :
da Silva-Bertani DCT; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Vileigas DF; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Mota GAF; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
de Souza SLB; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Sant'Ana PG; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Freire PP; Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo 18618970, Brazil.
de Tomasi LC; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Corrêa CR; Department of Pathology, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil.
Padovani CR; Department of Biostatistics, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo 18618970, Brazil.
Fernandes T; Laboratory of Biochemistry and Molecular Biology of the Exercise, School of Physical Education and Sport, University of São Paulo (USP), 05508-900 São Paulo, Brazil.
de Oliveira EM; Laboratory of Biochemistry and Molecular Biology of the Exercise, School of Physical Education and Sport, University of São Paulo (USP), 05508-900 São Paulo, Brazil.
Cicogna AC; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo 18618687, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Jul 01; Vol. 252, pp. 117650. Date of Electronic Publication: 2020 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adipose Tissue/*metabolism
Angiotensin II/*metabolism
Myocardium/*pathology
Obesity/*physiopathology
Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Collagen Type I/metabolism ; Collagen Type III/metabolism ; Diet, High-Fat/adverse effects ; Fibrosis ; Losartan/pharmacology ; Male ; Myocardium/metabolism ; Rats ; Rats, Wistar ; Renin-Angiotensin System/physiology
Czasopismo naukowe

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